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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Lurakem-40 Tablet is used to treat schizophrenia and bipolar disorder. It contains Lurasidone which works by blocking neurotransmitters and helps regulate mood, thoughts and behaviour. In some cases, this medicine may cause side effects such as nausea, vomiting, sleepiness, weight gain, indigestion, dry mouth, and restlessness. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Whats That

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Synonym :

LURASIDONE HYDROCHLORIDE

Composition :

LURASIDONE-40MG

Manufacturer/Marketer :

Alkem Laboratories Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Lurakem-40 Tablet

Lurakem-40 Tablet used in the treatment of schizophrenia (affects a person's ability to feel, think and behave clearly) and bipolar depression (mood swings). Schizophrenia is a mental condition in which the person may feel, hear or see things that are not there, believe things that are not true, or feel unusually suspicious or confused. Bipolar disorder is characterized by manic episodes in which a person experiences extreme mood swings (variance in thinking) and frequent mood and behaviour changes. 

Lurakem-40 Tablet contains ‘lurasidone’, which is an antipsychotic drug. It acts by blocking a hormone (dopamine) present in the brain responsible for developing symptoms of schizophrenia and bipolar disorder. Lurakem-40 Tablet also blocks other neurotransmitters in the brain, such as serotonin. By blocking both, Lurakem-40 Tablet helps to control the brain's activity and decrease the symptoms of schizophrenia and bipolar disease.

Take Lurakem-40 Tablet as prescribed by your doctor. You are advised to take Lurakem-40 Tablet for as long as your doctor has prescribed it for you, depending on your medical conditions. You may experience nausea, vomiting, sleepiness, weight gain, indigestion, dryness in the mouth, akathisia (inability to stay still), stomach discomfort, anxiety, upper abdominal pain, restlessness, agitation (nervous excitement), insomnia (difficulty in sleeping) and increased saliva production. Most of these side effects of Lurakem-40 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Lurakem-40 Tablet should not be taken in conditions like if you are allergic to lurasidone or any other ingredients present in it. Before taking Lurakem-40 Tablet , inform your doctor if you have problems associated with the liver, kidney or heart and low blood pressure. It is not recommended for use in children under 13 years of age. Before taking Lurakem-40 Tablet inform your doctor if you are older than 65 years of age as it causes more side effects. Tell your doctor if you are pregnant or breastfeeding. Lurakem-40 Tablet causes drowsiness and dizziness. Do not drive unless you are alert.

Uses of Lurakem-40 Tablet

Treatment of Schizophrenia, Bipolar disorder

Directions for Use

Take Lurakem-40 Tablet with or without food. Lurakem-40 Tablet should be swallowed as a whole with a glass of water; do not chew or crush the tablet. You are advised to take Lurakem-40 Tablet for as long as your doctor has prescribed it for you, depending on your medical condition.

Medicinal Benefits

Lurakem-40 Tablet is used to treat certain mood /mental diseases like schizophrenia and depression related to bipolar disorder. Lurakem-40 Tablet  helps you to feel less nervous, think more clearly and take part in daily life. It may also help to reduce hallucinations (seeing/hearing things that are not there). It alters brain function and improves mood, thinking ability, and social behaviour. It reduces the development of symptoms in patients with schizophrenia, bipolar disorder or other mood disorders. 

How Lurakem-40 Tablet Works

Lurakem-40 Tablet contains lurasidone, which is an antipsychotic drug. It acts by blocking a hormone (dopamine) present in the brain responsible for developing symptoms of schizophrenia and bipolar disorder. Lurakem-40 Tablet also blocks other neurotransmitters in the brain, such as serotonin. By blocking both, Lurakem-40 Tablet helps to control the brain's activity and decrease the symptoms of schizophrenia and bipolar disease.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Lurakem-40 Tablet

  • Drowsiness
  • Weight gain
  • Tremors, muscle stiffness, slow muscle movement
  • Feeling restless or unable to sit still
  • Nausea, vomiting
  • Runny nose
  • Sleep problems (insomnia)
  • Dry mouth
  • Abdominal discomfort
  • Agitation

What if I have taken an overdose of Lurakem-40 Tablet

Take Lurakem-40 Tablet only as prescribed by the doctor. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

