Genibone-500 Tablet is used to treat low blood calcium levels. Genibone-500 Tablet effectively treats various conditions caused by low calcium levels in the body, such as osteoporosis (weak and brittle bones), osteomalacia/rickets (weak bones), hypoparathyroidism (low levels of parathyroid hormone) and latent tetany (a muscle disease with low blood calcium levels). Genibone-500 Tablet can also be given to pregnant, nursing, and postmenopausal women to ensure that they are getting enough calcium. 

Genibone-500 Tablet consists of two medicines, namely: Calcium carbonate(mineral) and  Cholecalciferol(Vitamin D3). Calcium carbonate is a mineral that is used to prevent or treat a calcium deficiency. It provides essential nutrients to maintain bone formation and maintenance. Cholecalciferol(Vitamin D3) is used in the absorption of calcium in the blood. Which helps in the processing of essential minerals in the body like Calcium and Phosphorus. Lack of Vitamin D3 results in bone weakening, bone pain, and skin diseases. 

Take Genibone-500 Tablet as prescribed by your doctor. You are advised to take Genibone-500 Tablet as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, Genibone-500 Tablet can cause side effects like constipation or stomach upset, nausea, vomiting, loss of appetite, mood changes, weakness, tiredness, fast or pounding heartbeat, bone/muscle pain, and headache. Most of these side effects of Genibone-500 Tablet do not require medical attention and gradually resolve over time. However, if these side effects persist longer, please consult your doctor.

If you are known to be allergic to Genibone-500 Tablet or its inactive components, please inform your doctor. Pregnant or breastfeeding women should consult their doctor before taking Genibone-500 Tablet . Higher doses of Vitamin D than the recommended daily dose should be used in pregnant women only when advised by the doctor. Genibone-500 Tablet may pass into the breast milk. Hence, breastfeeding mothers need to seek medical advice before starting Genibone-500 Tablet . Do not take Genibone-500 Tablet if you have hypercalcemia (high calcium levels), hypervitaminosis D (high vitamin D levels), and malabsorption syndrome (difficulty absorbing nutrition from food). 

Genibone-500 Tablet is a combination of three drugs, Calcium carbonate(mineral) and cholecalciferol (Vitamin D3) used to treat low blood calcium levels and various associated conditions caused by low calcium levels in the body, such as osteoporosis (weak and brittle bones), osteomalacia/rickets (weak bones), hypoparathyroidism (low levels of parathyroid hormone) and tetany (a muscle disease with low blood calcium levels). Calcium carbonate is a mineral and prevents or treats calcium deficiency. It helps to maintain bone and teeth health. Cholecalciferol(Vitamin D3) treats calcium deficiency with hypoparathyroidism (the parathyroid glands' decreased activity) and metabolic bone diseases in people with chronic kidney failure. 

• Nausea
• Vomiting
• Headache
• Stomach pain
• Loss of appetite
• Constipation
• Mood changes
• Tiredness/ weakness
• Bone/muscle pain
• Fast or pounding heartbeat

If you are known to be allergic to Genibone-500 Tablet or any other medicines, please tell your doctor. If you are pregnant or planning to become pregnant, it is advised to inform your doctor before using Genibone-500 Tablet . Higher doses of Vitamin D than the recommended daily dose should be used in pregnant women only when advised by the doctor. Cholecalciferol in higher doses may harm the foetus. Genibone-500 Tablet may pass into the breast milk, hence consult your doctor before taking Genibone-500 Tablet if you are a breastfeeding mother. Genibone-500 Tablet should be used with caution in children and only if prescribed by a doctor. Cholecalciferol in Genibone-500 Tablet can affect growth in children. Inform your doctor if your child is not growing at a normal rate while using Genibone-500 Tablet . Genibone-500 Tablet is not recommended if you have hypercalcemia (high calcium levels), metastatic calcification (extra deposits of calcium in the body), hypervitaminosis D (high vitamin D levels), and malabsorption syndrome (difficulty absorbing nutrition from food). Inform your doctor before taking Genibone-500 Tablet if you have any heart/kidney/liver/blood vessel diseases, kidney stones, sarcoidosis (growth of inflammatory cells in different parts of the body), Crohn's disease (inflammatory bowel disease), Whipple's disease (bacterial infection affecting joints and digestive system), achlorhydria (little or no stomach acid), low levels of bile, and phosphate imbalance. Genibone-500 Tablet contains sugar or sorbitol; hence caution should be taken to have an intolerance to sugars, diabetes, and phenylketonuria (increased levels of an amino acid called phenylalanine).

