Isoniazid+pyridoxine
About Isoniazid+pyridoxine
Isoniazid+pyridoxine is used to treat tuberculosis. Tuberculosis is a serious infectious disease that mainly affects the lungs and can be passed on to others.
Isoniazid+pyridoxine is a combination of two drugs: isoniazid and pyridoxine (vitamin B6). Isoniazid works by killing the bacteria responsible for tuberculosis (TB). Additionally, pyridoxine helps treat nerve damage (neuritis) caused by TB medications like isoniazid.
Take Isoniazid+pyridoxine as prescribed. The dosage and duration of Isoniazid+pyridoxine may vary based on your specific condition and the severity of the infection. In some cases, you may experience certain common side effects, such as nausea, vomiting, diarrhoea, loss of appetite, constipation, stomach upset/pain, dry mouth, ringing in the ears, and dizziness. Most of these side effects do not require any medical attention, as they will gradually reduce over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
Do not stop taking Isoniazid+pyridoxine despite symptomatic relief. To ensure effective treatment, continue taking Isoniazid+pyridoxine for as long as it has been prescribed by your doctor. Maintain a gap of one hour between Isoniazid+pyridoxine and antacid medicines. Consult your doctor before taking Isoniazid+pyridoxine if you are pregnant or planning for pregnancy. Avoid breastfeeding while taking Isoniazid+pyridoxine, as high doses of pyridoxine can harm the baby. Refrain from alcohol and driving due to potential dizziness and blurred vision. Always inform your doctor of other medications you take when taking Isoniazid+pyridoxine.
Uses of Isoniazid+pyridoxine
Medicinal Benefits
Isoniazid+pyridoxine belongs to a group of medicines called anti-tuberculosis drugs. It contains two drugs, namely isoniazid and pyridoxine (vitamin B6). Isoniazid works by eliminating the bacteria responsible for tuberculosis (TB). Additionally, pyridoxine (vitamin B6) is a water-soluble vitamin that helps treat nerve damage (neuritis) caused by TB (tuberculosis) medications like isoniazid. It is also used to treat a specific type of anaemia (lack of red blood cells).
Directions for Use
Isoniazid+pyridoxine should be taken preferably after meals or as prescribed by a doctor to ensure effectiveness. Swallow it as a whole with a glass of water. Do not crush, chew, or break it.
Storage
Side Effects of Isoniazid+pyridoxine
- Headache
- Nausea
- Mild numbness or tingling
- Drowsiness
- Muscle weakness
- Dizziness
- Constipation
- Dry mouth
- Upset stomach
- Hypertension
- Severe stomach pain
- Enlarge breast tissue in men
- Ringing in the ear
- Loss of appetite
Drug Warnings
Do not take Isoniazid+pyridoxine if you are allergic to any of its contents. Before starting Isoniazid+pyridoxine, please inform your doctor if you have diabetes, seizures, HIV infection, peripheral neuropathy, kidney, or liver problems. Avoid foods and drinks containing histamine or tyramine, such as cured meat, matured cheese, soy, tuna, salmon, mackerel, wine, and beer, while taking Isoniazid+pyridoxine, as they might cause interaction. Maintain a gap between Isoniazid+pyridoxine and antacid medicines. Consult your doctor before taking Isoniazid+pyridoxine if you are pregnant or planning for pregnancy. Isoniazid+pyridoxine may cause blurred vision and drowsiness, so drive only if you are alert after taking Isoniazid+pyridoxine. Avoid alcohol consumption while taking Isoniazid+pyridoxine, as it could lead to increased drowsiness and liver damage.
Drug Interactions
Drug-Drug Interactions: Isoniazid+pyridoxine may interact with anticonvulsants (carbamazepine, primidone, or phenytoin); antacid (aluminium hydroxide gel); antibiotics (cycloserine and rifampin); analgesic (acetaminophen); antifungal (ketoconazole); opioid analgesic drug (alfentanil); benzodiazepines (diazepam); blood thinner (warfarin); steroids (hydrocortisone, betamethasone); and bronchodilator (theophylline).
Drug-Food Interactions: Avoid foods and drinks containing histamine or tyramine, such as cured meat, matured cheese, soy, tuna, salmon, mackerel, wine, and beer, while taking Isoniazid+pyridoxine, as they might interact with isoniazid.
