Cefoperazone
About Cefoperazone
Cefoperazone belongs to the group of medicines called antibiotics used to treat various bacterial infections such as respiratory tract (lungs) infection, urine infection, blood infection, meningitis (inflammation of the brain and spinal cord), gonorrhoea (sexually transmitted disease), skin, abdominal, bone, and joint infections. Bacterial infections are caused due to the multiplication of harmful bacteria inside or on the body. Infectious or harmful bacteria can make you sick and reproduce quickly in your body. These harmful bacteria produce chemicals known as toxins, which can damage tissue and make you ill. Cefoperazone does not work against infections caused by the virus, including cold and flu.
Cefoperazone is an antibiotic that contains Cefoperazone (cephalosporin antibiotic). Cefoperazone works by preventing the formation of bacterial cell covering, which is necessary for their survival by binding to the penicillin-binding proteins (PBPs), thus preventing cross-linking of nascent peptidoglycan and killing the bacteria. Thereby, Cefoperazone helps to treat bacterial infections.
You may experience diarrhoea, allergic reactions, abnormal liver function tests, and anaemia (a low number of red blood cells). Most of these side effects of Cefoperazone do not require medical attention and gradually resolve over time. However, if they persist, consult your doctor.
Before starting Cefoperazone, please inform your doctor if you have any allergy (against any antibiotic), kidney or liver problems. Do not take Cefoperazone on your own as self-medication may lead to antibiotic-resistance in which antibiotics fail to act against specific bacterial infections. Inform your doctor before taking Cefoperazone if you are pregnant or planning for pregnancy. Avoid taking Cefoperazone if you are breastfeeding as Cefoperazone may pass into breast milk. Avoid alcohol consumption while taking Cefoperazone to prevent unpleasant side effects.
Uses of Cefoperazone
Medicinal Benefits
Cefoperazone belongs to the group of medicines called antibiotics used to treat various bacterial infections such as respiratory tract (lungs) infection, urine infection, blood infection, meningitis (inflammation of the brain and spinal cord), gonorrhoea (sexually transmitted disease), skin, abdominal, bone, and joint infections. Cefoperazone contains Cefoperazone (cephalosporin antibiotic). It works by preventing the formation of bacterial cell covering, which is necessary for their survival by binding to the penicillin-binding proteins (PBPs), thus preventing cross-linking of nascent peptidoglycan and killing the bacteria. Thus, Cefoperazone helps to treat bacterial infections.
Directions for Use
Cefoperazone will be administered by a healthcare professional. Do not self-administer.
Storage
Side Effects of Cefoperazone
- Diarrhoea
- Allergic reaction
- Abnormal liver function tests
Drug Warnings
After taking Cefoperazone if you have allergy-like symptoms including rash, swelling of the face/lips/throat, difficulty in breathing, or tightness in the chest, immediately contact your doctor. Do not take Cefoperazone if you have an allergy to Cefoperazone, cephalosporins penicillin class of antibiotics as it may cause a skin rash, itching, and difficulty in breathing. People having liver disease or jaundice (yellowing of skin/eye) should not take Cefoperazone, as it can damage your liver severely. You may have diarrhoea in some cases as a common side effect which can be managed by taking it with any probiotics and plenty of fluids. Do not take antacids along with Cefoperazone; maintain a gap of 2-3 hours between both. Avoid alcohol consumption while taking Cefoperazone to prevent unpleasant side-effects. Cefoperazone may cause dizziness, so be cautious while driving. Inform your doctor about all the medicines you are taking and about your health condition to rule out any unpleasant side-effects.
Drug Interactions
Drug-Drug Interactions: Cefoperazone may have interaction with a diuretic (furosemide), anticoagulants (warfarin), and other antibiotics (gentamicin).
Drug-Food Interactions: No interactions found/established.
Drug-Disease interactions: Cefoperazone may have interactions with colitis (inflammation in the lining of the colon), seizures, dialysis, kidney, and liver dysfunction.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionAvoid consuming alcohol while taking Cefoperazone as it causes increased side effects.
Pregnancy
consult your doctorPlease consult your doctor if you are pregnant, your doctor will prescribe Cefoperazone only if the benefits outweigh the risks.
Breast Feeding
cautionA small amount of Cefoperazone may pass into breast milk. Avoid taking Cefoperazone if you are breastfeeding unless prescribed.
Driving
cautionCefoperazone may cause dizziness in some people, so it may affect your ability to drive.
Liver
consult your doctorDose adjustment may be needed. Please consult your doctor before taking Cefoperazone if you have liver impairment/liver disease.
