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Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Tykinax 5 Tablet is used to treat Renal Cell Carcinoma. It contains Axitinib, which works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body. It also decreases the blood supply to cancer tumors to slow down the growth of the tumor. In this way, Tykinax 5 Tablet stops the production, spread and growth of cancerous cells.

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Composition :

AXITINIB-5MG

Manufacturer/Marketer :

Dr Reddy's Laboratories Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Tykinax 5 Tablet

Tykinax 5 Tablet is an anti-cancer medicine used in the treatment of renal cell carcinoma. Renal cell carcinoma, also known as kidney cancer, is a disease in which the cancer or malignant cells grow uncontrollably in the kidney and form a tumour.

Tykinax 5 Tablet contains Axitinib as an active ingredient, which belongs to the class of medicines known as kinase inhibitors. It works by inhibiting the action of an enzyme (tyrosine kinase) and thus stops the abnormal growth of cancer cells.

Tykinax 5 Tablet may cause certain side effects such as diarrhea, rash, tiredness, decreased appetite, nausea, vomiting, increased blood pressure, muscle cramps, chest pain, weakness, dizziness, hoarseness, and constipation. Inform your doctor if any of these side effects bother you. Tykinax 5 Tablet should be taken as advised by your doctor.

Avoid taking Tykinax 5 Tablet if you are allergic to it or any other components of it. Before taking Tykinax 5 Tablet , inform your doctor if you have/had liver or kidney disease, gastrointestinal disorders, heart problems, thyroid disorders, or blood disorders. This medicine is known to cause embryo-fetal toxicity. Hence, it is not recommended for use in pregnancy and breastfeeding.

Uses of Tykinax 5 Tablet

Treatment of Renal Cell Carcinoma

Directions for Use

Take Tykinax 5 Tablet as prescribed by the doctor. It can be taken with or without food in a 12-hour interval. Swallow it as a whole with a glass of water. Do not crush, break, or chew the medicine. Avoid taking more than the prescribed dose of medicine.

Medicinal Benefits

Tykinax 5 Tablet contains Axitinib, which is used in treating advanced renal cell carcinoma after failure of prior systemic therapy. It works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body. It also decreases the blood supply to cancer tumors to slow down the growth of the tumor.  In this way, Tykinax 5 Tablet stops the body's production, spread and growth of cancerous cells.

How Tykinax 5 Tablet Works

Tykinax 5 Tablet contains Axitinib as an active ingredient, which belongs to the class of medicines known as kinase inhibitors. It works by inhibiting the action of an enzyme (tyrosine kinase) and thus stops the abnormal growth of cancer cells.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Tykinax 5 Tablet

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Tykinax 5 Tablet may include dizziness, coughing up blood, and seizures. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

To treat your condition effectually, continue taking Tykinax 5 Tablet for the period that your doctor has prescribed. Avoid taking Tykinax 5 Tablet if you are allergic to it or any other components present in it. Caution should be exercised if you have/had liver or kidney disease, any planned surgery, heart disease, stroke, blood or bleeding disorders, or gastrointestinal disorders. Inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment as this medicine is known to cause embryo-fetal toxicity. Breastfeeding should be discontinued in nursing mothers during the treatment as it passes into breast milk and may cause a possible risk to the infant. Avoid driving and operating machines, as this medicine may cause visual disturbances. This medicine is not recommended for use in children below 18 years of age as the safety and efficacy are not established. Tykinax 5 Tablet may cause hypertension, arterial and venous thrombotic events, hemorrhagic events, hypothyroidism, gastrointestinal perforation and fistula, Reversible Posterior Leukoencephalopathy Syndrome (RPLS), elevated liver enzymes in some patients. Hence, inform your doctor about your complete medication and medical history before taking Tykinax 5 Tablet .

Drug-Drug Interactions

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AxitinibFosphenytoin
Severe
AxitinibRitonavir
Severe

Drug-Drug Interactions

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AxitinibFosphenytoin
Severe
How does the drug interact with Tykinax 5 Tablet 14's:
Fosphenytoin may decrease the blood levels of Tykinax 5 Tablet 14's, which may make Tykinax 5 Tablet 14's less effective in treating your condition

How to manage the interaction:
Co-administration of Tykinax 5 Tablet 14's with Fosphenytoin can result in an interaction, but it can be taken if a doctor has advised it. Do not stop using any medications without talking to a doctor.
AxitinibRitonavir
Severe
How does the drug interact with Tykinax 5 Tablet 14's:
Taking Tykinax 5 Tablet 14's with ritonavir may significantly increase the blood levels of Tykinax 5 Tablet 14's.

How to manage the interaction:
There may be a possibility of interaction between Tykinax 5 Tablet 14's and Ritonavir, but it can be taken if prescribed by a doctor. However, if you experience chest pain or pressure, pain in the arms, back, neck, or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood or blood clots, and extreme stomach or abdominal pain, consult a doctor. Do not discontinue any medications without consulting a doctor.
AxitinibNefazodone
Severe
How does the drug interact with Tykinax 5 Tablet 14's:
Co-administration of Tykinax 5 Tablet 14's with nefazodone may cause Tykinax 5 Tablet 14's blood levels to rise significantly, leading to an increased risk of side effects.

