Pantoprazole+itopride
About Pantoprazole+itopride
Itopride+pantoprazole is a combination medicine used to treat acidity, gastroesophageal reflux disease (GERD), and peptic ulcers. Gastroesophageal reflux disease (GERD) occurs when stomach acid frequently flows back into the food pipe (oesophagus). Peptic ulcers are sores that develop on the inner lining of the intestine and stomach.
Itopride+pantoprazole is a combination of two drugs: Pantoprazole and Itopride. Pantoprazole works by blocking the action of an enzyme called the gastric proton pump, which is responsible for the production of acid. Itopride works by accelerating gastric emptying and improving gastric sensitivity and tension. It also has anti-emetic action. Together, Itopride+pantoprazole helps in preventing acid reflux, thereby providing relief from acidity.
You are advised to take Itopride+pantoprazole as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects such as headache, nausea, stomach pain, dizziness and diarrhoea. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
Inform your doctor before taking Itopride+pantoprazole if you have a history of gastrointestinal bleeding, mechanical perforation/obstruction, or movement disorder. On long-term treatment, Itopride+pantoprazole may cause osteoporosis and hypomagnesemia (low levels of magnesium). Consult your doctor if you are pregnant or breastfeeding. Itopride+pantoprazole may cause drowsiness, so drive only if you are alert. Itopride+pantoprazole should not be given to children as safety has not been established. Avoid consuming alcohol along with Itopride+pantoprazole as it could lead to increased drowsiness and can elevate the production of stomach acid.
Uses of Pantoprazole+itopride
Medicinal Benefits
- Itopride+pantoprazole is a combination of two drugs: Pantoprazole (a proton pump inhibitor) and Itopride (a prokinetic agent). Together, they provide the following medicinal benefits:
- Pantoprazole decreases excessive stomach acid production, preventing irritation and damage to the stomach and oesophagus.
- Itopride enhances stomach contractions, speeds up gastric emptying, and reduces bloating, nausea, and early satiety.
- The combined action of both medicines controls the backwards flow of stomach contents, providing relief from heartburn and indigestion.
- Reduced acid levels and improved stomach function help in the healing of peptic ulcers and prevent their recurrence.
- The dual mechanism offers comprehensive relief from symptoms of acid-peptic disorders, including gastro-oesophageal reflux disease (GERD).
Directions for Use
- Take Itopride+pantoprazole 30-60 minutes before food or as advised by your doctor.
- Follow your doctor's instructions on the dosage and timing of this medication to ensure safe and effective use.
- Swallow Itopride+pantoprazole as a whole with a glass of water.
- Do not crush, break, or chew it.
Storage
Side Effects of Pantoprazole+itopride
- Headache
- Nausea
- Stomach pain
- Dizziness
- Diarrhoea
Drug Warnings
- Do not use Itopride+pantoprazole if you are allergic to Pantoprazole, Itopride, or any ingredient in the medicine. Seek immediate medical help if you experience symptoms of an allergic reaction such as rash, swelling, or difficulty breathing.
- Inform your doctor about any history of gastrointestinal bleeding, stomach or intestinal perforation, bowel obstruction, movement disorders (such as Parkinson's disease), liver or kidney problems, autoimmune conditions (such as lupus), or electrolyte imbalances. Also, provide a complete list of all medications you are taking, as Itopride+pantoprazole may interact with certain drugs or require dose adjustments.
- Long-term use of Pantoprazole (typically beyond 3–12 months) may cause low magnesium levels, leading to tremors, muscle cramps, seizures, or abnormal heart rhythms. Periodic magnesium level monitoring is advised.
- Prolonged use of proton pump inhibitors like Pantoprazole (≥ 1 year) may increase the risk of bone fractures, particularly in the hip, wrist, or spine. Use the lowest effective dose for the shortest required duration.
- Extended use may reduce absorption of vitamin B₁₂, calcium, and iron, and may increase the risk of gastrointestinal infections (Clostridioides difficile), pneumonia, or formation of stomach polyps.
- Report any unusual symptoms such as joint pain, persistent rash, fever, or dark-colored urine, as these may indicate rare but serious side effects such as kidney inflammation or lupus-like reactions.
- Consult your doctor before using Itopride+pantoprazole if you are pregnant or breastfeeding, as safety data are limited. Use in children has not been established and is generally not recommended.
Drug Interactions
Drug-Drug Interactions: Inform the doctor if you are taking pain killers (aspirin, naproxen), an antidepressant (duloxetine), hypothyroidism (levothyroxine), statins (atorvastatin), blood thinner (clopidogrel), and vitamins (vitamin B12).
Drug-Food Interactions: No interactions found/established.
Drug-Disease Interactions: Inform the doctor if you have gastrointestinal bleeding, mechanical obstruction or perforation, Clostridium difficile-associated diarrhoea (CDAD), liver disease, bone fractures, or hypomagnesemia (low levels of magnesium).
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid consumption of alcohol while taking Itopride+pantoprazole. Alcohol intake leads to increased production of stomach acid, thereby increases acidity and heartburn.
Pregnancy
cautionConsult your doctor before taking Itopride+pantoprazole if you are pregnant; your doctor will prescribe only if the benefits outweigh the risks.
Breast Feeding
cautionConsult your doctor before taking Itopride+pantoprazole; your doctor will decide whether Itopride+pantoprazole can be taken by breastfeeding mothers or not.
Driving
cautionItopride+pantoprazole may cause dizziness. Do not drive or operate machinery unless you are alert.
