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Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

APNICAF 20MG INJECTION 3ML is used to treat apnea in premature newborns/neonates. By activating the respiratory centre and making it more sensitive to hypercapnia, this medication helps control the mean respiratory rate and tidal volume and enhances pulmonary blood flow. Common side effects include a fast heartbeat, irregular heartbeat, and hyperglycemia. It is a pediatric medication. Inform your doctor if your newborn is allergic to APNICAF 20MG INJECTION 3ML.
 

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Whats That

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Synonym :

CAFFEINE

Manufacturer/Marketer :

Abbott India Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About APNICAF 20MG INJECTION 3ML

APNICAF 20MG INJECTION 3ML belongs to a group of medicines known as methylxanthines. It is used to treat apnea of premature newborns. Apnea is a condition in which breathing is interrupted, causing abnormal heart rate and oxygen saturation changes. It is a common occurrence, particularly in premature infants.

APNICAF 20MG INJECTION 3ML contains 'Caffeine Citrate', which belongs to the central nervous system (CNS) stimulants class. This medicine stimulates the respiratory centre, sensitising it to hypercapnia. Thereby, APNICAF 20MG INJECTION 3ML effectively regulates the mean respiratory rate and tidal volume, improves pulmonary blood flow, and enhances the breathing pattern.

A paediatrician or healthcare professional will administer APNICAF 20MG INJECTION 3ML in a hospital setting. APNICAF 20MG INJECTION 3ML can cause side effects like a fast heartbeat, irregular heartbeat, and increased blood sugar levels. These side effects are not prevalent and vary from person to person. Consult your doctor if these symptoms continue or worsen.

Inform your doctor about the complete medical history of your infant. If you are nursing your infant and are being treated with this medication, avoid drinking coffee or using any other caffeine-containing products since caffeine passes into breast milk. This medication should be used with caution in infants with impaired hepatic or renal function. Before adjusting the dose, your doctor may assess your child's baseline serum caffeine levels if they were born to a mother who consumes caffeine.

Uses of APNICAF 20MG INJECTION 3ML

APNICAF 20MG INJECTION 3ML is commonly used to
1. Treat prematurity apnea:
Caffeine citrate is most commonly used to treat premature infants, particularly those born preterm. Premature babies, particularly those born before 28 weeks of gestation, may experience pauses in breathing lasting more than 20 seconds (apnea). This is known as apnea of prematurity, and caffeine citrate is used to stimulate the respiratory centre in the brain, hence improving breathing and decreasing apnea episodes.
2. Respiratory stimulation:
APNICAF 20MG INJECTION 3ML works as a central respiratory stimulant, which means it can be beneficial in instances when respiratory function is limited, particularly in preterm infants with underdeveloped respiratory systems.
3. Improvement of Diuresis:
Caffeine is a moderate diuretic, but this is not the primary reason for its usage in therapeutic settings.
4. Treatment for Neonatal Respiratory Depression:
Caffeine citrate may be utilised in newborns with respiratory depression, particularly when it is associated with disorders such as hypoxia or birth asphyxia.

Directions for Use

APNICAF 20MG INJECTION 3ML will be administered by a healthcare professional. Hence, do not self-administer to your newborn.

Medicinal Benefits

APNICAF 20MG INJECTION 3ML contains Caffeine Citrate as an active ingredient, which belongs to the central nervous system (CNS) stimulants class. By activating the respiratory centre and making it more sensitive to hypercapnia, this medication helps control the mean respiratory rate and tidal volume and enhances pulmonary blood flow.

How APNICAF 20MG INJECTION 3ML Works

APNICAF 20MG INJECTION 3ML contains Caffeine Citrate, which belongs to the central nervous system (CNS) stimulants class. It works in three different ways. This medicine stimulates the respiratory centre, sensitising it to hypercapnia. Thereby, APNICAF 20MG INJECTION 3ML effectively regulates the mean respiratory rate and tidal volume, improves pulmonary blood flow, and enhances the breathing pattern.

Storage

Store in a cool and dry place away from sunlight

Side Effects of APNICAF 20MG INJECTION 3ML

  • Fast heartbeat
  • Increased blood sugar levels
  • Irregular heartbeat
  • Pain at the site of injection

What if I have taken an overdose of APNICAF 20MG INJECTION 3ML

Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include anxiety, stomach pain, irregular/fast heartbeat, seizures, and trouble sleeping. If your newborn experiences these symptoms or if you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Inform your doctor about your infant's medical history. If you are breastfeeding and your infant is being treated with this medication, avoid drinking coffee or using any other caffeine-containing products since caffeine passes into breast milk. APNICAF 20MG INJECTION 3ML should only be used in a neonatal intensive care unit where adequate patient surveillance and monitoring facilities are available. Treatment should begin under the supervision of a neonatologist with experience in neonatal intensive care. This medication should be used with caution in infants with impaired liver or kidney function.

Drug-Drug Interactions

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CaffeineIsocarboxazid
Critical
CaffeineTranylcypromine
Critical

Drug-Drug Interactions

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CaffeineIsocarboxazid
Critical
How does the drug interact with Apnicaf 20mg Injection 3ml:
Taking these two together can cause your blood pressure to rise, a condition known as a hypertensive crisis.

How to manage the interaction:
Taking Apnicaf 20mg Injection 3ml with Isocarboxazid is not recommended, please consult your doctor before taking it. It can be taken if your doctor prescribes it. Do not stop taking any medication without consulting your doctor.
CaffeineTranylcypromine
Critical
How does the drug interact with Apnicaf 20mg Injection 3ml:
Coadministration of tranylcypromine with Apnicaf 20mg Injection 3ml can in cause severe high blood pressure.