Drug-disease interactions: Inform your doctor if you have diabetes, kidney, or chronic or acute liver problems.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeRefrain from alcohol consumption while taking Isoniazid+pyridoxine, as it could lead to increased drowsiness, dizziness, and liver damage.
Pregnancy
consult your doctorPlease consult your doctor if you are pregnant. Your doctor will prescribe Isoniazid+pyridoxine only if the benefits outweigh the risks.
Breast Feeding
consult your doctorConsult your doctor if you are a breastfeeding mother. Your doctor will prescribe Isoniazid+pyridoxine only if the benefits outweigh the risks.
Driving
cautionIsoniazid+pyridoxine may cause dizziness, blurred vision, drowsiness, numbness, and tingling sensation in hands and feet. Do not drive or operate machinery if you experience these symptoms.
Liver
consult your doctorPlease consult your doctor before taking Isoniazid+pyridoxine if you have liver impairment/liver disease.
Kidney
consult your doctorPlease consult your doctor if you have any concerns regarding this or if you have kidney impairment/kidney disease before taking Isoniazid+pyridoxine.
Children
cautionIsoniazid+pyridoxine can be used in children when prescribed by a doctor, who will determine the appropriate dose based on the child’s age and weight.
Habit Forming
Diet & Lifestyle Advise
- Avoid processed and fried foods.
- Avoid foods and drinks containing histamine or tyramine, such as cured meat, matured cheese, soy, tuna, salmon, mackerel, wine, and beer.
- Quit smoking and avoid alcohol consumption.
- Limit foods and beverages higher in added sugars, saturated fat, and sodium.
Special Advise
Your doctor may advise you to take regular liver tests while taking Isoniazid+pyridoxine to check how your liver functions.
Patients Concern
Disease/Condition Glossary
Tuberculosis (TB): Tuberculosis is an infectious disease that affects the lungs, but it can also spread to other body parts such as the kidneys, brain, spine, and bone marrow. Tuberculosis is caused by a bacteria named Mycobacterium tuberculosis. It is a contagious disease that can spread to others through small droplets released into the air by a person suffering from tuberculosis. Symptoms include a cough that lasts for a few weeks, pain while coughing or with normal breathing, unexplained fatigue, fever, night sweats, loss of appetite, and weight loss. People who smoke or consume alcohol, people diagnosed with HIV, and people with immune system problems are more likely at risk of developing active TB.
FAQs
Isoniazid+pyridoxine is used to treat tuberculosis (TB).
Isoniazid+pyridoxine is a combination of two drugs, namely isoniazid and pyridoxine (vitamin B6). Isoniazid works by eliminating the bacteria responsible for tuberculosis (TB). Additionally, vitamin B6 helps treat nerve damage (neuritis) caused by TB medications like isoniazid.
Do not stop taking Isoniazid+pyridoxine despite symptomatic relief. To treat your condition effectually, continue taking Isoniazid+pyridoxine for as long as it has been prescribed for you.
An overdose of Isoniazid+pyridoxine may lead to nausea, vomiting, dizziness, slurred speech, blurred vision, and visual hallucinations (including bright colours and strange designs). In some cases, overdose can lead to coma and seizures.
Isoniazid+pyridoxine contains isoniazid, which might interact with foods and drinks containing histamine or tyramine, such as cured meat, matured cheese, soy, tuna, salmon, mackerel, wine, and beer. Avoid these foods while taking Isoniazid+pyridoxine.
You are recommended to avoid alcohol while taking Isoniazid+pyridoxine to reduce unwanted side effects and excessive drowsiness. Please consult the doctor if you have any concerns.
Store Isoniazid+pyridoxine at room temperature. Keep out of reach and sight of children.
Isoniazid+pyridoxine is effective when taken as per the dose advised by your doctor for the recommended duration. Even if you start feeling better, do not stop the treatment early. Stopping it early may cause the symptoms to return or worsen.
Isoniazid+pyridoxine can cause constipation or dry mouth as common side effects. If you experience any of these, consult your doctor for advice.
Isoniazid+pyridoxine causes side effects such as nausea, vomiting, diarrhoea, loss of appetite, constipation, stomach upset/pain, dry mouth, ringing in the ears, and dizziness. Most of these side effects do not require any medical attention as they will gradually reduce over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
