Pantoprazole+levosulpiride
About Pantoprazole+levosulpiride
Pantoprazole+levosulpiride is used to treat gastro-oesophageal reflux disease (GERD), acidity, indigestion, heartburn, and peptic ulcers. Gastroesophageal reflux disease occurs when stomach acid frequently flows back into the food pipe (oesophagus). This causes acidity and heartburn.
Pantoprazole+levosulpiride is a combination of Pantoprazole and Levosulpiride. Pantoprazole lowers acid production in the stomach. Levosulpiride works by increasing the pressure of the inferior oesophageal (food pipe) sphincter, thereby preventing the backflow of food and acid into the mouth.
In some cases, you may experience certain common side effects such as headache, nausea, vomiting, gas, dry mouth, dizziness and diarrhoea. Most of these side effects do not require medical attention. However, talk to your doctor if you experience these side effects persistently.
Inform your doctor before taking Pantoprazole+levosulpiride if you have a history of gastrointestinal bleeding or intestinal obstruction. On long-term treatment, Pantoprazole+levosulpiride may cause osteoporosis and hypomagnesemia (low magnesium levels). Consult your doctor if you are pregnant or breastfeeding.
Uses of Pantoprazole+levosulpiride
Medicinal Benefits
- Pantoprazole+levosulpiride is used to treat gastro-oesophageal reflux disease, acidity, indigestion, heartburn, and peptic ulcers.
- It helps lower acid production in the stomach.
- Reduces heartburn and acid reflux symptoms.
- Prevents food and acid from flowing back into the esophagus (food pipe).
- Supports the healing of the esophagus lining.
- Relieves nausea, vomiting, and bloating.
Directions for Use
- Pantoprazole+levosulpiride should be taken 60 minutes before a meal to maximize its effects.
- It is usually taken once daily, preferably in the morning, or as prescribed by your doctor.
- Swallow Pantoprazole+levosulpiride as a whole with a glass of water.
- Do not crush, break, or open it.
Storage
Side Effects of Pantoprazole+levosulpiride
- Headache
- Nausea
- Vomiting
- Gas
- Dry mouth
- Dizziness
- Diarrhoea
Drug Warnings
- Do not take Pantoprazole+levosulpiride if you are allergic to any of its contents.
- Inform your doctor if you have a history of pheochromocytoma (tumour of the adrenal gland), epilepsy, mania, gastrointestinal bleeding, intestinal obstruction, or severe kidney and liver impairment.
- Pantoprazole+levosulpiride may cause osteoporosis (weak, brittle bones) and hypomagnesemia (low magnesium levels) with long-term treatment.
- Consult your doctor if you are pregnant or breastfeeding. Pantoprazole+levosulpiride may cause dizziness and drowsiness, so drive only if you are alert.
- Pantoprazole+levosulpiride should not be given to children as safety and effectiveness have not been established.
- Avoid consuming alcohol along with Pantoprazole+levosulpiride as it could lead to increased drowsiness and can elevate the production of stomach acid.
Drug Interactions
Drug-Drug Interactions: Pantoprazole+levosulpiride may interact with medicines such as anti-fungal (ketoconazole, itraconazole, posaconazole) anti-cancer (erlotinib), blood thinner (warfarin, phenprocoumon), anti-HIV (atazanavir), a drug used to treat rheumatoid arthritis, psoriasis, and cancer (methotrexate), anti-depressant (fluvoxamine), antibiotic (rifampicin), and herbal supplement (St John’s wort).
Drug-Food Interactions: Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
Drug-Disease Interactions: Inform your doctor if you have gastrointestinal bleeding, intestinal obstruction, pheochromocytoma (tumour of the adrenal gland), epilepsy, mania, Clostridium difficile-associated diarrhoea (CDAD), liver disease, bone fractures, hypomagnesemia (low levels of magnesium).
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid consumption of alcohol while taking Pantoprazole+levosulpiride. Alcohol intake leads to increased production of stomach acid, thereby increases acidity and heartburn.
Pregnancy
consult your doctorConsult your doctor before taking Pantoprazole+levosulpiride if you are pregnant; your doctor will prescribe only if the benefits outweigh the risks.
Breast Feeding
consult your doctorPantoprazole+levosulpiride may pass into breast milk. Consult your doctor before taking Pantoprazole+levosulpiride; your doctor will decide whether Pantoprazole+levosulpiride can be taken by breastfeeding mothers or not.
Driving
cautionPantoprazole+levosulpiride causes dizziness and drowsiness. Do not drive or operate machinery unless you are alert.
