Naproxen+domperidone
About Naproxen+domperidone
Domperidone+naproxen belongs to the group of medications called analgesics. It treats migraine headaches. Besides this, it can also be used to reduce pain in rheumatoid arthritis, gout and dysmenorrhea (menstrual pain). Migraine is a condition characterized by intense headaches. Pain is a symptom that occurs due to various underlying conditions.
Domperidone+naproxen is a combination of two drugs: Naproxen and Domperidone. Naproxen works by blocking the action of the cyclo-oxygenase (COX) enzyme in the body that produces certain chemical substances such as prostaglandins that cause pain and swelling. Domperidone is an antiemetic agent which prevents nausea and vomiting symptoms by blocking certain receptors (like dopamine and serotonin) that stimulate the vomiting centre (chemoreceptor trigger zone – CTZ) located in the brain.
Take Domperidone+naproxen as prescribed by your doctor. You are advised to take Domperidone+naproxen for as long as your doctor has prescribed it for you based on your medical condition. Common side-effects of Domperidone+naproxen are dryness of the mouth, abdominal pain, constipation, drowsiness, dizziness, visual disturbances, hearing problems and headache. Consult your doctor if you feel any discomfort.
Before taking the Domperidone+naproxen, let your doctor know about all your allergic or hypersensitivity reactions to medicines or food. If you are pregnant or breastfeeding, please tell your doctor so that your doctor will weigh the benefits and any potential risks before prescribing it to you. Also, inform the doctor if you have a history of heart rhythm problems or ulcers due to pain killers. Patients with age above 65 years, pre-existing cardiac diseases such as heart failure, hypertension or stroke, gastrointestinal bleeding (due to pain killers), gastric ;ulcers, respiratory diseases such as asthma, liver diseases, kidney diseases or bleeding disorders should use Domperidone+naproxen only when prescribed by a doctor.
Uses of Naproxen+domperidone
• Effective Pain Relief: Domperidone+naproxen is commonly prescribed to alleviate moderate to severe pain, including headaches, dental pain, menstrual cramps, and postoperative discomfort. It works by blocking the production of chemicals responsible for inflammation and pain.
• Powerful Anti-inflammatory Action: With its active ingredient naproxen, Domperidone+naproxen helps reduce inflammation associated with conditions like osteoarthritis and rheumatoid arthritis, providing relief from joint pain and swelling.
• Fever Management: Domperidone+naproxen is also effective in lowering fever across various conditions, offering relief and aiding the body's recovery process.
• Relief for Muscle Pain: Whether due to exercise, strains, or injuries, Domperidone+naproxen can help alleviate muscle pain, improving comfort and mobility.
Medicinal Benefits
Domperidone+naproxen is a combination of naproxen and domperidone. Naproxen is an anti-inflammatory (reduce inflammation) and analgesic (reduce pain) agent. It inhibits the synthesis of prostaglandins, which are inflammatory mediators, thereby reducing pain and inflammation. Domperidone acts by enhancing gastric peristalsis (movements) to empty stomach. Easy movement of food through the stomach helps in relieving nausea and vomiting. It blocks the dopamine receptors present at the chemoreceptor trigger zone (responsible for regulating nausea and vomiting).
Directions for Use
Swallow it as a whole with water; do not crush, break or chew it.
Storage
Side Effects of Naproxen+domperidone
Abdominal pain
Constipation
Indigestion
Flatulence
Dry mouth
Glossitis (inflammation of the tongue)
Diarrhoea
Drowsiness
Dizziness
Headache
Vision problems
Hearing problems
Drug Warnings
Inform your doctor if you are taking any of the anticoagulants (warfarin), other NSAIDs (ibuprofen, ketorolac), corticosteroids (prednisolone), antidepressants (citalopram, fluoxetine, paroxetine, duloxetine, venlafaxine), or any other dietary or herbal supplements. Long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as naproxen may increase the risk of heart attack or stroke and stomach ulcers. The risk of developing ulcers is higher if you have a history of ulcers, have bleeding disorders, older in age, alcoholic or have multiple diseases. The risk of having a heart attack increases if you smoke, or you or your family has a history of heart failure, stroke, or hypertension. Call for medical help immediately, if you experience chest pain, shortness of breath, blood in the stool or dark stools, heartburn, or any other abnormal signs.
