Nimesulide+paracetamol
About Nimesulide+paracetamol
Nimesulide+paracetamol belongs to a class of painkillers called non-steroidal anti-inflammatory drugs (NSAIDs) used to relieve pain in conditions like osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and dysmenorrhea. Besides this, it is also useful for dental pain, muscle pain, back pain, ear pain, and throat pain.
Nimesulide+paracetamol is composed of two medicines: Nimesulide and Paracetamol. Nimesulide+paracetamol works by blocking the effect of prostaglandins, a chemical responsible for inducing pain and inflammation in the body. It also lowers the elevated body temperature by promoting heat loss (through sweating), which helps reset the hypothalamic thermostat. Together, Nimesulide+paracetamol helps relieve pain.
Take Nimesulide+paracetamol exactly as directed by your doctor. The most common side effects of Nimesulide+paracetamol are loss of appetite (in case of liver condition), nausea, vomiting, abdominal pain, persistent tiredness or dark/discoloured urine. It is not necessary for everyone to experience the above side effects. In case of any discomfort, speak with your doctor.
Do not take Nimesulide+paracetamol if you are allergic to painkillers like aspirin, ibuprofen, naproxen or diclofenac. It is not recommended for use in children, people with liver disease, heart disease or gastric ulcers/bleeding problems. Nimesulide+paracetamol may be associated with a small increase in heart attack risk (myocardial infarction). Avoid alcohol consumption as it may damage your liver and cause increased side effects on taking this medicine. Consult your doctor if your pain, inflammation and fever symptoms do not disappear even after ten days.
Uses of Nimesulide+paracetamol
Medicinal Benefits
Nimesulide+paracetamol comprises nimesulide and paracetamol, primarily used to treat mild to moderate pain. Nimesulide+paracetamol is prescribed mainly to treat pain and relieve discomfort caused by conditions like tooth pain, arthritis, period pain and other types of short-term pains. It helps treat pain by blocking the chemical messenger in the brain responsible for causing fever, pain and inflammation. Nimesulide works by blocking the effect of a chemical known as prostaglandin, responsible for inducing pain and inflammation in our body. On the other hand, Paracetamol lowers the elevated body temperature and mild pain by inhibiting prostaglandin synthesis by promoting heat loss (through sweating) that helps reset the hypothalamic thermostat. Paracetamol has the advantage of producing less gastric irritation than other painkillers like aspirin.
Directions for Use
Storage
Side Effects of Nimesulide+paracetamol
- Nausea
- Vomiting
- Loss of appetite
- Abdominal pain
- Persistent tiredness
- Dark/discoloured urine
Drug Warnings
Nimesulide+paracetamol is contraindicated in patients with a history of hypersensitivity (allergic) reaction to Nimesulide+paracetamol, paracetamol, nimesulide, or other pain killers. Please inform your doctor before starting Nimesulide+paracetamol if you have an active stomach ulcer, recent gastrointestinal bleeding, asthma, recent by-pass heart surgery or severe kidney/liver impairment. Nimesulide present in Nimesulide+paracetamol is known to affect fertility, so if you are planning for pregnancy, contact the doctor. Nimesulide+paracetamol should be avoided in both pregnant (especially last trimester of pregnancy) and breastfeeding women, as it may pass the milk affecting the baby. Patients with heart diseases and recent stroke (bleeding in the brain) should not take Nimesulide+paracetamol as a substitute for aspirin. It should not be given to children (below 12 years) with symptoms of fever and chills or suffering from influenza (flu) or chickenpox.
Drug Interactions
Drug-Drug Interactions: Nimesulide+paracetamol is shown to interact with various drugs. Some of them include lithium, anticancer/antimetabolites (methotrexate), blood thinner or anticoagulant (warfarin, coumadin, aspirin), blood pressure or heart medicine, nausea medicine (metoclopramide, domperidone), diuretic/water pills (thiazides, furosemide), steroid medicine (prednisone), quinolones antibiotics (ciprofloxacin), respiratory medicines (theophyllines, ephedrine), immune system affecting medicine (cyclosporine), cholesterol-reducing medicine (colestyramine) and antidepressants (duloxetine). These drugs may affect the working of Nimesulide+paracetamol and may alter its efficacy.
