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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Alsiva 40Mg Tablet is used to treat schizophrenia and bipolar disorder. It contains Lurasidone which works by blocking neurotransmitters and helps regulate mood, thoughts and behaviour. In some cases, this medicine may cause side effects such as nausea, vomiting, sleepiness, weight gain, indigestion, dry mouth, and restlessness. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Whats That

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Synonym :

LURASIDONE HYDROCHLORIDE

Composition :

LURASIDONE-40MG

Manufacturer/Marketer :

Alembic Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Alsiva 40Mg Tablet

Alsiva 40Mg Tablet used in the treatment of schizophrenia (affects a person's ability to feel, think and behave clearly) and bipolar depression (mood swings). Schizophrenia is a mental condition in which the person may feel, hear or see things that are not there, believe things that are not true, or feel unusually suspicious or confused. Bipolar disorder is characterized by manic episodes in which a person experiences extreme mood swings (variance in thinking) and frequent mood and behaviour changes. 

Alsiva 40Mg Tablet contains ‘lurasidone’, which is an antipsychotic drug. It acts by blocking a hormone (dopamine) present in the brain responsible for developing symptoms of schizophrenia and bipolar disorder. Alsiva 40Mg Tablet also blocks other neurotransmitters in the brain, such as serotonin. By blocking both, Alsiva 40Mg Tablet helps to control the brain's activity and decrease the symptoms of schizophrenia and bipolar disease.

Take Alsiva 40Mg Tablet as prescribed by your doctor. You are advised to take Alsiva 40Mg Tablet for as long as your doctor has prescribed it for you, depending on your medical conditions. You may experience nausea, vomiting, sleepiness, weight gain, indigestion, dryness in the mouth, akathisia (inability to stay still), stomach discomfort, anxiety, upper abdominal pain, restlessness, agitation (nervous excitement), insomnia (difficulty in sleeping) and increased saliva production. Most of these side effects of Alsiva 40Mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Alsiva 40Mg Tablet should not be taken in conditions like if you are allergic to lurasidone or any other ingredients present in it. Before taking Alsiva 40Mg Tablet, inform your doctor if you have problems associated with the liver, kidney or heart and low blood pressure. It is not recommended for use in children under 13 years of age. Before taking Alsiva 40Mg Tablet inform your doctor if you are older than 65 years of age as it causes more side effects. Tell your doctor if you are pregnant or breastfeeding. Alsiva 40Mg Tablet causes drowsiness and dizziness. Do not drive unless you are alert.

Uses of Alsiva 40Mg Tablet

Treatment of Schizophrenia, Bipolar disorder

Directions for Use

Take Alsiva 40Mg Tablet with or without food. Alsiva 40Mg Tablet should be swallowed as a whole with a glass of water; do not chew or crush the tablet. You are advised to take Alsiva 40Mg Tablet for as long as your doctor has prescribed it for you, depending on your medical condition.

Medicinal Benefits

Alsiva 40Mg Tablet is used to treat certain mood /mental diseases like schizophrenia and depression related to bipolar disorder. Alsiva 40Mg Tablet helps you to feel less nervous, think more clearly and take part in daily life. It may also help to reduce hallucinations (seeing/hearing things that are not there). It alters brain function and improves mood, thinking ability, and social behaviour. It reduces the development of symptoms in patients with schizophrenia, bipolar disorder or other mood disorders. 

How Alsiva 40Mg Tablet Works

Alsiva 40Mg Tablet contains lurasidone, which is an antipsychotic drug. It acts by blocking a hormone (dopamine) present in the brain responsible for developing symptoms of schizophrenia and bipolar disorder. Alsiva 40Mg Tablet also blocks other neurotransmitters in the brain, such as serotonin. By blocking both, Alsiva 40Mg Tablet helps to control the brain's activity and decrease the symptoms of schizophrenia and bipolar disease.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Alsiva 40Mg Tablet

  • Drowsiness
  • Weight gain
  • Tremors, muscle stiffness, slow muscle movement
  • Feeling restless or unable to sit still
  • Nausea, vomiting
  • Runny nose
  • Sleep problems (insomnia)
  • Dry mouth
  • Abdominal discomfort
  • Agitation

What if I have taken an overdose of Alsiva 40Mg Tablet

Take Alsiva 40Mg Tablet only as prescribed by the doctor. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

