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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Azadine Injection is used to treat Myelodysplastic syndrome, chronic myelomonocytic leukaemia, and acute myeloid leukaemia. It contains Azacitidine, a nucleoside metabolic inhibitor which works by preventing cancer cells from growing. It incorporates into the genetic material of the cells and interferes with the production of new DNA and RNA. This helps correct problems with the maturation and growth of young blood cells in the bone marrow, which causes myelodysplastic disorders.

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Whats That

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Composition :

AZACITIDINE-100MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

Jan-27

About Azadine Injection

Azadine Injection belongs to the group of medicines called anti-metabolites used in adults with higher-risk myelodysplastic syndromes, chronic myelomonocytic leukaemia, and acute myeloid leukaemia. These conditions affect the bone marrow and could cause problems with normal blood cell production.

Azadine Injection contains Azacitidine, which works by preventing cancer cells from growing. It helps the bone marrow in the production of normal blood cells and kills abnormal cells in the bone marrow.

In some cases, Azadine Injection may cause side effects such as nausea, vomiting, diarrhoea, constipation, weakness, headache, and injection site reactions. Most of these side effects may not require medical attention and resolve gradually over time. Do not be reluctant to talk with your doctor if any of the side effects persist or worsen.

Do not use Azadine Injection if you are pregnant or breastfeeding. Consult a doctor immediately if you become pregnant during treatment with Azadine Injection. This medicine is not recommended for children as safety and effectiveness have not been established. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

Uses of Azadine Injection

Treatment of Myelodysplastic syndrome, chronic myelomonocytic leukaemia, and acute myeloid leukaemia

Directions for Use

Azadine Injection will be administered by a qualified physician; do not self-administer.

Medicinal Benefits

Azadine Injection belongs to the group of medicines called anti-metabolites used to treat myelodysplastic syndromes, chronic myelomonocytic leukaemia, and acute myeloid leukaemia. Azadine Injection contains Azacitidine, a nucleoside metabolic inhibitor which works by preventing cancer cells from growing. It incorporates into the genetic material of the cells and interferes with the production of new DNA and RNA. This helps correct problems with the maturation and growth of young blood cells in the bone marrow, which causes myelodysplastic disorders.

How Azadine Injection Works

Azadine Injection contains Azacitidine, which works by preventing cancer cells from growing. It helps the bone marrow in the production of normal blood cells and kills abnormal cells in the bone marrow.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Azadine Injection

  • Reduced blood count (red blood count, white blood count, and platelets)
  • Nausea
  • Vomiting
  • Diarrhoea
  • Constipation
  • Headache
  • Tiredness
  • Dizziness
  • Pneumonia
  • Injection site reaction (redness, pain or a skin reaction)

What if I have taken an overdose of Azadine Injection

As Azadine Injection is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away. Overdose of Azadine Injection may cause diarrhoea, nausea and vomiting.

Drug Warnings

Do not use Azadine Injection if you are allergic to any of its components, have advanced liver cancer, or are breastfeeding. Inform the doctor if you have a low number of platelets, red or white blood cells, heart condition or heart attack, lung, kidney or liver diseases. Seek immediate medical attention if you experience symptoms of liver failure (jaundice, abdominal bloating, shaking, drowsiness, and easy bruising), kidney failure (back pain, increased thirst, swelling of legs and feet, reduced passing of water, dizziness, rapid pulse, nausea, vomiting, reduced appetite, confusion, fatigue or restlessness), fever, pneumonia (shortness of breath or chest pain accompanied with fever), low levels of platelets (bleeding such as blood in stools due to bleeding in the stomach), or allergic reaction (rash, difficulty breathing, itching, or swelling of lips).

Drug-Drug Interactions

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AzacitidineYellow fever vaccine
Critical
AzacitidineThalidomide
Severe

Drug-Drug Interactions

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AzacitidineYellow fever vaccine
Critical
How does the drug interact with Azadine Injection 30 ml:
Taking Yellow fever vaccine with Azadine Injection 30 ml can increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Azadine Injection 30 ml and the Yellow fever vaccine, you can take these medicines together if prescribed by a doctor. If you notice any signs of infection, it's important to contact a doctor right away. Do not stop using any medications without consulting a doctor.
AzacitidineThalidomide
Severe
How does the drug interact with Azadine Injection 30 ml:
Taking thalidomide together with Azadine Injection 30 ml may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Azadine Injection 30 ml together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
AzacitidineNatalizumab
Severe
How does the drug interact with Azadine Injection 30 ml:
Taking Azadine Injection 30 ml with Natalizumab can raise the risk of severe infections.

How to manage the interaction:
There may be a possibility of interaction between Azadine Injection 30 ml and Natalizumab, but it can be taken if prescribed by a doctor. However, if you have any of these symptoms- fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, blood in phlegm(a thick secretion in the airway during disease and inflammation), losing weight, or pain while peeing, progressive weakness on one side of the body, clumsiness of limbs, disturbance of vision, confusion, or changes in thinking, memory and personality, make sure to contact a doctor immediately. Do not stop using any medications without a doctor's advice.
AzacitidineBCG vaccine
Severe
How does the drug interact with Azadine Injection 30 ml:
Taking BCG vaccine with Azadine Injection 30 ml can increase the risk of infection.