Drug Interactions
Drug-drug interactions: Domperidone+naproxen may interact with other NSAIDs (ketorolac), anticoagulants (warfarin), corticosteroids (prednisolone), anti-hypertensive medications (ramipril and amlodipine), antibiotics (amikacin), lipid-lowering drugs (atorvastatin), and antidepressants (citalopram and fluoxetine).
Drug-food interactions: No interactions found.
Drug-disease interactions: Patients with peptic ulcers, inflammatory bowel disease (inflammation of the digestive tract), liver diseases, kidney diseases, heart problems, and respiratory diseases should take the Domperidone+naproxen only when prescribed by a doctor.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionIt is advised not to take alcohol as Domperidone+naproxen can cause dizziness or drowsiness.
Pregnancy
cautionDomperidone+naproxen should be used in pregnant women only if clinically needed, and the benefits outweigh the risks.
Breast Feeding
cautionDomperidone+naproxen should be used in breastfeeding mothers only if the benefits outweigh the risks.
Driving
unsafeIt is unsafe to drive after taking Domperidone+naproxen as it impacts your ability to drive or operate machinery.
Liver
cautionLimited information was available for the use of Domperidone+naproxen in patients suffering from liver impairment. Please consult your doctor if you have any concerns regarding using Domperidone+naproxen in patients with liver impairment. Your doctor will prescribe only if the benefits outweigh the risks.
Kidney
cautionLimited information was available for the use of Domperidone+naproxen in patients suffering from kidney impairment. Please consult your doctor if you have any concerns regarding using Domperidone+naproxen in patients with kidney impairment. Your doctor will prescribe only if the benefits outweigh the risks.
Children
cautionDomperidone+naproxen should be used in children below 12 years of age only when prescribed by a child specialist.
Habit Forming
Diet & Lifestyle Advise
Drink plenty of fluids to avoid gastrointestinal problems.
Avoid triggers that can increase your migraine headache.
Take enough rest.
Acupuncture, massage and physical therapy may also be helpful.
De-stress yourself by meditating, reading books, taking a warm bubble bath or listen to soothing music.
Avoid smoking and alcohol consumption.
Performing yoga may also help in improving joint flexibility and pain management.
Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.
Special Advise
Your doctor may monitor liver function and kidney function if you are taking Domperidone+naproxen for long-term.
Taking meals at the same time every day and sufficient sleep might help in avoiding migraine attacks. You are recommended to avoid loud music, noisy place, extreme temperatures and bright light. Also, avoid consumption of chocolates, cheese, processed food, smoking and alcohol.
Patients Concern
Disease/Condition Glossary
Migraine: Migraine is a condition characterized by intense headaches. It also causes nausea, vomiting, sensitivity to light and sound and difficulty speaking. Bright lights, strong smells, certain foods, loud sounds, stress and hormonal changes act as triggers for migraine. These triggers lead to acute attacks. Acute migraine attacks result in throbbing headaches and pain in the eyes, face or neck.
Pain: Pain is a widely used term used to describe unpleasant feelings or discomfort. It ranges from mild to severe. The severity of the pain depends on the underlying condition.
Rheumatoid arthritis: Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue) which leads to joint pain and damage. Symptoms of rheumatoid arthritis include pain, swelling, stiffness, deformities and loss of joint function.
Gout: Gout is an inflammatory condition in which uric acid deposits and crystallizes in the joints. It is characterized by acute, severe, and recurring pain attacks, especially at night, redness and swelling in the affected joints.
Dysmenorrhea: Dysmenorrhea refers to abdominal cramps/pain and an unpleasant sensory/emotional experience associated with irregular periods. It occurs just before or during menses. Menstrual cramps that cause throbbing pain in the lower belly during periods may vary from mild to severe. Some of the common symptoms of menstrual cramps include an aching pain in your belly (sometimes severe), a feeling of pressure in your belly, pain in your hips, lower back, and inner thighs.
FAQs
Domperidone+naproxen is used to treat migraine headaches, pain associated with conditions like rheumatoid arthritis, gout and dysmenorrhea (menstrual pain).
