Dapagliflozin+metformin+glimepiride
About Dapagliflozin+metformin+glimepiride
Dapagliflozin+glimepiride+metformin is an antidiabetic medicine used to treat diabetes. It is used for the treatment of Type II Diabetes. Type II Diabetes Mellitus is a chronic condition that influences the body's metabolism of glucose or blood sugar. Insulin resistance or insufficient insulin production are the two main causes of type 2 diabetes.
Dapagliflozin+glimepiride+metformin contains Dapagliflozin (sodium-glucose cotransporter-2 inhibitors), Metformin (biguanides), and Glimepiride (sulfonylurea), which work by increasing the amounts of certain natural substances that lower blood sugar when it is high.
Dapagliflozin+glimepiride+metformin may cause certain side effects, such as vomiting, nausea, abdominal pain, headache, and allergic reactions. If these side effects persist or worsen, please consult your doctor. Dapagliflozin+glimepiride+metformin should be taken as prescribed by your doctor.
Dapagliflozin+glimepiride+metformin should be avoided if you are allergic to any of the medicines or their components. Inform your doctor about your medical history and the medicines you are taking, including herbs and supplements, before starting the treatment with Dapagliflozin+glimepiride+metformin. This can help prevent unwanted effects. Let your doctor know if you are pregnant or breastfeeding before taking Dapagliflozin+glimepiride+metformin. It is not recommended for use in children below 18 years of age.
Uses of Dapagliflozin+metformin+glimepiride
Medicinal Benefits
Dapagliflozin+glimepiride+metformin is a combination of three drugs, namely: Dapagliflozin, Metformin and Glimepiride. Dapagliflozin+glimepiride+metformin belongs to the group of anti-diabetic medicines used to treat type-2 diabetes mellitus. Dapagliflozin helps remove excess sugar from the body via urine. Metformin helps reduce the sugar production by cells in the liver and delays sugar absorption from the intestines. Glimepiride works by stimulating beta cells in the pancreas that produce insulin. Thus, insulin helps to remove sugar from the blood.
Directions for Use
Storage
Side Effects of Dapagliflozin+metformin+glimepiride
- Headache
- Nausea
- Stomach upset
- Vomiting
- Abdominal pain
- Allergic reactions
- Hypoglycaemia (low blood sugar)
Drug Warnings
Dapagliflozin+glimepiride+metformin should be avoided if you are allergic to any of the medicines or their components. Before starting the treatment, inform your doctor about your medical history and the medications you take, including herbs and supplements, to rule out any side effects. It is unknown whether Dapagliflozin+glimepiride+metformin can be given to pregnant women or breastfeeding mothers. Hence, inform your doctor if you are pregnant or breastfeeding. It is not recommended for use in children below 18 years of age. Avoid drinking alcohol while on Dapagliflozin+glimepiride+metformin as it increases the risk of hypoglycemia and lactic acidosis (when the lactic acid increases in the body, which impacts the functioning of various organs in the body). Inform your doctor if you have any liver/kidney disease, heart problems, and hypertension before taking Dapagliflozin+glimepiride+metformin.
Drug Interactions
Drug-Drug Interactions: Dapagliflozin+glimepiride+metformin interacts with an anti-depressant (bupropion), drugs used to treat glaucoma, antibiotics (cephalexin, ciprofloxacin), heart condition drugs (digoxin), anti-epileptic drugs (topiramate, lamotrigine).
Drug-Food Interactions: Intake of excessive alcoholic beverages may increase the chance of a life-threatening condition known as Lactic acidosis. So, avoid intake of alcoholic beverages with Dapagliflozin+glimepiride+metformin.
Drug-Disease Interactions: Inform your doctor if you have any kidney or liver disease or heart problems.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAlcohol increases the impact of metformin on lactate metabolism. Hence, you should not consume excessive amounts of alcohol, either temporarily or permanently, while taking Dapagliflozin+glimepiride+metformin.
Pregnancy
cautionThere are no adequate studies on the effect of Dapagliflozin+glimepiride+metformin in pregnancy. If you are pregnant or planning pregnancy, inform your doctor before taking Dapagliflozin+glimepiride+metformin.
Breast Feeding
cautionDapagliflozin+glimepiride+metformin is generally not recommended in breastfeeding. Hence, if you are breastfeeding, inform your doctor before using Dapagliflozin+glimepiride+metformin.
Driving
cautionDapagliflozin+glimepiride+metformin usually does not affect your ability to drive or operate machinery.
Liver
cautionDapagliflozin+glimepiride+metformin may cause lactic acidosis due to metformin accumulation. The risk increases with hepatic insufficiency. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.
Kidney
cautionRenal impairment also increases the risk of lactic acidosis. Hence, Dapagliflozin+glimepiride+metformin should be used cautiously if you have kidney problems. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.
Children
unsafeDapagliflozin+glimepiride+metformin is not recommended for children below 18 years as the safety and effectiveness were not established.
Habit Forming
Diet & Lifestyle Advise
- Try doing 30 minutes of moderate-intensity physical activity or one hour and 15 minutes of high-intensity exercise weekly.
- Include your diet with whole grain foods, fruits and veggies and other fiber-enriched foods.
- Add omega-3 fatty acid-containing oils for daily cooking.
- Avoid taking too much stress as it may elevate your blood sugar level. You can adopt stress management techniques like mindfulness, meditation, or yoga to control stress-related blood sugar changes.
- Loss of weight gradually to achieve a healthy body mass index (18.5 to 24.9).
- Keep your blood pressure as normal (140/90) as possible, as it reduces the risk of cardiovascular diseases in diabetes patients.
- Avoid smoking and alcohol consumption while on treatment with Dapagliflozin+glimepiride+metformin.
- Take short, frequent meals, and avoid prolonged fasting when taking Dapagliflozin+glimepiride+metformin.
Special Advise
- Dapagliflozin+glimepiride+metformin may sometimes cause hypoglycemia (low blood sugar levels) as a side effect. Always carry a sugary food such as candy or fruit juice and consume them if you experience hypoglycaemia.
- Your doctor may advise frequent blood tests to check your blood sugar levels.
- Lifestyle modifications are the most important step in controlling blood sugar levels.
Patients Concern
Disease/Condition Glossary
Type II Diabetes Mellitus: It is a chronic and lifelong condition wherein the body doesn’t use insulin effectively, which causes unusual blood glucose levels. Therefore, people affected with type 2 diabetes either do not produce enough insulin or there is resistance to the action of insulin. Individuals middle-aged or older are most likely to suffer from type 2 diabetes, which is also known as adult-onset diabetes. Symptoms of type 2 diabetes include increased thirst, frequent urination at night, slow wound healing, increased hunger, fatigue, weight gain, and blurred vision.
FAQs
Dapagliflozin+glimepiride+metformin is used for the treatment of Type II Diabetes.
Dapagliflozin+glimepiride+metformin contains Dapagliflozin, Metformin, and Glimepiride, which work by increasing the amounts of certain natural substances that lower blood sugar when it is high.
Please consult your doctor if you have concerns and for more information on this.
If you forget to take Dapagliflozin+glimepiride+metformin, take it as soon as you remember. However, if it is time for the next dose, avoid taking it and do not double dose to make up for the missed dose. Taking an overdose might cause your sugar level to fall down rapidly.