Liver
cautionDose adjustment may be needed. Consult your doctor before taking Itopride+pantoprazole if you have a liver impairment or any concerns regarding this.
Kidney
cautionDose adjustment may be needed. Consult your doctor before taking Itopride+pantoprazole if you have kidney impairment or any concerns regarding this.
Children
unsafeItopride+pantoprazole should not be given to children as safety and effectiveness were not established.
Habit Forming
Diet & Lifestyle Advise
- Eat smaller meals more often.
- Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
- Maintain a healthy weight through regular exercise.
- Avoid lying down after eating.
- Avoid tight-fitting clothes.
- Maintain a healthy weight through regular exercise.
- Practice relaxation techniques and avoid stress by doing yoga or meditation.
- Avoid foods such as high-fat food, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea and soda.
- Avoid sitting continuously as it may trigger acidity. Take a break of 5 minutes, every hour, by doing brisk walking or stretching.
Patients Concern
Disease/Condition Glossary
Acidity: The stomach is usually protected from acid by a mucous layer. In some cases, due to excess acid production, the mucous layer gets eroded, which leads to complications like GERD, acidity, and peptic ulcers.
Gastroesophageal reflux disease (GERD): Gastroesophageal reflux disease (GERD) occurs when stomach acid frequently flows back into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe and causes heartburn. Symptoms include heartburn, sour or bitter taste in the mouth, and difficulty swallowing.
Peptic ulcers: They are sores that develop on the lining of the stomach and intestine due to erosion of the stomach's protective lining. Symptoms include nausea, changes in appetite, bloody or dark stools, unexplained weight loss, vomiting, and indigestion.
FAQs
Itopride+pantoprazole is used to treat acidity, GERD (gastro-oesophagal reflux disease), and peptic ulcers.
Itopride+pantoprazole is a combination of two drugs, namely: Pantoprazole and Itopride. Pantoprazole works by blocking the action of an enzyme called gastric proton pump, responsible for the production of acid. Itopride works by accelerating gastric emptying and improves gastric sensitivity and tension. Together, Itopride+pantoprazole helps in preventing acid reflux, thereby provides relief from acidity.
Talk to your doctor if you do not feel better even after taking Itopride+pantoprazole for 14 days. Do not take Itopride+pantoprazole for longer durations unless prescribed by the doctor.
Diarrhoea might be a side-effect of Itopride+pantoprazole. Drink enough fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.
Avoid lying down immediately after meals to prevent acid reflux. Raise the head of the bed 10-20cm by putting a pillow so that the head and chest are above the waist. This helps in preventing acid reflux.
Itopride+pantoprazole may increase the risk of osteoporosis (weak and brittle bones). This mainly occurs in people taking higher doses of Itopride+pantoprazole for longer durations. Consult your doctor if you have any concerns.
Take Itopride+pantoprazole exactly as prescribed by your doctor. To avoid heartburn and acid reflux, it is recommended to take Itopride+pantoprazole 30 to 60 minutes before food.
Usually, Itopride+pantoprazole begins to work 2 to 4 hours after it is taken. However, it may vary from person to person.
Yes, Itopride+pantoprazole may cause constipation as a side effect. It can be minimized by drinking plenty of water or eating foods that will help you stay hydrated and also increase your intake of high-fibre foods like raw fruits, whole grains, and vegetables.
No, a single dose of Itopride+pantoprazole is usually not sufficient for treating conditions like GERD (gastro-oesophageal reflux disease) or peptic ulcers. Therefore, it’s important to follow your doctor's instructions and complete the full course of treatment to see full benefits.
Itopride+pantoprazole is generally considered safe when taken as prescribed by your doctor. Do not exceed the recommended daily dose.
The long term side effects of Itopride+pantoprazole are osteoporosis and hypomagnesemia (low levels of magnesium).
Take Itopride+pantoprazole exactly as prescribed by your doctor. It is recommended to take Itopride+pantoprazole 30 to 60 minutes before food, preferably in the morning.
No, do not stop taking Itopride+pantoprazole without consulting your doctor, even if you start feeling better. Stopping Itopride+pantoprazole too early may cause your symptoms to return or worsen, and it might not fully treat the underlying condition. Always follow your doctor's instructions and complete the full course of treatment to ensure the best results.
Weight gain is not a common side effect of Itopride+pantoprazole. However, the long-term use of proton pump inhibitors (PPIs) like pantoprazole may indirectly cause weight gain through changes in appetite and food intake. To overcome this side effect, follow a balanced diet and consult your doctor. If you have any concerns, consult your doctor.
No, avoid drinking alcohol while taking Itopride+pantoprazole as it causes increased production of stomach acid, thereby increasing acidity and heartburn.
Yes, you can take antacids 2 hours before or after taking Itopride+pantoprazole, to prevent any possible interactions, this allows the antacids to work effectively without interfering with the absorption of Itopride+pantoprazole. However, please consult a doctor before taking other medicines with Itopride+pantoprazole.
To get relieve from acidity, include high-fibre foods like whole grains, vegetables and fruits, alkaline foods such as cauliflower, fennel, and nuts, watery foods like celery, cucumber, lettuce, and watermelon, lean proteins and ginger as they can help reduce acid reflux symptoms.
You are recommended to consult a doctor before taking pain killers along with Itopride+pantoprazole.
The common side effects of Itopride+pantoprazole are headache, nausea, stomach pain, dizziness and diarrhoea. If any of these side effects persist or worsen, please consult your doctor.
