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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Croner 5mg Tablet is used to treat heavy, painful, or irregular periods, premenstrual syndrome (PMS), and endometriosis. Additionally, it may be used in the treatment of breast cancer. It contains Norethisterone, which works by restoring the hormone levels in the body. In some cases, this medicine may cause side effects such as unusual vaginal bleeding or spotting, dizziness, dry mouth, constipation, nausea, and diarrhoea. Let the doctor know if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Drug-Drug Interactions

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Severe

Drug-Drug Interactions

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Severe
How does the drug interact with Croner 5mg Tablet:
Using Felbamate and Croner 5mg Tablet together can reduce the blood levels and effects of norethindrone.

How to manage the interaction:
There may be a possibility of interaction between Croner 5mg Tablet and Felbamate, but it can be taken if prescribed by a doctor. If you notice any unusual symptoms like changes in your menstrual cycle, excessive bleeding, make sure to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Croner 5mg Tablet:
Coadministration of Croner 5mg Tablet and primidone can reduce the blood levels and effects of Croner 5mg Tablet and increase the risk of bleeding.

How to manage the interaction:
Although there is an interaction between Croner 5mg Tablet and Primidone, they can be taken together if prescribed by a doctor. However, if you experience abnormal bleeding, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Croner 5mg Tablet:
Taking griseofulvin with Croner 5mg Tablet may reduce blood levels and the effects of Croner 5mg Tablet.

How to manage the interaction:
Although there is a possible interaction between Griseofulvin and Croner 5mg Tablet, you can take these medicines together if prescribed by a doctor. However, if you experience any of these symptoms like unexpected bleeding or abnormal bleeding, it's important to contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NorethisteroneFosamprenavir
Severe
How does the drug interact with Croner 5mg Tablet:
Using norethindrone together with fosamprenavir may decrease the effects of fosamprenavir.

How to manage the interaction:
Taking Croner 5mg Tablet with Fosamprenavir together can result in an interaction, but it can be taken if your doctor has advised it. If you're taking birth control and experiencing any symptoms, it's important to reach out to a doctor right away. They can recommend other options that won't interfere with your medication. Do not discontinue any medications without consulting a doctor.
NorethisteroneFosphenytoin
Severe
How does the drug interact with Croner 5mg Tablet:
Coadministration of Croner 5mg Tablet with Fosphenytoin can reduces the blood levels and effects of Croner 5mg Tablet .

How to manage the interaction:
Taking Croner 5mg Tablet with Fosphenytoin together can result in an interaction, but it can be taken if your doctor has advised it. If you experience symptoms of abnormal bleeding while using birth control, it's important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
NorethisteroneBexarotene
Severe
How does the drug interact with Croner 5mg Tablet:
Coadministration of Bexarotene and Croner 5mg Tablet together can decrease the effectiveness of norethindrone and increase the risk of unintended pregnancy.

How to manage the interaction:
Combining Bexarotene with Croner 5mg Tablet can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms like increased hot flashes, vaginal dryness, or menstrual abnormalities, contact the doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Croner 5mg Tablet:
Coadministration of Acitretin with Croner 5mg Tablet may interfere with the contraceptive effect of Croner 5mg Tablet.

How to manage the interaction:
Acitretin and Croner 5mg Tablet should be used together only if prescribed by your doctor. Use of at least two methods of effective contraception is mandatory during acitretin therapy and for at least 3 years after stopping therapy.
How does the drug interact with Croner 5mg Tablet:
Coadministration of Croner 5mg Tablet with Dabrafenib can reduce the metabolism and decrease the levels of Croner 5mg Tablet in the body.

How to manage the interaction:
Taking Croner 5mg Tablet with Dabrafenib together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of hot flashes, vaginal dryness, or abnormal bleeding, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Croner 5mg Tablet:
The combined use of Croner 5mg Tablet and phenobarbital can reduce the blood levels and effects of Croner 5mg Tablet.

How to manage the interaction:
Although taking phenobarbital and Croner 5mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. If you experience any symptoms like abnormal bleeding, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Croner 5mg Tablet:
Coadministration of Croner 5mg Tablet with Topiramate can reduce the blood levels and effects of norethindrone in the body. This increases the risk of severe bleeding and unintended pregnancy.

How to manage the interaction:
Taking Croner 5mg Tablet and topiramate together can result in an interaction; it can be taken if your doctor has advised it. However, if you notice any symptoms of abnormal bleeding, hot flashes or vaginal dryness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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NORETHISTERONE-5MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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NORETHISTERONE-5MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Consuming Grapefruit juice may increase the blood levels of Croner 5mg Tablet. Avoid or limit the consumption of grapefruit and grapefruit juice while taking the Croner 5mg Tablet dose. Avoid or limit the consumption of grapefruit and grapefruit juice while taking the Croner 5mg Tablet dose.

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