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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Zofer 4 Tablet is used in the prevention of vomiting and nausea that usually occur after cancer chemotherapy, radiation treatment or surgery. It contains Ondanestron, which works by blocking the action of a chemical in the body (serotonin) responsible for causing nausea and vomiting. It may cause side effects such as feeling of warmth, constipation, headache, diarrhoea, headache, drowsiness, feeling of tiredness. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

ONDANSETRON-4MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Zofer 4 Tablet

Zofer 4 Tablet belongs to a group of medications called ' anti-emetics' primarily used in the prevention of vomiting (being sick) and nausea (feeling sick) that usually occur after cancer chemotherapy, radiation treatment or surgery. Nausea is an uneasy feeling in which a person feels an urge to vomit while vomiting is the natural response to the body to forcefully discharge the stomach contents.

Zofer 4 Tablet contains 'Ondanestron' that works by blocking the action of a chemical in the body (serotonin) responsible for causing nausea and vomiting. As a result, Zofer 4 Tablet prevents the sensation of nausea and vomiting caused due to conditions like surgery, cancer chemotherapy, pregnancy or motion sickness.

Take Zofer 4 Tablet as prescribed. Your doctor will advise you on how often you take Zofer 4 Tablet based on your medical condition. A person taking Zofer 4 Tablet often experience side effects that include a feeling of warmth, constipation, headache, diarrhoea, headache, drowsiness, feeling of tiredness. Although, not every person faces the side effects of Zofer 4 Tablet , and even some of the unpleasant effects of Zofer 4 Tablet do not require medical attention.

The use of Zofer 4 Tablet is restricted in persons who are allergic to any of the ingredients present in this medicine. Tell your doctor if you are facing liver, kidney, or heart disorders. Zofer 4 Tablet should be used during pregnancy or breastfeeding after consulting a doctor. Zofer 4 Tablet contains lactose so tell your doctor if you have an intolerance to some sugars.

Uses of Zofer 4 Tablet

Zofer 4 Tablet is used in the prevention of Nausea and Vomiting. The detailed uses of Zofer 4 Tablet are as follows:
•Chemotherapy-Induced Nausea: Zofer 4 Tablet is frequently prescribed to alleviate nausea and vomiting caused by chemotherapy treatments.
•Radiation Therapy Support: Zofer 4 Tablet can help manage nausea and vomiting experienced by patients undergoing radiation therapy, improving treatment tolerance.
•Postoperative Nausea Relief: Many patients experience nausea after surgical procedures, and Zofer 4 Tablet is effective in controlling and reducing these symptoms.

Directions for Use

Tablet: It can be taken with or without a meal as advised by the doctor. Swallow the tablet as a whole with a glass of water. Do not break, crush or chew it. Oral disintegrating tablet/Mouth dissolving tablet (tablet MD): Check the label for directions before use. Do not handle the tablet with wet hands. Place the tablet in the mouth and allow it to dissolve. Do not swallow it as a whole.

Medicinal Benefits

Zofer 4 Tablet belongs to a group of medications called anti-emetics used to prevent nausea and vomiting associated with conditions like cancer chemotherapy, radiotherapy, surgery, pregnancy and motion sickness in adults and children above 4 years of age. When serotonin level increases in the blood, it stimulates the CTZ receptor (chemoreceptor trigger zone) located in the brain responsible for controlling nausea and vomiting. Zofer 4 Tablet acts by inhibiting the release of this serotonin, thereby preventing nausea and vomiting. 

How Zofer 4 Tablet Works

Zofer 4 Tablet contains 'Ondanestron' that works by blocking the action of a chemical in the body (serotonin) responsible for causing nausea and vomiting. As a result, Zofer 4 Tablet prevents the sensation of nausea and vomiting caused due to conditions like surgery, cancer chemotherapy, pregnancy or motion sickness.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Zofer 4 Tablet

  • Sensations of flushing
  • Constipation
  • Headache
  • Confusion
  • Dizziness
  • Fast heartbeat
  • Fever
  • Headache
  • Shortness of breath
  • Weakness

What if I have taken an overdose of Zofer 4 Tablet

Do not take more than the prescribed dose of Zofer 4 Tablet as it may cause overdose. The symptoms of overdose include sudden loss of vision for a short time, irregular heartbeat, constipation, fainting, dizziness or lightheadedness. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Tell your doctor if you are dealing with an uneven heart, liver problems, or any other problem. Tell your doctor if you are taking medicine for epilepsy, cancer medicines, and abnormal heartbeats. Zofer 4 Tablet may affect a person's ability to drive. Therefore, should avoid driving or operating any machine. People with an irregular heartbeat (arrhythmia), and phenylketonuria (too much of protein phenylalanine in the blood) should not take Zofer 4 Tablet as it may cause serious conditions. The liver patient should not take more than 8 mg of Zofer 4 Tablet daily. Zofer 4 Tablet should be used during pregnancy or breastfeeding after consultation with a doctor. Taking Zofer 4 Tablet with apomorphine can cause a sharp dip in blood pressure, even leading to death, so avoid its intake together.

