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Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Jan 1, 2025 | 9:32 AM IST

Kabimustine 100 mg Injection 1's is used to treat Non-Hodgkin's disease and Chronic Lymphocytic Leukaemia. Kabimustine 100 mg Injection 1's contains Bendamustine; it works by inhibiting the DNA and RNA transcription that is essential for protein synthesis. This causes shrinkage of tumor cells and thereby prevents the growth and further spread of cancerous or non-cancerous cells. This medication is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand.

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Prescription drug

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Synonym :

BENDAMUSTINE HYDROCHLORIDE

Composition :

BENDAMUSTINE-100MG

Manufacturer/Marketer :

Fresenius Kabi India Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

About Kabimustine 100 mg Injection 1's

Kabimustine 100 mg Injection 1's belongs to a class of anti-cancer medicines used in the treatment of Leukemia. Leukemia, also known as blood cancer, is a cancer of blood cells or blood-forming tissues. This medicine is used in the treatment of Chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin’s leukemia (NHL) that has progressed during six months of treatment with rituximab or rituximab-containing treatment.

Kabimustine 100 mg Injection 1's contains Bendamustine, which belongs to the alkylating agents class. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis.

Kabimustine 100 mg Injection 1's may cause certain side effects, such as nausea, vomiting, diarrhea, stomach pain, anorexia, decreased weight, constipation, fever, decreased platelet count, fatigue, cough, headache, rash, injection site reactions and pain at the site of injection. If the side effects bother you, inform your doctor. A trained healthcare professional will administer Kabimustine 100 mg Injection 1's. Hence, do not self-administer.

Kabimustine 100 mg Injection 1's should be avoided if you are allergic to it or any other components present in it. Before receiving this injection, inform your doctor if you have any pre-existing or a history of liver/kidney disease, cardiac disorders, cancer, active infections, skin problems, or any allergic conditions. Kabimustine 100 mg Injection 1's is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand.

Uses of Kabimustine 100 mg Injection 1's

Treatment of Non-Hodgkin's disease and Chronic Lymphocytic Leukaemia

Medicinal Benefits

Kabimustine 100 mg Injection 1's contains Bendamustine, which belongs to the class of alkylating agents. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis. This causes shrinkage of tumor cells and thereby prevents the growth and further spread of cancerous or non-cancerous cells. This medicine is used in the treatment of chronic lymphocytic leukemia and non-Hodgkin’s leukemia.

Side Effects of Kabimustine 100 mg Injection 1's

  • Diarrhoea
  • Back pain
  • Vomiting
  • Stomach pain
  • Cough
  • Bruising or bleeding gums
  • Pain at the site of injection
  • Fever
  • Anorexia
  • Constipation
  • Decreased platelet count
  • Rashes
  • Decreased weight
  • Injection site reactions

Directions for Use

A trained healthcare professional will administer Kabimustine 100 mg Injection 1's. Hence, do not self-administer. 

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Kabimustine 100 mg Injection 1's should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before receiving this injection, inform your doctor if you have any history of liver/kidney disease, cardiac disorders, cancer, active infections, skin problems, or any allergic conditions. Kabimustine 100 mg Injection 1's may cause myelosuppression, active infections, severe skin reactions, tumor lysis syndrome (tumor cells release their contents into the bloodstream), other malignancies, and hypersensitivity reactions in some patients. Hence, careful monitoring should be done during the entire treatment. Kabimustine 100 mg Injection 1's may cause embryo-fetal toxicity. Hence, if you are pregnant or planning to become pregnant, inform your doctor beforehand. Before nursing, a breastfeeding mother should ask her oncologist whether this medicine is safe for use or not. Kabimustine 100 mg Injection 1's is not recommended for use in children as the safety and efficacy are not established.

Therapeutic Class

ANTINEOPLASTIC

Diet & Lifestyle Advise

  • After your treatment begins, dietary adjustments can help you control side effects.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • Plant-based proteins are among the greatest meals to take during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans, and legumes.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast and fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

How Kabimustine 100 mg Injection 1's Works

Kabimustine 100 mg Injection 1's contains Bendamustine, which belongs to the alkylating agents class. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis.

What if I have taken an overdose of Kabimustine 100 mg Injection 1's

As Kabimustine 100 mg Injection 1's is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away. Overdose of Kabimustine 100 mg Injection 1's may cause rapid, irregular, or pounding heartbeat.
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Alcohol

Caution

Limit or avoid consumption of alcohol as it may worsen your condition.

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Pregnancy

Unsafe

Kabimustine 100 mg Injection 1's is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Kabimustine 100 mg Injection 1's. Use reliable methods of birth control while on treatment with Kabimustine 100 mg Injection 1's.

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Breast Feeding

Caution

If you are a nursing mother, inform your doctor before receiving Kabimustine 100 mg Injection 1's. You should not breastfeed while on treatment with Kabimustine 100 mg Injection 1's.

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Driving

Not applicable

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Kabimustine 100 mg Injection 1's. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition. Kabimustine 100 mg Injection 1's is not recommended for use in patients with severe liver disease.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving Kabimustine 100 mg Injection 1's. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition. This medicine should be avoided for patients with CrCl <40 ml/min.

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Children

Unsafe

Kabimustine 100 mg Injection 1's is not recommended for use in children as the safety and efficacy is not established.

Country of origin

India

Manufacturer/Marketer address

Fresenius Kabi Ag , Else-Krã¶Ner-Straãÿe 1 , 61352 Bad Homburg , Germany
Other Info - KAB0117

Author Details

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FAQs

Kabimustine 100 mg Injection 1's is used to treat Non-Hodgkin’s disease and Chronic Lymphocytic Leukaemia.
Kabimustine 100 mg Injection 1's contains Bendamustine, which inhibits the DNA and RNA transcription essential for cancer cell growth.
Kabimustine 100 mg Injection 1's may cause reactivation of serious infections, myelosuppression, tumour lysis syndrome, and anaphylactic reactions in some patients. Hence, inform your oncologist about your complete medical history, including current medication, to rule out any side effects/interactions.
Kabimustine 100 mg Injection 1's is safe when used as per the dose and duration advised by a doctor.
Kabimustine 100 mg Injection 1's has the vesicant (irritant) properties.
Yes, the use of Kabimustine 100 mg Injection 1's can cause hair loss and constipation as a side effect. This will gradually reduce over time and does not require any medical attention. However, please contact a doctor if this condition persists for longer or worsens.
Kabimustine 100 mg Injection 1's can cross the blood-brain barrier and can be utilized for treating cancers that have spread to the brain.
Kabimustine 100 mg Injection 1's may cause side effects such as diarrhoea, back pain, vomiting, stomach pain, cough, pain at the site of injection, fever, constipation, decreased blood pressure, rashes, and decreased weight. Please, contact a doctor if these side effects persist for longer durations.

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