Kidney
consult your doctorDose adjustment may be needed. Please consult your doctor if you have any concerns regarding this or if you have kidney impairment/kidney disease before taking Cefoperazone.
Children
safe if prescribedFor children, Cefoperazone is safe if prescribed by the doctor. Consult your doctor for more infoemation.
Habit Forming
Diet & Lifestyle Advise
- Probiotics should be taken after taking the entire course of Cefoperazone to restore some healthy bacteria in the intestines that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yoghurt, cheese, sauerkraut, kombucha, and kimchi can help to restore the good bacteria of the intestine.
- Include more fibre-enriched food in your diet, as it can be easily digested by gut bacteria, which helps stimulate their growth. Thus, fibre-rich foods may help restore healthy gut bacteria after a course of antibiotics. Whole grains like whole-grain bread and brown rice should be included in your diet.
- Avoid intake of alcoholic beverages with Cefoperazone as it can make you dehydrated and may affect your sleep. This can make it harder for your body to aid the Cefoperazone in fighting off infections.
Special Advise
- Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection harder to treat.
- Discontinue Cefoperazone and inform your doctor immediately if you develop a rash, itchy skin, swelling of the face and mouth, or difficulty breathing.
- Diarrhoea may occur as a side effect but should stop when your course is complete. Inform your doctor if it does not stop or if you find blood in your stools.
- Cefoperazone is preferably taken with food to avoid an upset stomach.
- Some people may be allergic to Cefoperazone or other penicillin or cephalosporin antibiotics. Therefore, a prior sensitivity test may be necessary. Inform your doctor if you are allergic to any medicine, particularly antibiotics belonging to these groups.
- If you feel nauseous after taking Cefoperazone, stick to simple meals like porridge, khichdi, dal roti, and other home-cooked meals. Avoid spicy and fatty food.
Patients Concern
Disease/Condition Glossary
Bacterial infections: A bacterial infection is a condition when harmful bacteria enter, multiply, and infect our body. Infectious or harmful bacteria can make you sick and reproduce quickly in your body. These destructive bacteria produce chemicals known as toxins, which can damage tissue and make you ill. It can target any body part and multiply very quickly. When infected with bacteria, you can experience generalized symptoms, like fevers, chills, and fatigue. Bacteria are of various forms comprising commonly of spherical, rod, and spiral-shaped. Bacterial infections vary from minor illnesses like sore throat and ear infections to severe brain infections like meningitis and encephalitis. Anyone can become infected with a bacterial infection. However, people with weak immune systems or taking immunosuppressive medicine are more prone to bacterial infection.
FAQs
Cefoperazone is used to treat various bacterial infections, such as respiratory tract (lungs) infections, urine infections, blood infections, meningitis (inflammation of the brain and spinal cord), gonorrhoea (sexually transmitted disease), and skin, abdominal, bone, and joint infections.
Cefoperazone is an antibiotic that contains Cefoperazone (cephalosporin antibiotic). Cefoperazone works by preventing the formation of bacterial cell covering, which is necessary for their survival by binding to the penicillin-binding proteins (PBPs), thus preventing cross-linking of nascent peptidoglycan and kills the bacteria. Thereby, Cefoperazone helps to treat bacterial infections.
Inform your doctor if you do not feel better even after finishing the full course of treatment. You must also inform your doctor if the symptoms get worse while using this medicine.
Usually, Cefoperazone starts working soon after taking it. It may take a few days to kill all the dangerous bacteria and make you feel better.
Cefoperazone may cause Clostridium difficile-associated diarrhoea (CDAD). Treatment with antibiotics alters the normal flora, leading to overgrowth of Clostridium difficile; this causes diarrhoea. Drink lots of fluids and eat fibre-rich food if you experience diarrhoea. If you find blood in your stools (tarry stools) or if you experience prolonged diarrhoea with abdominal pain, stop taking Cefoperazone and consult your doctor. Do not take anti-diarrhoeal medicine on your own.
It's generally not recommended to consume alcohol while taking Cefoperazone, as it can increase gastrointestinal issues, enhance sedative effects, and interfere with the antibiotic's effectiveness. Consult your doctor for personalized advice.
As Cefoperazone is administered in a hospital by a healthcare provider, Therefore, the chances of missing a dose is less. However, if you have any concerns, contact your doctor. Do not self-administer.
Common side effects of Cefoperazone include diarrhoea, allergic reactions, abnormal liver function tests, and anemia. Most of these side effects are temporary and resolve on their own. However, if they persist, consult your doctor for proper evaluation and guidance.