Drug-Drug Interactions

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OndansetronZiprasidone
Critical
OndansetronFluoxetine
Severe

Drug-Drug Interactions

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OndansetronZiprasidone
Critical
How does the drug interact with Zofer 4 Tablet:
Taking Zofer 4 Tablet with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Zofer 4 Tablet with Ziprasidone is not recommended, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
OndansetronFluoxetine
Severe
How does the drug interact with Zofer 4 Tablet:
Co-administration of Zofer 4 Tablet with Fluoxetine can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin builds up in body).

How to manage the interaction:
Although taking Zofer 4 Tablet along with fluoxetine can result in an interaction, it can be taken if a doctor has advised it. However, if you have sudden dizziness, lightheadedness, fainting, confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles, or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea, or fast or rapid heartbeats during therapy, consult the doctor. Do not stop using any medications without talking to a doctor.
OndansetronFentanyl
Severe
How does the drug interact with Zofer 4 Tablet:
Taking fentanyl with Zofer 4 Tablet may increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although taking fentanyl with Zofer 4 Tablet can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience confusion, hallucinations (seeing and hearing things that do not exist), increased heart rate, fever, excessive sweating, muscle pain or stiffness, stomach cramps, vomiting, or diarrhoea, consult a doctor. Do not discontinue any medications without consulting your doctor.
OndansetronSumatriptan
Severe
How does the drug interact with Zofer 4 Tablet:
Using Zofer 4 Tablet together with Sumatriptan might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Co-administration of Zofer 4 Tablet along with sumatriptan can lead to an interaction, it should be taken only if recommended by a doctor. However, if you experience symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, a shaking sensation, incoordination, stomach cramp, nausea, vomiting, and diarrhea, see a doctor. Do not discontinue any medications without a doctor's advice.
OndansetronFluvoxamine
Severe
How does the drug interact with Zofer 4 Tablet:
When Zofer 4 Tablet is taken with fluvoxamine, can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin builds up in body).

How to manage the interaction:
Co-administration of Zofer 4 Tablet along with fluvoxamine can result in an interaction, it can be taken if a doctor has advised it. However, if you have sudden dizziness, lightheadedness, fainting, confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles, or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea, or fast or rapid heartbeats during therapy, consult the doctor. Do not discontinue any medications without a doctor's advice.
OndansetronAlfuzosin
Severe
How does the drug interact with Zofer 4 Tablet:
Taking Zofer 4 Tablet along with alfuzosin can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Although taking Zofer 4 Tablet along with alfuzosin can lead to interaction, they can be taken if prescribed by a doctor. Contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.
OndansetronMirtazapine
Severe
How does the drug interact with Zofer 4 Tablet:
Using Zofer 4 Tablet with mirtazapine might raise serotonin hormone levels in the body, affects the brain and nerve cells.

How to manage the interaction:
Co-administration of Zofer 4 Tablet along with mirtazapine can result in an interaction, it can be taken if a doctor has advised it. However, if you have sudden dizziness, lightheadedness, fainting, confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles, or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea, or fast or rapid heartbeats during therapy, consult the doctor. Do not discontinue any medications without a doctor's advice.
OndansetronRibociclib
Severe
How does the drug interact with Zofer 4 Tablet:
Taking Zofer 4 Tablet with ribociclib increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Co-administration of Zofer 4 Tablet along with ribociclib can result in an interaction, it can be taken if a doctor has advised it. However, consult a doctor if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat. Do not discontinue any medications without a doctor's advice.
OndansetronBedaquiline
Severe
How does the drug interact with Zofer 4 Tablet:
Taking Zofer 4 Tablet with bedaquiline increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Co-administration of Zofer 4 Tablet along with bedaquiline can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, get medical help immediately. Do not discontinue any medications without a doctor's advice.
OndansetronLinezolid
Severe
How does the drug interact with Zofer 4 Tablet:
When Zofer 4 Tablet is taken with linezolid it can cause serotonin syndrome. (a condition in which a chemical called serotonin builds up in body).

How to manage the interaction:
Co-administration of Zofer 4 Tablet along with linezolid can lead to an interaction, it can be taken if recommended by a doctor. However, if you experience symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, incoordination, stomach pain, nausea, vomiting, and diarrhea, consult the doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • A person should take a healthy diet that includes lots of fruits and vegetables, lean meats, skinless poultry, nuts, fish, whole grains, plant-based oils, and low-fat dairy products will help to keep a person in good health and avoid chances of nausea and vomiting. 

