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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Calpol 650 Plus Tablet is used to reduce fever and treat mild to moderate pain. Also, it is used to relieve headaches, migraines, toothaches, period pain, back pain, muscle pain, and rheumatic pains. It contains Paracetamol, which works by inhibiting the production of certain chemical messengers in the brain known as prostaglandins. Thus, reduces pain. Also, it affects an area of the brain that regulates body temperature, known as the hypothalamic heat-regulating centre. Thereby, it reduces fever. In some cases, it may cause side effects such as nausea, stomach pain and dark-coloured urine.

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Composition :

PARACETAMOL-650MG

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

Calpol 650 Plus Tablet belongs to the group of medicines called analgesics (pain killers) and antipyretics (fever-reducing agents) used to reduce fever and treat mild to moderate pain. It is also used to relieve headaches, migraine, toothache, period pain, back pain, muscle pain, and rheumatic pain. Pain and fever are caused by the activation of pain receptors due to the release of certain natural chemicals in the body, like prostaglandin. 

Calpol 650 Plus Tablet works by inhibiting the production of certain chemical messengers in the brain known as prostaglandins, reducing pain. Also, Calpol 650 Plus Tablet affects an area of the brain that regulates body temperature, known as the hypothalamic heat-regulating centre, reducing fever.

Take Calpol 650 Plus Tablet as advised by your physician. Your doctor will recommend how often you need to take Calpol 650 Plus Tablet based on your medical condition. In some cases, Calpol 650 Plus Tablet may cause side effects such as nausea, stomach pain and dark-coloured urine. Most of these side effects of Calpol 650 Plus Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. 

Avoid taking Calpol 650 Plus Tablet if allergic to it. Calpol 650 Plus Tablet is not recommended for children below 6 years of age. If you are pregnant or breastfeeding, please consult a physician before using Calpol 650 Plus Tablet . Avoid alcohol consumption with Calpol 650 Plus Tablet as it may increase the risk of liver damage. If you have an impaired nutritional state caused by anorexia (eating disorder), malnutrition or alcohol abuse or if you are dehydrated, inform your doctor before taking Calpol 650 Plus Tablet .

Treatment of Fever, Pain relief.
Tablet: Swallow it as a whole with a glass of water. It can be taken with or without food anytime. Do not crush, break or chew it.Oral liquid: Shake the bottle well before use. Take the suggested dose by mouth using the measuring cup/dosing syringe/dropper provided by the pack.

Calpol 650 Plus Tablet contains Paracetamol, an analgesic (pain killer) and antipyretic (reduces fever). It inhibits the production of certain chemical messengers in the brain known as prostaglandins, reducing pain. Also, Calpol 650 Plus Tablet affects an area of the brain that regulates body temperature known as the hypothalamic heat-regulating centre, reducing fever.

Calpol 650 Plus Tablet works by inhibiting the production of certain chemical messengers in the brain known as prostaglandins, reducing pain. Also, Calpol 650 Plus Tablet affects an area of the brain that regulates body temperature, known as the hypothalamic heat-regulating centre, reducing fever.
Store in a cool and dry place away from sunlight
  • Nausea
  • Stomach pain
  • Dark coloured urine
Do not take more than the suggested dose of Calpol 650 Plus Tablet as it may cause overdose resulting in the increased risk of delayed, serious liver damage. The symptoms of overdose include vomiting, nausea, diarrhoea, stomach pain and loss of appetite. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Avoid taking Calpol 650 Plus Tablet if allergic to it. Calpol 650 Plus Tablet is not recommended for children below 6 years of age. If you are pregnant or breastfeeding, please consult a physician before using Calpol 650 Plus Tablet . Avoid alcohol consumption with Calpol 650 Plus Tablet as it may increase the risk of liver damage. If you have an impaired nutritional state caused by anorexia (eating disorder), wrong nutrition or alcohol abuse or if you are dehydrated, inform your doctor before taking Calpol 650 Plus Tablet . Avoid taking more than recommended doses as it may increase the risk of serious liver damage.

verifiedApollotooltip
ParacetamolKetoconazole
Severe
ParacetamolOxazepam
Severe

Drug-Drug Interactions

ParacetamolKetoconazole
Severe
How does the drug interact with Calpol 650 Plus Tablet 15's:
Co-administration of Calpol 650 Plus Tablet 15's and Ketoconazole may increase the risk of liver injury.

How to manage the interaction:
Although there is a possible interaction between Calpol 650 Plus Tablet 15's and Ketoconazole, you can take these medicines together if prescribed by a doctor. However, if you have joint pain or swelling, fever, chills, unusual bleeding or bruising, skin rash, itching, over-tiredness, nausea, vomiting, loss of appetite, stomach pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact a doctor immediately as these may be signs and symptoms of liver damage. Do not discontinue the medication without consulting a doctor.
ParacetamolOxazepam
Severe
How does the drug interact with Calpol 650 Plus Tablet 15's:
Co-administration of Calpol 650 Plus Tablet 15's may decrease the excretion rate of Oxazepam which could result in a higher serum level.

