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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Capsulemide 40 Capsule is used to treat prostate cancer. It contains Enzalutamide, an androgen receptor blocker (inhibitor) that blocks testosterone from reaching prostate cancer cells. Most prostate cancers require testosterone to grow; this can slow the growth of the cancer and may shrink it. Enzalutamide is only for use in men. Men using this medication must use effective birth control whenever they have sex during their treatment and for three months after their final dose.

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Composition :

ENZALUTAMIDE-40MG

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Capsulemide 40 Capsule

Capsulemide 40 Capsule belongs to a group of medicines known as androgen receptor inhibitors. It is used to treat prostate cancer. Cancer is a condition where cells in a specific body part grow and reproduce uncontrollably. The cancerous cells can attack and destroy surrounding healthy tissue, including organs. Prostate cancer is a type of cancer that only occurs in men and affects the prostate gland, a tiny gland under the bladder that produces semen.

Capsulemide 40 Capsule contains Enzalutamide, an androgen receptor blocker (inhibitor). Enzalutamide blocks testosterone from reaching prostate cancer cells. Most prostate cancers require testosterone to grow. This can slow the growth of the cancer and may shrink it.

Use this medicine as directed by your doctor. You may sometimes experience trouble breathing (pneumonia), weakness or feeling more tired than usual, back pain, diarrhoea, pain in your joints, swelling (in your hands, arms, legs or feet), muscle or bone pain, muscle weakness, headache, cold-like symptoms, dizziness, high blood pressure and trouble falling or staying asleep (insomnia). Most of these side effects may gradually resolve over time. However, if the side effects persist or worsen, consult your doctor.

Enzalutamide is only for use in men. Men using this Capsulemide 40 Capsule must use effective birth control whenever they have sex during your treatment and for three months after their final dose. In rare cases, Capsulemide 40 Capsule may cause seizures, so tell your doctor if you have or have ever had seizures. Because of the risk of seizure associated with Capsulemide 40 Capsule use, patients should be advised of the risk of engaging in any activity where sudden loss of consciousness could cause serious harm to themselves or others. Consumption of alcohol is strictly avoided.

Uses of Capsulemide 40 Capsule

Treatment of Prostate Cancer

Directions for Use

Tablet/capsule: Swallow it as a whole with water; do not crush or chew it.

Solution: Shake the bottle well before use. Take the prescribed dose by mouth using the measuring cup provided by the pack.

Medicinal Benefits

Capsulemide 40 Capsule contains Enzalutamide, which belongs to a group of medicines known as androgen receptor inhibitors. Most prostate cancers require testosterone to grow. In men, the testicles produce the majority of testosterone. Adrenal glands (Just above each kidney) produce a small quantity of testosterone. Enzalutamide is preventing testosterone from reaching cancer cells in the prostate. This can inhibit the growth of the cancer and even cause it to shrink.

How Capsulemide 40 Capsule Works

Capsulemide 40 Capsule contains Enzalutamide, an androgen receptor blocker (inhibitor). Enzalutamide blocks testosterone from reaching prostate cancer cells. Most prostate cancers require testosterone to grow. This can slow the growth of the cancer and may shrink it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Capsulemide 40 Capsule

  • Feeling sick (nausea)
  • Being sick (vomiting)
  • Asthenia/fatigue/weakness
  • Back pain
  • Diarrhea
  • Cold like symptoms
  • Arthralgia (joint pain)
  • Hot flush
  • Peripheral edema
  • Musculoskeletal pain
  • Headache
  • Upper respiratory infection
  • Muscular weakness
  • Dizziness
  • Insomnia
  • Lower respiratory infection
  • Spinal cord compression
  • Cauda equina syndrome
  • Hematuria (blood in urine)
  • Paresthesia (tingling or prickling sensation)
  • Anxiety
  • Hypertension

What if I have taken an overdose of Capsulemide 40 Capsule

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Capsulemide 40 Capsule may include seizures. Seek immediate medical attention if you observe any symptoms or think you might have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

Do not take Capsulemide 40 Capsule if you are allergic or hypersensitive to any component present in it. You must take Enzalutamide according to the instructions your doctor or pharmacist gives you. You must take Enzalutamide exactly as prescribed by your doctor or pharmacist. You must take the correct dose, not more or less. Consult your healthcare team before discontinuing Capsulemide 40 Capsule or missing a dose. Talk to your doctor before taking Capsulemide 40 Capsule if you have severe allergic reactions to medicines or foods or suffer from any medical illness. Use a condom or effective birth control method if you are having sex with pregnant women or women who can become pregnant.