It is advisable to you not take Lurakem-40 Tablet if you are allergic to lurasidone or any ingredients present in it. Before taking Lurakem-40 Tablet , inform your doctor if you have low blood pressure, stroke, liver problems, seizures, diabetes, dementia (memory loss), alcohol or drug abuse, sleep apnea (a sleep disorder) and urinary retention. Inform your doctor if you have epilepsy/fits, an increase in your weight, history of blood clots before taking Lurakem-40 Tablet . Tell your doctor immediately if you develop suicidal thoughts, or your depression worsens after taking Lurakem-40 Tablet . There is a greater chance of death in senior adults who take Lurakem-40 Tablet for mental problems caused by dementia (thinking and suicidal symptoms). Most of the deaths were related to infection or heart disease. Avoid drinking alcohol while taking Lurakem-40 Tablet as it may worsen the side effects. Tell your doctor if you are pregnant or breastfeeding. Lurakem-40 Tablet causes drowsiness and dizziness. Do not drive unless you are alert.

Drug-Drug Interactions

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LurasidonePosaconazole
Critical
LurasidoneRifabutin
Critical

Drug-Drug Interactions

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LurasidonePosaconazole
Critical
How does the drug interact with Lurakem-40 Tablet 10's:
Taking Lurakem-40 Tablet 10's together with posaconazole may result in significantly higher Lurakem-40 Tablet 10's blood levels.

How to manage the interaction:
Although there is an interaction between Lurakem-40 Tablet 10's and posaconazole, they can be used if prescribed by a doctor. However, consult a doctor if you have any abnormal muscle activity, dizziness, lightheadedness, headache, flushing, or fainting. Do not discontinue any medications without consulting a doctor.
LurasidoneRifabutin
Critical
How does the drug interact with Lurakem-40 Tablet 10's:
Lurakem-40 Tablet 10's administration with Rifabutin may result in significantly lower blood levels of Lurakem-40 Tablet 10's.

How to manage the interaction:
There is an interaction between Lurakem-40 Tablet 10's and Rifabutin, so it is not recommended that you take it unless a doctor has prescribed it. Consult a doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
LurasidoneRifapentine
Critical
How does the drug interact with Lurakem-40 Tablet 10's:
Lurakem-40 Tablet 10's co-administration with Rifapentine may result in significantly lower blood levels of Lurakem-40 Tablet 10's, making the medication less effective or ineffective in treating your illness.

How to manage the interaction:
There is an interaction between Lurakem-40 Tablet 10's and Rifapentine, so it is not recommended that you take it unless your doctor has prescribed it. Consult a doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
LurasidonePhenytoin
Critical
How does the drug interact with Lurakem-40 Tablet 10's:
Using Lurakem-40 Tablet 10's together with phenytoin may significantly decrease the blood levels of Lurakem-40 Tablet 10's.

How to manage the interaction:
Using Lurakem-40 Tablet 10's with phenytoin is not recommended, it can be taken if a doctor has prescribed it. Consult a doctor, if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
LurasidonePhenobarbital
Critical
How does the drug interact with Lurakem-40 Tablet 10's:
Co-administration of Lurakem-40 Tablet 10's with Phenobarbitalmay result in significantly lower blood levels of Lurakem-40 Tablet 10's, making the medication less effective or ineffective in treating the illness.

How to manage the interaction:
There is an interaction between Lurakem-40 Tablet 10's and phenobarbital,so it is not recommended. You can take it if a doctor has prescribed it. Consult a doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
LurasidoneTelaprevir
Critical
How does the drug interact with Lurakem-40 Tablet 10's:
Using Lurakem-40 Tablet 10's together with Telaprevir may result in significantly higher Lurakem-40 Tablet 10's blood levels. This may increase the possibility of side effects like Parkinson's disease. (It is a brain disorder that produces uncontrollable movements.)

How to manage the interaction:
While Lurakem-40 Tablet 10's and Telaprevir may interact, it is not recommended, but they can be used if prescribed by a doctor. Consult a doctor if you have any abnormal muscle activity, fits, high blood sugar, high sugars, high cholesterol, heat intolerance or heat stroke, dizziness, lightheadedness, headache, flushing, fainting, or heart palpitations. Do not discontinue any medications without consulting a doctor.
LurasidoneCeritinib
Critical
How does the drug interact with Lurakem-40 Tablet 10's:
Using Lurakem-40 Tablet 10's together with Ceritinib may result in significantly increase the blood levels of Lurakem-40 Tablet 10's.