Drug-Food Interactions: Excessive intake of alcoholic beverages, caffeine-containing food or drinks like coffee, tea, chocolate, and some fizzy drinks should be avoided while taking Nimesulide+paracetamol. Taking together may lead to drowsiness and dizziness and sleepiness.
Drug-Disease Interactions: Nimesulide+paracetamol should not recommend for people having bleeding disorders, like haemophilia, von Willebrand disease, or low blood platelets. Besides this, it should not be given to children suffering from influenza (flu) or chickenpox. It should also be avoided in case of the presence of gastric or duodenal ulcers.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionTaking Nimesulide+paracetamol with alcohol may cause dizziness or drowsiness. Besides this, it can also damage your liver if taken for a longer duration. So, avoid or limit the intake of alcoholic beverages with Nimesulide+paracetamol.
Pregnancy
unsafeUse of Nimesulide+paracetamol during pregnancy is not recommended as taking this medicine during the last 3 months of pregnancy may harm the unborn baby. Consult your doctor for further advice.
Breast Feeding
unsafeUse of Nimesulide+paracetamol during breastfeeding is not recommended as it may pass through the milk and harm the baby. Consult your doctor for further advice.
Driving
cautionAfter taking Nimesulide+paracetamol, you may notice dizziness, sleepiness, drowsiness. So, you should stop taking Nimesulide+paracetamol and contact your doctor.
Liver
cautionNimesulide+paracetamol to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.
Kidney
cautionNimesulide+paracetamol to be taken with caution, especially if you have a history of Kidney diseases/conditions. The dose may have to be adjusted by your doctor.
Children
cautionNimesulide+paracetamol is contraindicated in children below 20 kg body weight or younger than 6 years of age. It may cause kidney problems in children and adolescents who are dehydrated.
Habit Forming
Diet & Lifestyle Advise
- Include more glucosamine, chondroitin sulphate, vitamin D, and calcium-enriched supplements. Besides this, turmeric and fish oils can help reduce inflammation in the tissue.
- Please do not go for heavy exercise as it may increase your joint pain in arthritis. Instead, you can do stretching low,, impact aerobic exercises like walking on a treadmill, bike riding and swimming. You can also strengthen your muscles by lifting light weights.
- In chronic arthritis or joint pain conditions, fish like salmon, trout, tuna and sardines. These fishes are enriched with omega-3 fatty acids that minimize chemical cytokines, which ramp up inflammation.
- Your sitting posture is important, especially when you have pain and inflammation. Try to sit as little as possible and only for a short time. Long-term immobility is harmful in conditions like arthritis. Use back support like a rolled-up towel to minimise pain at the back of your spine curve. Keep your knees and hips at a right angle. Besides this, you can also use a footrest if required.
Special Advise
Inform your doctor about any bleeding disorders as nimesulide in Nimesulide+paracetamol should be taken with care as it may interference in the functioning of platelets.
Patients Concern
Disease/Condition Glossary
Pain: Pain can be short-term (acute) or long-term (chronic) in nature. Acute pain is, for a short time, caused by damage to the tissues of the muscle, bone or organs. At the same time, chronic pain lasts for a longer duration; it is caused by pathologies like nerve damage, osteoarthritis and dental pain due to damage to the tooth nerve, infection, decay, extraction or injury. Many women have painful periods known as dysmenorrhea, most often menstrual cramps. On the other hand, osteoarthritis is a degenerative disease that results in chronic pain in joints (especially the knee) and stiffness, making daily tasks difficult.
FAQs
Nimesulide+paracetamol is used to relieve pain in conditions like osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and dysmenorrhea. Besides this, it is also useful for dental pain, muscle pain, back pain, ear pain, and throat pain.
Nimesulide+paracetamol works by blocking the effect of prostaglandins, a chemical responsible for inducing pain and inflammation in our bodies.
No, Nimesulide+paracetamol is not indicated for stomach pain. If you have stomach pain post-ingestion, it may be a sign of stomach ulcer or gastric bleeding. Do not take Nimesulide+paracetamol in this condition. It is better to inform your doctor in case of stomach pain post-ingestion of this medication.
No, Nimesulide+paracetamol should not be taken as a long term medication as it may lead to stomach ulcers/bleeding and kidney problems. For best results of Nimesulide+paracetamol, take it in doses and duration mentioned by your doctor.