  • One should avoid taking greasy or oily foods as this food triggers nausea and vomit.

  • Eat cool foods instead of hot and spicy foods.

  • Include clear broths, non-fat yoghurt, fruit juice, sherbet, and sports drinks for fluid make up which has got lost due to vomiting. 

 

Habit Forming

No

Therapeutic Class

ANTIEMETICS

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Alcohol

Unsafe

One should avoid consuming alcohol while taking Zofer 4 Tablet as this medicine can interact with alcohol and may worsen the side effects.

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Pregnancy

Safe if prescribed

Zofer 4 Tablet could be used during pregnancy after consulting a doctor.

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Breast Feeding

Safe if prescribed

Zofer 4 Tablet could be used during breastfeeding after consulting a doctor.

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Driving

Caution

Zofer 4 Tablet may cause lightheadedness in the body, so a person taking Zofer 4 Tablet should avoid driving or operating any heavy machinery or tasks that require mental alertness.

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Liver

Safe if prescribed

In persons dealing with liver problems, the use of Zofer 4 Tablet is allowed if prescribed by the doctor. However, in patients with severe liver problems should take a low dose of Zofer 4 Tablet as much as possible. Do not take more than 8 mg of Zofer 4 Tablet per day in case of liver disease.

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Kidney

Safe if prescribed

The use of Zofer 4 Tablet is safe in patients dealing with kidney disorders. No dose adjustment is required.

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Children

Safe if prescribed

Zofer 4 Tablet should not be given to the children below 4 years of age. The use of Zofer 4 Tablet is safe in children above 4 years of age if prescribed by the doctor.

FAQs

Zofer 4 Tablet is indicated in the treatment of nausea and vomiting.

Zofer 4 Tablet works by blocking the action of a chemical in the body (serotonin) responsible for causing nausea and vomiting.

Zofer 4 Tablet may cause changes in the vision, so one should avoid driving or operating any machine that required mental alertness.

People with an irregular heartbeat (arrhythmia), and phenylketonuria (too much of protein phenylalanine in the blood) should not take Zofer 4 Tablet as it may cause serious conditions. The liver patient should not take more than 8 mg of Zofer 4 Tablet daily. Taking Zofer 4 Tablet with apomorphine can cause a sharp dip in blood pressure, even leading to death, so avoid its intake together.

Zofer 4 Tablet is an anti-sickness medicine that takes about 1-2 hours to show its action.

Zofer 4 Tablet contains Ondansetron, an antiemetic drug.

Zofer 4 Tablet is ineffective in preventing nausea associated with motion sickness.

Before taking the Zofer 4 Tablet , let your doctor know about all your medical conditions, sensitivities, and medications you are using. Also, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Yes, Zofer 4 Tablet might make you feel sleepy or tired.

Zofer 4 Tablet usually works quickly, usually within 30 minutes, but it can take up to two hours for the full effect.

Common side effects of Zofer 4 Tablet may include warmth, constipation, headache, diarrhoea, drowsiness, and tiredness. However, not every person faces these side effects, and even some of the unpleasant effects of Zofer 4 Tablet do not require medical attention.

Zofer 4 Tablet was not found to be beneficial in the treatment of seasickness.

Zofer 4 Tablet works by blocking the action of a chemical in the body (serotonin) that is responsible for causing nausea and vomiting. As a result, Zofer 4 Tablet prevents the sensation of nausea and vomiting caused by conditions like surgery, cancer chemotherapy, pregnancy or motion sickness.

Yes, you can take Zofer 4 Tablet half an hour to 1 hour before meals.

If you forget to take a dose of Zofer 4 Tablet , take it as soon as you remember. But, if it is time for your next dose, skip the missed dose and take your regular dose. Do not take a double dose to make up for a forgotten dose.

Zofer 4 Tablet may cause changes in the vision, so one should avoid driving or operating any machine that requires mental alertness.

Suppose you took more than the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Zofer 4 Tablet may include constipation, dizziness or lightheadedness, fainting, irregular heartbeat, and sudden loss of vision for a short time. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

No, Zofer 4 Tablet is not a steroid. Zofer 4 Tablet belongs to a class of drugs known as anti-emetics.

While specific dosing instructions will vary depending on your individual needs and medical history. Always follow your doctor's prescribed dosage and timing for taking these medications.

Take Zofer 4 Tablet exactly as prescribed by the doctor. Take it at the same time daily as it will help you to remember taking the medication.

Yes, Zofer 4 Tablet has also been prescribed during pregnancy to help with symptoms of nausea and vomiting in pregnancy.

Country of origin

India

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - ZOF0007

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