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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Xpreza 100 mg Injection is used to treat Myelodysplastic syndrome, chronic myelomonocytic leukaemia, and acute myeloid leukaemia. It contains Azacitidine, a nucleoside metabolic inhibitor which works by preventing cancer cells from growing. It incorporates into the genetic material of the cells and interferes with the production of new DNA and RNA. This helps correct problems with the maturation and growth of young blood cells in the bone marrow, which causes myelodysplastic disorders.

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Whats That

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Composition :

AZACITIDINE-100MG

Manufacturer/Marketer :

Natco Pharma Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

Jan-27

About Xpreza 100 mg Injection

Xpreza 100 mg Injection belongs to the group of medicines called anti-metabolites used in adults with higher-risk myelodysplastic syndromes, chronic myelomonocytic leukaemia, and acute myeloid leukaemia. These conditions affect the bone marrow and could cause problems with normal blood cell production.

Xpreza 100 mg Injection contains Azacitidine, which works by preventing cancer cells from growing. It helps the bone marrow in the production of normal blood cells and kills abnormal cells in the bone marrow.

In some cases, Xpreza 100 mg Injection may cause side effects such as nausea, vomiting, diarrhoea, constipation, weakness, headache, and injection site reactions. Most of these side effects may not require medical attention and resolve gradually over time. Do not be reluctant to talk with your doctor if any of the side effects persist or worsen.

Do not use Xpreza 100 mg Injection if you are pregnant or breastfeeding. Consult a doctor immediately if you become pregnant during treatment with Xpreza 100 mg Injection. This medicine is not recommended for children as safety and effectiveness have not been established. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

Uses of Xpreza 100 mg Injection

Treatment of Myelodysplastic syndrome, chronic myelomonocytic leukaemia, and acute myeloid leukaemia

Directions for Use

Xpreza 100 mg Injection will be administered by a qualified physician; do not self-administer.

Medicinal Benefits

Xpreza 100 mg Injection belongs to the group of medicines called anti-metabolites used to treat myelodysplastic syndromes, chronic myelomonocytic leukaemia, and acute myeloid leukaemia. Xpreza 100 mg Injection contains Azacitidine, a nucleoside metabolic inhibitor which works by preventing cancer cells from growing. It incorporates into the genetic material of the cells and interferes with the production of new DNA and RNA. This helps correct problems with the maturation and growth of young blood cells in the bone marrow, which causes myelodysplastic disorders.

How Xpreza 100 mg Injection Works

Xpreza 100 mg Injection contains Azacitidine, which works by preventing cancer cells from growing. It helps the bone marrow in the production of normal blood cells and kills abnormal cells in the bone marrow.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Xpreza 100 mg Injection

  • Reduced blood count (red blood count, white blood count, and platelets)
  • Nausea
  • Vomiting
  • Diarrhoea
  • Constipation
  • Headache
  • Tiredness
  • Dizziness
  • Pneumonia
  • Injection site reaction (redness, pain or a skin reaction)

What if I have taken an overdose of Xpreza 100 mg Injection

As Xpreza 100 mg Injection is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away. Overdose of Xpreza 100 mg Injection may cause diarrhoea, nausea and vomiting.

Drug Warnings

Do not use Xpreza 100 mg Injection if you are allergic to any of its components, have advanced liver cancer, or are breastfeeding. Inform the doctor if you have a low number of platelets, red or white blood cells, heart condition or heart attack, lung, kidney or liver diseases. Seek immediate medical attention if you experience symptoms of liver failure (jaundice, abdominal bloating, shaking, drowsiness, and easy bruising), kidney failure (back pain, increased thirst, swelling of legs and feet, reduced passing of water, dizziness, rapid pulse, nausea, vomiting, reduced appetite, confusion, fatigue or restlessness), fever, pneumonia (shortness of breath or chest pain accompanied with fever), low levels of platelets (bleeding such as blood in stools due to bleeding in the stomach), or allergic reaction (rash, difficulty breathing, itching, or swelling of lips).

Drug-Drug Interactions

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AzacitidineYellow fever vaccine
Critical
AzacitidineGolimumab
Severe

Drug-Drug Interactions

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AzacitidineYellow fever vaccine
Critical
How does the drug interact with Xpreza 100 mg Injection 1's:
Taking Yellow fever vaccine with Xpreza 100 mg Injection 1's can increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Xpreza 100 mg Injection 1's and the Yellow fever vaccine, you can take these medicines together if prescribed by a doctor. If you notice any signs of infection, it's important to contact a doctor right away. Do not stop using any medications without consulting a doctor.
AzacitidineGolimumab
Severe
How does the drug interact with Xpreza 100 mg Injection 1's:
Taking Xpreza 100 mg Injection 1's with Golimumab can raise the risk of severe infections.

How to manage the interaction:
Co-administration of Xpreza 100 mg Injection 1's with Golimumab can result in an interaction, but it can be taken if a doctor has advised it. However, if you have any of these symptom's fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain or burning while peeing - make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.
AzacitidineAdalimumab
Severe
How does the drug interact with Xpreza 100 mg Injection 1's:
Taking Adalimumab with Xpreza 100 mg Injection 1's may raise the risk of severe infections.

How to manage the interaction:
Taking Xpreza 100 mg Injection 1's with Adalimumab together can result in an interaction, but it can be taken if a doctor has advised it. However, if you have any of these symptom's fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain or burning while peeing - make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.
AzacitidineThalidomide
Severe
How does the drug interact with Xpreza 100 mg Injection 1's:
Taking thalidomide together with Xpreza 100 mg Injection 1's may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Xpreza 100 mg Injection 1's together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
AzacitidineFilgrastim
Severe
How does the drug interact with Xpreza 100 mg Injection 1's:
Coadministration of Filgrastim with Xpreza 100 mg Injection 1's can reduce the effects of Filgrastim.

