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Norethisterone

About Norethisterone

Norethisterone belongs to the class of medicines called progestogens used to treat heavy, painful, or irregular periods, premenstrual syndrome (PMS), and endometriosis. Additionally, Norethisterone may be used in the treatment of breast cancer. Endometriosis is a disorder in which the uterus's tissue lining (endometrium) grows on the ovaries, bowel, or tissues lining the pelvis. The most common symptom is pelvic pain.

Norethisterone contains Norethisterone that works by mimicking the activity of the natural hormone progesterone. Thereby, it restores hormone levels in the body and regulates the growth and shedding of the womb lining. Thus, it helps to treat menstrual disorders.

Take Norethisterone as prescribed by your doctor. You are advised to take Norethisterone for as long as your doctor has prescribed it for you based on your medical condition. In some cases, you may experience unusual vaginal bleeding or spotting, dizziness, dry mouth, constipation, nausea, diarrhoea, headache, breast pain, and tenderness. Most of these side effects of Norethisterone do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Norethisterone or any other medicines, please tell your doctor. Norethisterone is not recommended for pregnant women as it may harm the unborn baby. If you are breastfeeding, consult a doctor before taking Norethisterone. It is advised to use effective non-hormonal contraceptives such as condoms to avoid pregnancy while taking Norethisterone. You are advised to stop smoking while taking Norethisterone as it may increase the risk of adverse effects.

Uses of Norethisterone

Treatment of Heavy, painful or irregular periods, Premenstrual syndrome (PMS), Endometriosis, Breast cancer.

Medicinal Benefits

Norethisterone contains Norethisterone, a synthetic hormone that mimics the activity of the natural hormone progesterone. Thereby, it restores hormone levels in the body and regulates the growth and shedding of the womb lining. Thus, it helps to treat menstrual disorders.

Directions for Use

Take Norethisterone with or without food as advised by your doctor. Swallow it as a whole with a glass of water. Do not crush, chew or break it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Norethisterone

  • Unusual vaginal bleeding or spotting
  • Dizziness
  • Dry mouth
  • Constipation
  • Nausea
  • Diarrhea
  • Headache
  • Breast pain and tenderness

Drug Warnings

If you are allergic to Norethisterone or any other medicines, please tell your doctor. Norethisterone is not recommended for pregnant women as it may harm an unborn baby. If you are breastfeeding, consult a doctor before taking Norethisterone. It is advised to use effective non-hormonal contraceptives such as condoms to avoid pregnancy while taking Norethisterone. You are advised to stop smoking while taking Norethisterone as it may increase the risk of adverse effects. If you are about to undergo any surgery, please inform your doctor that you are taking Norethisterone as it may increase the effect of certain anesthetics. If you experience sudden shortness of breath, rapid heartbeat, sudden, severe, sharp pain in the chest, or cough up blood, stop taking Norethisterone and consult a doctor immediately as these might be signs of a blood clot in the lungs.

Drug Interactions

Drug-Drug Interactions: Norethisterone may interact with anticonvulsants (carbamazepine, phenytoin), antiviral drugs (nelfinavir, ritonavir), a medicine used to treat Cushing’s syndrome (aminoglutethimide), antibiotics (co-trimoxazole, rifampicin, tetracycline), immunosuppressant (ciclosporin).

Drug-Food Interaction: Norethisterone may interact with St. John’s wort (herbal medicine used to treat depression). Also, limit the intake of grapefruit juice with Norethisterone as it may increase the levels of Norethisterone in the blood.  

Drug-Disease Interactions: Avoid taking Norethisterone if you have vaginal bleeding, blood clots, severe itching, porphyria (blood disorder), liver problems, angina (chest pain), or if you ever had a heart attack, jaundice, or pemphigoid gestationis (an itchy rash that develops into blisters). If you have asthma, migraine headaches, epilepsy (fits), kidney or heart problems, inform your doctor before taking Norethisterone.

Drug-Drug Interactions Checker List:

  • CARBAMAZEPINE
  • PHENYTOIN
  • NELFINAVIR
  • RITONAVIR
  • AMINOGLUTETHIMIDE
  • COTRIMOXAZOLE
  • RIFAMPICIN
  • TETRACYCLINE
  • CICLOSPORIN
  • Safety Advice

    • Safety Warning

      Alcohol

      caution

      The interaction of Norethisterone with alcohol is unknown. Please consult a doctor before consuming alcohol while using Norethisterone.

    • Safety Warning

      Pregnancy

      unsafe

      Norethisterone is a category X pregnancy drug and is not recommended for use during pregnancy as it may harm the unborn baby. Please consult a doctor if you are pregnant or planning for pregnancy.

    • Safety Warning

      Breast Feeding

      caution

      Norethisterone is given to breastfeeding women only if the doctor thinks benefits are greater than risks. Please consult a doctor if you are breastfeeding.

    • Safety Warning

      Driving

      safe if prescribed

      Norethisterone usually does not affect your ability to drive or operate machinery.

    • Safety Warning

      Liver

      unsafe

      Norethisterone is not recommended if you have liver disease. However, if you have any concerns regarding this, please consult a doctor.

