TEGAFUR+GIMERACIL+OTERACIL
About
GIMERACIL+OTERACIL+TEGAFUR is indicated in the treatment of stomach/gastric cancer. Stomach (gastric) cancer is a type of cancer that originates in the cells lining the stomach. Symptoms may include feeling bloated after eating, nausea, heartburn or indigestion.
GIMERACIL+OTERACIL+TEGAFUR contains Tegafur, Gimeracil and Oteracil, which work by inhibiting the genetic material and preventing the growth of cancer cells. Thereby, it helps treat stomach cancer.
In some cases, GIMERACIL+OTERACIL+TEGAFUR may cause side effects such as nausea, vomiting, diarrhoea, and constipation. Do not be reluctant to talk with your doctor if any of the side effects persist or worsen.
Do not use GIMERACIL+OTERACIL+TEGAFUR if you are pregnant or breastfeeding. GIMERACIL+OTERACIL+TEGAFUR is not recommended for children as safety and effectiveness have not been established. Keep the doctor informed about your health condition and medications to rule out any side effects/interactions.
Uses of TEGAFUR+GIMERACIL+OTERACIL
Medicinal Benefits
GIMERACIL+OTERACIL+TEGAFUR is indicated in the treatment of stomach/gastric cancer. GIMERACIL+OTERACIL+TEGAFUR contains Tegafur, Gimeracil and Oteracil. Tegafur is converted into the active drug 5FU (fluorouracil) in the liver and then absorbed by tumour cells. It inhibits the synthesis of genetic material (DNA and RNA) and prevents the growth of cancer cells. Gimeracil prevents the degradation of 5FU, and Oteracil inhibits the gastrointestinal toxicity of 5FU. Together, GIMERACIL+OTERACIL+TEGAFUR helps treat stomach cancer.
Directions for Use
Storage
Side Effects of TEGAFUR+GIMERACIL+OTERACIL
- Diarrhoea
- Nausea
- Vomiting
- Constipation
In-Depth Precautions and Warning
Drug Warnings
Do not take GIMERACIL+OTERACIL+TEGAFUR if you are allergic to any of its components, if you are pregnant or breastfeeding, if you have a history of severe and unexpected reactions to fluoropyrimidine therapy, known dihydropyrimidine dehydrogenase (DPD) deficiency, severe bone marrow suppression, or end-stage renal disease requiring dialysis. Inform the doctor if you have bone marrow suppression, diarrhoea, dehydration, kidney or liver problems, or eye toxicity. GIMERACIL+OTERACIL+TEGAFUR is not recommended for use in children below 18 years. Let the doctor know if you take other medicines, including supplements and herbal products.
Drug Interactions
Drug-Drug Interactions: Inform the doctor if you are taking fluoropyrimidines (capecitabine, 5-FU, flucytosine), CYP2A6 inhibitors, or anti-viral agents (sorivudine, brivudine).
Drug-Food Interactions: No interactions found/established.
Drug-Disease Interactions: Inform the doctor if you have bone marrow suppression, end-stage kidney disease, glucose/galactose intolerance, or malabsorption.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
consult your doctorIt is not known if alcohol affects GIMERACIL+OTERACIL+TEGAFUR. Please consult your doctor.
Pregnancy
unsafeGIMERACIL+OTERACIL+TEGAFUR is not recommended during pregnancy as it may cause foetal harm. Consult the doctor immediately if you become pregnant during treatment with GIMERACIL+OTERACIL+TEGAFUR.
Breast Feeding
unsafeIt is not known if this medicine passes into breast milk. Therefore, breastfeeding is not recommended during treatment with GIMERACIL+OTERACIL+TEGAFUR.
Driving
cautionGIMERACIL+OTERACIL+TEGAFUR may cause fatigue, dizziness and blurred vision. Drive or operate heavy machinery only if you are alert.
Liver
consult your doctorConsult the doctor if you have a history of liver problems.
Kidney
cautionGIMERACIL+OTERACIL+TEGAFUR is not recommended in patients with end-stage renal disease requiring dialysis. Consult the doctor if you have kidney problems.
Children
unsafeGIMERACIL+OTERACIL+TEGAFUR is not recommended for children below 18 years as safety and effectiveness have not been established.
Habit Forming
Diet & Lifestyle Advise
- Light exercises are recommended as they promote mobility, balance, and well-being.
- Rest well when you are feeling tired.
- Maintain adequate hydration unless informed by the doctor to restrict fluids.
- Avoid drinking fluid with meals, particularly carbonated beverages.
- Do not consume caffeine, spicy and processed foods.
- Limit alcohol consumption and avoid smoking.
- Include fruits, vegetables, and whole grains in your diet.
- Maintain a healthy body weight.
- Cut down on salty foods.
Special Advise
- Women of childbearing potential are advised to avoid becoming pregnant during treatment with GIMERACIL+OTERACIL+TEGAFUR. Consult the doctor immediately if you become pregnant during treatment.
- Both male and female patients should take contraceptive measures during treatment and for 6 months after stopping the treatment.
Patients Concern
Disease/Condition Glossary
Stomach/gastric cancer: Stomach (gastric) cancer is a type of cancer that originates in the cells lining the stomach. During the early stages of the disease, there may be no noticeable symptoms. However, as the cancer progresses, the symptoms include feeling bloated after eating, feeling full after consuming small quantities of food, nausea, heartburn or indigestion. Risk factors that may increase the likelihood of developing stomach cancer include smoking and a diet that consists of highly processed or salty foods. Treatment options for stomach cancer include surgery, medication, radiation and chemotherapy.
FAQs
GIMERACIL+OTERACIL+TEGAFUR is used to treat gastric/stomach cancer.
GIMERACIL+OTERACIL+TEGAFUR works by preventing the growth of cancer cells. Thereby, it helps treat stomach cancer.
GIMERACIL+OTERACIL+TEGAFUR may have anti-fertility effects, which may be irreversible. Talk to the doctor regarding fertility preservation prior to the start of the treatment or if you have any concerns.
Diarrhoea could be a side effect of GIMERACIL+OTERACIL+TEGAFUR. Consult the doctor if you experience diarrhoea. The doctor may monitor you carefully and give fluid/electrolyte replacement if you are dehydrated.