How to manage the interaction:
Although there is an interaction between filgrastim and Xpreza 100 mg Injection 1's, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
AzacitidineEtanercept
Severe
How does the drug interact with Xpreza 100 mg Injection 1's:
When Etanercept is used with Xpreza 100 mg Injection 1's, the likelihood or severity of infection may increase.

How to manage the interaction:
There may be a possibility of interaction between Etanercept and Xpreza 100 mg Injection 1's, but it can be taken if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
AzacitidineTofacitinib
Severe
How does the drug interact with Xpreza 100 mg Injection 1's:
Taking Xpreza 100 mg Injection 1's with tofacitinib can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Xpreza 100 mg Injection 1's and Tofacitinib, you can take these medicines together if prescribed by a doctor. However, consult a doctor immediately if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or irritated skin, body sores, or discomfort or burning during urination. Do not discontinue any medications without consulting a doctor.
AzacitidineFingolimod
Severe
How does the drug interact with Xpreza 100 mg Injection 1's:
The use of fingolimod in conjunction with Xpreza 100 mg Injection 1's may raise the risk of severe infections.

How to manage the interaction:
Co-administration of Xpreza 100 mg Injection 1's with Fingolimod can possibly result in an interaction, but it can be taken if your doctor has advised it. However, Consult a doctor immediately if you have a fever, chills, diarrhoea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination. Do not discontinue any medications without consulting a doctor.
AzacitidineCladribine
Severe
How does the drug interact with Xpreza 100 mg Injection 1's:
The use of cladribine with Xpreza 100 mg Injection 1's can increase the risk of infections.

How to manage the interaction:
Taking Xpreza 100 mg Injection 1's with Cladribine together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience a fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
AzacitidineClozapine
Severe
How does the drug interact with Xpreza 100 mg Injection 1's:
Using clozapine together with Xpreza 100 mg Injection 1's can lower white blood cell count and may affect the bone marrow function, that may develop serious infections as a result.

How to manage the interaction:
There may be a possibility of interaction between Xpreza 100 mg Injection 1's and Clozapine, but it can be taken if prescribed by a doctor. However, consult a doctor immediately if you have a fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include vegetables and fruits in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.
  • Get optimal sleep; rest well.
  • Drink enough water and eat a balanced diet.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Xpreza 100 mg Injection Substitute

Substitutes safety advice
  • Azadine Injection 30 ml

    by Others

    143.73per tablet
  • Azatend Injection 1's

    by Others

    3243.10per tablet
  • Azzure Injection 1's

    by Others

    7380.00per tablet
  • Azaplast 100 mg Injection 1's

    by Others

    3344.57per tablet
  • Azactiv 100 mg Injection 1's

    by Others

    2394.90per tablet
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Alcohol

Consult your doctor

It is not known if alcohol affects Xpreza 100 mg Injection. Please consult your doctor.

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Pregnancy

Unsafe

Azacitidine belongs to pregnancy category D. Xpreza 100 mg Injection should not be used during pregnancy as it may harm the baby. Consult the doctor immediately if you become pregnant during treatment with Xpreza 100 mg Injection.

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Breast Feeding

Unsafe

It is unknown if Azacitidine passes into breast milk. Breastfeeding is not recommended during treatment with Xpreza 100 mg Injection.

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Driving

Caution

Xpreza 100 mg Injection may cause dizziness and tiredness. Avoid driving or operating machinery if you experience any side effects that might lessen your ability to do so.

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Liver

Caution

If you have a history of liver disease, inform your doctor before receiving Xpreza 100 mg Injection. This medicine should be used with caution in patients with severe pre-existing liver impairment.

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Kidney

Caution

If you have a history of kidney disease, inform your doctor before receiving Xpreza 100 mg Injection. Monitoring patients with kidney impairment is advised.

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Children

Unsafe

Xpreza 100 mg Injection is not recommended for children below 18 years as safety and effectiveness have not been established.

FAQs

Xpreza 100 mg Injection is used to treat Myelodysplastic syndrome, chronic myelomonocytic leukaemia, and acute myeloid leukaemia.
Xpreza 100 mg Injection works by preventing cancer cells from growing. Thereby, it helps treat cancer.
Men should avoid fathering a child whilst on treatment with Xpreza 100 mg Injection. Consult the doctor if you wish to conserve your sperm before starting the treatment. Use effective contraception during the treatment with Xpreza 100 mg Injection and for three months after stopping the treatment.
Xpreza 100 mg Injection may cause a serious immune reaction known as differentiation syndrome. Consult the doctor immediately if you experience fever, rash, difficulty breathing, cough, decreased urine, rapid weight gain, low blood pressure, or swelling of the legs or arms.
No, Xpreza 100 mg Injection is not a vesicant. It is a cytotoxic chemotherapy drug used to treat certain types of blood cancer, such as myelodysplastic syndrome (MDS). It is not known to cause severe tissue damage if it leaks from the injection site.
No, Xpreza 100 mg Injection does not cause hair loss.
Yes, Xpreza 100 mg Injection is a type of chemotherapy. It is used to treat certain types of blood cancers, such as myelodysplastic syndrome (MDS) and some forms of leukaemia.
Yes, Xpreza 100 mg Injection is a cytotoxic drug. It works by interfering with the growth of cancer cells, which helps to slow down or stop their multiplication.
The common side effects of Xpreza 100 mg Injection are nausea, vomiting, diarrhoea, constipation, weakness, headache, and injection site reactions. If any of these side effects persist or worsen, please consult your doctor.

Country of origin

INDIA

Manufacturer/Marketer address

Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Other Info - XPR0016

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