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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Oct 9, 2024 | 12:36 PM IST
Admatop 2.5 Injection contains topotecan which is used in the treatment of ovarian and small cell lung cancer. It is an anticancer medicine which works by binding to the cell's DNA, and stops it from naturally dividing and functioning, ultimately destroying it. This medicine can sometimes be used for treating other cancer conditions aswell. Common side effects inculde nausea, diarrhoea, vomiting, thrombocytopenia (a low platelet count), peripheral neuropathy and electrolyte disturbance.
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Prescription drug

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Composition

TOPOTECAN-2.5MG

Manufacturer/Marketer

United Biotech Pvt Ltd

Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Apr-26

for this medicine

About Admatop 2.5 Injection

Admatop 2.5 Injection belongs to a group of medicines called 'anti-cancer/anti-neoplastic agents', used to treat ovarian and small cell lung cancer. On the other hand, it may use to treat advanced cervical cancer if surgery or radiotherapy treatment is not possible. It may sometimes be used to treat other cancers. Ovarian cancer begins in the ovaries (a pair of female reproductive glands in which the ova, or eggs, are formed). Small-cell lung cancer is a disease in which malignant (cancer) cells form in the lung tissues.

Admatop 2.5 Injection contains 'Topotecan'. It works by penetrating into the cell wall and binding to the cell's DNA, stopping it from naturally dividing and functioning, ultimately destroying it. These medicines target cancer cells because they often affect rapidly dividing cells.

The amount of medicine that you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer or condition being treated. Your doctor will determine your dose and schedule. Admatop 2.5 Injection is prescribed by a doctor experienced in the use of medications to treat cancer. You may sometimes experience nausea, diarrhoea, vomiting, thrombocytopenia (a low platelet count), peripheral neuropathy (nerves malfunction), nephrotoxicity at high doses, and electrolyte disturbances. Most of these side effects of Admatop 2.5 Injection do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

To treat your condition effectually, continue taking Admatop 2.5 Injection for as long as your doctor has prescribed. Do not stop using the Admatop 2.5 Injection midway. Talk to your doctor before taking Admatop 2.5 Injection if you have severe allergic reactions to Admatop 2.5 Injection or other medicines or suffer from severe lung problems, Infections, renal dysfunction, hepatic disorders and blood cell counts are too low. Avoid taking Admatop 2.5 Injection if you are pregnant or breastfeeding because this Admatop 2.5 Injection can cause harmful effects on the unborn baby. Both women and men using this Admatop 2.5 Injection should use birth control to avoid pregnancy.

Uses of Admatop 2.5 Injection

Treatment of Ovarian cancer and Small cell lung cancer

Medicinal Benefits

Admatop 2.5 Injection contains 'Topotecan', which belongs to a group of anti-cancer medicines used to treat ovarian cancer and small cell lung cancer. It works by damaging the genetic material (DNA) of the cancer cells, which stops their growth and multiplication. It can be used alone or together with other chemotherapy drugs depending on the type of cancer you have.

Directions for Use

Admatop 2.5 Injection will be administered by a qualified healthcare professional. Hence, do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Admatop 2.5 Injection

  • Feeling generally weak and tired (temporary anaemia)
  • Low white blood cell count (neutropenia)
  • Unusual bruising or bleeding
  • Weight loss and loss of appetite (anorexia)
  • Tiredness
  • Weakness
  • Feeling sick (nausea)
  • Being sick (vomiting)
  • Diarrhoea
  • Stomach pain
  • Constipation
  • Inflammation and ulcers of the mouth, tongue or gums
  • Inflammation and ulcers of the mouth, tongue or gums
  • High body temperature (fever)
  • Hair loss
  • Headache
  • Allergic or hypersensitivity reactions (rash)
  • Yellow skin
  • Itching sensation
  • Feeling unwell (malaise)
  • Deficiency of the blood (pancytopenia)

Drug Warnings

Admatop 2.5 Injection will be administered by a healthcare professional. To treat your condition effectually, continue taking Admatop 2.5 Injection for as long as your doctor has prescribed. Do not stop Admatop 2.5 Injection midway. Talk to your doctor before taking Admatop 2.5 Injection if you have severe allergic reactions to Admatop 2.5 Injection or other medicines or suffer from severe lung problems, Infections, renal dysfunction, thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), hepatic disorders. Admatop 2.5 Injection should not be employed in patients with severe bone marrow depression or significant bleeding. Avoid taking Admatop 2.5 Injection if you are pregnant or breastfeeding because this Admatop 2.5 Injection can cause harmful effects on the unborn baby. Both women and men using this Admatop 2.5 Injection should use birth control to avoid pregnancy. Peripheral blood counts should be frequently monitored during Admatop 2.5 Injection treatment and appropriate until recovery is achieved. Do not receive any kind of immunization or vaccination without your doctor's approval while taking the Admatop 2.5 Injection.

Drug Interactions

Drug-Drug Interactions: Admatop 2.5 Injection interacts with medicines used in the treatment of chemotherapy (e.g. Paclitaxel), angiogenesis inhibitors (e.g. bevacizumab) and anti-tumour antibiotic medications (e.g. Doxorubicin).

