Metformin+teneligliptin
About Metformin+teneligliptin
Metformin+teneligliptin belongs to the group of medications called ‘antidiabetic agents’ used to treat type 2 diabetes mellitus. This medication improves glycaemic control in diabetic patients who do not react well to Metformin alone.
Metformin+teneligliptin contains Metformin and Teneligliptin. Metformin acts by decreasing liver glucose production and intestinal glucose uptake. On the other hand, Teneligliptin increases the insulin levels in the body and reduces the glucagon levels. Together, Metformin+teneligliptin helps treat type 2 diabetes.
Metformin+teneligliptin may cause side effects such as nausea, vomiting, diarrhoea, headache, stomach ache, respiratory infection, weight gain, and sweating. Most of these side effects may not require medical attention and will likely resolve over time. However, if the side effects persist or worsen, consult your doctor.
Do not take Metformin+teneligliptin if you are allergic to any of its contents. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Let your doctor know if you are taking any other medicines or have pre-existing medical conditions to prevent any potential interactions.
Uses of Metformin+teneligliptin
• Management of Type 2 Diabetes Mellitus: Metformin+teneligliptin improves glycemic control in adults with Type 2 Diabetes Mellitus.
• Improves Insulin Sensitivity: Metformin+teneligliptin helps the body respond better to insulin.
• Reduces Glucose Production: Metformin+teneligliptin suppresses excess sugar made by the liver.
• Adjunct to lifestyle and therapy: Metformin+teneligliptin is prescribed alongside a healthy diet, regular physical activity to manage type 2 diabetes more effectively.
Medicinal Benefits
- Metformin+teneligliptin is indicated for the management of type 2 diabetes mellitus in adults. It contains Metformin and Teneligliptin.
- Metformin is a biguanide, which works by reducing the production of glucose in the liver and decreasing its absorption from the intestines, thereby lowering blood sugar levels.
- Teneligliptin is a dipeptidyl peptidase 4 (DPP-4) inhibitor that increases insulin secretion and decreases glucagon levels in the blood, especially after meals.
- It is used when patients are unable to achieve sufficient glycemic control through lifestyle modifications such as diet and physical activity alone.
- Metformin+teneligliptin is suitable for patients who have not responded adequately to treatment with sulfonylureas (e.g., glimepiride, gliclazide) in combination with dietary control and exercise.
- It may also be prescribed when treatment with thiazolidinediones (e.g., pioglitazone) along with diet and exercise has failed to achieve satisfactory blood glucose control.
Directions for Use
- Metformin+teneligliptin can be taken with or without food. However, taking it with food may help reduce stomach upset.
- It is recommended to take Metformin+teneligliptin once daily or as advised by your doctor.
- Swallow Metformin+teneligliptin as a whole with a glass of water.
- Do not crush, chew, or break it.
Storage
Side Effects of Metformin+teneligliptin
- Nausea
- Vomiting
- Diarrhoea
- Headache
- Stomach ache
- Respiratory infection
- Weight gain
- Sweating
- Palpitations
- Numbness
- Vision problems
Drug Warnings
- Do not take Metformin+teneligliptin if you are allergic to any of its components, or if you have severe ketosis, type 1 diabetes, diabetic coma, or a history of diabetic coma.
- Inform your doctor if you have liver, kidney or heart problems, severe infection, severe trauma, adrenal insufficiency, bowel obstruction, irregular heartbeat, or are due to undergo surgery.
- Metformin+teneligliptin may cause ‘lactic acidosis’ (buildup of lactic acid in the blood). Consult your doctor if you experience abdominal pain, muscle cramps, vomiting, severe fatigue, or difficulty breathing. It is a life-threatening condition that requires immediate medical attention.
- Do not consume excess alcohol, as it increases the risk of lactic acidosis.
- Metformin+teneligliptin may lower vitamin B12 levels, so it is recommended to take blood tests regularly to identify any vitamin deficiencies.
Drug Interactions
Drug-Drug Interactions: Metformin+teneligliptin may have an interaction with medicines used to treat bacterial infections (rifampicin, tetracycline, Clarithromycin), a medicine used to treat fungal infections (fluconazole), other oral antidiabetics, medicines used to treat gout (probenecid).
Drug-Food interactions: Intake of excess alcohol may increase the chance of a life-threatening condition known as lactic acidosis.
Drug-Disease Interactions: Metformin+teneligliptin should be avoided in patients with heart diseases (congestive heart failure and myocardial infarction), vitamin B12 deficiency, alcoholism, type I diabetes, bladder cancer, oedema (fluid retention), liver disease, premenopausal anovulation, obesity (weight gain), anaemia should avoid intake of Metformin+teneligliptin.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionAlcohol may increase the risk of side effects and worsen the condition.
Pregnancy
cautionMetformin+teneligliptin is a category C drug. So, it should be used only when the benefits of this medicine outweigh the risks.
Breast Feeding
cautionMetformin+teneligliptin should not be used in breastfeeding mothers as it may get secreted in the breast milk and cause unwanted effects in the nursing babies.
Driving
cautionMetformin+teneligliptin may cause vision problems. So, do not drive or operate heavy machinery if you have any problems with your vision while using Metformin+teneligliptin.
Liver
cautionMetformin+teneligliptin should be taken with caution in patients with liver diseases. The dose may have to be adjusted by your doctor.
Kidney
cautionMetformin+teneligliptin should be taken with caution, especially if you have a history of kidney diseases. The dose may have to be adjusted by your doctor.
Children
cautionMetformin+teneligliptin is not recommended for use in children below 18 years of age.
Habit Forming
Diet & Lifestyle Advise
- Eat at regular intervals. Do not take a long gap between a meal or snack.