How to manage the interaction:
Taking Tykinax 5 Tablet 14's with Nefazodone together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience high blood pressure, diarrhea, nausea, vomiting, constipation, decreased appetite, weight loss, rash, itching or peeling of skin on the hands and feet, chest pain or pressure, pain in the arms, back, neck or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, seizures, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood or blood clots, and severe stomach or abdominal pain, consult a doctor. Do not stop using any medications without a doctor’s advice.
AxitinibNelfinavir
Severe
How does the drug interact with Tykinax 5 Tablet 14's:
When Tykinax 5 Tablet 14's is taken with Nelfinavir, the body's ability to break down Tykinax 5 Tablet 14's may be reduced.

How to manage the interaction:
There may be a possibility of interaction between Tykinax 5 Tablet 14's and Nelfinavir, but it can be taken if prescribed by a doctor. However, if you experience Chest pain or pressure, pain in the arms, back, neck, or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, seizures, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood or blood clots, and extreme stomach or abdominal pain, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
AxitinibDelavirdine
Severe
How does the drug interact with Tykinax 5 Tablet 14's:
Co-administration of Tykinax 5 Tablet 14's with Delavirdine may cause Tykinax 5 Tablet 14's blood levels to rise significantly, leading to an increased risk of side effects.

How to manage the interaction:
Co-administration of Tykinax 5 Tablet 14's with Delavirdine can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience high blood pressure, diarrhea, nausea, vomiting, constipation, decreased appetite, weight loss, rash, itching or peeling of skin on the hands and feet, chest pain or pressure, pain in the arms, back, neck or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, seizures, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood or blood clots, and severe stomach or abdominal pain, consult a doctor. Do not stop using any medications without a doctor's advice.
AxitinibEtravirine
Severe
How does the drug interact with Tykinax 5 Tablet 14's:
Etravirine may decrease the blood levels of Tykinax 5 Tablet 14's, which may make Tykinax 5 Tablet 14's less effective in treating the condition.

How to manage the interaction:
Taking Tykinax 5 Tablet 14's with Etravirine together can result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
AxitinibClarithromycin
Severe
How does the drug interact with Tykinax 5 Tablet 14's:
Co-administration of Clarithromycin may increase the blood levels of Tykinax 5 Tablet 14's may increase side effects.

How to manage the interaction:
Although there is a possible interaction Clarithromycin can be taken with Tykinax 5 Tablet 14's if prescribed by the doctor. Seek immediate medical attention if you develop chest pain or pressure; coughing up or vomiting blood or blood clots; pain in the arms, back, neck, or jaw; swelling; shortness of breath; numbness or weakness on one side of the body; headache; vision changes; seizures, unusual bleeding or bruising; red or black stools; and severe stomach or abdominal pain. Do not discontinue the medication without consulting a doctor.
AxitinibPosaconazole
Severe
How does the drug interact with Tykinax 5 Tablet 14's:
Taking Tykinax 5 Tablet 14's with posaconazole can increase the blood levels of Tykinax 5 Tablet 14's. This may raise the risk of side effects.

How to manage the interaction:
Although there is an interaction between posaconazole and Tykinax 5 Tablet 14's, they can be taken together if prescribed by a doctor. However, if you experience diarrhea, nausea, vomiting, constipation, decreased appetite, weight loss, and rash, itching or peeling of skin on the hands and feet, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
AxitinibLomitapide
Severe
How does the drug interact with Tykinax 5 Tablet 14's:
When Tykinax 5 Tablet 14's is taken with Lomitapide, increases the risk of liver damage.

How to manage the interaction:
Although there is a possible interaction between Tykinax 5 Tablet 14's and Lomitapide, you can take these medicines together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact the doctor right away. Do not discontinue any medications without consulting a doctor.
AxitinibLeflunomide
Severe
How does the drug interact with Tykinax 5 Tablet 14's:
When Tykinax 5 Tablet 14's is taken with Leflunomide, the risk of liver problems increases.

How to manage the interaction:
Although there is an interaction between leflunomide and Tykinax 5 Tablet 14's can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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AXITINIB-5MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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AXITINIB-5MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consuming grapefruit or grapefruit juice might raise the medication's levels in the blood leading to side effects such as high blood pressure, diarrhea, nausea, vomiting, constipation, decreased appetite, weight loss, and rash, itching or peeling of skin on the hands and feet. Avoid consuming grapefruit or grapefruit juice during treatment with Tykinax 5 Tablet 14's.