It is advisable to you not take Alsiva 40Mg Tablet if you are allergic to lurasidone or any ingredients present in it. Before taking Alsiva 40Mg Tablet, inform your doctor if you have low blood pressure, stroke, liver problems, seizures, diabetes, dementia (memory loss), alcohol or drug abuse, sleep apnea (a sleep disorder) and urinary retention. Inform your doctor if you have epilepsy/fits, an increase in your weight, history of blood clots before taking Alsiva 40Mg Tablet. Tell your doctor immediately if you develop suicidal thoughts, or your depression worsens after taking Alsiva 40Mg Tablet. There is a greater chance of death in senior adults who take Alsiva 40Mg Tablet for mental problems caused by dementia (thinking and suicidal symptoms). Most of the deaths were related to infection or heart disease. Avoid drinking alcohol while taking Alsiva 40Mg Tablet as it may worsen the side effects. Tell your doctor if you are pregnant or breastfeeding. Alsiva 40Mg Tablet causes drowsiness and dizziness. Do not drive unless you are alert.

Drug-Drug Interactions

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LurasidonePosaconazole
Critical
LurasidoneRifabutin
Critical

Drug-Drug Interactions

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LurasidonePosaconazole
Critical
How does the drug interact with Alsiva 40Mg Tablet:
Taking Alsiva 40Mg Tablet together with posaconazole may result in significantly higher Alsiva 40Mg Tablet blood levels.

How to manage the interaction:
Although there is an interaction between Alsiva 40Mg Tablet and posaconazole, they can be used if prescribed by a doctor. However, consult a doctor if you have any abnormal muscle activity, dizziness, lightheadedness, headache, flushing, or fainting. Do not discontinue any medications without consulting a doctor.
LurasidoneRifabutin
Critical
How does the drug interact with Alsiva 40Mg Tablet:
Alsiva 40Mg Tablet administration with Rifabutin may result in significantly lower blood levels of Alsiva 40Mg Tablet.

How to manage the interaction:
There is an interaction between Alsiva 40Mg Tablet and Rifabutin, so it is not recommended that you take it unless a doctor has prescribed it. Consult a doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
LurasidoneRifapentine
Critical
How does the drug interact with Alsiva 40Mg Tablet:
Alsiva 40Mg Tablet co-administration with Rifapentine may result in significantly lower blood levels of Alsiva 40Mg Tablet, making the medication less effective or ineffective in treating your illness.

How to manage the interaction:
There is an interaction between Alsiva 40Mg Tablet and Rifapentine, so it is not recommended that you take it unless your doctor has prescribed it. Consult a doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
LurasidonePhenytoin
Critical
How does the drug interact with Alsiva 40Mg Tablet:
Using Alsiva 40Mg Tablet together with phenytoin may significantly decrease the blood levels of Alsiva 40Mg Tablet.

How to manage the interaction:
Using Alsiva 40Mg Tablet with phenytoin is not recommended, it can be taken if a doctor has prescribed it. Consult a doctor, if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
LurasidonePhenobarbital
Critical
How does the drug interact with Alsiva 40Mg Tablet:
Co-administration of Alsiva 40Mg Tablet with Phenobarbitalmay result in significantly lower blood levels of Alsiva 40Mg Tablet, making the medication less effective or ineffective in treating the illness.

How to manage the interaction:
There is an interaction between Alsiva 40Mg Tablet and phenobarbital,so it is not recommended. You can take it if a doctor has prescribed it. Consult a doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
LurasidoneTelaprevir
Critical
How does the drug interact with Alsiva 40Mg Tablet:
Using Alsiva 40Mg Tablet together with Telaprevir may result in significantly higher Alsiva 40Mg Tablet blood levels. This may increase the possibility of side effects like Parkinson's disease. (It is a brain disorder that produces uncontrollable movements.)

How to manage the interaction:
While Alsiva 40Mg Tablet and Telaprevir may interact, it is not recommended, but they can be used if prescribed by a doctor. Consult a doctor if you have any abnormal muscle activity, fits, high blood sugar, high sugars, high cholesterol, heat intolerance or heat stroke, dizziness, lightheadedness, headache, flushing, fainting, or heart palpitations. Do not discontinue any medications without consulting a doctor.
LurasidoneCeritinib
Critical
How does the drug interact with Alsiva 40Mg Tablet:
Using Alsiva 40Mg Tablet together with Ceritinib may result in significantly increase the blood levels of Alsiva 40Mg Tablet.