How to manage the interaction:
Although there is a possible interaction between Oxazepam and Calpol 650 Plus Tablet 15's, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
ParacetamolValdecoxib
Severe
How does the drug interact with Calpol 650 Plus Tablet 15's:
Co-administration of Calpol 650 Plus Tablet 15's and Valdecoxib may increase the risk or severity of adverse effects.

How to manage the interaction:
Although there is a possible interaction between Calpol 650 Plus Tablet 15's and Valdecoxib, you can take these medicines together if prescribed by a doctor. However, if the side effects worsen, please consult a doctor.
ParacetamolMipomersen
Severe
How does the drug interact with Calpol 650 Plus Tablet 15's:
Co-administration of Mipomersen with Calpol 650 Plus Tablet 15's may increase the risk or severity of liver injury.

How to manage the interaction:
There may be a possibility of interaction between Calpol 650 Plus Tablet 15's and Mipomersen, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
ParacetamolLeflunomide
Severe
How does the drug interact with Calpol 650 Plus Tablet 15's:
Co-administration of Calpol 650 Plus Tablet 15's and Leflunomide may increase the risk of liver problems.

How to manage the interaction:
Although there is a possible interaction between Calpol 650 Plus Tablet 15's and Leflunomide, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ParacetamolKetamine
Severe
How does the drug interact with Calpol 650 Plus Tablet 15's:
Co-administration of ketamine and Calpol 650 Plus Tablet 15's may decrease the effectiveness of Ketamine which could result in a higher blood level.

How to manage the interaction:
Although taking Ketamine and Calpol 650 Plus Tablet 15's together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you're feeling very sleepy or having trouble breathing, it's important to contact your doctor right away. Do not stop using any medications without a doctor's advice.
ParacetamolLomitapide
Severe
How does the drug interact with Calpol 650 Plus Tablet 15's:
Co-administration of Lomitapide and Calpol 650 Plus Tablet 15's may increase the risk of severity of liver injury.

How to manage the interaction:
Although there is a possible interaction between Calpol 650 Plus Tablet 15's and Lomitapide, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
ParacetamolTeriflunomide
Severe
How does the drug interact with Calpol 650 Plus Tablet 15's:
Co-administration of Teriflunomide with Calpol 650 Plus Tablet 15's may increase the risk or severity of Liver problems.

How to manage the interaction:
Taking Calpol 650 Plus Tablet 15's with Teriflunomide together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

  • Get adequate sleep, as resting the muscles can help in reducing inflammation and swelling.
  • Follow heat or cold therapy, and regularly apply a cold or hot compress on the joints for 15-20 minutes.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat foods rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids, such as soy, berries, broccoli, grapes, and green tea, help reduce inflammation. 
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Avoid smoking and alcohol consumption.
No
ANALGESIC AND ANTIPYRETIC AGENT

Calpol 650 Plus Tablet Substitute

Substitutes safety advice
  • Malidens 650 mg Tablet 10's

    1.98per tablet
  • Aquris Acupara 650 mg Tablet 10's

    2.10per tablet
  • Dolo-650 Tablet 15's

    by AYUR

    2.01per tablet
  • Crocin 650 Tablet 15's

    2.01per tablet
  • Pacimol 650 Tablet 15's

    2.01per tablet
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Unsafe

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Caution

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Caution

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Safe

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Caution

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Caution

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Consult your doctor

FAQs

Calpol 650 Plus Tablet is used to provide relief from fever and mild-to-moderate pain.
Calpol 650 Plus Tablet works by inhibiting the production of certain chemical messengers in the brain known as prostaglandins. Thus reducing pain. Also, Calpol 650 Plus Tablet affects an area of the brain that regulates body temperature known as the hypothalamic heat-regulating centre. Thus, it reduces fever.
You are not recommended to take Calpol 650 Plus Tablet with warfarin as co-administration of these two medicines may increase the risk of bleeding more easily. However, if you are supposed to use these medicines together, you are advised to contact your physician so that the dose may be adjusted appropriately and used safely.
Calpol 650 Plus Tablet may affect how certain tests work, such as blood sugar tests and uric acid tests. Therefore, if you are about to undergo a blood test or any laboratory tests, inform your physician or lab technician that you are taking Calpol 650 Plus Tablet .
You are not recommended to take Calpol 650 Plus Tablet with other paracetamol-containing products as it may cause paracetamol overdose.
If you take more than the suggested doses of Calpol 650 Plus Tablet , it may cause an overdose and lead to serious liver damage. The symptoms of overdose include vomiting, loss of appetite, stomach pain, paleness and nausea. However, if you notice any of these symptoms while taking Calpol 650 Plus Tablet , please consult a doctor immediately.
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