EFONIDIPINE+METOPROLOL

Do not use EFONIDIPINE+METOPROLOL if you are allergic to EFONIDIPINE+METOPROLOL or its components. Please inform your doctor if you are using any prescription and non-prescription medications, including vitamins, before starting EFONIDIPINE+METOPROLOL. Let your doctor know if you have any history of severe heart, kidney, or liver diseases. EFONIDIPINE+METOPROLOL should not be administered to pregnant women and women suspected of being pregnant. Mothers on EFONIDIPINE+METOPROLOL treatment should avoid breastfeeding. EFONIDIPINE+METOPROLOL is not recommended in children and adolescents under 18 years due to a lack of information for this age group. Grapefruit and grapefruit juice can increase the blood levels of efonidipine, which can cause an unpredictable increase in its blood pressure-lowering effect. So, it is recommended not to drink grapefruit juice or eat grapefruit while taking this medicine.

Drug-Drug Interactions: EFONIDIPINE+METOPROLOL may interact with other antihypertensive agents (e.g. clonidine), antiretroviral medications (e.g. atazanavir, saquinavir) stomach acid reducers (e.g. cimetidine) and immunomodulating medications (e.g. tacrolimus, fingolimod).

Drug-Food Interactions: Avoid drinking grapefruit juice or eating grapefruit while taking this medicine. Alcohol consumption should be avoided.

Drug-Disease Interactions: EFONIDIPINE+METOPROLOL may interact with disease conditions, including liver disease, recent heart attack, heart failure, or severe increase in blood pressure (hypertensive crisis), bradyarrhythmia/AV block, cardiogenic shock/hypotension, CHF (Congestive heart failure), diabetes, hemodialysis, hypersensitivity, ischemic heart disease, and PVD (peripheral arterial disease).

• Keep your weight under control with a BMI of 18.5-24.9.
• Do regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the week. Doing this can help lower your raised blood pressure by about 5 mm Hg.
• Opt for a diet rich in whole grains, fruits, veggies, and low-fat dairy products.
• Limit sodium chloride (table salt) intake in your daily diet.
• If you are taking alcohol, only one serving for women and two serving for men is advisable.
• Quitting smoking is the best strategy to lower the risk of heart disease.
• Avoid chronic stress, as it can raise your blood pressure. Try to enjoy and spend time with your loved ones to cope with stress and practice mindfulness techniques.
• Monitor your blood pressure daily, and immediately contact your doctor if there is too much fluctuation.
• Try to include heart-healthy omega-3 fatty acid-containing food and drinks in your daily diet. You can also use low-fat cooking oil like olive, soybean, canola, and coconut oil, as they may help lower your blood pressure.

• Monitor your blood pressure regularly and seek medical advice if you notice any drastic fluctuations.
• EFONIDIPINE+METOPROLOL may affect patients with hepatic impairment; hence, it is used cautiously, and Liver function monitoring and Liver Function Tests are advised to monitor the liver enzyme changes.
• Your doctor may advise you to get a regular kidney function test and blood examinations for potassium levels and other electrolytes while using EFONIDIPINE+METOPROLOL to rule out any renal impairment.
• Grapefruit juice and grapefruit should not be consumed by people taking EFONIDIPINE+METOPROLOL. This is because grapefruit and grapefruit juice can increase the blood levels of the active ingredient amlodipine in EFONIDIPINE+METOPROLOL, which can cause an unpredictable increase in the blood pressure-lowering effect of EFONIDIPINE+METOPROLOL.