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NEBIVOLOL+INDAPAMIDE

About

INDAPAMIDE+NEBIVOLOL is a combination drug containing antihypertensive medication, primarily used to treat high blood pressure (hypertension). Hypertension (High blood pressure) is a condition in which the force exerted by the blood against the artery walls becomes so high that it causes health problems, such as heart disease. It is also used to reduce strokes and chest pain (angina) caused by the arteries' blockage. In addition to this, INDAPAMIDE+NEBIVOLOL is also used to treat preterm labour.

INDAPAMIDE+NEBIVOLOL contains Nebivolol and Indapamide. Nebivolol is a beta-blocker;  that relaxes and widens the blood vessels making it easier for the heart to pump blood to all parts of the body. This helps in decreasing the blood pressure and the risk of having a heart attack or stroke. Indapamide is a thiazide diuretic that inhibits excess salt absorption in the body, resulting in increased chloride, sodium, and water excretion through urine. This diuresis process (increased urine production) and excess salts and fluid removal help lower blood pressure. 

Take INDAPAMIDE+NEBIVOLOL as prescribed by your doctor. You are advised to take INDAPAMIDE+NEBIVOLOL for as long as your doctor has prescribed it for you, depending upon your medical condition. You may experience nausea, constipation, fatigue, headache, stomach pain, diarrhoea, indigestion, weakness, dizziness, cough, peripheral oedema (swelling in feet and hands), nervousness, hypertonia (increased muscle tone) in some cases. Most of these side effects of INDAPAMIDE+NEBIVOLOL do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Try not to stop taking this medicine of your own as it may suddenly increase blood pressure, chest pain or may cause a heart attack. Let your doctor know if you have any liver or heart problems, are pregnant or breastfeeding. You should monitor your blood pressure regularly to be sure that the INDAPAMIDE+NEBIVOLOL is working efficiently. And also, a healthy diet, regular exercise is necessary to keep blood pressure under control. Do not eat grapefruit or drink grapefruit juice while you're taking nifedipine. It can make side effects worse. Even a small reduction in sodium in your diet helps improve your heart's health and reduce blood pressure. Avoid alcohol consumption while taking INDAPAMIDE+NEBIVOLOL as it might lower the blood pressure than normal.

Uses of NEBIVOLOL+INDAPAMIDE

Treatment of Hypertension (high blood pressure).

Medicinal Benefits

INDAPAMIDE+NEBIVOLOL is a combination drug containing antihypertensive medication, Nebivolol, and Indapamide, primarily used to treat high blood pressure (hypertension). In addition to this, nebivolol also helps prevent increased heart rate and controls heart pumping strength, and indapamide also treats fluid retention and overload (oedema) in congestive heart failure patients. Nebivolol is a beta-blocker;  that relaxes and widens the blood vessels making it easier for the heart to pump blood to all parts of the body. This helps in decreasing the blood pressure and the risk of having a heart attack or stroke. Indapamide is a thiazide diuretic that inhibits excess salt absorption in the body, resulting in increased chloride, sodium, and water excretion through urine. This diuresis process (increased urine production) and excess salts and fluid removal help lower blood pressure. 

Directions for Use

Swallow INDAPAMIDE+NEBIVOLOL as a whole with a glass of water. Do not crush, chew, or break it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of NEBIVOLOL+INDAPAMIDE

  • Nausea
  • Constipation
  • Fatigue
  • Headache
  • Stomach pain
  • Diarrhoea
  • Indigestion
  • Weakness
  • Dizziness, Infection 
  • Cough
  • Peripheral oedema (swelling in feet and hands)
  • Nervousness

In-Depth Precautions and Warning

Drug Warnings

Do not skip any doses or stop taking INDAPAMIDE+NEBIVOLOL without consulting your doctor. Avoid intake of INDAPAMIDE+NEBIVOLOL if you are allergic to any of its contents. Talk to your doctor if you have heart, kidney, or liver problems. Do not take INDAPAMIDE+NEBIVOLOL if you have low blood pressure, serious circulation problems in arms and legs, very slow heartbeat, serious heart rhythm problems, recent heart failure, asthma, liver function disorder, or metabolic disorder. Avoid taking INDAPAMIDE+NEBIVOLOL if you are pregnant or breast-feeding, and talk to your doctor. Avoid alcohol consumption while taking INDAPAMIDE+NEBIVOLOL as it might lower the blood pressure than normal. INDAPAMIDE+NEBIVOLOL is not recommended for children below the age of 18 years as the efficacy and safety have not been established. Regular monitoring of blood pressure, electrolyte levels, and kidney functioning is advised while taking INDAPAMIDE+NEBIVOLOL.