How to manage the interaction:
Alsiva 40Mg Tablet and Ceritinib together are not recommended as they can lead to an interaction. They can be used if prescribed by a doctor. However, consult a doctor if you experience low blood pressure, such as dizziness, lightheadedness, headache, flushing, fainting, and heart palpitations. Do not discontinue any medications without consulting a doctor.
LurasidoneEnzalutamide
Critical
How does the drug interact with Alsiva 40Mg Tablet:
Co-administration of Alsiva 40Mg Tablet with Enzalutamide may result in significantly lower blood levels of Alsiva 40Mg Tablet, making the medication less effective.

How to manage the interaction:
Taking Alsiva 40Mg Tablet with Enzalutamide is not recommended as it may lead to interaction, it can be taken if prescribed by the doctor. Consult a doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
LurasidoneCarbamazepine
Critical
How does the drug interact with Alsiva 40Mg Tablet:
Co-administration of Alsiva 40Mg Tablet with carbamazepine may result in significantly lower blood levels of Alsiva 40Mg Tablet, making the medication less effective.

How to manage the interaction:
Although there is an interaction between Alsiva 40Mg Tablet and carbamazepine, it is not recommended that you take it unless your doctor has prescribed it. Consult a doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
LurasidoneVoriconazole
Critical
How does the drug interact with Alsiva 40Mg Tablet:
Using Alsiva 40Mg Tablet together with Voriconazole may result in significantly higher Alsiva 40Mg Tablet blood levels.

How to manage the interaction:
While Alsiva 40Mg Tablet and Voriconazole may interact, it is not recommended that they be used unless prescribed by a doctor. Consult a doctor if you have any abnormal muscle activity, dizziness, headache, or heart palpitations. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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LURASIDONE-40MGGrapefruit and Grapefruit Juice
Severe

Drug-Food Interactions

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LURASIDONE-40MGGrapefruit and Grapefruit Juice
Severe
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Taking grapefruit juice with Alsiva 40Mg Tablet treatment can increase the levels of Alsiva 40Mg Tablet which can increase the risk or severity of side effects. Taking grapefruit juice with Alsiva 40Mg Tablet should be avoided as it can result in an interaction. Contact a doctor immediately if you experience symptoms like abnormal muscle movements, seizures, dizziness, lightheadedness, headache, flushing, fainting, and heart palpitations. Do not stop using any medications without talking to a doctor.

Diet & Lifestyle Advise

  • Do not take grapefruit or grapefruit juice while using Alsiva 40Mg Tablet as it may alter the effects of the medicine.
  • Avoid intense exercise as it is harder for the body to cool down when it gets very hot. So, drink plenty of fluids and avoid going out in hot weather.
  • Do not take alcohol as it increases drowsiness and also worsens the disease condition. 
  • Eat healthily and keep a check on your weight regularly.

Habit Forming

No

Therapeutic Class

ANTIPSYCHOTICS

Alsiva 40Mg Tablet Substitute

Substitutes safety advice
  • Luramax 40 Tablet 10's

    by AYUR

    13.50per tablet
  • Lurasid 40 Tablet 10's

    by AYUR

    14.13per tablet
  • Lurafic 40mg Tablet 10's

    by AYUR

    22.10per tablet
  • Lurace 40 Tablet 10's

    by AYUR

    13.95per tablet
  • Lurata 40 Tablet 10's

    by AYUR

    15.80per tablet
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Alcohol

Unsafe

Avoid consuming alcohol while on treatment with Alsiva 40Mg Tablet as it may increase the risk of side effects.

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Pregnancy

Caution

Alsiva 40Mg Tablet is not recommended for use in pregnancy. Hence, if you are pregnant, inform your doctor before taking Alsiva 40Mg Tablet. Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

It is not known if Alsiva 40Mg Tablet passes into the breastmilk. If you are breastfeeding, consult your doctor before taking Alsiva 40Mg Tablet, your doctor will prescribe this medicine if the benefits outweigh the risks.

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Driving

Caution

Alsiva 40Mg Tablet may cause dizziness. So, it is not recommended to drive or operate heavy machinery after taking Alsiva 40Mg Tablet.

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Liver

Caution

Alsiva 40Mg Tablet should be used with caution in patients with liver disease. If you have liver disease, inform your doctor before taking Alsiva 40Mg Tablet. Your doctor may adjust the dose based on your condition.

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Kidney

Caution

Alsiva 40Mg Tablet should be used with caution in patients with kidney disease. If you have kidney disease, inform your doctor before taking Alsiva 40Mg Tablet. Your doctor may adjust the dose based on your condition.

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Children

Unsafe

Alsiva 40Mg Tablet is not recommended for use in children under 13 years.

