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Vericiguat

About Vericiguat

Vericiguat is used to reduce the risk of death and the need for hospitalization in adults with heart failure. Heart failure is a condition in which the heart is unable to pump blood as effectively as it should.

Vericiguat contains Vericiguat, which works by relaxing the blood vessels in the lungs to allow blood to flow easily.

Sometimes, Vericiguat may cause hypotension, anaemia, dizziness and light-headedness as side effects. Most of these side effects are temporary, do not require medical attention, and gradually resolve over time. However, if the side effects persist or worsen, contact your doctor.

Before taking Vericiguat, inform your doctor about all your allergic to medicines or food. Vericiguat can cause fetal harm when administered to a pregnant woman. Using effective contraceptive methods is recommended while on therapy with Vericiguat. Breastfeeding is usually not advised during this treatment.

Uses of Vericiguat

Vericiguat is used in the management of systolic heart failure to reduce mortality and hospitalizations. The detailed uses of Vericiguat are as follows: • Chronic heart failure with reduced ejection fraction (HFrEF): Vericiguat is used in adults with symptomatic chronic heart failure who have a left ventricular ejection fraction (LVEF) less than 45%. It helps the heart pump blood more efficiently by stimulating soluble guanylate cyclase (sGC), an enzyme involved in cardiovascular regulation. • Post-hospitalization heart failure management: Vericiguat is prescribed to reduce the risk of cardiovascular death and heart failure-related hospitalizations in patients who have recently been hospitalized for heart failure or required outpatient intravenous (IV) diuretics. • Improved blood circulation: Vericiguat works by relaxing blood vessels and improving blood flow, which helps reduce the workload on the heart and alleviates symptoms like breathlessness, fatigue, and swelling.

Medicinal Benefits

  • Vericiguat contains Vericiguat, a soluble guanylate cyclase (sGC) stimulator.
  • It is primarily used in adults who have symptoms of chronic (long-term) heart failure, have recently been hospitalised or require intravenous (IV) medications.
  • Vericiguat is also used in patients who have an ejection fraction (amount of blood pumped with each heartbeat of less than 45 per cent) to reduce the risk of death and the need to be hospitalized.
  • Vericiguat works by relaxing the blood vessels in the lungs to allow blood to flow easily.

Directions for Use

  • Take Vericiguat with food or as advised by your doctor.
  • It is recommended to take Vericiguat once daily; however, follow your doctor’s advice regarding the dosage and duration.
  • Swallow the tablet as a whole with water. Tablets may be crushed and mixed with water for patients who have difficulty swallowing.
  • Do not chew Vericiguat.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Vericiguat

  • Hypotension (low blood pressure)
  • Anaemia (low red blood cells)
  • Dizziness
  • Light-headedness

Drug Warnings

  • Before taking Vericiguat, let your doctor know about any allergies or hypersensitivities to medicines or food.
  • Do not use Vericiguat and any medication for erectile dysfunction (male impotence) simultaneously.
  • Please check with your doctor before using Vericiguat if you have/had anaemia, low blood pressure, or any severe medical illness.
  • Before starting Vericiguat, inform your doctor about your medical history and ongoing therapies to rule out potential adverse effects or interactions.
  • Vericiguat can cause fetal harm when administered to a pregnant woman.
  • Using effective contraceptive methods is recommended while on therapy with Vericiguat.
  • Breastfeeding is usually not advised during this treatment.
  • Vericiguat is not recommended for use in children below 16 years.

Drug Interactions

Drug-Drug interactions: Vericiguat may interact with medicines used for erectile dysfunction (e.g. avanafil, sildenafil, vardenafil, tadalafil) and certain medications used to treat pulmonary arterial hypertension (e.g. riociguat)

Drug-Food Interactions: Avoid the consumption of alcoholic beverages.

Drug-Disease Interactions: Inform your doctor if you have/had anaemia (low red blood cells), low blood pressure, and liver or kidney impairment.

Drug-Drug Interactions Checker List:

  • AVANAFIL
  • VARDENAFIL
  • TADALAFIL
  • RIOCIGAUT
  • Safety Advice

    • Safety Warning

      Alcohol

      unsafe

      Intake of alcohol should be avoided with Vericiguat.

    • Safety Warning

      Pregnancy

      unsafe

      Vericiguat should not be used during pregnancy. So, inform your doctor if you are pregnant or suspect pregnancy. You or your partner must use a reliable form of contraception to prevent pregnancy while taking Vericiguat.

    • Safety Warning

      Breast Feeding

      unsafe

      You should not breastfeed while taking this medication.

    • Safety Warning

      Driving

      unsafe

      Vericiguat may cause dizziness. So, driving vehicles and operating machinery which requires concentration should be avoided.

    • Safety Warning

      Liver

      caution

      Caution is advised. Vericiguat has not been studied in patients with severe hepatic impairment. Inform your doctor before using Vericiguat if you have liver problems or a history of liver conditions.

    • Safety Warning

      Kidney

      caution

      Caution is advised. Inform your doctor before using Vericiguat if you have kidney problems or a history of kidney conditions.

    • Safety Warning

      Children

      unsafe

      The safety and effectiveness of Vericiguat in children have not been established.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • Follow a cholesterol-lowering diet.
    • Consume low salt and a low-fat diet.
    • Exercise regularly. It helps in maintaining proper weight and lowers cholesterol.
    • Limit salt and sugar intake.
    • Avoid smoking and alcohol consumption.
    • Choose healthy fats and cut down on trans fats.
    • Include omega-3 fatty acids, fibre-rich food, fruits, and vegetables.
    • Get active by doing physical activities such as swimming, brisk walking, or jogging. Take the stairs instead of elevators/lifts.

    Patients Concern

    Disease/Condition Glossary

    Heart failure: Heart failure is a condition in which the heart is unable to pump blood as effectively as it should. Conditions such as coronary artery disease, arrhythmia, congenital heart defect, diabetes, overactive/underactive thyroid, or high blood pressure make the heart too weak to pump blood efficiently. Symptoms of heart failure include shortness of breath, rapid heartbeat, swollen legs, and fatigue. People with disease conditions such as diabetes, thyroid problems, anaemia, emphysema, and behavioural conditions like smoking and being overweight are at an increased risk of developing heart failure.

    FAQs

    Vericiguat is used to reduce the risk of death and the need for hospitalization in adults with heart failure.

    Vericiguat contains Vericiguat, which works by relaxing the blood vessels and allowing blood to flow easily. As a result, the heart can pump more efficiently and does not have to work as hard. As a result, it helps to lower the risk of death and hospitalization in people with heart failure.

    No, you should not combine Vericiguat with an erectile dysfunction medicine such as sildenafil or tadalafil since it may interfere with the blood pressure-lowering action of Vericiguat.

    Yes, dizziness or light-headedness is the most common side effect encountered while using Vericiguat. Please take sufficient rest. If the problem persists, consult your doctor.

    Vericiguat may not be recommended for patients with hypotension (low blood pressure); inform your doctor before using Vericiguat if you have a history of hypotension.

    Available Medicines for

    Vericiguat

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