Naproxen works by inhibiting the cyclo-oxygenase (COX) enzyme in the body, which creates chemical compounds such as prostaglandins, which induce pain and swelling. Domperidone is an antiemetic that blocks certain receptors (such as dopamine and serotonin) that stimulate the brain's vomiting centre (chemoreceptor trigger zone - CTZ).
Domperidone+naproxen cannot permanently cure migraine. It can provide relief from pain and headache.
Domperidone+naproxen on prolonged or frequent use can cause liver or kidney problems. Therefore, it should be only used for a duration as prescribed by the doctor.
Arthritis is a chronic condition of joints with pain and inflammation. Domperidone+naproxen does not cure arthritis but relieves symptoms of arthritis-like joint pain, swelling and stiffness.
Yes, Domperidone+naproxen may increase the risk of heart problems such as heart attack and stroke, especially when used in high doses or for a prolonged duration. It is advised to inform your doctor if you have any of these conditions or have a history of heart problems or stroke before taking the Domperidone+naproxen.
Dry mouth may be caused by Domperidone in Domperidone+naproxen. Chew a sugar-free sweet or sugar-free gum.
Yes, Domperidone+naproxen is a painkiller. It contains Naproxen, a nonsteroidal anti-inflammatory drug (NSAID) that helps reduce pain and inflammation, while Domperidone helps manage nausea, which is common in migraines. Besides this, it can also be used to reduce pain in gout, rheumatoid arthritis, and dysmenorrhea (menstrual pain).
Domperidone+naproxen usually starts working within 30-60 minutes after oral intake. However, the exact time may vary based on individual response and medical condition. Always consult your doctor for personalized guidance and proper usage.
To ensure safe and effective treatment, it's helpful to know that Domperidone+naproxen may have a potential impact on blood pressure, but with proper monitoring, you can minimize risks. By working closely with your healthcare provider, you can enjoy the benefits of Domperidone+naproxen while maintaining healthy blood pressure. Open communication with your doctor is key to a successful treatment plan.
Domperidone+naproxen is a combination medication that pairs a nonsteroidal anti-inflammatory drug (NSAID) with an antiemetic and prokinetic agent. This combination helps relieve pain and prevents nausea, improving overall comfort.
The side effects of Domperidone+naproxen include dryness of the mouth, constipation, abdominal pain, drowsiness, dizziness, visual disturbances, hearing problems and headache. Most of these side effects do not require medical attention and gradually resolve over time. However, please consult your doctor if any symptoms persist or worsen.
You should consult your doctor before stopping Domperidone+naproxen, even if your migraine is relieved. It is generally used as needed for migraine attacks, but stopping suddenly without medical advice may not be ideal. Follow the dosage instructions provided by your doctor and complete the entire treatment course to treat your medical condition effectively.
Yes, Domperidone+naproxen may cause diarrhoea, a common side effect. If you experience this symptom, drink plenty of water to stay hydrated, take probiotics, avoid spicy, fatty, or dairy foods, and limit caffeine intake to manage diarrhoea.
To ensure a safe and effective treatment experience with Domperidone+naproxen, it's essential to be aware of certain contraindications. By knowing these guidelines, you can minimize risks and maximize benefits. Domperidone+naproxen is not recommended for individuals with NSAID hypersensitivity, NSAID-induced asthma, or severe allergic reactions, as well as during pregnancy, especially after 30 weeks, and in cases of severe liver impairment, heart conditions, or significant electrolyte disturbances. Additionally, caution is advised for patients with gastrointestinal bleeding, obstruction, or prolactin-releasing pituitary tumours and when taking QT-prolonging drugs or potent CYP3A4 inhibitors. By working closely with your healthcare provider, you can navigate these guidelines and enjoy a successful treatment outcome.
Yes, prolonged or frequent use of Domperidone+naproxen may cause kidney damage as it contains Naproxen, an NSAID, which can affect kidney function, especially with long-term use. Therefore, it should only be used as a doctor prescribes to minimize the risk.
No, you should not take a higher than the recommended dose of Domperidone+naproxen, as it may cause serious side effects like irregular heartbeat, drowsiness, extreme tiredness, nausea, stomach pain, and breathing difficulties. If you accidentally take more than the prescribed dose, seek immediate medical attention.
Domperidone+naproxen should be stored in a cool, dry place away from sunlight. Keep it out of sight and reach of children.