Diet & Lifestyle Advise

  • Physical activity helps strengthen muscles, reduces fatigue, helps in weight loss, and gives strength. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Getting adequate sleep as resting helps improve your health and mental ability and improves attention.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Eat food rich in antioxidants such as berries, spinach, etc.
  • Foods containing fibre help in better digestion. These include beans, peas, lentils, whole grains, nuts, and seeds.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Tykinax 5 Tablet Substitute

Substitutes safety advice
  • Axpero 5 mg Tablet 14's

    by AYUR

    141.08per tablet
  • INLYTA 5MG TABLETLET 14'S

    2623.47per tablet
  • Bexinib 5mg Tablet 14's

    357.58per tablet
  • Axzyb Tablet 30's

    114.80per tablet
  • Raxitinib 5 mg Tablet 14's

    148.11per tablet
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Alcohol

Caution

Limit alcohol consumption while taking Tykinax 5 Tablet .

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Pregnancy

Unsafe

Tykinax 5 Tablet is not recommended for use in pregnancy as it may cause embryo-fetal toxicity and harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before taking Tykinax 5 Tablet . You should not become pregnant while you are taking Tykinax 5 Tablet . Using effective birth control methods while on treatment with Tykinax 5 Tablet is suggested.

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Breast Feeding

Caution

It is not known whether Tykinax 5 Tablet passes into breastmilk. Hence, if you are breastfeeding, inform your doctor before taking Tykinax 5 Tablet . Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Unsafe

Tykinax 5 Tablet may cause dizziness and visual disturbances in some patients. Hence, do not drive, operate machinery, or engage in any activity that needs clear vision until you are confident that you can do so safely while you are on treatment with Tykinax 5 Tablet .

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Liver

Caution

If you have a pre-existing or a history of liver problems, tell your doctor before taking this medicine. Tykinax 5 Tablet is known to cause elevated liver enzymes, which may be fatal. Hence, this medicine should be taken cautiously in patients with moderate liver impairment. Your doctor may suggest tests to monitor your liver function while on treatment with this medicine.

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Kidney

Caution

If you have a pre-existing or a history of kidney diseases, inform your doctor before taking Tykinax 5 Tablet . Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Tykinax 5 Tablet is not recommended for use in children below 18 years of age as the safety and efficacy is not established.

FAQs

Tykinax 5 Tablet is used to treat Renal Cell Carcinoma.
Tykinax 5 Tablet contains Axitinib, which works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells.
Tykinax 5 Tablet is safe to be taken by a diabetic person. However, take Tykinax 5 Tablet only after consulting with a doctor, as they may adjust the dosing according to your condition.
Tykinax 5 Tablet may cause thyroid dysfunction, leading to decreased thyroid hormone levels. This effect causes hypothyroidism. So, notify your doctor if you feel extremely tired, colder than others, sudden weight gain/ weight loss, hair loss, or change in voice while using this medicine.
The possible signs and symptoms of kidney cancer are haematuria (blood in urine), low back pain on one side, fever, fatigue, weight loss, loss of appetite, anaemia (low blood count), and a lump on the side or lower back.
Tykinax 5 Tablet should be taken for as long as it has been prescribed by the doctor. The doctor will determine the duration of the treatment based on your condition.
Seek medical attention immediately if you have swelling in your lower legs, fast heartbeats, or trouble breathing as it may be a sign of a heart problem.
Your doctor may suggest blood tests, and liver & kidney function tests before starting Tykinax 5 Tablet . If you are female, you will have to take a pregnancy test before starting treatment.
People who are allergic to any of the components in Tykinax 5 Tablet should not take this medicine. It is also not recommended during pregnancy and breastfeeding.
Yes, Tykinax 5 Tablet might decrease fertility in men and women. Talk to the doctor if you have any concerns regarding fertility during treatment with Tykinax 5 Tablet .
Fatigue could be a side effect of Tykinax 5 Tablet . To cope with fatigue rest properly, eat healthy food, limit alcohol/caffeine, and manage stress. However, consult the doctor if you have excessive tiredness as it could be a sign of heart failure.
Consult your doctor if you get tired more easily, generally feel colder than other people, or your voice deepens whilst taking this medicine as these could be signs of the thyroid problem. The doctor will recommend thyroid function tests before and during treatment with Tykinax 5 Tablet .
Posterior Reversible Leukoencephalopathy Syndrome is a neurological condition characterised by headache, seizures (fits), confusion, and changes in vision with or without high blood pressure. Consult the doctor immediately if you notice these symptoms.
Swelling of the abdomen, legs or ankles, protruding neck veins, excessive tiredness, and shortness of breath could be an indication of heart failure. Consult the doctor if you experience these symptoms.
Store Tykinax 5 Tablet at room temperature, in a dry place. Keep out of sight and reach of children.
Tykinax 5 Tablet may cause side effects such as diarrhoea, rash, tiredness, decreased appetite, nausea, vomiting, increased blood pressure, muscle cramps, chest pain, weakness, dizziness, hoarseness, and constipation. Inform your doctor if any of these side effects bother you.

Country of origin

India

Manufacturer/Marketer address

Dr. Reddy'S Laboratories Ltd., 8-2-337, Road No. 3, Banjara Hills, Hyderabad, Telangana 500034, India
Other Info - TYK0004

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