apollo
0
Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Xtandi 40 mg Soft Capsule is used to treat prostate cancer. It contains Enzalutamide, an androgen receptor blocker (inhibitor) that blocks testosterone from reaching prostate cancer cells. Most prostate cancers require testosterone to grow; this can slow the growth of the cancer and may shrink it. Enzalutamide is only for use in men. Men using this medication must use effective birth control whenever they have sex during their treatment and for three months after their final dose.

Read more
rxMedicinePrescription drug

Whats That

tooltip

Composition :

ENZALUTAMIDE-40MG

Manufacturer/Marketer :

Astellas Pharma India Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Jan-27

About Xtandi 40 mg Soft Capsule

Xtandi 40 mg Soft Capsule belongs to a group of medicines known as androgen receptor inhibitors. It is used to treat prostate cancer. Cancer is a condition where cells in a specific body part grow and reproduce uncontrollably. The cancerous cells can attack and destroy surrounding healthy tissue, including organs. Prostate cancer is a type of cancer that only occurs in men and affects the prostate gland, a tiny gland under the bladder that produces semen.

Xtandi 40 mg Soft Capsule contains Enzalutamide, an androgen receptor blocker (inhibitor). Enzalutamide blocks testosterone from reaching prostate cancer cells. Most prostate cancers require testosterone to grow. This can slow the growth of the cancer and may shrink it.

Use this medicine as directed by your doctor. You may sometimes experience trouble breathing (pneumonia), weakness or feeling more tired than usual, back pain, diarrhoea, pain in your joints, swelling (in your hands, arms, legs or feet), muscle or bone pain, muscle weakness, headache, cold-like symptoms, dizziness, high blood pressure and trouble falling or staying asleep (insomnia). Most of these side effects may gradually resolve over time. However, if the side effects persist or worsen, consult your doctor.

Enzalutamide is only for use in men. Men using this Xtandi 40 mg Soft Capsule must use effective birth control whenever they have sex during your treatment and for three months after their final dose. In rare cases, Xtandi 40 mg Soft Capsule may cause seizures, so tell your doctor if you have or have ever had seizures. Because of the risk of seizure associated with Xtandi 40 mg Soft Capsule use, patients should be advised of the risk of engaging in any activity where sudden loss of consciousness could cause serious harm to themselves or others. Consumption of alcohol is strictly avoided.

Uses of Xtandi 40 mg Soft Capsule

Treatment of Prostate Cancer

Directions for Use

Tablet/capsule: Swallow it as a whole with water; do not crush or chew it.

Solution: Shake the bottle well before use. Take the prescribed dose by mouth using the measuring cup provided by the pack.

Medicinal Benefits

Xtandi 40 mg Soft Capsule contains Enzalutamide, which belongs to a group of medicines known as androgen receptor inhibitors. Most prostate cancers require testosterone to grow. In men, the testicles produce the majority of testosterone. Adrenal glands (Just above each kidney) produce a small quantity of testosterone. Enzalutamide is preventing testosterone from reaching cancer cells in the prostate. This can inhibit the growth of the cancer and even cause it to shrink.

How Xtandi 40 mg Soft Capsule Works

Xtandi 40 mg Soft Capsule contains Enzalutamide, an androgen receptor blocker (inhibitor). Enzalutamide blocks testosterone from reaching prostate cancer cells. Most prostate cancers require testosterone to grow. This can slow the growth of the cancer and may shrink it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Xtandi 40 mg Soft Capsule

  • Feeling sick (nausea)
  • Being sick (vomiting)
  • Asthenia/fatigue/weakness
  • Back pain
  • Diarrhea
  • Cold like symptoms
  • Arthralgia (joint pain)
  • Hot flush
  • Peripheral edema
  • Musculoskeletal pain
  • Headache
  • Upper respiratory infection
  • Muscular weakness
  • Dizziness
  • Insomnia
  • Lower respiratory infection
  • Spinal cord compression
  • Cauda equina syndrome
  • Hematuria (blood in urine)
  • Paresthesia (tingling or prickling sensation)
  • Anxiety
  • Hypertension

What if I have taken an overdose of Xtandi 40 mg Soft Capsule

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Xtandi 40 mg Soft Capsule may include seizures. Seek immediate medical attention if you observe any symptoms or think you might have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

Do not take Xtandi 40 mg Soft Capsule if you are allergic or hypersensitive to any component present in it. You must take Enzalutamide according to the instructions your doctor or pharmacist gives you. You must take Enzalutamide exactly as prescribed by your doctor or pharmacist. You must take the correct dose, not more or less. Consult your healthcare team before discontinuing Xtandi 40 mg Soft Capsule or missing a dose. Talk to your doctor before taking Xtandi 40 mg Soft Capsule if you have severe allergic reactions to medicines or foods or suffer from any medical illness. Use a condom or effective birth control method if you are having sex with pregnant women or women who can become pregnant.

