Vascel 20IU Injection 1 ml belongs to the class of antidiuretic hormones. It is used to treat diabetes insipidus and to control bleeding from esophagal varices. It can also be used to increase blood pressure in adults with vasodilatory shock who remain hypotensive despite fluids and catecholamines. Diabetes insipidus is a rare form of diabetes, causing the production of large quantities of urine.

Vascel 20IU Injection 1 ml contains Vasopressin, a human-made form of Vasopressin (antidiuretic hormone). When your body cannot produce enough Vasopressin, Vascel 20IU Injection 1 ml is used to replace it. It also helps treat diabetes insipidus (a rare form of diabetes causing the production of large quantities of urine) by increasing the amount of water reabsorption from the kidneys. Vascel 20IU Injection 1 ml helps to control bleeding from esophagal varices by increasing plasma levels of factor VIII activity in patients with bleeding disorders. Besides this, Vasopressin causes vasoconstriction by binding to V1 receptors on vascular smooth muscle. Thus, Vasopressin helps to increase blood pressure in adults with vasodilatory shock who remain hypotensive despite fluids and catecholamines.

Vascel 20IU Injection 1 ml will be administered by a healthcare professional; do not self-administer. The common side effects of Vascel 20IU Injection 1 ml include nausea, vomiting, fatigue, fast or irregular heart rate, hyponatremia (low blood sodium levels), ischemia (restriction in blood supply), and redness/pain/swelling at the injection site. These side effects may not occur in everyone using this medication and gradually resolve over time. If the side effects persist longer or worsen, please seek a doctor's advice.

Before starting Vascel 20IU Injection 1 ml, let your doctor know if you have any medical history of kidney impairment, cerebral vascular disorder, peripheral arterial disease, ischemic heart disease, congestive heart failure, seizures, asthma, fluid retention, or migraine. While using Vascel 20IU Injection 1 ml, avoid drinking large amounts of fluid, including alcohol, since it could lead to the build-up of water in the body. Inform your doctor if you are pregnant or breastfeeding. Vascel 20IU Injection 1 ml can cause water intoxication characterised by drowsiness, being uninterested in anything (listless) and headaches. If you notice any of these signs, seek immediate medical help. If it is not corrected, water intoxication can lead to fits or even coma.

Vascel 20IU Injection 1 ml contains Vasopressin, an antidiuretic (that controls fluid balance) hormone synthesized in the hypothalamus of the pituitary gland. When your body cannot produce enough Vasopressin, Vascel 20IU Injection 1 ml is used to replace it. It helps treat diabetes insipidus. (a rare form of diabetes causing the production of large quantities of urine). Vasopressin increases the amount of water absorbed back into your kidneys. Thus, it helps treat diabetes insipidus. Vascel 20IU Injection 1 ml increases plasma levels of factor VIII activity in patients with bleeding disorders. Thus, it helps to control bleeding from esophageal varices. Besides this, Vasopressin causes vasoconstriction by binding to V1 receptors on vascular smooth muscle. Thus, Vasopressin helps to increase blood pressure in adults with vasodilatory shock who remain hypotensive despite fluids and catecholamines.

• Nausea
• Vomiting
• Fatigue
• Fast or irregular heart rate
• Hyponatremia (low blood sodium levels)
• Ischemia (restriction in blood supply)
• Redness/pain/swelling at the injection site

It is recommended not to use if you are allergic to vasopressin or any of the other ingredients present in Vascel 20IU Injection 1 ml or suffer from any diseases or conditions associated with your blood vessels, especially the blood vessels of your heart, suffer from a certain type of kidney disease called chronic nephritis with nitrogen retention (your doctor will advise you) or if you are intended to receive halogenated anaesthetic agents during surgical procedures. Caution and regular monitoring are essential while using Vascel 20IU Injection 1 ml if you have asthma, allergic conditions, migraine, epilepsy (fits), high blood pressure, heart or kidney disease, obstruction of the blood vessels of the heart, or undergone removal of the pituitary gland. So, before taking the Vascel 20IU Injection 1 ml, let your doctor know about all your medical conditions, sensitivities, and all medications you are using. It may cause maternal adverse reactions like tonic uterine contractions. 

Drug-Drug Interactions: Vascel 20IU Injection 1 ml may interact with antiarrhythmic medication (e.g. amiodarone, dronedarone), anticancer medications (e.g. cabozantinib), antiretroviral medication (e.g. efavirenz), and antibiotic medications (e.g. gatifloxacin).

Drug-Food Interactions: Avoid drinking large amounts of fluids and alcohol while being treated with Vascel 20IU Injection 1 ml.

Drug-Disease Interactions: Vascel 20IU Injection 1 ml interacts with disease conditions, including nephritis (an inflammation of the nephrons, which are part of the kidneys), renal impairment, vascular disease, and fluid overload (a condition where you have too much fluid volume in your body), and hyponatremia (A condition that occurs when the level of sodium in the blood is too low).

• AMIODARONE
• DRONEDARONE
• CABOZANTINIB
• EFAVIRENZ
• GATIFLOXACIN

• Maintain a fibre-rich diet and include healthy carbohydrates from fruits, vegetables and whole grains.
• Reduce the amount of salt and protein in your diet, which will help your kidneys to produce less urine.
• Avoid drinking coffee, tea, cola, energy drinks, or other caffeine sources before bedtime since it can lead to increased urination. 
• Avoid activities that cause dehydration, such as excessive physical exercise or spending time in the heat.
• Optimal water intake is recommended to prevent dehydration due to excessive urination.

• Regular monitoring of electrolytes is essential to rule out chances of fluid imbalance.
• If you are more frequently urinating than usual, it is advised to consult your endocrinologist to check for any hormonal abnormalities.
• Your doctor may advise kidney functioning tests to monitor for renal impairment.

Diabetes insipidus: It is a condition in which the body fails to control fluid balance, resulting in excessive urination. 

Hypotension: Low blood pressure is when blood pressure drops below the normal range. It can cause dizziness, weakness, fainting, and risk of injury from falls. Also, severely low blood pressure can deprive your body of enough oxygen to carry out its functions, damaging your heart and brain. Systolic pressure is the pressure when the heart pumps blood out. On the other hand, diastolic pressure is the pressure in arteries when the heart rests between heartbeats. Ideal blood pressure should be 120/80 mmHg. Hypotension exists when the systolic pressure is less than 90 mmHg, and the diastolic pressure is less than 60 mmHg.