apollo
0
Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Alphosin-B Injection is used to treat severe fungal infections. It contains Amphotericin B, which kills fungi by destroying the fungal outer cell membrane. In some cases, this medicine may cause side effects such as fever, chills, nausea, vomiting, headache, muscle cramps or pain. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
Read more
rxMedicinePrescription drug

Whats That

tooltip
Consult Doctor

Synonym :

LIPOSOMAL AMPHOTERICIN B

Composition :

AMPHOTERICIN B-50MG

Manufacturer/Marketer :

AAA Pharma Trade Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Alphosin-B Injection

Alphosin-B Injection belongs to a class of medication called 'antifungal' used to treat severe fungal infections like leishmaniasis. A fungal infection is a disease in which fungi attack the tissue and cause infection. Fungi are commonly present in nature but do not cause infections normally. However, if the person has a weak immune system, certain types of fungi may infect them. 

Alphosin-B Injection contains Amphotericin B, which kills fungi by destroying the fungal outer cell membrane. The fungal cell membranes are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents.

Alphosin-B Injection is given by a doctor or nurse. In some cases, you may experience fever, chills, irregular heartbeat, high or low blood pressure, breathing problems, nausea, vomiting, headache, shaking, muscle cramps or pain. Most of these side effects of Alphosin-B Injection do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Alphosin-B Injection or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to inform your doctor before using Alphosin-B Injection. Alphosin-B Injection is not recommended for children below one month as the safety and effectiveness were not established. Avoid driving after taking Alphosin-B Injection as it may affect your ability to drive. If you experience severe adverse effects such as chest pain or difficulty in breathing, or encephalopathy (a brain disease which may cause you to behave strangely, be confused or feel drowsy), seek immediate medical help.

Uses of Alphosin-B Injection

Treatment of Severe fungal infections

Directions for Use

Alphosin-B Injection will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Alphosin-B Injection contains Amphotericin B, an antifungal used to treat severe fungal infections. The fungal cell membranes are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Alphosin-B Injection damages fungal cell membranes and kills fungi. Alphosin-B Injection is used to treat infections such as blood infection with candida, cryptococcus, fusarium, zygomycetes, aspergillus, coccidiodes or blastomycetes, or cryptococcal meningitis (inflammation of the brain).

How Alphosin-B Injection Works

Alphosin-B Injection contains Amphotericin B, which kills fungi by destroying the fungal outer cell membrane. The fungal cell membranes are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Alphosin-B Injection

  • Fever

  • Chills
  • Irregular heartbeat
  • High or low blood pressure
  • Breathing problems
  • Nausea
  • Vomiting
  • Headache
  • Shaking
  • Muscle cramps or pain

What if I have taken an overdose of Alphosin-B Injection

Since Alphosin-B Injection is administered by a healthcare professional, an overdose is unlikely to occur. However, seek medical attention if you experience any unusual symptoms.

Drug Warnings

If you are allergic to Amphotericin B or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to consult a doctor before using Alphosin-B Injection. Alphosin-B Injection is not recommended for children below one month as the safety and effectiveness were not established. Avoid driving after taking Alphosin-B Injection as it may affect your ability to drive. If you experience severe adverse effects such as chest pain, difficulty breathing, or encephalopathy (a brain disease that may cause you to behave strangely, be confused or feel drowsy), seek immediate medical help. If you have diabetes, electrolyte imbalance (low magnesium or potassium levels in the blood), kidney, liver or heart problems, inform your doctor before taking Alphosin-B Injection.

Drug-Drug Interactions

verifiedApollotooltip
Amphotericin bStreptozocin
Critical
Amphotericin bAciclovir
Severe

Drug-Drug Interactions

Login/Sign Up

Amphotericin bStreptozocin
Critical
How does the drug interact with Alphosin-B Injection 1's:
Taking Alphosin-B Injection 1's and streptozocin together can enhance kidney injury and can cause damage to the ear.

How to manage the interaction:
Taking Streptozocin with Alphosin-B Injection 1's is not recommended as it can result in an interaction, it can be taken if a doctor has advised it.
Amphotericin bAciclovir
Severe
How does the drug interact with Alphosin-B Injection 1's:
Coadministration of Aciclovir with Alphosin-B Injection 1's can increase the risk or severity of kidney disorder.