    • Safety Warning

      Kidney

      caution

      Take Norethisterone with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

    • Safety Warning

      Children

      caution

      Norethisterone is not recommended for use in children under 18 years.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • Avoid fried and processed foods.
    • Include fiber-rich foods like whole grains, fruits, and vegetables in your diet.
    • Avoid refined carbohydrates that are high in sugars.
    • Replace animal proteins (like eggs, fish, and meat) with vegetable protein sources (nuts, seeds, and beans).
    • Avoid drinking excess alcohol or caffeinated drinks as they can worsen the symptoms.
    • Maintain a healthy weight, do moderate exercise regularly.
    • Avoid smoking and alcohol intake.

    Special Advise

    • Norethisterone may interfere with certain laboratory tests. Therefore, inform your doctor that you are taking Norethisterone before undergoing any tests.

    Patients Concern

    Disease/Condition Glossary

    Endometriosis: It is a disorder in which the tissue lining the uterus (endometrium) grows on the ovaries, bowel, or tissues lining the pelvis. The most common symptom is pelvic pain. Other symptoms of endometriosis include lower back pain, painful periods, heavy menstrual bleeding, pain following sexual intercourse, or discomfort with bowel movements. 

    FAQs

    Norethisterone is used to treat heavy, painful, or irregular periods, premenstrual syndrome (PMS), and endometriosis. Additionally, Norethisterone may be used in the treatment of breast cancer.

    Norethisterone contains Norethisterone, a synthetic hormone that works by mimicking the activity of the natural hormone progesterone. Thereby, it restores hormone levels in the body and regulates the growth and shedding of the womb lining. Thus, it helps to treat menstrual disorders.

    Norethisterone may be used to delay periods. Norethisterone keeps progesterone levels high and prevents shedding of the womb lining. However, please consult a doctor before using Norethisterone.

    Norethisterone may increase the risk of a blood clot in the veins of the leg, especially if you are overweight, smoking, or have a history of a blood clot in the lungs or veins, repeated miscarriage or have major surgery, serious injury, or systemic lupus erythematosus (autoimmune disease). Therefore, please inform your doctor if you have any of these conditions before taking Norethisterone.

    You are not recommended to take Norethisterone with rifampicin as it may decrease the levels of Norethisterone in blood and reduce its effectiveness. However, please consult a doctor before taking Norethisterone with other medicines.

    Periods usually resume within 3 days of discontinuing Norethisterone. However, please consult a doctor if you have any concerns regarding this.

    Norethisterone may cause changes in blood sugar levels. Therefore, it is advised to regularly monitor blood sugar levels while taking Norethisterone and inform your doctor if you have diabetes before taking Norethisterone.

    No, Norethisterone is not a contraceptive on its own.

    No, Norethisterone is unlikely to cause weight loss.

    The recommended dosage can vary greatly depending on the reason for taking the medication. It's crucial to follow your doctor's instructions precisely. Taking an incorrect dosage can lead to ineffective treatment or adverse side effects.

    No, Norethisterone does not cause miscarriages. However, it is not safe to take Norethisterone during pregnancy.

    Norethisterone can generally be taken either before or after a meal. There is no strict requirement regarding the timing of food intake.

    Norethisterone contains Norethisterone, a second-generation progestin.

    The duration of Norethisterone use can vary depending on the specific medical condition being treated.

    Yes, Norethisterone treats irregular menstrual cycles.

    Even after taking Norethisterone and having unprotected sex, one can get pregnant. However, Norethisterone is a category X pregnancy drug. It is not recommended for use during pregnancy as it may harm the unborn baby. Please consult a doctor if you are pregnant or planning for pregnancy.

    Common side effects of Norethisterone may cause unusual vaginal bleeding or spotting, dizziness, dry mouth, constipation, nausea, diarrhoea, headache, breast pain, and tenderness. Most of these side effects of Norethisterone do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

    Yes, Norethisterone can lead to weight gain in some persons. However, it's crucial to remember that this isn't a common adverse effect. The potential risk of weight gain varies based on the individual and the dosage. Talk to your doctor or pharmacist if you are concerned about weight gain or have any other questions regarding norethisterone acetate. They can provide personalized information based on your circumstances.

    Limited research is available. Seek medical attention from your doctor if you have any questions. Remember that self-medication can be risky. Always consult with a healthcare professional for proper diagnosis and treatment.

    Yes, bleeding may occasionally occur while taking Norethisterone. If you're experiencing bleeding while on Norethisterone and you're concerned, it's important to consult with your healthcare provider. They can determine if the bleeding is normal or if there's another underlying issue.

    Norethisterone usually stops irregular bleeding within a few days, but this varies from person to person. If bleeding persists or worsens, consult your doctor.

    The duration of Norethisterone use depends on your specific medical condition and the reason for taking it.

    The exact dosage and schedule for Norethisterone will vary based on your individual health needs. It is important to follow your doctor's instructions to ensure effective treatment and minimize side effects.

    If you forget a dose of Norethisterone, take it as soon as possible. If it's been more than 12 hours, skip the missed dose and continue with your regular schedule or as directed by the physician.

    Yes, Norethisterone can interact with other medications. It's important to avoid taking Norethisterone with any medications without consulting your doctor first. They can assess the potential risks and benefits and recommend alternative treatments if necessary.

    Store in a cool and dry place away from sunlight. Keep Norethisterone out of reach and out of sight to children.

    Norethisterone can be used to treat long-term disorders like endometriosis. But you should talk to your doctor about the long-term advantages and risks.

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    Norethisterone

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