Yes, Nimesulide+paracetamol should be preferably be taken with food to avoid an upset stomach. If taken on an empty stomach, it may cause stomach irritation and upset stomach.
You should not take Nimesulide+paracetamol if you have history of peptic ulceration, history of gastrointestinal haemorrhage, Crohn's disease or ulcerative colitis.
You should avoid intake of Nimesulide+paracetamol if you are allergic to Nimesulide+paracetamol, nimesulide or paracetamol, a regular heavy alcohol drinker, liver disease (increased liver enzyme), any type of recent ulcer or bleeding, suffering from flu or fever (with chills), in the last trimester of pregnancy or breastfeeding mother.
No, Nimesulide+paracetamol should not be taken if you plan to get pregnant as it contains nimesulide, which may affect your fertility. So, before starting Nimesulide+paracetamol, please consult your doctor.
Taking Nimesulide+paracetamol for six months is not advised without medical guidance as it may lead to stomach ulcers or bleeding and kidney problems. It’s best to consult with a doctor before using this medication for an extended time.
Though Nimesulide+paracetamol may be used for tooth pain, it should not be used in children unless advised by the doctor. Please consult the doctor before using Nimesulide+paracetamol in children; the doctor will prescribe appropriate medicine based on the child’s condition.
Nimesulide+paracetamol is a combination medication that belongs to the class of painkillers called non-steroidal anti-inflammatory drugs. It is mainly prescribed to treat pain and relieve discomfort caused by tooth pain, arthritis, period pain, and other types of short-term pains.
As Nimesulide+paracetamol is indicated for short-term pain relief, it can be discontinued if the pain is relieved. However, it is advised to take Nimesulide+paracetamol for the prescribed duration to treat your condition effectively.
Taking Nimesulide+paracetamol may cause nausea and vomiting. If you feel sick, talk to your doctor or pharmacist for help. To cope with nausea and vomiting, take your medicine with food or milk, eat small meals, and stay hydrated. Avoid spicy foods and lying down after taking the medicine. Try ginger products like ginger tea or candies. If your symptoms are severe, ask your doctor for help.
Don't take Nimesulide+paracetamol if you're allergic to it or other painkillers, have stomach ulcers or bleeding, asthma, recent heart surgery, severe kidney or liver problems. Consult the doctor if you are pregnant or breastfeeding. Always inform your doctor if you have any of these conditions before taking Nimesulide+paracetamol.
Nimesulide+paracetamol can be taken with vitamin B-complex if prescribed by your doctor. Please consult your doctor if you have any concerns.
No, Nimesulide+paracetamol is not intended to treat stomach pain. If you're unsure about the cause of your stomach pain or if it's a persistent issue, it’s best to consult a doctor to determine the cause and get the most appropriate treatment.
Nimesulide+paracetamol may cause harm to the liver, especially if used for a longer duration or in higher doses. So, do not take a higher dose than the recommended dose of Nimesulide+paracetamol.
Taking more than the recommended dose of Nimesulide+paracetamol is dangerous. Overuse of Nimesulide+paracetamol can harm your liver and kidney, which can be life-threatening. Always follow the dosage instructions as advised by the doctor.
Nimesulide+paracetamol should be stored in a cool and dry place away from the sunlight. Keep away from children and pets.
Though Nimesulide+paracetamol may help lower body temperature, it is primarily used in the treatment of pain relief. Consult your doctor before taking Nimesulide+paracetamol for fever if you have any concerns.
Follow your doctor's advice and take the right amount of medicine. Inform your doctor about any health problems, allergies, or other drugs you're taking. Be aware of side effects and take care of yourself. If you're pregnant while on treatment, inform your doctor immediately. Don't take other medications unless instructed by the doctor. Alcohol consumption should be avoided. By following these precautions, you'll benefit most from your medicine and stay safe.
The common side effects of Nimesulide+paracetamol include loss of appetite, nausea, vomiting, abdominal pain, persistent tiredness, or dark/discoloured urine. Everyone doesn't need to experience the above side effects. In case of any discomfort, speak with your doctor.
You are recommended to consult your doctor before taking other medications while using Nimesulide+paracetamol to avoid drug interactions.
If you suspect an overdose of Nimesulide+paracetamol, seek medical help immediately. Quick action can help prevent serious harm, so don’t wait to seek medical attention.