How to manage the interaction:
Co-administration of Azadine Injection 30 ml with BCG vaccine can result in an interaction, but it can be taken if a doctor has advised it. If you notice any signs of infection, it's important to contact a doctor right away. Do not stop using any medications without consulting a doctor.
AzacitidineBaricitinib
Severe
How does the drug interact with Azadine Injection 30 ml:
Taking baricitinib and Azadine Injection 30 ml can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Azadine Injection 30 ml if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscular aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.
AzacitidineAdalimumab
Severe
How does the drug interact with Azadine Injection 30 ml:
Taking Adalimumab with Azadine Injection 30 ml may raise the risk of severe infections.

How to manage the interaction:
Taking Azadine Injection 30 ml with Adalimumab together can result in an interaction, but it can be taken if a doctor has advised it. However, if you have any of these symptom's fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain or burning while peeing - make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.
AzacitidineEfalizumab
Severe
How does the drug interact with Azadine Injection 30 ml:
Using efalizumab together with Azadine Injection 30 ml may increase the risk of serious infections.

How to manage the interaction:
Taking Azadine Injection 30 ml with Efalizumab together can result in an interaction, but it can be taken if a doctor has advised it. If you have any of these symptoms - complications, infection, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, pain or burning during urination - make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.
AzacitidineFilgrastim
Severe
How does the drug interact with Azadine Injection 30 ml:
Coadministration of Filgrastim with Azadine Injection 30 ml can reduce the effects of Filgrastim.

How to manage the interaction:
Although there is an interaction between filgrastim and Azadine Injection 30 ml, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
AzacitidineClozapine
Severe
How does the drug interact with Azadine Injection 30 ml:
Using clozapine together with Azadine Injection 30 ml can lower white blood cell count and may affect the bone marrow function, that may develop serious infections as a result.

How to manage the interaction:
There may be a possibility of interaction between Azadine Injection 30 ml and Clozapine, but it can be taken if prescribed by a doctor. However, consult a doctor immediately if you have a fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination. Do not stop using any medications without a doctor's advice.
AzacitidineFingolimod
Severe
How does the drug interact with Azadine Injection 30 ml:
The use of fingolimod in conjunction with Azadine Injection 30 ml may raise the risk of severe infections.

How to manage the interaction:
Co-administration of Azadine Injection 30 ml with Fingolimod can possibly result in an interaction, but it can be taken if your doctor has advised it. However, Consult a doctor immediately if you have a fever, chills, diarrhoea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include vegetables and fruits in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.
  • Get optimal sleep; rest well.
  • Drink enough water and eat a balanced diet.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Azadine Injection Substitute

Substitutes safety advice
  • Xpreza 100 mg Injection 1's

    by Others

    3512.10per tablet
  • Azatend Injection 1's

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    3243.10per tablet
  • Azzure Injection 1's

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    7380.00per tablet
  • Azaplast 100 mg Injection 1's

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    3344.57per tablet
  • Azactiv 100 mg Injection 1's

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    2394.90per tablet
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Alcohol

Consult your doctor

It is not known if alcohol affects Azadine Injection. Please consult your doctor.

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Pregnancy

Unsafe

Azacitidine belongs to pregnancy category D. Azadine Injection should not be used during pregnancy as it may harm the baby. Consult the doctor immediately if you become pregnant during treatment with Azadine Injection.

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Breast Feeding

Unsafe

It is unknown if Azacitidine passes into breast milk. Breastfeeding is not recommended during treatment with Azadine Injection.

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Driving

Caution

Azadine Injection may cause dizziness and tiredness. Avoid driving or operating machinery if you experience any side effects that might lessen your ability to do so.

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Liver

Caution

If you have a history of liver disease, inform your doctor before receiving Azadine Injection. This medicine should be used with caution in patients with severe pre-existing liver impairment.

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Kidney

Caution

If you have a history of kidney disease, inform your doctor before receiving Azadine Injection. Monitoring patients with kidney impairment is advised.

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Children

Unsafe

Azadine Injection is not recommended for children below 18 years as safety and effectiveness have not been established.

FAQs

Azadine Injection is used to treat Myelodysplastic syndrome, chronic myelomonocytic leukaemia, and acute myeloid leukaemia.
Azadine Injection works by preventing cancer cells from growing. Thereby, it helps treat cancer.
Men should avoid fathering a child whilst on treatment with Azadine Injection. Consult the doctor if you wish to conserve your sperm before starting the treatment. Use effective contraception during the treatment with Azadine Injection and for three months after stopping the treatment.
Azadine Injection may cause a serious immune reaction known as differentiation syndrome. Consult the doctor immediately if you experience fever, rash, difficulty breathing, cough, decreased urine, rapid weight gain, low blood pressure, or swelling of the legs or arms.
No, Azadine Injection is not a vesicant. It is a cytotoxic chemotherapy drug used to treat certain types of blood cancer, such as myelodysplastic syndrome (MDS). It is not known to cause severe tissue damage if it leaks from the injection site.
No, Azadine Injection does not cause hair loss.
Yes, Azadine Injection is a type of chemotherapy. It is used to treat certain types of blood cancers, such as myelodysplastic syndrome (MDS) and some forms of leukaemia.
Yes, Azadine Injection is a cytotoxic drug. It works by interfering with the growth of cancer cells, which helps to slow down or stop their multiplication.
The common side effects of Azadine Injection are nausea, vomiting, diarrhoea, constipation, weakness, headache, and injection site reactions. If any of these side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - AZA0046

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