Drug-Food Interactions: Avoid the consumption of alcohol and caffeine while taking Admatop 2.5 Injection.

Drug-Disease Interactions: Inform your doctor before taking the Admatop 2.5 Injection. It requires close monitoring if you suffer from Infections (bacterial/fungal/protozoal/viral), bleeding disorders, myelosuppression, bone marrow depression/low blood counts, renal dysfunction or disorders, interstitial lung disease, and diarrhoea.

Drug-Drug Interactions Checker List

  • PACLITAXEL
  • BEVACIZUMAB

Habit Forming

No

Diet & Lifestyle Advise

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugars.

Special Advise

  • Admatop 2.5 Injection should be taken under strict medical supervision. The doctor will regularly monitor your condition while taking Admatop 2.5 Injection.
  • Your doctor may get routine blood tests done to monitor your liver function, electrolyte levels, and blood cell count in your blood.
  • Peripheral blood counts should be frequently monitored during Admatop 2.5 Injection treatment and, when appropriate until recovery is achieved.
  • Avoid unnecessary or prolonged exposure to sunlight and UV light (such as tanning booths) and wear protective clothing, sunglasses, and sunscreen. Admatop 2.5 Injection may make your skin sensitive to sunlight.

Disease/Condition Glossary

Cancer: Cancer is a condition where cells in a specific body part grow and reproduce uncontrollably. The cancerous cells can invade and destroy surrounding healthy tissue, including organs. Cancer sometimes begins in one body part before spreading to other areas.

Ovarian cancer: Ovarian cancer is a type of cancer that begins in the ovaries (one of a pair of female reproductive glands in which the ova, or eggs, are formed).

Small cell lung cancer: Small cell lung cancer is a disease in which malignant (cancer) cells form in the lung tissues.

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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Admatop 2.5 Injection.

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Pregnancy

Unsafe

Admatop 2.5 Injection should not be used during pregnancy because it can harm your fetus (newborn baby). Both women of childbearing potential and men must use an effective contraception method while taking Admatop 2.5 Injection and at least for six months later treatment. Your doctor will weigh the benefits and risks before prescribing this medicine.

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Breast Feeding

Unsafe

Admatop 2.5 Injection should not be used during breastfeeding as it passes into the breastmilk and may harm your baby. Hence, if you are breastfeeding, inform your doctor before receiving this medicine.

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Driving

Caution

Admatop 2.5 Injection may affect your reactions and your ability to drive.Note: Possible side effects of chemotherapy with Admatop 2.5 Injection may occur, such as nausea and vomiting. If you are affected by these side effects, do not drive and/or operate machines that require your alertness.

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Liver

Caution

If you have had a history or evidence of liver impairment, please inform your doctor before taking the Admatop 2.5 Injection. Your doctor may adjust the dose or prescribe a suitable alternative if necessary based on your condition.

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Kidney

Caution

If you have had a history or evidence of kidney diseases, please inform your doctor before taking the Admatop 2.5 Injection. Your doctor may adjust the dose or prescribe a suitable alternative if necessary based on your condition.

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Children

Unsafe

The safety and effectiveness of Admatop 2.5 Injection in pediatric patients have not been established. Please consult your doctor. Your doctor will weigh the benefits and any potential risks before prescribing this medicine.

Country of origin

India

Manufacturer/Marketer address

FC/B-1 (Extn.), Mohan Co-operative Industrial Estate Mathura Road, New Delhi - 110 044
Other Info - ADM0077

Author Details

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FAQs

Admatop 2.5 Injection belongs to a group of medicines called anti-cancer drugs used in the treatment of ovarian cancer and small cell lung cancer. It is also used to treat advanced cervical cancer if surgery or radiotherapy treatment is not possible.
Admatop 2.5 Injection contains 'Topotecan'. Topotecan works by breaching the cellular wall and binding to the cell’s DNA, preventing the cell from dividing and functioning normally, which eventually kills the cell.
If you are allergic to topotecan or any other ingredients in this medication, are breastfeeding, or have too low blood cell counts, you should not use Admatop 2.5 Injection.
Yes, Admatop 2.5 Injection can cause low neutrophils levels, a type of white blood cells that help fight infections. If your white blood cells become low, you can be at higher risk for infections. Tell your doctor if you develop a fever or have an infection.
Avoid taking Admatop 2.5 Injection if you are pregnant because Admatop 2.5 Injection can cause harmful effects on the unborn baby. Females should follow effective birth control methods during treatment and at least six months after the final dose of Admatop 2.5 Injection.
The live vaccine may not work while on treatment with Admatop 2.5 Injection. Do not have immunizations/vaccinations without talking to your doctor first. Also, avoid contact with people who recently had immunizations /vaccinations.
Admatop 2.5 Injection is used to treat ovarian or small cell lung cancer that has come back after chemotherapy. On the other hand, it can also treat advanced cervical cancer if surgery or radiotherapy treatment is not possible. When treating cervical cancer, Admatop 2.5 Injection is used with another medication called cisplatin.

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