Daclatasvir+sofosbuvir
About Daclatasvir+sofosbuvir
Daclatasvir+sofosbuvir belongs to a class of drugs called antivirals. It is used to treat chronic HCV (Hepatitis C virus) infection. Hepatitis C is a viral infection that causes inflammation or swelling in the liver, which can lead to severe liver damage. It is caused by the hepatitis C virus (HCV) and spreads through contact when infected blood enters the bloodstream of someone who is not infected.
Daclatasvir+sofosbuvir contains antiviral drugs daclatasvir and sofosbuvir reduce the amount of the virus in the body, which is how they treat chronic hepatitis C (HCV). They function by preventing the activity of two proteins that are necessary for the virus to replicate.
Daclatasvir+sofosbuvir should be taken in the dose and duration prescribed by the doctor. In some cases, Daclatasvir+sofosbuvir may cause common side effects such as nausea, diarrhoea, abdominal pain, difficulty sleeping, dizziness, tiredness, headache, insomnia (sleeplessness), and joint or muscle pain. Typically, these side effects do not require medical attention and will subside independently. However, if they persist or become more severe, please consult your doctor.
Please inform your doctor if you are allergic to any of the ingredients in Daclatasvir+sofosbuvir or taking any other medications. Avoid using Daclatasvir+sofosbuvir if you are pregnant or planning to become pregnant and are not using birth control. Both you and your partner should use effective birth control methods during treatment and for 5 weeks after finishing the medication. If you become pregnant during treatment, contact your doctor immediately. Daclatasvir+sofosbuvir is not recommended for use in children below 18 years of age, as its efficacy and safety have not been established in this age group. Also, inform your doctor if you have any pre-existing conditions, such as diabetes, hepatitis B, a history of liver transplant, heart or kidney problems, or HIV (human immunodeficiency virus) infection, before starting Daclatasvir+sofosbuvir.
Uses of Daclatasvir+sofosbuvir
Medicinal Benefits
Daclatasvir+sofosbuvir belongs to a class of drugs called 'antivirals,' primarily used to treat chronic HCV (Hepatitis C virus) infection, particularly genotype 3. It contains antiviral drugs daclatasvir and sofosbuvir, which reduce the amount of the virus in the body, which is how they treat chronic hepatitis C (HCV). They function by preventing the activity of two proteins that are necessary for the virus to replicate.
Directions for Use
Take Daclatasvir+sofosbuvir as advised by your doctor. Swallow this medication as a whole with a glass of water. Do not chew, break, or crush it.
Storage
Side Effects of Daclatasvir+sofosbuvir
- Nausea
- Diarrhoea
- Abdominal pain
- Difficulty sleeping
- Dizziness
- Tiredness
- Headache
- Insomnia (sleeplessness)
- Joint or muscle pain
Drug Warnings
Please inform your doctor if you are allergic to any ingredients in Daclatasvir+sofosbuvir or if you are taking any other medications, including prescription and over-the-counter (OTC) drugs, vitamins, or herbal supplements. If you are taking Daclatasvir+sofosbuvir along with amiodarone (a medication for irregular heartbeats), you may need regular heart monitoring, as it could excessively slow your heart rate (severe bradycardia). Avoid using Daclatasvir+sofosbuvir if you are pregnant or planning to become pregnant and are not using birth control. Both you and your partner should use effective birth control methods during treatment and for 5 weeks after finishing the medication. If you become pregnant during treatment, contact your doctor immediately. Daclatasvir+sofosbuvir is not recommended for use in children below 18 years of age, as its efficacy and safety have not been established in this age group. If you are infected with hepatitis C, take the necessary precautions to prevent spreading the infection to others. Before starting treatment, you should be tested for current and past hepatitis B (HBV) infections, as HBV reactivation can occur in people with both HCV and HBV, especially if treated for HCV but not HBV. Additionally, inform your doctor if you have any pre-existing conditions, such as diabetes, hepatitis B, a history of liver transplant, heart or kidney problems, or HIV (human immunodeficiency virus) infection, before starting Daclatasvir+sofosbuvir.
Drug Interactions
Drug-Drug Interactions: Daclatasvir+sofosbuvir may interact with certain medications, including antibiotics (Rifampicin, Clarithromycin), antivirals (Ritonavir, Atazanavir, Emtricitabine), blood thinners (Warfarin), medications for seizures or epilepsy (Phenytoin, Carbamazepine, Oxcarbazepine, Phenobarbital), cholesterol-lowering drugs (Rosuvastatin), corticosteroids (Dexamethasone), heart rhythm medications (Amiodarone, Digoxin), and herbal remedies for depression (St. John’s wort).
Drug-Food Interactions: No interactions found/established.
Drug-Disease Interactions: Inform your doctor if you have any pre-existing medical conditions, such as diabetes, hepatitis B, a history of liver transplant, heart or kidney problems, or HIV (human immunodeficiency virus) infection, before starting Daclatasvir+sofosbuvir.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
consult your doctorIt is not known if Daclatasvir+sofosbuvir interacts with alcohol. Please consult your doctor.
Pregnancy
unsafeDaclatasvir+sofosbuvir should not be taken by pregnant women or by women of reproductive age who are not taking contraception. For five weeks following the completion of treatment with Daclatasvir+sofosbuvir, the use of highly effective contraception should be maintained.