Drug-Drug Interactions

verifiedApollotooltip
EnzalutamideRegorafenib
Critical
EnzalutamideDronedarone
Critical

Drug-Drug Interactions

Login/Sign Up

EnzalutamideRegorafenib
Critical
How does the drug interact with Xtandi 40 mg Soft Capsule 28's:
Taking Xtandi 40 mg Soft Capsule 28's with Regorafenib may decrease the blood levels of Regorafenib, which may make Regorafenib less effective in treating your condition.

How to manage the interaction:
Taking Xtandi 40 mg Soft Capsule 28's with Regorafenib is not recommended, as it may lead to an interaction, it can be taken if prescribed by the doctor. Do not discontinue any medications without a doctor's advice.
EnzalutamideDronedarone
Critical
How does the drug interact with Xtandi 40 mg Soft Capsule 28's:
Co-administration of Xtandi 40 mg Soft Capsule 28's and Dronedarone together can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Xtandi 40 mg Soft Capsule 28's and Dronedarone together is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
EnzalutamideZiprasidone
Critical
How does the drug interact with Xtandi 40 mg Soft Capsule 28's:
Taking Xtandi 40 mg Soft Capsule 28's with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Xtandi 40 mg Soft Capsule 28's with Ziprasidone is not recommended, as it may lead to an interaction it can be taken if prescribed by the doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
EnzalutamideRanolazine
Critical
How does the drug interact with Xtandi 40 mg Soft Capsule 28's:
Taking Xtandi 40 mg Soft Capsule 28's may decrease the blood levels of Ranolazine, which may make Ranolazine less effective.

How to manage the interaction:
Taking Xtandi 40 mg Soft Capsule 28's with Ranolazine is not recommended, as it may lead to an interaction, it can be taken if prescribed by the doctor. Do not discontinue any medications without a doctor's advice.
EnzalutamideLurasidone
Critical
How does the drug interact with Xtandi 40 mg Soft Capsule 28's:
Co-administration of Lurasidone with Xtandi 40 mg Soft Capsule 28's may result in significantly lower blood levels of Lurasidone, making the medication less effective.

How to manage the interaction:
Taking Lurasidone with Xtandi 40 mg Soft Capsule 28's is not recommended as it may lead to interaction, it can be taken if prescribed by the doctor. Consult a doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
EnzalutamideFentanyl
Severe
How does the drug interact with Xtandi 40 mg Soft Capsule 28's:
Coadministration of fentanyl and Xtandi 40 mg Soft Capsule 28's can lower the levels of fentanyl in the blood, which could decrease the effectiveness of the medication.

How to manage the interaction:
Although taking Fentanyl with Xtandi 40 mg Soft Capsule 28's can result in an interaction, they can be taken together if prescribed by your doctor. However, consult a doctor immediately if you experience watery eyes, fever, rapid heart rate, body aches, abdominal cramping, vomiting, or diarrhoea. Do not discontinue using any medications without consulting a doctor.
EnzalutamideCariprazine
Severe
How does the drug interact with Xtandi 40 mg Soft Capsule 28's:
When Cariprazine is taken with Xtandi 40 mg Soft Capsule 28's, it reduces the blood levels of cariprazine which may make the medication less effective.

How to manage the interaction:
Although taking Cariprazine and Xtandi 40 mg Soft Capsule 28's together can cause an interaction, it can be taken if your doctor has suggested it. If you notice any unusual symptoms or if your condition worsens, make sure to contact a doctor. Do not stop using any medications without talking to a doctor.
EnzalutamideNicardipine
Severe
How does the drug interact with Xtandi 40 mg Soft Capsule 28's:
Taking Xtandi 40 mg Soft Capsule 28's with Nicardipine may decrease the blood levels of Nicardipine, which may make Nicardipine less effective in treating your condition.

