Alectinib

To treat your condition effectually, continue taking Alectinib for the period that your doctor has prescribed. Caution should be exercised if you have/had liver or kidney disease, lung disease other than lung cancer, heart problems, slow heart rate, severe cough, and breathing difficulty. This medicine is known to cause embryo-fetal toxicity. Hence, inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment. Breastfeeding should be discontinued in nursing mothers during the treatment as it passes into breast milk and may cause a possible risk to the infant. Alectinib is known to cause hepatotoxicity, renal impairment, interstitial lung disease, bradycardia, and severe myalgia in some patients. Hence, inform your doctor if you observe any symptoms such as dark-coloured urine, muscle pain or tenderness, yellowing of eyes, trouble breathing, cough, swelling of your feet and hands, and lightheadedness. Avoid driving and operating machines; this medicine may make you dizzy or sleepy. This medicine is not recommended for use in children below 18 years of age as the safety and efficacy are not established.

Drug-Drug Interactions: Alectinib may have interaction with disease-modifying antirheumatic drugs (leflunomide), immunomodulatory drugs (teriflunomide), anti-cancer drugs (pexidartinib), etc.

Drug-Food Interactions: Avoid alcohol consumption and smoking.

Dug-Disease Interactions: Tell your doctor if you have liver or kidney disease, lung disease problems, breathing problems, or heart problems.

• Physical activity helps strengthen muscles, reduces fatigue, helps in weight loss, and gives strength. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
• Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
• Getting adequate sleep as resting helps improve your health and mental ability and improves attention.
• De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
• Eat food rich in antioxidants such as berries, spinach, etc.
• Foods containing fibre help in better digestion. These include beans, peas, lentils, whole grains, nuts, and seeds.
• Avoid smoking and alcohol consumption.

• Your doctor may suggest periodic liver function tests every two weeks for the first three months of treatment, then once a month or as clinically required, with more frequent testing in individuals who develop transaminase and other enzyme deficiencies. Bilirubin levels rise. In the event of significant ALT, AST, or bilirubin rises, withhold, then cut the dose or quit Alectinib permanently.
• Avoid being under the sun for a long time, as prolonged duration of sun exposure may cause serious hypersensitivity reactions.
• Frequent creatine phosphokinase (CPK) levels should be monitored every two weeks during the first month of the treatment.