Drug-Drug Interactions

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EnzalutamideRanolazine
Critical
EnzalutamideDronedarone
Critical

Drug-Drug Interactions

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EnzalutamideRanolazine
Critical
How does the drug interact with Capsulemide 40 Capsule 28's:
Taking Capsulemide 40 Capsule 28's may decrease the blood levels of Ranolazine, which may make Ranolazine less effective.

How to manage the interaction:
Taking Capsulemide 40 Capsule 28's with Ranolazine is not recommended, as it may lead to an interaction, it can be taken if prescribed by the doctor. Do not discontinue any medications without a doctor's advice.
EnzalutamideDronedarone
Critical
How does the drug interact with Capsulemide 40 Capsule 28's:
Co-administration of Capsulemide 40 Capsule 28's and Dronedarone together can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Capsulemide 40 Capsule 28's and Dronedarone together is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
EnzalutamideLurasidone
Critical
How does the drug interact with Capsulemide 40 Capsule 28's:
Co-administration of Lurasidone with Capsulemide 40 Capsule 28's may result in significantly lower blood levels of Lurasidone, making the medication less effective.

How to manage the interaction:
Taking Lurasidone with Capsulemide 40 Capsule 28's is not recommended as it may lead to interaction, it can be taken if prescribed by the doctor. Consult a doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
EnzalutamideRegorafenib
Critical
How does the drug interact with Capsulemide 40 Capsule 28's:
Taking Capsulemide 40 Capsule 28's with Regorafenib may decrease the blood levels of Regorafenib, which may make Regorafenib less effective in treating your condition.

How to manage the interaction:
Taking Capsulemide 40 Capsule 28's with Regorafenib is not recommended, as it may lead to an interaction, it can be taken if prescribed by the doctor. Do not discontinue any medications without a doctor's advice.
EnzalutamideZiprasidone
Critical
How does the drug interact with Capsulemide 40 Capsule 28's:
Taking Capsulemide 40 Capsule 28's with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Capsulemide 40 Capsule 28's with Ziprasidone is not recommended, as it may lead to an interaction it can be taken if prescribed by the doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
EnzalutamideDroperidol
Severe
How does the drug interact with Capsulemide 40 Capsule 28's:
Taking Capsulemide 40 Capsule 28's and Droperidol together can increase the chance of a serious abnormal heart rhythm. If you suffer from any heart conditions, or electrolyte disturbances (such as magnesium or potassium deficiency brought on by severe or prolonged diarrhea or vomiting), you may be at higher risk.

How to manage the interaction:
Taking Capsulemide 40 Capsule 28's and Droperidol together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, drowsiness, confusion, muscle pain, nausea, or vomiting or rapid heartbeat, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
EnzalutamideTacrolimus
Severe
How does the drug interact with Capsulemide 40 Capsule 28's:
Taking Tacrolimus with Capsulemide 40 Capsule 28's may reduce the levels of Tacrolimus, which may make Tacrolimus less effective in treating your condition.

How to manage the interaction:
Although taking Tacrolimus and Capsulemide 40 Capsule 28's together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience any unusual symptoms consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
EnzalutamideIvabradine
Severe
How does the drug interact with Capsulemide 40 Capsule 28's:
Taking Capsulemide 40 Capsule 28's with Ivabradine may decrease the blood levels of Ivabradine, which may make Ivabradine less effective in treating your condition.