How to manage the interaction:
Lurakem-40 Tablet 10's and Ceritinib together are not recommended as they can lead to an interaction. They can be used if prescribed by a doctor. However, consult a doctor if you experience low blood pressure, such as dizziness, lightheadedness, headache, flushing, fainting, and heart palpitations. Do not discontinue any medications without consulting a doctor.
LurasidoneEnzalutamide
Critical
How does the drug interact with Lurakem-40 Tablet 10's:
Co-administration of Lurakem-40 Tablet 10's with Enzalutamide may result in significantly lower blood levels of Lurakem-40 Tablet 10's, making the medication less effective.

How to manage the interaction:
Taking Lurakem-40 Tablet 10's with Enzalutamide is not recommended as it may lead to interaction, it can be taken if prescribed by the doctor. Consult a doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
LurasidoneCarbamazepine
Critical
How does the drug interact with Lurakem-40 Tablet 10's:
Co-administration of Lurakem-40 Tablet 10's with carbamazepine may result in significantly lower blood levels of Lurakem-40 Tablet 10's, making the medication less effective.

How to manage the interaction:
Although there is an interaction between Lurakem-40 Tablet 10's and carbamazepine, it is not recommended that you take it unless your doctor has prescribed it. Consult a doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
LurasidoneVoriconazole
Critical
How does the drug interact with Lurakem-40 Tablet 10's:
Using Lurakem-40 Tablet 10's together with Voriconazole may result in significantly higher Lurakem-40 Tablet 10's blood levels.

How to manage the interaction:
While Lurakem-40 Tablet 10's and Voriconazole may interact, it is not recommended that they be used unless prescribed by a doctor. Consult a doctor if you have any abnormal muscle activity, dizziness, headache, or heart palpitations. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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LURASIDONE-40MGGrapefruit and Grapefruit Juice
Severe

Drug-Food Interactions

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LURASIDONE-40MGGrapefruit and Grapefruit Juice
Severe
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Taking grapefruit juice with Lurakem-40 Tablet 10's treatment can increase the levels of Lurakem-40 Tablet 10's which can increase the risk or severity of side effects. Taking grapefruit juice with Lurakem-40 Tablet 10's should be avoided as it can result in an interaction. Contact a doctor immediately if you experience symptoms like abnormal muscle movements, seizures, dizziness, lightheadedness, headache, flushing, fainting, and heart palpitations. Do not stop using any medications without talking to a doctor.

Diet & Lifestyle Advise

  • Do not take grapefruit or grapefruit juice while using Lurakem-40 Tablet as it may alter the effects of the medicine.
  • Avoid intense exercise as it is harder for the body to cool down when it gets very hot. So, drink plenty of fluids and avoid going out in hot weather.
  • Do not take alcohol as it increases drowsiness and also worsens the disease condition. 
  • Eat healthily and keep a check on your weight regularly.

Habit Forming

No

Therapeutic Class

ANTIPSYCHOTICS

Lurakem-40 Tablet Substitute

Substitutes safety advice
  • Luramax 40 Tablet 10's

    by AYUR

    13.50per tablet
  • Lurasid 40 Tablet 10's

    by AYUR

    14.13per tablet
  • Lurafic 40mg Tablet 10's

    by AYUR

    22.10per tablet
  • Lurace 40 Tablet 10's

    by AYUR

    13.95per tablet
  • Lurata 40 Tablet 10's

    by AYUR

    15.80per tablet
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Alcohol

Unsafe

Avoid consuming alcohol while on treatment with Lurakem-40 Tablet as it may increase the risk of side effects.

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Pregnancy

Caution

Lurakem-40 Tablet is not recommended for use in pregnancy. Hence, if you are pregnant, inform your doctor before taking Lurakem-40 Tablet . Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

It is not known if Lurakem-40 Tablet passes into the breastmilk. If you are breastfeeding, consult your doctor before taking Lurakem-40 Tablet , your doctor will prescribe this medicine if the benefits outweigh the risks.

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Driving

Caution

Lurakem-40 Tablet may cause dizziness. So, it is not recommended to drive or operate heavy machinery after taking Lurakem-40 Tablet .

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Liver

Caution

Lurakem-40 Tablet should be used with caution in patients with liver disease. If you have liver disease, inform your doctor before taking Lurakem-40 Tablet . Your doctor may adjust the dose based on your condition.