Breast Feeding
cautionIt is unknown whether Daclatasvir+sofosbuvir passes into breast milk. Therefore, you should avoid breastfeeding while undergoing treatment with Daclatasvir+sofosbuvir. Please consult your doctor for advice.
Driving
cautionDaclatasvir+sofosbuvir may cause dizziness. Do not drive or operate heavy machinery if you are not fully alert.
Liver
cautionDaclatasvir+sofosbuvir does not need to be dosage adjusted for patients with mild, moderate, or severe liver impairment. In patients with decompensated cirrhosis, the safety and effectiveness of this medicine have not been proven.
Kidney
cautionIt is not necessary to change the dosage of Daclatasvir+sofosbuvir for patients with mild to moderate kidney impairment. In patients with end-stage kidney disease (ESRD) requiring hemodialysis or severe renal impairment (estimated glomerular filtration rate [eGFR] <30 mL/min/1.73 m2), the safety and dosage of sofosbuvir have not been determined.
Children
unsafeDaclatasvir+sofosbuvir is not recommended for use in children below 18 years of age, as its efficacy and safety have not been established in this age group.
Habit Forming
Diet & Lifestyle Advise
- Maintain a healthy weight through diet and exercise to support liver health.
- Avoid smoking and alcohol consumption to reduce the risk of liver damage.
- Consider getting vaccinated for hepatitis A and B to protect your liver health.
- Follow a balanced diet rich in fruits, vegetables, fibre, and protein; avoid excessive fats and processed foods.
- Monitor salt and protein intake if liver damage is severe, with guidance from your doctor or dietitian.
- Avoid sharing personal items like razors or toothbrushes to prevent the spreading of hepatitis C.
- Clean wounds and surfaces with household bleach to reduce transmission risks.
- Use condoms during sex, especially during sex with new partners, to lower the risk of transmission.
- Consult your doctor before travelling abroad to ensure necessary precautions and medication storage for hepatitis C.
- Pregnancy is possible with hepatitis C, but discuss with your doctor to understand the risks and medications' effects on pregnancy.
Special Advise
- It is advised to closely monitor liver and kidney function tests while undergoing treatment with Daclatasvir+sofosbuvir.
- Your healthcare provider will advise blood tests before, during, and after your treatment with Daclatasvir+sofosbuvir to determine which other medications you may need and for how long, as well as to verify the effectiveness of the treatment.
Patients Concern
Disease/Condition Glossary
HCV (Hepatitis C virus) infection: It is a viral infection that causes inflammation or swelling in the liver, which can lead to serious liver damage. It is caused by the hepatitis C virus (HCV) and spreads through contact when infected blood enters the bloodstream of someone who is not infected. The infection begins with what is called an acute phase, but this phase often goes unnoticed because it usually does not cause any symptoms. If symptoms do appear, they may include yellowing of the skin (jaundice), fatigue, nausea, fever, and muscle aches. If the infection lasts for a long time, it becomes chronic hepatitis C, which can remain symptom-free for many years. Symptoms usually only appear once the virus has caused enough liver damage. These symptoms can include easy bruising or bleeding, extreme fatigue, yellowing of the skin, dark urine, swollen legs, drowsiness, and slurred speech.
FAQs
Daclatasvir+sofosbuvir belongs to a class of drugs called antivirals. It is used to treat chronic Hepatitis C virus (HCV) infection.
Daclatasvir+sofosbuvir contains antiviral drugs daclatasvir and sofosbuvir, which reduce the amount of the virus in the body, which is how they treat chronic hepatitis C (HCV). They function by preventing the activity of two proteins that are necessary for the virus to replicate.
Daclatasvir+sofosbuvir may cause common side effects, such as nausea, diarrhoea, abdominal pain, difficulty sleeping, dizziness, tiredness, headache, insomnia (sleeplessness), and joint or muscle pain in some cases. These side effects are usually mild and tend to go away on their own without requiring medical treatment. However, if they persist or become more severe, please consult your doctor.
Yes, hepatitis C virus (HCV) infection is contagious and can spread through contact with the blood of an infected person. To reduce the risk of spreading the virus, it is advised not to share personal items or needles that may have come into contact with an infected individual's blood.
Daclatasvir+sofosbuvir is an antiviral drug that can successfully treat Hepatitis C. However, the effectiveness of the treatment varies depending on factors such as the specific type of Hepatitis C, the degree of liver damage, any other existing health conditions, and how well the patient responds to the medication. It is essential to follow your doctor's instructions closely and keep up with regular check-ups during and after treatment to increase the chances of a successful cure.
You should be cautious when using Daclatasvir+sofosbuvir if you are currently taking or have taken amiodarone in the past few months. Contact your doctor immediately if you experience symptoms of a slow heartbeat, such as chest pain, dizziness, fainting, confusion, memory issues, fatigue, weakness, or shortness of breath. If Daclatasvir+sofosbuvir treatment is necessary, you may need additional heart monitoring.
No, do not use Daclatasvir+sofosbuvir if you are pregnant or planning to become pregnant and are not using birth control. Both you and your partner should use effective birth control methods during treatment and for 5 weeks after finishing the medication. If you become pregnant during treatment, contact your doctor immediately.
