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Trastuzumab+pertuzumab

About Trastuzumab+pertuzumab

Trastuzumab+pertuzumab belongs to the group of anti-cancer medicines indicated in the treatment of breast cancer. This medicine only works if the cancer is HER2 (Human epidermal growth factor 2)-positive. Breast cancer is the cancer that forms in the breast tissue.

Trastuzumab+pertuzumab contains Trastuzumab and Pertuzumab, which work by locking onto HER2 on the cancer cells. They stop the cancer cells from growing and kill them, helping treat breast cancer.

In some cases, Trastuzumab+pertuzumab may cause side effects, such as hair loss, nausea, anaemia, joint pain, and weakness. Do not be reluctant to talk with your doctor if any of the side effects persist or worsen.

Trastuzumab+pertuzumab is not recommended if you are pregnant or breastfeeding. The safety and effectiveness of Trastuzumab+pertuzumab in children below 18 years have not been established. Keep the doctor informed about your health condition and medications to rule out any side effects/interactions.

Uses of Trastuzumab+pertuzumab

Treatment of breast cancer

Medicinal Benefits

Trastuzumab+pertuzumab is used to treat breast cancer. It contains Trastuzumab and Pertuzumab, which are targeted cancer drugs called monoclonal antibodies. Trastuzumab+pertuzumab works by locking onto HER2 (Human epidermal growth factor 2, a protein that makes cancer cells grow and divide). It stops the cancer cells from growing and kills them, thus helping treat breast cancer.

Directions for Use

Trastuzumab+pertuzumab will be administered by a healthcare professional; do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Trastuzumab+pertuzumab

  • Diarrhoea
  • Nausea
  • Anaemia (decreased red blood cell count)
  • Arthralgia (joint pain)
  • Asthenia (weakness)
  • Alopecia (hair loss)

Drug Warnings

Do not use Trastuzumab+pertuzumab if you are allergic to any of its components. Inform the doctor if you have/had heart problems (like heart failure, irregular heartbeats, recent heart attack, uncontrolled high blood pressure), if you have had anthracyclines (doxorubicin or epirubicin) or if you have had radiotherapy to the chest area as they may increase the risk of heart problems. Trastuzumab+pertuzumab is not recommended for use during pregnancy, lactation, or in children. Consult the doctor if you experience symptoms of infection (change in temperature, aching muscles, headaches, feeling cold and shivery and generally unwell), skin/nail problems (raised, red, itchy rash which looks like nettle rash), eye problems (blurred vision, sore, red, itchy, dry eyes or an infection), heart problems (low/high blood pressure, irregular heartbeat, feeling confused, dizzy and faint, persistent cough that gets worse at night, a wheeze and fast heart rate, swelling in your legs or tummy, chest pain, and shortness of breath), or lung problems (chest pain, a dry cough, and changes in breathing). 

Drug Interactions

Drug-Drug Interactions: No interactions found/established.

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: No interactions found/established.

Drug-Drug Interactions Checker List:

Safety Advice

  • Safety Warning

    Alcohol

    consult your doctor

    It is not known if alcohol affects Trastuzumab+pertuzumab. Please consult the doctor.

  • Safety Warning

    Pregnancy

    unsafe

    Trastuzumab+pertuzumab may cause foetal harm. Consult the doctor if you are pregnant, think you may be pregnant or if you are planning for pregnancy.

  • Safety Warning

    Breast Feeding

    unsafe

    This medicine may pass into breast milk. Therefore, avoid breastfeeding during treatment and 7 months after the last dose.

  • Safety Warning

    Driving

    caution

    Trastuzumab+pertuzumab may cause headache, tiredness or dizziness. Drive or operate machinery only if you are alert.

  • Safety Warning

    Liver

    consult your doctor

    If you have a history of liver problems, inform the doctor before receiving Trastuzumab+pertuzumab.

  • Safety Warning

    Kidney

    consult your doctor

    If you have a history of kidney problems, inform the doctor before receiving Trastuzumab+pertuzumab.

  • Safety Warning

    Children

    unsafe

    Trastuzumab+pertuzumab is not recommended for children below 18 years as the safety and effectiveness have not been established.

Habit Forming

No

Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include fruits and vegetables in your diet.
  • Avoid fast, fried, processed meats, refined carbs, and added sugar.
  • Get optimal sleep; rest well.

Special Advise

  • Avoid becoming pregnant during treatment with Trastuzumab+pertuzumab and for 7 months after the last dose. Talk to the doctor about effective contraception before starting the treatment.
  • Consult the doctor if you or your partner become pregnant during therapy.
  • The doctor may recommend blood tests before and during the treatment. Regular liver and kidney function monitoring may also be advised.
  • Regular heart tests (such as ECG) are recommended for monitoring heart function.

Patients Concern

Disease/Condition Glossary

Breast cancer: It is a type of cancer that develops in the breast when the breast cells begin to grow abnormally. Breast cancer may form in lobules (glands that produce milk), ducts of the breast (the pathway that brings milk from glands to the nipple), the fatty tissue or the fibrous connective tissue within the breast. The tumour cells invade other healthy breast cells and can travel to lymph nodes, a primary pathway for the cancer cells to move to other parts of the body. Symptoms of breast cancer include a lump in the breast or tissue thickening which feels different than the normal surrounding tissues, breast pain, redness, swelling, nipple discharge other than breast milk, bloody discharge, unexplained change in shape, size or appearance of the breast, peeling, flaking or scaling of the skin, and a lump or swelling under the arm.

FAQs

Trastuzumab+pertuzumab is used to treat breast cancer.

Trastuzumab+pertuzumab works by stopping the growth of cancer cells and killing them. Thereby, it helps treat cancer.

Trastuzumab+pertuzumab may increase the risk of infections due to decreased white blood cells. Seek medical attention if you notice symptoms of infection such as changes in temperature, muscle aches, feeling unwell, headaches, cold, and shivery.

Do not undergo immunisations with live vaccine whilst on treatment with Trastuzumab+pertuzumab and for 12 months after the last dose. Consult the doctor regarding how long you should avoid live vaccines.

You could lose all your hair, including eyelashes, underarms, eyebrows, legs and sometimes pubic hair. The hair might grow back once the treatment is completed. However, it may be softer, in a different colour, or curlier than before.

Available Medicines for

Trastuzumab+pertuzumab

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