Drug Interactions

Drug-Drug Interaction: INDAPAMIDE+NEBIVOLOL may have interaction with diuretic medications (hydrochlorothiazide, furosemide), anti-hypertensive drugs (chlorthalidone, ramipril, metoprolol, amlodipine), drugs treating mental illness (alprazolam, amisulpride), painkillers (ibuprofen, naproxen), anti-depressants (lithium), diabetic drugs (Insulin glargine, metformin), drugs treating stomach acid (esomeprazole), fits medicine (clonazepam), corticosteroids (prednisone), drugs treating impotence (sildenafil). Maintain a gap of two hours between INDAPAMIDE+NEBIVOLOL and multivitamins and minerals as they might decrease the effects of INDAPAMIDE+NEBIVOLOL.

Drug-Food Interaction: Maintain low salt and low-fat diet while taking INDAPAMIDE+NEBIVOLOL. Avoid alcohol consumption while taking INDAPAMIDE+NEBIVOLOL as it might lower the blood pressure than normal. Avoid foods containing high cholesterol while taking INDAPAMIDE+NEBIVOLOL.

Drug-Disease Interaction: INDAPAMIDE+NEBIVOLOL may have interactions with diabetes, hypersensitivity, liver impairment, high cholesterol, hyperthyroidism, psoriasis, kidney impairment, asthma, heart problems, such as bradyarrhythmia, cardiogenic shock, low blood pressure, fast heart rate, ischemic heart disease, and congestive heart failure, and low potassium levels (hypokalemia).

Drug-Drug Interactions Checker List:

  • HYDROCHLOROTHIAZIDE
  • FUROSEMIDE
  • CHLORTHALIDONE
  • RAMIPRIL
  • METOPROLOL
  • AMLODIPINE
  • ALPRAZOLAM
  • AMISULPRIDE
  • IBUPROFEN
  • NAPROXEN
  • LITHIUM
  • INSULIN GLARGINE
  • METFORMIN
  • ESOMEPRAZOLE
  • PREDNISONE
  • SILDENAFIL
  • Safety Advice

    • Safety Warning

      Alcohol

      unsafe

      Alcohol may lower your blood pressure. It would help if you avoided or limit consuming alcohol whilst taking this medicine

    • Safety Warning

      Pregnancy

      caution

      It is not recommended to take INDAPAMIDE+NEBIVOLOL while pregnant as it is a pregnancy category C drug, and it is unknown whether it will harm the baby. Please consult your doctor if you have any concerns regarding this; your doctor will prescribe you INDAPAMIDE+NEBIVOLOL only if the benefits outweigh the risks.

    • Safety Warning

      Breast Feeding

      caution

      There are limited studies on how INDAPAMIDE+NEBIVOLOL affects the breastfed infants. However, Indapamide in INDAPAMIDE+NEBIVOLOL may pass into the breast milk during breastfeeding. Please consult your doctor before using INDAPAMIDE+NEBIVOLOL if you are a lactating mother.

    • Safety Warning

      Driving

      caution

      INDAPAMIDE+NEBIVOLOL may cause side effects due to lowering of the blood pressure such as dizziness or tiredness. If you feel dizzy or tired when taking this medicine, do not drive or use any tools or machines.

    • Safety Warning

      Liver

      caution

      Dose adjustment may be needed. INDAPAMIDE+NEBIVOLOL should be used with caution in patients with liver impairment/liver disease. Please consult your doctor if you have kidney impairment or any concerns regarding this.

    • Safety Warning

      Kidney

      caution

      Dose adjustment may be needed. INDAPAMIDE+NEBIVOLOL should be used with caution in patients with kidney impairment/kidney disease. Please consult your doctor if you have kidney impairment or any concerns regarding this.