How to manage the interaction:
Taking Aciclovir with Alphosin-B Injection 1's together can result in an interaction, it can be taken if a doctor has advised it. Consult a doctor if you experience irregular urination, muscle ache, shortness if breath, or palpitations. Do not discontinue any medications without consulting a doctor.
Amphotericin bEverolimus
Severe
How does the drug interact with Alphosin-B Injection 1's:
Coadministration of Alphosin-B Injection 1's and Everolimus can increase the risk of kidney problems.

How to manage the interaction:
Taking Alphosin-B Injection 1's with Everolimus together can result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm. Do not discontinue any medications without a doctor's advice.
Amphotericin bZiprasidone
Severe
How does the drug interact with Alphosin-B Injection 1's:
Co-administration of Ziprasidone with Alphosin-B Injection 1's may raise the chance of a significantly abnormal heart rhythm.

How to manage the interaction:
There may be a possibility of interaction between Alphosin-B Injection 1's and Ziprasidone, but it can be taken if prescribed by a doctor. However, if you experience abrupt dizziness, lightheadedness, fainting, or rapid or pounding heartbeats, weakness, tiredness, drowsiness, confusion, muscle pain, cramps, nausea, or vomiting, contact a doctor immediately. You may need regular monitoring of your electrolyte (magnesium, potassium) levels. Do not stop using any medications without talking to a doctor.
Amphotericin bPimozide
Severe
How does the drug interact with Alphosin-B Injection 1's:
Pimozide used with Alphosin-B Injection 1's may raise the chance of a significantly abnormal heart rhythm, although it is a rare side effect.

How to manage the interaction:
Although taking Alphosin-B Injection 1's and Pimozide together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, weakness, tiredness, drowsiness, confusion, muscle pain, cramps, dizziness, nausea, or vomiting, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
Amphotericin bTenofovir alafenamide
Severe
How does the drug interact with Alphosin-B Injection 1's:
Tenofovir alafenamide can cause kidney problems and taking it with amikacin, can enhance the risk.

How to manage the interaction:
There may be a possibility of interaction between Alphosin-B Injection 1's and Tenofovir alafenamide, but it can be taken if prescribed by a doctor. However, consult a doctor if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm. Do not discontinue any medications without a doctor's advice.
Amphotericin bDronedarone
Severe
How does the drug interact with Alphosin-B Injection 1's:
Dronedarone used with Alphosin-B Injection 1's may raise the chance of a significantly abnormal heart rhythm, although it is a rare side effect.

How to manage the interaction:
Although there is a possible interaction between Alphosin-B Injection 1's and Dronedarone, you can take these medicines together if prescribed by a doctor. You should also notify a doctor if you suffer any of the following symptoms: weakness, weariness, sleepiness, disorientation, muscular pain, cramps, dizziness, nausea, or vomiting. Do not stop using any medications without talking to a doctor.
Amphotericin bSirolimus
Severe
How does the drug interact with Alphosin-B Injection 1's:
Coadministration of Sirolimus with Alphosin-B Injection 1's can increase the risk or severity of kidney problems.

How to manage the interaction:
Although taking Alphosin-B Injection 1's and sirolimus together can result in an interaction, it can be taken if a doctor has prescribed it. Consult a doctor if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm. Do not discontinue any medications without a doctor's advice.
Amphotericin bIopamidol
Severe
How does the drug interact with Alphosin-B Injection 1's:
Coadministration of Alphosin-B Injection 1's and Iopamidol may increase the risk of kidney problem.

How to manage the interaction:
Taking Alphosin-B Injection 1's with Iopamidol together can result in an interaction, but it can be taken if a doctor has advised it. It's important to keep an eye on how much you pee. If you notice any changes like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm let the doctor know right away. Do not discontinue any medications without consulting a doctor.
Amphotericin bArsenic trioxide
Severe
How does the drug interact with Alphosin-B Injection 1's:
Using arsenic trioxide together with Alphosin-B Injection 1's cholesteryl sulfate can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Co-administration of Alphosin-B Injection 1's with Arsenic trioxide can result in an interaction, but it can be taken if a doctor has advised it. If you experience irregular heartbeat, feeling suddenly dizzy or lightheaded, fainting, a fast or strong heartbeat, feeling weak or tired, feeling sleepy or confused, muscle pain, or feeling sick to your stomach. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

Login/Sign Up

Diet & Lifestyle Advise

  • Wash your hands regularly and keep your hands clean to prevent the spread of germs.