- Monitor your blood sugar level regularly, especially when there are a lot of fluctuations.
- Invest at least 150 minutes of moderate-intensity physical activity and 15 minutes of high-intensity exercise every week.
- Lose weight gradually to achieve a healthy body mass index (18.5 to 24.9).
- Replace refined carbohydrate-containing foods with whole grain foods and increase fruits, veggies, and other fibre-enriched foods.
- Reduce saturated fat intake (or hidden fats) in food like chips, crisps, pastries, biscuits, and samosas. Choose omega-3 fatty acid-containing oils for daily cooking. You may use palm oil, mustard oil, groundnut oil, rice bran oil, and safflower oil for frying.
- Do not take stress as it may elevate your blood sugar level. You may adopt stress management techniques like mindfulness, yoga, or meditation to control stress-related blood sugar changes.
- Opt for low-fat dairy products (low-fat yoghurt, fat-free milk, and cheese, etc.).
- Keep your blood pressure as normal (120/80) as possible, as it reduces the risk of heart disease in diabetes patients.
Special Advise
- Metformin+teneligliptin shows optimum effects when you follow healthy lifestyle changes like weight loss, regular exercise, healthy diet, etc.
- Keep taking the drug even if you think your blood sugar levels are under control. If you miss a dose, do not take a larger dose; consult your treating physician for advice.
- Take short, frequent meals, and avoid prolonged fasting when taking this drug. Beware of hypoglycemia symptoms, including sweating, dizziness, palpitations, shivering, intense thirst, dry mouth, dry skin, frequent urination, etc. Whenever you experience the above-mentioned symptoms, immediately consume 5-6 candies or 3 glucose biscuits or 3 teaspoons of honey/sugar and also get in touch with your physician. Make sure to carry these with you at all times, especially for long travels.
- Avoid drinking alcohol while on this drug as it increases the risk of hypoglycemia (a decrease in blood sugar, which might be fatal in some cases) and lactic acidosis (when the lactic acid increases in the body, which impacts various organs in the body).
Patients Concern
Disease/Condition Glossary
Type 2 diabetes mellitus: It is a chronic condition in which blood glucose levels are elevated in the body. Insulin is responsible for the utilisation of glucose by the cells. In type 2 diabetes, the body cells do not respond to insulin, or in later stages, the body may not produce enough insulin. Symptoms include excessive thirst, excessive hunger, fatigue, increased appetite and dry mouth. This condition may worsen over time and cause toxic effects if not properly treated.
FAQs
Metformin+teneligliptin is used to treat Type 2 diabetes mellitus. It improves glycaemic control in diabetic patients who do not react well to Metformin alone.
Metformin+teneligliptin is a combination of two antidiabetic medicines, Metformin and Teneligliptin. It works by increasing insulin production, helping to restore your body's appropriate response to insulin, especially in muscle and fatty tissues, thereby lowering your elevated blood sugar levels.
Hypoglycemia refers to low blood glucose levels. Metformin+teneligliptin may cause hypoglycemia. Hypoglycemia can occur if you miss or delay your food, drink alcohol, engage in intense exercise, or take other antidiabetic medicine along with this medicine. So, take your medicine as advised by your doctor to avoid any unwanted effects of this medicine.
If you feel that your blood sugar levels are dropping, eat glucose tablets or chocolate immediately. This will help to increase your sugar levels instantly. So, it is always advised to carry glucose tablets or sugar candies with you.
Yes, Metformin+teneligliptin is safe to use if taken in the dose and duration prescribed by the doctor.
Metformin+teneligliptin may cause nausea and vomiting as side effects. Consume bland food and water, avoid foods with strong smells, spicy food, caffeine, alcohol and carbonated drinks.
Metformin+teneligliptin is contraindicated in people who are allergic to any of its components, patients having severe ketoacidosis, diabetic coma or pre-coma, type 1 diabetes, severe infection, severe trauma and severe external injury and in patients with a history of lactic acidosis.
Metformin+teneligliptin can cause lactic acidosis, a rare but serious metabolic complication. Consult the doctor if you notice symptoms of lactic acidosis like abdominal pain, vomiting, muscle cramps, difficulty breathing, reduced body temperature and heartbeat, and severe tiredness.
Long-term use of Metformin+teneligliptin may lead to vitamin B12 deficiency as Metformin+teneligliptin might interfere with the absorption of vitamin B12. Consult the doctor if you experience symptoms of vitamin B12 deficiency like tingling sensations and numbness in hands and feet, urinary problems, weakness, change in mental status and difficulty in maintaining balance.
Store Metformin+teneligliptin at room temperature, in a dry place. Keep it out of sight and reach of children.
Metformin+teneligliptin is not recommended during pregnancy as its safety in pregnant women is unknown. Contact the doctor if you are pregnant, planning for pregnancy or think you may be pregnant.
Metformin+teneligliptin is not recommended for nursing mothers as this medicine may get secreted in the breast milk and cause unwanted effects in the nursing babies. Contact the doctor if you are breastfeeding.
Metformin+teneligliptin is not recommended for use in children below 18 years of age.
Overdose of Metformin+teneligliptin might cause lactic acidosis. Symptoms of lactic acidosis may include nausea, vomiting, and weakness. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.
Side effects of Metformin+teneligliptin include nausea, vomiting, diarrhoea, headache, stomach ache, respiratory infection, weight gain, sweating, palpitations, and vision problems. Consult the doctor if any of the side effects persist or worsen.
Consult the doctor if you have severe joint pain after taking Metformin+teneligliptin. The doctor might ask you to discontinue the medicine if appropriate.
