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Written By , M Pharmacy
Reviewed By , MPharma., PhD
Last Updated Jan 1, 2025 | 9:32 AM IST

Azadine Injection is used to treat Myelodysplastic syndrome, chronic myelomonocytic leukaemia, and acute myeloid leukaemia. It contains Azacitidine, a nucleoside metabolic inhibitor which works by preventing cancer cells from growing. It incorporates into the genetic material of the cells and interferes with the production of new DNA and RNA. This helps correct problems with the maturation and growth of young blood cells in the bone marrow, which causes myelodysplastic disorders.

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Prescription drug

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Composition :

AZACITIDINE-100MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

PARENTERAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Azadine Injection

Azadine Injection belongs to the group of medicines called anti-metabolites used in adults with higher-risk myelodysplastic syndromes, chronic myelomonocytic leukaemia, and acute myeloid leukaemia. These conditions affect the bone marrow and could cause problems with normal blood cell production.

Azadine Injection contains Azacitidine, which works by preventing cancer cells from growing. It helps the bone marrow in the production of normal blood cells and kills abnormal cells in the bone marrow.

In some cases, Azadine Injection may cause side effects such as nausea, vomiting, diarrhoea, constipation, weakness, headache, and injection site reactions. Most of these side effects may not require medical attention and resolve gradually over time. Do not be reluctant to talk with your doctor if any of the side effects persist or worsen.

Do not use Azadine Injection if you are pregnant or breastfeeding. Consult a doctor immediately if you become pregnant during treatment with Azadine Injection. This medicine is not recommended for children as safety and effectiveness have not been established. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

Uses of Azadine Injection

Treatment of Myelodysplastic syndrome, chronic myelomonocytic leukaemia, and acute myeloid leukaemia

Medicinal Benefits

Azadine Injection belongs to the group of medicines called anti-metabolites used to treat myelodysplastic syndromes, chronic myelomonocytic leukaemia, and acute myeloid leukaemia. Azadine Injection contains Azacitidine, a nucleoside metabolic inhibitor which works by preventing cancer cells from growing. It incorporates into the genetic material of the cells and interferes with the production of new DNA and RNA. This helps correct problems with the maturation and growth of young blood cells in the bone marrow, which causes myelodysplastic disorders.

Side Effects of Azadine Injection

  • Reduced blood count (red blood count, white blood count, and platelets)
  • Nausea
  • Vomiting
  • Diarrhoea
  • Constipation
  • Headache
  • Tiredness
  • Dizziness
  • Pneumonia
  • Injection site reaction (redness, pain or a skin reaction)

Directions for Use

Azadine Injection will be administered by a qualified physician; do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not use Azadine Injection if you are allergic to any of its components, have advanced liver cancer, or are breastfeeding. Inform the doctor if you have a low number of platelets, red or white blood cells, heart condition or heart attack, lung, kidney or liver diseases. Seek immediate medical attention if you experience symptoms of liver failure (jaundice, abdominal bloating, shaking, drowsiness, and easy bruising), kidney failure (back pain, increased thirst, swelling of legs and feet, reduced passing of water, dizziness, rapid pulse, nausea, vomiting, reduced appetite, confusion, fatigue or restlessness), fever, pneumonia (shortness of breath or chest pain accompanied with fever), low levels of platelets (bleeding such as blood in stools due to bleeding in the stomach), or allergic reaction (rash, difficulty breathing, itching, or swelling of lips).

Therapeutic Class

CHEMOTHERAPY

Drug-Drug Interactions

verifiedApollotooltip
AzacitidineYellow fever vaccine
Critical
AzacitidineNatalizumab
Severe

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include vegetables and fruits in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.
  • Get optimal sleep; rest well.
  • Drink enough water and eat a balanced diet.

Habit Forming

No

How Azadine Injection Works

Azadine Injection contains Azacitidine, which works by preventing cancer cells from growing. It helps the bone marrow in the production of normal blood cells and kills abnormal cells in the bone marrow.

What if I have taken an overdose of Azadine Injection

As Azadine Injection is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away. Overdose of Azadine Injection may cause diarrhoea, nausea and vomiting.
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Alcohol

Consult your doctor

It is not known if alcohol affects Azadine Injection. Please consult your doctor.

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Pregnancy

Unsafe

Azacitidine belongs to pregnancy category D. Azadine Injection should not be used during pregnancy as it may harm the baby. Consult the doctor immediately if you become pregnant during treatment with Azadine Injection.

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Breast Feeding

Unsafe

It is unknown if Azacitidine passes into breast milk. Breastfeeding is not recommended during treatment with Azadine Injection.

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Driving

Caution

Azadine Injection may cause dizziness and tiredness. Avoid driving or operating machinery if you experience any side effects that might lessen your ability to do so.

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Liver

Caution

If you have a history of liver disease, inform your doctor before receiving Azadine Injection. This medicine should be used with caution in patients with severe pre-existing liver impairment.

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Kidney

Caution

If you have a history of kidney disease, inform your doctor before receiving Azadine Injection. Monitoring patients with kidney impairment is advised.

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Children

Unsafe

Azadine Injection is not recommended for children below 18 years as safety and effectiveness have not been established.

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - AZA0046

Author Details

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FAQs

Azadine Injection is used to treat Myelodysplastic syndrome, chronic myelomonocytic leukaemia, and acute myeloid leukaemia.
Azadine Injection works by preventing cancer cells from growing. Thereby, it helps treat cancer.
Men should avoid fathering a child whilst on treatment with Azadine Injection. Consult the doctor if you wish to conserve your sperm before starting the treatment. Use effective contraception during the treatment with Azadine Injection and for three months after stopping the treatment.
Azadine Injection may cause a serious immune reaction known as differentiation syndrome. Consult the doctor immediately if you experience fever, rash, difficulty breathing, cough, decreased urine, rapid weight gain, low blood pressure, or swelling of the legs or arms.
No, Azadine Injection is not a vesicant. It is a cytotoxic chemotherapy drug used to treat certain types of blood cancer, such as myelodysplastic syndrome (MDS). It is not known to cause severe tissue damage if it leaks from the injection site.
No, Azadine Injection does not cause hair loss.
Yes, Azadine Injection is a type of chemotherapy. It is used to treat certain types of blood cancers, such as myelodysplastic syndrome (MDS) and some forms of leukaemia.
Yes, Azadine Injection is a cytotoxic drug. It works by interfering with the growth of cancer cells, which helps to slow down or stop their multiplication.
The common side effects of Azadine Injection are nausea, vomiting, diarrhoea, constipation, weakness, headache, and injection site reactions. If any of these side effects persist or worsen, please consult your doctor.

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