Drug-Drug Interactions: Genibone-500 Tablet may interact with calcium supplements (ergocalciferol, calcitriol), drugs treating bone loss (alendronate), diuretics (bendroflumethiazide, chlortalidone, indapamide), a drug used to treat heart disease (digoxin), antacids (magnesium hydroxide), steroid medicines (hydrocortisone, prednisolone, dexamethasone), central nervous system stimulants (dextroamphetamine, amphetamine), anti-depressants (duloxetine), minerals (ferrous sulfate), anti-ulcer drugs (ranitidine), synthetic thyroid hormone (levothyroxine), painkillers (aspirin), anti-clotting drugs (anisindione, dicumarol, warfarin), drugs treating high cholesterol levels (cholestyramine, colesevelam, colestipol), and drugs that treat high blood phosphorus levels (sevelamer), antibiotics (tetracycline, doxycycline, minocycline), quinolone antibiotics (ciprofloxacin, levofloxacin), weight-loss drugs (orlistat), and anti-cancer medication (estramustine).

Drug-Food Interactions: Avoid or reduce the intake of caffeine, soft drinks, and alcohol that inhibit calcium absorption.

Drug-Disease Interactions: Genibone-500 Tablet is contraindicated in hypercalcemia (high calcium level in blood), hypervitaminosis D (high vitamin D level in the body), Vitamin D toxicity, malabsorption syndrome, heart/kidney/liver/blood vessel diseases, kidney stones, sarcoidosis (growth of tiny collections of inflammatory cells (granulomas) in any part of your body), Crohn's disease, Whipple's disease (a bacterial infection that most often affects joints and digestive system), achlorhydria (absence of stomach acid), low levels of bile, and phosphate imbalance. 

• DOXYCYCLINE
• MINOCYCLINE
• CALCITRIOL
• CIPROFLOXACIN
• LEVOFLOXACIN
• ORLISTAT
• ESTRAMUSTINE
• TETRACYCLINE
• SEVELAMER
• COLESTIPOL
• CHOLESTYRAMINE
• COLESEVELAM
• WARFARIN
• DICUMAROL
• ANISINDIONE
• ASPIRIN
• LEVOTHYROXINE SODIUM
• RANITIDINE
• FERROUS SULPHATE
• DULOXETINE
• AMPHETAMINE
• ERGOCALCIFEROL
• ALENDRONATE SODIUM
• BENDROFLUMETHIAZIDE
• CHLORTALIDONE
• INDAPAMIDE
• MAGNESIUM HYDROXIDE
• DIGOXIN
• DEXTROAMPHETAMINE
• DEXAMETHASONE
• PREDNISOLONE
• HYDROCORTISONE

• Include dairy products like milk, yoghurt, cheese, or milk-based custard in your diet.
• Eat daily a serving of broccoli, cabbage, bok choy, spinach, and other green leafy vegetables.
• Snack on calcium-rich nuts like Brazil nuts or almonds.
• Sprinkle sesame seeds over your food, vegetables, and salads. Sesame seeds are high in calcium.
• Avoid or reduce the intake of caffeine, soft drinks, and alcohol that inhibit calcium absorption.
• Replace the meat with tofu for extra calcium in your food.

• Clinical monitoring of serum electrolyte concentrations and cardiac function is recommended.
• A low phosphate diet is recommended to control serum phosphorus levels in patients undergoing dialysis.

Osteoporosis: It is a bone disease that weakens and brittle bones by decreasing bone density.  As bones become less dense, they weaken and are more likely to break. Breaking a bone is a serious complication of osteoporosis, especially in older patients. Women are much more likely to develop osteoporosis than are men. Signs and symptoms include back pain caused by a fractured or collapsed vertebra, loss of height over time, a stooped posture, and a bone that breaks much more easily than expected.

Osteomalacia/Rickets: A bone disease caused by softening and weakening bones in children due to inadequate vitamin D. Adults can experience a similar condition known as osteomalacia. It causes bone pain, poor growth, and soft, weak bones that can lead to bone deformities.

Tetany: A disease condition due to low levels of calcium (hypocalcemia) in the body causes cramps and spasms in the hands, feet, and larynx (voice box).

Hypoparathyroidism: It is a disease characterized by low levels of parathyroid hormone. This can cause low calcium levels and trigger tetany.