  • Avoid dusty activities and digging in the soil.
  • Wear shoes, a long-sleeved t-shirt and long pants while doing outdoor activities such as yard work, gardening or visiting wooded areas to protect from fungus commonly present in the environment.
  • Maintain a diet that is low in sugar, refined carbohydrates, mould-containing foods and yeast.

Habit Forming

No

Therapeutic Class

ANTIFUNGALS

Alphosin-B Injection Substitute

Substitutes safety advice
  • AMPHOTIN 50MG INJECTION

    214.20per tablet
  • Amphotret 50 mg Injection 1's

    214.70per tablet
  • Ambisome Injection 1's

    6876.32per tablet
  • Amfocare 50 mg Injection 1's

    204.30per tablet
  • Amphomul 50 Injection 1's

    1990.40per tablet
bannner image

Alcohol

Caution

The interaction of Alphosin-B Injection with alcohol is unknown. Please consult your doctor if you have any concerns regarding this.

bannner image

Pregnancy

Consult your doctor

Alphosin-B Injection is a Category B pregnancy drug and is given to a pregnant woman if the doctor thinks the benefits outweigh the risks. Please consult your doctor if you are pregnant or planning pregnancy.

bannner image

Breast Feeding

Consult your doctor

It is unknown whether Alphosin-B Injection is excreted in human milk. If you are breastfeeding, inform your doctor before receiving this injection.

bannner image

Driving

Caution

Avoid driving after taking Alphosin-B Injection as it may affect your ability to drive or operate machinery.

bannner image

Liver

Consult your doctor

Inform your doctor if you have a history of liver diseases/conditions before receiving Alphosin-B Injection.

bannner image

Kidney

Consult your doctor

Inform your doctor if you have a history of kidney diseases/conditions before receiving Alphosin-B Injection.

bannner image

Children

Caution

Alphosin-B Injection is not recommended for children below one month as the safety and effectiveness were not established.

FAQs

Alphosin-B Injection is used to treat severe fungal infections like leishmaniasis.
Alphosin-B Injection contains Amphotericin B, an antifungal that works by damaging fungal cell membranes, thereby killing fungi.
You are not recommended to take Alphosin-B Injection with furosemide as co-administration of these medicines may increase the risk of hypokalaemia (low potassium levels in the blood), and in severe cases, it may lead to paralysis, muscle weakness, irregular heart rhythm, difficulty in breathing or swallowing. However, please consult your doctor before taking Alphosin-B Injection with other medicines.
Alphosin-B Injection may cause blue lips and skin, probably during infusion or in the initial 2 days of treatment. However, your doctor or nurse may arrange certain simple treatments to control such adverse effects.
Yes, a test dose of Alphosin-B Injection may be given in smaller amounts before starting the treatment to check if you are sensitive to any of the ingredients.
You are recommended to use Alphosin-B Injection for as long as your doctor has prescribed it. However, the usual treatment is for a minimum of 14 days. Please consult a doctor if you experience any difficulty while taking Alphosin-B Injection.
Alphosin-B Injection is not used to treat viral infections. Alphosin-B Injection is an antifungal that kills fungi and is used to treat severe fungal infections.
Alphosin-B Injection is an antifungal medication used to treat severe fungal infections like leishmaniasis. It kills fungi by destroying the fungal outer cell membrane.
Alphosin-B Injection will be administered intravenously by a healthcare professional; do not self-administer.
Alphosin-B Injection is fungicidal in nature, it works by killing the infection-causing fungus.
Inform the doctor if you are allergic to any of the components in Alphosin-B Injection or if you experience allergic reactions during treatment with Alphosin-B Injection. Let the doctor know if you have kidney problems, diabetes, or if you are taking any other medicines.
Alphosin-B Injection is an antifungal medication used to treat severe fungal infections like leishmaniasis
Alphosin-B Injection may cause side effects like fever, chills, nausea, vomiting, headache, muscle cramps or pain. Most of these side effects of Alphosin-B Injection do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

E-11, Moti Nagar , New Delhi-110015
Other Info - ALP0267

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
icon image

Keep Refrigerated. Do not freeze.

Author Details

Doctor imageWe provide you with authentic, trustworthy and relevant information

whatsapp Floating Button