Zotide One 600 mcg Pre Filled Pen belongs to the class of medication called 'anabolic (promoting bone formation) agent' indicated for prevention and treatment of osteoporosis in adults and helps to strengthen the bone. This medicine also helps to reduce the risk of spine and hip fractures. Osteoporosis is a medical condition in which bone becomes thin or weak. The chance of developing osteoporosis increases with age, after menopause or by taking corticosteroid medications (such as prednisone) for a long period. If proper treatment is not provided then it can even result in broken bones.

Zotide One 600 mcg Pre Filled Pen contains Teriparatide a synthetic form of the human parathyroid hormone, which helps to regulate calcium metabolism. Zotide One 600 mcg Pre Filled Pen works by causing the body to build new bone by increasing bone strength and bone mass density (BMD) (thickness) and reduce the risk of fractures by stimulating bone formation. It also increases the thickness of bone and rebuilds bones which reduces the risk of spine and hip fractures.

Zotide One 600 mcg Pre Filled Pen will be administered by a healthcare professional; do not self-administer. In some cases, Zotide One 600 mcg Pre Filled Pen can cause side effects like nausea, vomiting,  joint pain, leg cramps, swelling/redness at the injection site, upset stomach, diarrhea, constipation, runny nose, cough, and throat irritation. Most of these side effects of Zotide One 600 mcg Pre Filled Pen do not require medical attention and gradually resolve over time. However, if these side effects persist longer, please consult your doctor.

To treat your condition effectually, continue taking Zotide One 600 mcg Pre Filled Pen for as long as your doctor has prescribed. Consult your doctor before taking Zotide One 600 mcg Pre Filled Pen if you are pregnant or breastfeeding; your doctor will prescribe you Zotide One 600 mcg Pre Filled Pen only if the benefits outweigh the risks. Zotide One 600 mcg Pre Filled Pen is not recommended for children below 18 years of age.  Tell your doctor that you are taking Zotide One 600 mcg Pre Filled Pen before you have any lab test as this medicine could interfere with the results. Zotide One 600 mcg Pre Filled Pen may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up. Inform your doctor about your health condition and medications before taking Zotide One 600 mcg Pre Filled Pen to rule out any side effects. Zotide One 600 mcg Pre Filled Pen is a cold chain medicine, and so it has to be stored in the refrigerator between 2-8 degrees Celsius else its efficiency might be lost. Do not store in the freezer or the fridge.

Zotide One 600 mcg Pre Filled Pen is a synthetic form of a natural human hormone called parathyroid hormone (PTH) that is prescribed to prevent and treat osteoporosis in persons with weak bones. It prevents the loss of bones that happens after menopause and helps to rebuild bones. Zotide One 600 mcg Pre Filled Pen contains Teriparatide which works by causing the body to build new bone and by increasing bone strength and bone mass density (BMD) (thickness) and reduce the risk of fractures by stimulating bone formation. It also increases the thickness of bone and rebuilds bones which reduces the risk of spine and hip fractures. Zotide One 600 mcg Pre Filled Pen is also indicated for the treatment of increasing bone mass in people with osteoporosis, glucocorticoid-induced osteoporosis.

• Nausea
• Vomiting
• Joint pain,
• Leg cramps
• Swelling/redness at the injection site
• Feeling dizzy, tired, or weak
• Upset stomach
• Diarrhea 
• Constipation
• Runny nose
• Cough
• Throat irritation

Zotide One 600 mcg Pre Filled Pen is not recommended if you have hypercalcemia (high calcium levels) or an overactive parathyroid gland, metastatic calcification (extra deposits of calcium in the body) and malabsorption syndrome (difficulty absorbing nutrition from food), kidney stones, kidney problems (moderate renal impairment), Paget’s disease of bone (abnormal bone changes), history of skeletal malignancies. It is important that your doctor check your progress regularly to make sure that Zotide One 600 mcg Pre Filled Pen is working properly. Blood and urine tests may be needed to check for unwanted effects. Zotide One 600 mcg Pre Filled Pen can increase the amount of calcium in your blood or urine. Talk to your doctor before or while using Zotide One 600 mcg Pre Filled Pen if you have continuing nausea, vomiting, constipation, low energy or muscle weakness. These may be signs there is too much calcium in your blood. Consult your doctor before taking Zotide One 600 mcg Pre Filled Pen if you are pregnant or breastfeeding; your doctor will prescribe you Zotide One 600 mcg Pre Filled Pen only if the benefits outweigh the risks. Zotide One 600 mcg Pre Filled Pen should not be given to children as safety and efficacy have not been established. Do not take Zotide One 600 mcg Pre Filled Pen for longer durations unless prescribed by your doctor. If your condition does not improve even after taking the Zotide One 600 mcg Pre Filled Pen full course, please consult your doctor.  Zotide One 600 mcg Pre Filled Pen may increase the risk of having cancer while taking longer durations. Talk to your doctor if you have concerns about this risk. Avoid consuming alcohol along with Zotide One 600 mcg Pre Filled Pen as it could lead to increased drowsiness. Inform your doctor about your health condition and medications before taking Zotide One 600 mcg Pre Filled Pen to rule out any side effects.

Drug-Drug interaction: Zotide One 600 mcg Pre Filled Pen may interact with a medicine used to treat heart disease (digoxin, digitalis), medication is used to treat psoriasis (calcitriol topical, calcipotriene topical), water pills (furosemide, hydrochlorothiazide).

Drug-Food interaction: No interaction found.

Drug-Disease interaction: Zotide One 600 mcg Pre Filled Pen is not allowed to use in some patients dealing with hyperparathyroidism, malignancy (cancer), metabolic bone disorder, orthostatic hypotension (low blood pressure when standing up from sitting or lying down), renal impairment, urolithiasis (stone formation in the bladder or urinary tract).

• DIGOXIN
• DIGITALIS
• CALCITRIOL
• CALCIPOTRIENE
• FUROSEMIDE
• HYDROCHLOROTHIAZIDE

• A person should consume calcium and vitamin D in their diet as it helps make stronger bones and avoid everyday osteoporosis dangers.
• A post-menopausal woman should limit salt intake as it can pose a high risk of losing more bone minerals than other women of the same age.
• Do regular exercise like weight-bearing exercises which are important for maintaining bone health.
• Calcium is important for making bones strong. Vitamin D is equally important, which helps to ensure the absorption and retention of calcium in bones, so take food high in calcium and vitamins.

• Certain diagnostic test like blood test measures the level of calcitonin in your blood and bone density scan is used to check bone mineral density (BMD).
• Zotide One 600 mcg Pre Filled Pen should not be prescribed for patients at increased baseline risk of osteosarcoma (bone cancer).
• Clinical monitoring of urine tests or serum electrolyte concentrations is recommended.
• Do not take Zotide One 600 mcg Pre Filled Pen for longer durations unless prescribed by your doctor.

Osteoporosis: It is a medical condition that causes thinning and weakening of the bones. The chance of developing osteoporosis increases with age, after menopause or by taking corticosteroid medications (such as prednisone) for a long period. If proper treatment is not provided then it can even result in broken bones. In starting days, osteoporosis does not show any symptoms.  However, if proper treatment is not provided then it can even lead to broken bones. In Osteoporosis, bones can break at any time even during daily activities like lifting or even from minor activities. Fractures usually occur at the hip, spine or wrist which can even lead to stooped posture (‘dowager’s hump’) and loss of movement.