How to manage the interaction:
Taking Apnicaf 20mg Injection 3ml with Tranylcypromine is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience headache, confusion, blurred vision, problems with speech or balance, nausea, vomiting, chest pain, convulsions, and sudden numbness or weakness (especially on one side of the body). Do not discontinue any medications without consulting a doctor.
CaffeinePhenelzine
Critical
How does the drug interact with Apnicaf 20mg Injection 3ml:
Taking these two together can cause your blood pressure to rise, a condition known as a hypertensive crisis.

How to manage the interaction:
Taking Apnicaf 20mg Injection 3ml with Phenelzine is not recommended, please consult your doctor before taking it. They can be taken if your doctor advises it. Do not stop taking any medication without consulting your doctor.
CaffeineLinezolid
Critical
How does the drug interact with Apnicaf 20mg Injection 3ml:
Taking these two together can cause your blood pressure to rise, a condition known as a hypertensive crisis.

How to manage the interaction:
Taking Apnicaf 20mg Injection 3ml with Linezolid is not recommended, please consult your doctor before taking it. It can be taken if your doctor prescribes it. Do not stop taking any medication without consulting your doctor.
CaffeineEsketamine
Severe
How does the drug interact with Apnicaf 20mg Injection 3ml:
Esketamine can cause increase in blood pressure and using it with Apnicaf 20mg Injection 3ml may increase the risk.

How to manage the interaction:
Although there is a possible interaction between Apnicaf 20mg Injection 3ml and Esketamine, it can be taken together if prescribed by your doctor. Do not discontinue using any medications without consulting your doctor.
CaffeineDipyridamole
Severe
How does the drug interact with Apnicaf 20mg Injection 3ml:
Concomitant use of Apnicaf 20mg Injection 3ml with dipyridamole may decrease the effects of dipyridamole.

How to manage the interaction:
Although there is an interaction, Apnicaf 20mg Injection 3ml can be taken with dipyridamole if prescribed by the doctor. Avoiding Apnicaf 20mg Injection 3ml for 12 to 24 hours before dipyridamole administration is advised.
CaffeineCocaine
Severe
How does the drug interact with Apnicaf 20mg Injection 3ml:
Coadministration of Apnicaf 20mg Injection 3ml with cocaine can increase the risk of irregular heart rhythm.

How to manage the interaction:
Although there is an interaction, Apnicaf 20mg Injection 3ml can be taken with cocaine if prescribed by the doctor. However, contact your doctor if you experience dizziness, lightheadedness, palpitations, and shortness of breath. Do not discontinue using any medication without contacting a doctor.
CaffeineBupropion
Severe
How does the drug interact with Apnicaf 20mg Injection 3ml:
Bupropion and Apnicaf 20mg Injection 3ml can increase blood pressure. Concomitant use may have additive effects.

How to manage the interaction:
Although there is an interaction, Apnicaf 20mg Injection 3ml can be taken with bupropion if prescribed by the doctor. Regular monitoring of blood pressure is advised.
CaffeineTizanidine
Severe
How does the drug interact with Apnicaf 20mg Injection 3ml:
Coadministration of Apnicaf 20mg Injection 3ml with Tizanidine may increase the blood levels and effects of tizanidine. This may cause excessive blood pressure, especially when rising from a sitting or lying position.

How to manage the interaction:
Although there is an interaction, Apnicaf 20mg Injection 3ml can be taken with tizanidine if prescribed by the doctor. Contact your doctor if you experience dizziness, excessive sweating, or palpitations. Do not stop using any medicine without consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

MISCELLANEOUS

APNICAF 20MG INJECTION 3ML Substitute

Substitutes safety advice
  • Capnea Solution 1ml

    by Others

    247.50per tablet
  • Apnicaf Oral Solution 3 ml

    by Others

    241.20per tablet
  • CAFIRATE SOLUTION 1.5ML

    by Others

    371.30per tablet
  • Capnea Injection 1 ml

    by Others

    252.50per tablet
  • Cafirate 20mg Injection 1ml

    by AYUR

    252.45per tablet
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Alcohol

Not applicable

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Pregnancy

Not applicable

-

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Breast Feeding

Caution

APNICAF 20MG INJECTION 3ML is intended for use in newborns/neonates only. If your infant is being treated with this medication, avoid drinking coffee or using any other caffeine-containing products since caffeine passes into breast milk.

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Driving

Not applicable

-

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Liver

Caution

APNICAF 20MG INJECTION 3ML should be used with caution in infants with impaired liver function.

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Kidney

Caution

APNICAF 20MG INJECTION 3ML should be used with caution in infants with impaired kidney function.

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Children

Consult your doctor

APNICAF 20MG INJECTION 3ML is intended for use in premature newborns and neonates. Consult your doctor for more information.

FAQs

APNICAF 20MG INJECTION 3ML is used in the treatment of apnea of premature newborns.

APNICAF 20MG INJECTION 3ML contains 'Caffeine Citrate', which belongs to the central nervous system (CNS) stimulants class. This medicine stimulates the respiratory center, sensitizing it to hypercapnia. Thereby APNICAF 20MG INJECTION 3ML effectively regulates the mean respiratory rate and tidal volume, improves pulmonary blood flow, and enhances the breathing pattern.

No, it is intended to treat apnea in premature newborns and neonates.

The dosage is determined by your babys weight, medical problems, and responsiveness to therapy. Before determining the dose, it is also necessary to establish the baseline serum caffeine levels in children born to caffeine-consuming mothers.

Country of origin

India

Manufacturer/Marketer address

16th Floor, Godrej BKC, Plot – C, “G” Block, Bandra-Kurla Complex, Bandra (East), Mumbai – 400 051, India
Other Info - APN0012

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