Liver
consult your doctorDose adjustment may be needed. Consult your doctor before taking Pantoprazole+levosulpiride if you have a liver impairment or any concerns regarding this.
Kidney
consult your doctorDose adjustment may be needed. Consult your doctor before taking Pantoprazole+levosulpiride if you have kidney impairment or any concerns regarding this.
Children
unsafePantoprazole+levosulpiride should not be given to children as the safety and effectiveness were not established.
Habit Forming
Diet & Lifestyle Advise
- Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
- Eat smaller meals more often.
- Maintain a healthy weight through regular exercise.
- Avoid lying down after eating.
- Avoid tight-fitting clothes.
- Practise relaxation techniques and avoid stress by doing yoga or meditation.
- Avoid foods such as high-fat foods, spicy foods, chocolates, citrus fruits, pineapple, tomatoes, onions, garlic, tea, and soda.
- Avoid sitting continuously, as it may trigger acidity. Take a 5-minute break every hour by doing brisk walking or stretching.
Patients Concern
Disease/Condition Glossary
Acidity: The stomach is usually protected from acid by a mucous layer. In some cases, due to excess acid production, the mucous layer gets eroded, which leads to complications like GERD, acidity, heartburn, and peptic ulcers.
Gastroesophageal reflux disease (GERD): It occurs when stomach acid frequently flows back into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe and causes heartburn and acidity. Symptoms include heartburn, sour or bitter taste in the mouth, and difficulty swallowing.
Peptic ulcers: Peptic ulcers are sores that develop on the lining of the stomach and intestine due to erosion of the stomach's protective lining. Symptoms include nausea, changes in appetite, bloody or dark stools, unexplained weight loss, vomiting, and indigestion.
Indigestion: Indigestion is the feeling of fullness. It occurs due to slow gastric emptying. Symptoms include stomach pain, bloating, heartburn, nausea and vomiting.
FAQs
Pantoprazole+levosulpiride is used to treat Gastro-oesophageal reflux disease, acidity, indigestion, heartburn, and peptic ulcers.
Pantoprazole+levosulpiride works by blocking the action of an enzyme called the gastric proton pump, which is responsible for the production of acid. It prevents the backflow of food and acid into the mouth.
Avoid lying down immediately after meals to prevent acid reflux. Raise the head of the bed 10-20cm by putting a pillow so that the head and chest are above the waist. This helps in preventing acid reflux.
Pantoprazole+levosulpiride contains pantoprazole, which might increase the risk of osteoporosis (weak and brittle bones). This mainly occurs in people taking higher doses of Pantoprazole+levosulpiride for longer durations. Your doctor may prescribe calcium and vitamin D supplements if you are at risk of osteoporosis.
Do not take Pantoprazole+levosulpiride for longer durations unless prescribed by the doctor. Talk to your doctor if you do not find symptomatic relief. The doctor may monitor your condition regularly if you are on long term treatment with Pantoprazole+levosulpiride.
Dry mouth could be a side effect of Pantoprazole+levosulpiride. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might help in stimulating saliva and thereby prevent drying of the mouth.
Diarrhoea might be a side-effect of Pantoprazole+levosulpiride. Drink enough fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.
Pantocid and Pantoprazole+levosulpiride contain different active ingredients. Pantocid contains pantoprazole, which is a proton pump inhibitor that reduces the amount of acid produced in the stomach. Pantoprazole+levosulpiride contains a combination of pantoprazole and levosulpiride. Pantoprazole reduces stomach acid, while levosulpiride is a prokinetic agent that helps improve gastric motility and reduce symptoms like bloating and nausea. Your doctor will prescribe the appropriate medication based on your medical history and the cause of your condition.
Take Pantoprazole+levosulpiride one hour before a meal, ideally in the morning. This helps ensure the medication is absorbed correctly and works effectively to reduce stomach acid and improve gastric motility. Consult your doctor if you have any concerns regarding frequency and timing.
The use of Pantoprazole+levosulpiride is contraindicated in certain patient populations. Specifically, this combination is not recommended for individuals with a known allergy to any of the formulation components. Additionally, it is contraindicated in patients with severe liver impairment, as well as those who are pregnant or breastfeeding. Furthermore, it is not suitable for patients with prolactin-dependent tumours. It is essential to consult a healthcare provider before initiating treatment with it to ensure safe and effective use.
The use of Pantoprazole+levosulpiride can cause dizziness in some patients. If you experience dizziness, avoiding activities requiring mental focus, such as driving, is best until you feel better.