How to manage the interaction:
Although taking Capsulemide 40 Capsule 28's and Ivabradine together can result in an interaction, it can be taken if your doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
EnzalutamideNifedipine
Severe
How does the drug interact with Capsulemide 40 Capsule 28's:
Taking Capsulemide 40 Capsule 28's with Nifedipine may decrease the blood levels of Nifedipine, which may make Nifedipine less effective in treating your condition.

How to manage the interaction:
Although taking Capsulemide 40 Capsule 28's and Nifedipine together can result in an interaction, it can be taken if your doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
EnzalutamideAripiprazole
Severe
How does the drug interact with Capsulemide 40 Capsule 28's:
When Aripiprazole is taken with Capsulemide 40 Capsule 28's, the amount of Aripiprazole in the blood may decrease. This might reduce aripiprazole's ability to effectively treat disease.

How to manage the interaction:
Although there is a possible interaction between Capsulemide 40 Capsule 28's and Aripiprazole, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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ENZALUTAMIDE-40MGHerbal products/medicines
Moderate

Drug-Food Interactions

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ENZALUTAMIDE-40MGHerbal products/medicines
Moderate
Common Foods to Avoid:
St. John’S Wort

How to manage the interaction:
Taking St. John's Wort products during Capsulemide 40 Capsule 28's treatment may lead to decrease in the effectiveness of Capsulemide 40 Capsule 28's. Avoid St. John's Wort products during Capsulemide 40 Capsule 28's treatment

Diet & Lifestyle Advise

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast, fried, processed meats, refined carbs and added sugars.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Capsulemide 40 Capsule Substitute

Substitutes safety advice
  • Enzamide 40mg Capsule 28's

    by AYUR

    9430.00per tablet
  • Obnyx Capsule 4's

    by AYUR

    192.60per tablet
  • Azel 40 mg Capsule 28's

    by AYUR

    254.79per tablet
  • Xylutide 40 Softgel Cap 4'S

    250.43per tablet
  • Adleap 40 mg Capsule 28's

    140.29per tablet
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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Capsulemide 40 Capsule .

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Pregnancy

Unsafe

Enzalutamide is only for use in men. Women should not take this medication.

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Breast Feeding

Unsafe

Enzalutamide is only for use in men. Women should not take this medication.

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Driving

Caution

Capsulemide 40 Capsule may affect your reactions and your ability to drive. Do not drive and/or operate machines that require your alertness.

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Liver

Consult your doctor

In patients with mild or moderate liver impairment, there is no need to alter the initial dose. There is no information available on patients with severe liver impairment.

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Kidney

Consult your doctor

In patients with mild or moderate kidney impairment, there is no need to alter the initial dose. There is no information available on patients with severe kidney impairment.

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Children

Caution

The safety and effectiveness of Capsulemide 40 Capsule in pediatric patients have not been established.

FAQs

Capsulemide 40 Capsule is used to treat prostate cancer in men.
Most prostate cancers require testosterone to grow. Capsulemide 40 Capsule contains Enzalutamide, which blocks testosterone, a hormone, from reaching prostate cancer cells. Thus, Capsulemide 40 Capsule can slow the cancer's growth and cause it to shrink.
Capsulemide 40 Capsule is only for use in men. Women should not take this medication, especially if they are or may become pregnant or are breast-feeding.
In some cases, Capsulemide 40 Capsule may cause decreased fertility in men. However, you should not assume that your female partner cannot become pregnant. Please discuss with your doctor if you have any concerns.
Enzalutamide, a prostate cancer medication, is used to treat prostate cancer.
Seizures may occur in patients receiving Capsulemide 40 Capsule . So, patients who have had a seizure, please inform your doctor about your condition. Your doctor may monitor your condition closely.
Yes, Enzalutamide was generally a well-tolerated medication. Take Capsulemide 40 Capsule pills exactly as directed by your healthcare provider. Do not change your dose or stop taking Capsulemide 40 Capsule unless your healthcare physician instructs you. If you encounter side symptoms, your healthcare provider may temporarily discontinue your Capsulemide 40 Capsule therapy or adjust your Capsulemide 40 Capsule dose.

Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - CAP0251

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