FAQs

Alsiva 40Mg Tablet is used in the treatment of schizophrenia (affects a person's ability to feel, think and behave clearly) and bipolar depression (mood swings). It helps you to feel less nervous, think more clearly and take part in daily life.
Alsiva 40Mg Tablet may cause an increase in blood glucose (sugar) levels. So, regular monitoring of blood sugar levels is advised while taking Alsiva 40Mg Tablet. Diabetes patients should consult a doctor before taking Alsiva 40Mg Tablet.
Weight gain is a common side effect of Alsiva 40Mg Tablet, although not everyone is affected. If you experience weight gain on taking Alsiva 40Mg Tablet, inform your doctor. Eating a healthy diet and frequent exercise can help you maintain your weight.
Alcohol should be avoided while taking Alsiva 40Mg Tablet since taking both together may lead to severe side effects. You should not drink grapefruit juice while on Alsiva 40Mg Tablet as it affects the way it works.
Alsiva 40Mg Tablet may raise the risk of death in older persons who suffer from memory loss, perplexity, or have lost touch with reality. It is critical to understand that Alsiva 40Mg Tablet may cause suicidal behaviour or thoughts in certain children, adolescents, and young adults during the first few months of treatment and when the dose is adjusted.
Dry mouth could be a side-effect of Alsiva 40Mg Tablet. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly and chewing sugar-free gum/candy might help in stimulating saliva and thereby prevents drying of the mouth.
Alsiva 40Mg Tablet is an antipsychotic drug that works by blocking a hormone (dopamine) present in the brain responsible for developing symptoms of schizophrenia (a serious mental illness affecting thoughts, feelings, and behaviours) and bipolar disorder (a mental illness that causes mood swings, energy fluctuations, and concentration issues). It also blocks other neurotransmitters in the brain, such as serotonin. By blocking both dopamine and serotonin, Alsiva 40Mg Tablet helps to control brain activity and decreasesthe symptoms of schizophrenia and bipolar disorder.
The common side effects of Alsiva 40Mg Tablet include nausea, vomiting, weight gain, indigestion, sleepiness, dryness in the mouth, increased saliva production, akathisia (inability to stay still), anxiety, upper abdominal pain, restlessness, agitation (nervous excitement), and insomnia (difficulty in sleeping). Most of these side effects of Alsiva 40Mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
No, Alsiva 40Mg Tablet should not be used during pregnancy unless prescribed by the doctor. Taking Alsiva 40Mg Tablet in the later months of pregnancy may lead to extrapyramidal (uncontrolled body movements or muscle stiffness in the baby) or withdrawal symptoms after birth such as muscle stiffness, weakness, shakiness, sleepiness, breathing problems, agitation, and difficulty feeding. If you are pregnant or planning for pregnancy, please consult your doctor before taking Alsiva 40Mg Tablet. The doctor will prescribe Alsiva 40Mg Tablet only if the benefits outweigh the risks and will monitor the baby closely after birth.
Close monitoring for the emergence or worsening of suicidal behaviour and thoughts is recommended in patients taking Alsiva 40Mg Tablet. Alsiva 40Mg Tablet may increase blood sugar levels in diabetic patients, especially in those with schizophrenia. So, you should immediately inform your doctor if you experience symptoms such as increased thirst, frequent urination, fatigue, or increased appetite. It may also lead to weight gain, increase prolactin, cholesterol, and triglyceride levels, and decrease white blood cell count. Hence, regular monitoring of blood sugar levels, blood cell counts, hormone levels (prolactin), and cholesterol levels is advised while taking Alsiva 40Mg Tablet. 
Alsiva 40Mg Tablet should be taken with food for better absorption of the medicine. It should be swallowed whole with a glass of water; do not chew or crush the tablet.
Alsiva 40Mg Tablet may take several weeks or longer before you experience any improvement in your symptoms. Continue to take Alsiva 40Mg Tablet even if you feel well, and do not stop taking it without talking to your doctor.
Yes, Alsiva 40Mg Tablet can cause dizziness, fainting, and lightheadedness when you stand up too quickly after lying down. This is more likely to happen when you first start taking Alsiva 40Mg Tablet or if your dose changes. To help prevent this problem, rise slowly from the bed and allow your feet to rest on the floor for a few minutes before standing up.

Country of origin

India

Manufacturer/Marketer address

Alembic Road, Vadodara - 390 003, Gujarat,INDIA
Other Info - ALS0030

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