Metoprolol+amlodipine

• Do not stop taking this medicine suddenly without medical advice, as it can cause severe chest pain, abnormal heart rhythms, or even a heart attack. Your doctor will reduce the dose gradually to prevent these risks.
• This medicine can lower your blood pressure or slow your heart rate too much, leading to dizziness, fainting, or fatigue. Inform your doctor immediately if these symptoms occur.
• Use with caution if you have diabetes, as Metoprolol may mask the warning signs of low blood sugar and increase the risk of hypoglycemia, especially if you use insulin or other diabetes medicines.
• Avoid using this medicine unless specifically prescribed by your doctor if you have asthma, severe breathing problems, or a history of bronchospasm, as beta-blockers like Metoprolol can worsen breathing difficulties.
• Inform your doctor about heart conditions such as heart failure, heart block, sick sinus syndrome, or severe circulation problems, as special monitoring or dose changes may be needed.
• Tell your doctor about all medicines, supplements, or herbal remedies you are taking (such as clonidine, digoxin, certain antidepressants, or other blood pressure drugs), as they may interact and increase the risk of side effects.

Drug-Drug Interaction: Metoprolol+amlodipine is known to interact with blood pressure-lowering drugs (acebutolol, atenolol, bisoprolol, carteolol, esmolol, metoprolol, nadolol, nebivolol, sotalol, lisinopril, enalapril, diltiazem, prazosin, terazosin, doxazosin), asthma medications (theophylline), diuretics (fluoxetine), an antidepressant (paroxetine), heart rhythm related medicines (propafenone, digoxin), antifungal (ketoconazole, itraconazole), and antiviral (ritonavir).

Drug-Food Interaction: Metoprolol+amlodipine has an interaction with grapefruit and high-protein foods. Hence, it should not be taken with Metoprolol+amlodipine. Using Metoprolol+amlodipine together with multivitamins/minerals may decrease the effects of Metoprolol+amlodipine. If it is necessary, you should maintain at least 2 hours of a gap between the administration of Metoprolol+amlodipine and multivitamins/minerals.

Drug-Disease Interaction: Metoprolol+amlodipine should not be given to individuals with diabetes, asthma, cardiogenic shock (when the heart fails to pump required blood to the body), heart valve problems (stenosis), low blood pressure (hypotension), coronary heart disease, liver disease, or heart failure.

• Maintain a healthy body weight, ideally with a BMI between 18.5 and 24.9, as excess weight increases the risk of high blood pressure and heart disease.
• Engage in regular physical activity, aiming for at least 150 minutes of moderate-intensity exercise per week (e.g., brisk walking, cycling, swimming) to help lower blood pressure by about 5–8 mmHg.
• Limit sodium intake to ≤2300 mg per day, with an ideal goal of 1500 mg daily for adults with high blood pressure or heart problems.
• If you drink alcohol, limit intake to up to 1 drink per day for women and up to 2 drinks per day for men, as excessive drinking can raise blood pressure.
• Quit smoking, as it significantly increases the risk of heart attack, stroke, and complications from high blood pressure.
• Manage stress through relaxation techniques, deep breathing, mindfulness, adequate sleep, and spending time with loved ones to help maintain stable blood pressure levels.
• Monitor blood pressure regularly at home and keep a record. Contact your doctor promptly if you notice frequent or large fluctuations.
• Eat a heart-healthy diet, rich in fruits, vegetables, whole grains, lean protein, and omega-3 fatty acids (from fish, flaxseeds, or walnuts) to support cardiovascular health.
• Use healthy cooking oils such as olive, canola, or soybean oil, and limit saturated fats to help manage blood pressure and improve heart health.
• Follow your doctor’s advice strictly regarding medications, diet, and lifestyle adjustments to reduce the risk of severe heart complications.