    • Safety Warning

      Children

      unsafe

      INDAPAMIDE+NEBIVOLOL is not recommended for use in people below 18 years of age.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • Keep your weight under control with a body mass index (BMI) between 19.5 and 24.9.
    • Do regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the week. Doing this can help you to lower your raised blood pressure by about 5 mm of Hg.
    • Limit sodium chloride intake (table salt) in your daily diet to 2300 mg per day or less than 1500 mg is ideal for most adults.
    • If you are taking alcohol, use only one serving for women and two servings for men.
    • Quit smoking to lower the risk of heart diseases. 
    • Avoid chronic stress as it can raise your blood pressure. Try to enjoy and spent time with your loved ones to cope with stress.
    • Monitor your blood pressure daily, and if you notice any fluctuations frequently, please contact your doctor immediately.
    • Try including heart-healthy omega 3 fatty acid-containing foods in your daily diet. You can also use low-fat cooking oils like olive oil, soybean oil, canola oil, and coconut oil that help in lowering your elevated blood pressure.

    Special Advise

    • Monitor your blood pressure regularly and seek medical advice if you notice any drastic fluctuations.
    • Let your doctor know if you are advised for any blood examinations as, diuretics like Indapamide can cause changes in the laboratory parameters like low potassium levels in the blood, low sodium in the blood, low blood pressure, increase in uric acid, increase in blood glucose levels in diabetic patients, increase in calcium levels in the blood, and increase in the liver enzyme levels. 
    • Athletes should be aware that Indapamide in INDAPAMIDE+NEBIVOLOL gives a positive reaction in doping tests.

    Patients Concern

    Disease/Condition Glossary

    Hypertension: It is a chronic condition when blood pressure is too high. Blood pressure is defined as the amount of blood pumped by the heart and the amount of resistance exerted by the arteries against the blood flow. If the heart pumps more blood, then arteries become narrower, and in turn, blood pressure becomes high. If blood pressure becomes uncontrolled, it may lead to serious heart diseases, including stroke and heart attack. Additionally, high blood pressure can also cause brain damage (stroke) and kidney failure. Blood pressure is expressed as systolic and diastolic pressures. Systolic blood pressure represents the contraction and relaxation of the heart. Diastolic pressure is exerted in the blood vessels when the heart beats and is in the resting state. Ideal blood pressure should be between 90/60mmHg and 120/80mmHg. Hypertension is detected when systolic blood pressure is more than 140mmHg, and diastolic pressure is higher than 90mmHg. Some of the symptoms of hypertension include headache, nose bleed, vomiting, and chest pain.

    FAQs

    INDAPAMIDE+NEBIVOLOL is used to treat high blood pressure (hypertension).

    INDAPAMIDE+NEBIVOLOL contains Nebivolol and Indapamide. Nebivolol works by relaxing and widening the blood vessels making it easier for the heart to pump blood to all parts of the body. This helps in decreasing the blood pressure and the risk of having a heart attack or stroke. Indapamide inhibits excess salt absorption in the body, resulting in increased chloride, sodium, and water excretion through urine. This diuresis process (increased urine production) and excess salts and fluid removal help lower blood pressure.Â

    Please do not stop taking INDAPAMIDE+NEBIVOLOL without consulting your doctor on your own as it may lead to a rise in blood pressure. Continue taking INDAPAMIDE+NEBIVOLOL for as long as your doctor has prescribed it to you. Do not be reluctant to speak with your doctor if you experience any difficulty while taking INDAPAMIDE+NEBIVOLOL.

    If you have diabetes, you should monitor your blood glucose levels often as INDAPAMIDE+NEBIVOLOL might mask hypoglycemia symptoms (low glucose levels). However, please consult your doctor before taking INDAPAMIDE+NEBIVOLOL if you have diabetes

    INDAPAMIDE+NEBIVOLOL may cause swelling of hands or feet. This could be due to edema (fluid retention). Talk to your doctor if you think you have gained weight or have trouble breathing while taking INDAPAMIDE+NEBIVOLOL.

    Do not overdose on INDAPAMIDE+NEBIVOLOL or any medicine, which could lead to very unpleasant side effects. Take INDAPAMIDE+NEBIVOLOL only as prescribed by your doctor. An overdose of INDAPAMIDE+NEBIVOLOL can cause a very slow heartbeat, low blood pressure, breathlessness, and acute heart failure. Rush to your nearest doctor as early as possible if you have overdosed on INDAPAMIDE+NEBIVOLOL.

    Available Medicines for

    NEBIVOLOL+INDAPAMIDE

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