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Kidney

Caution

Lurakem-40 Tablet should be used with caution in patients with kidney disease. If you have kidney disease, inform your doctor before taking Lurakem-40 Tablet . Your doctor may adjust the dose based on your condition.

bannner image

Children

Unsafe

Lurakem-40 Tablet is not recommended for use in children under 13 years.

FAQs

Lurakem-40 Tablet is used in the treatment of schizophrenia (affects a person's ability to feel, think and behave clearly) and bipolar depression (mood swings). It helps you to feel less nervous, think more clearly and take part in daily life.
Lurakem-40 Tablet may cause an increase in blood glucose (sugar) levels. So, regular monitoring of blood sugar levels is advised while taking Lurakem-40 Tablet . Diabetes patients should consult a doctor before taking Lurakem-40 Tablet .
Weight gain is a common side effect of Lurakem-40 Tablet , although not everyone is affected. If you experience weight gain on taking Lurakem-40 Tablet , inform your doctor. Eating a healthy diet and frequent exercise can help you maintain your weight.
Alcohol should be avoided while taking Lurakem-40 Tablet since taking both together may lead to severe side effects. You should not drink grapefruit juice while on Lurakem-40 Tablet as it affects the way it works.
Lurakem-40 Tablet may raise the risk of death in older persons who suffer from memory loss, perplexity, or have lost touch with reality. It is critical to understand that Lurakem-40 Tablet may cause suicidal behaviour or thoughts in certain children, adolescents, and young adults during the first few months of treatment and when the dose is adjusted.
Dry mouth could be a side-effect of Lurakem-40 Tablet . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly and chewing sugar-free gum/candy might help in stimulating saliva and thereby prevents drying of the mouth.
Lurakem-40 Tablet is an antipsychotic drug that works by blocking a hormone (dopamine) present in the brain responsible for developing symptoms of schizophrenia (a serious mental illness affecting thoughts, feelings, and behaviours) and bipolar disorder (a mental illness that causes mood swings, energy fluctuations, and concentration issues). It also blocks other neurotransmitters in the brain, such as serotonin. By blocking both dopamine and serotonin, Lurakem-40 Tablet helps to control brain activity and decreasesthe symptoms of schizophrenia and bipolar disorder.
The common side effects of Lurakem-40 Tablet include nausea, vomiting, weight gain, indigestion, sleepiness, dryness in the mouth, increased saliva production, akathisia (inability to stay still), anxiety, upper abdominal pain, restlessness, agitation (nervous excitement), and insomnia (difficulty in sleeping). Most of these side effects of Lurakem-40 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
No, Lurakem-40 Tablet should not be used during pregnancy unless prescribed by the doctor. Taking Lurakem-40 Tablet in the later months of pregnancy may lead to extrapyramidal (uncontrolled body movements or muscle stiffness in the baby) or withdrawal symptoms after birth such as muscle stiffness, weakness, shakiness, sleepiness, breathing problems, agitation, and difficulty feeding. If you are pregnant or planning for pregnancy, please consult your doctor before taking Lurakem-40 Tablet . The doctor will prescribe Lurakem-40 Tablet only if the benefits outweigh the risks and will monitor the baby closely after birth.
Close monitoring for the emergence or worsening of suicidal behaviour and thoughts is recommended in patients taking Lurakem-40 Tablet . Lurakem-40 Tablet may increase blood sugar levels in diabetic patients, especially in those with schizophrenia. So, you should immediately inform your doctor if you experience symptoms such as increased thirst, frequent urination, fatigue, or increased appetite. It may also lead to weight gain, increase prolactin, cholesterol, and triglyceride levels, and decrease white blood cell count. Hence, regular monitoring of blood sugar levels, blood cell counts, hormone levels (prolactin), and cholesterol levels is advised while taking Lurakem-40 Tablet . 
Lurakem-40 Tablet should be taken with food for better absorption of the medicine. It should be swallowed whole with a glass of water; do not chew or crush the tablet.
Lurakem-40 Tablet may take several weeks or longer before you experience any improvement in your symptoms. Continue to take Lurakem-40 Tablet even if you feel well, and do not stop taking it without talking to your doctor.
Yes, Lurakem-40 Tablet can cause dizziness, fainting, and lightheadedness when you stand up too quickly after lying down. This is more likely to happen when you first start taking Lurakem-40 Tablet or if your dose changes. To help prevent this problem, rise slowly from the bed and allow your feet to rest on the floor for a few minutes before standing up.

Country of origin

India

Manufacturer/Marketer address

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Other Info - LUR0016

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