How to manage the interaction:
Although taking Xtandi 40 mg Soft Capsule 28's and Nicardipine together can possibly result in an interaction, it can be taken if your doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
EnzalutamideEscitalopram
Severe
How does the drug interact with Xtandi 40 mg Soft Capsule 28's:
Using escitalopram together with Xtandi 40 mg Soft Capsule 28's can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Xtandi 40 mg Soft Capsule 28's and Escitalopram together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
EnzalutamideMacitentan
Severe
How does the drug interact with Xtandi 40 mg Soft Capsule 28's:
Taking Xtandi 40 mg Soft Capsule 28's with Macitentan may decrease the blood levels of Macitentan, which may make Macitentan less effective in treating your condition.

How to manage the interaction:
Although taking Xtandi 40 mg Soft Capsule 28's and Macitentan together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience any symptoms like- watery eyes, a runny nose, sneezing, yawning, sweating heavily, fever, chills, flushing, restlessness, irritability, anxiety, eye problems, shaking, rapid heartbeat, body aches, involuntary twitching and kicking, stomach pain, diarrhea, consult the doctor. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
ENZALUTAMIDE-40MGHerbal products/medicines
Moderate

Drug-Food Interactions

Login/Sign Up

ENZALUTAMIDE-40MGHerbal products/medicines
Moderate
Common Foods to Avoid:
St. John’S Wort

How to manage the interaction:
Taking St. John's Wort products during Xtandi 40 mg Soft Capsule 28's treatment may lead to decrease in the effectiveness of Xtandi 40 mg Soft Capsule 28's. Avoid St. John's Wort products during Xtandi 40 mg Soft Capsule 28's treatment

Diet & Lifestyle Advise

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast, fried, processed meats, refined carbs and added sugars.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Xtandi 40 mg Soft Capsule Substitute

Substitutes safety advice
  • Enzamide 40mg Capsule 28's

    by AYUR

    336.79per tablet
  • Obnyx Capsule 4's

    by AYUR

    192.60per tablet
  • Azel 40 mg Capsule 28's

    by AYUR

    254.79per tablet
  • Xylutide 40 Softgel Cap 4'S

    by Others

    250.43per tablet
  • Adleap 40 mg Capsule 28's

    by Others

    140.29per tablet
bannner image

Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Xtandi 40 mg Soft Capsule .

bannner image

Pregnancy

Unsafe

Enzalutamide is only for use in men. Women should not take this medication.

bannner image

Breast Feeding

Unsafe

Enzalutamide is only for use in men. Women should not take this medication.

bannner image

Driving

Caution

Xtandi 40 mg Soft Capsule may affect your reactions and your ability to drive. Do not drive and/or operate machines that require your alertness.

bannner image

Liver

Consult your doctor

In patients with mild or moderate liver impairment, there is no need to alter the initial dose. There is no information available on patients with severe liver impairment.

bannner image

Kidney

Consult your doctor

In patients with mild or moderate kidney impairment, there is no need to alter the initial dose. There is no information available on patients with severe kidney impairment.

bannner image

Children

Caution

The safety and effectiveness of Xtandi 40 mg Soft Capsule in pediatric patients have not been established.

FAQs

Xtandi 40 mg Soft Capsule is used to treat prostate cancer in men.
Most prostate cancers require testosterone to grow. Xtandi 40 mg Soft Capsule contains Enzalutamide, which blocks testosterone, a hormone, from reaching prostate cancer cells. Thus, Xtandi 40 mg Soft Capsule can slow the cancer's growth and cause it to shrink.
Xtandi 40 mg Soft Capsule is only for use in men. Women should not take this medication, especially if they are or may become pregnant or are breast-feeding.
In some cases, Xtandi 40 mg Soft Capsule may cause decreased fertility in men. However, you should not assume that your female partner cannot become pregnant. Please discuss with your doctor if you have any concerns.
Enzalutamide, a prostate cancer medication, is used to treat prostate cancer.
Seizures may occur in patients receiving Xtandi 40 mg Soft Capsule . So, patients who have had a seizure, please inform your doctor about your condition. Your doctor may monitor your condition closely.
Yes, Enzalutamide was generally a well-tolerated medication. Take Xtandi 40 mg Soft Capsule pills exactly as directed by your healthcare provider. Do not change your dose or stop taking Xtandi 40 mg Soft Capsule unless your healthcare physician instructs you. If you encounter side symptoms, your healthcare provider may temporarily discontinue your Xtandi 40 mg Soft Capsule therapy or adjust your Xtandi 40 mg Soft Capsule dose.

Country of origin

India

Manufacturer/Marketer address

Astellas Pharma India Pvt Ltd, 301, 3Rd Floor, C And B Square, 127 Andheri Kurla Road, Chakala, Andheri East, Mumbai 400 069.
Other Info - XTA0017

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
whatsapp Floating Button