Axishil 5mg Tablet is an anti-cancer medicine used in the treatment of renal cell carcinoma. Renal cell carcinoma, also known as kidney cancer, is a disease in which the cancer or malignant cells grow uncontrollably in the kidney and form a tumour.

Axishil 5mg Tablet contains Axitinib as an active ingredient, which belongs to the class of medicines known as kinase inhibitors. It works by inhibiting the action of an enzyme (tyrosine kinase) and thus stops the abnormal growth of cancer cells.

Axishil 5mg Tablet may cause certain side effects such as diarrhea, rash, tiredness, decreased appetite, nausea, vomiting, increased blood pressure, muscle cramps, chest pain, weakness, dizziness, hoarseness, and constipation. Inform your doctor if any of these side effects bother you. Axishil 5mg Tablet should be taken as advised by your doctor.

Avoid taking Axishil 5mg Tablet if you are allergic to it or any other components of it. Before taking Axishil 5mg Tablet, inform your doctor if you have/had liver or kidney disease, gastrointestinal disorders, heart problems, thyroid disorders, or blood disorders. This medicine is known to cause embryo-fetal toxicity. Hence, it is not recommended for use in pregnancy and breastfeeding.

Axishil 5mg Tablet contains Axitinib, which is used in treating advanced renal cell carcinoma after failure of prior systemic therapy. It works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body. It also decreases the blood supply to cancer tumors to slow down the growth of the tumor.  In this way, Axishil 5mg Tablet stops the body's production, spread and growth of cancerous cells.

To treat your condition effectually, continue taking Axishil 5mg Tablet for the period that your doctor has prescribed. Avoid taking Axishil 5mg Tablet if you are allergic to it or any other components present in it. Caution should be exercised if you have/had liver or kidney disease, any planned surgery, heart disease, stroke, blood or bleeding disorders, or gastrointestinal disorders. Inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment as this medicine is known to cause embryo-fetal toxicity. Breastfeeding should be discontinued in nursing mothers during the treatment as it passes into breast milk and may cause a possible risk to the infant. Avoid driving and operating machines, as this medicine may cause visual disturbances. This medicine is not recommended for use in children below 18 years of age as the safety and efficacy are not established. Axishil 5mg Tablet may cause hypertension, arterial and venous thrombotic events, hemorrhagic events, hypothyroidism, gastrointestinal perforation and fistula, Reversible Posterior Leukoencephalopathy Syndrome (RPLS), elevated liver enzymes in some patients. Hence, inform your doctor about your complete medication and medical history before taking Axishil 5mg Tablet.

Drug-Drug Interactions: Axishil 5mg Tablet may have interaction with strong CYP3A4/5 inhibitors (clarithromycin, diltiazem, erythromycin, itraconazole, ketoconazole, ritonavir), strong CYP3A4/5 inducers (carbamazepine, rifampicin, phenytoin, phenobarbitone, dexamethasone).

Drug-Food Interactions: Avoid alcohol consumption and smoking.

Dug-Disease Interactions: Tell your doctor if you have liver or kidney disease, heart problems, GI perforation, lung toxicity, thyroid dysfunction, or thromboembolism before starting the treatment.

• CLARITHROMYCIN
• ITRACONAZOLE
• KETOCONAZOLE
• RITONAVIR
• DILTIAZEM
• CARBAMAZEPINE
• PHENYTOIN
• RIFAMPICIN
• DEXAMETHASONE

• Physical activity helps strengthen muscles, reduces fatigue, helps in weight loss, and gives strength. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
• Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
• Getting adequate sleep as resting helps improve your health and mental ability and improves attention.
• De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
• Eat food rich in antioxidants such as berries, spinach, etc.
• Foods containing fibre help in better digestion. These include beans, peas, lentils, whole grains, nuts, and seeds.
• Avoid smoking and alcohol consumption.
• Maintain a healthy weight.

• Your doctor may suggest periodic liver function tests and urine test to monitor the function of the liver and presence of protein in urine due to the use of Axishil 5mg Tablet.
• It is advised to use contraceptive pills while using Axishil 5mg Tablet to prevent pregnancy.
• Seek medical attention immediately if you have swelling in your lower legs, fast heartbeats, or trouble breathing as it may be a sign of a heart problem.

Renal Cell Carcinoma: Also known as kidney cancer. It is the most common type of cancer seen in adults. This condition occurs when cancer/ malignant cells grow uncontrollably in the kidney and form a tumor. Advanced kidney cancer (metastatic renal cell carcinoma) occurs when the malignant cells spread to other parts of the body. Symptoms include red, orange, or pink-coloured urine due to the presence of blood in the urine.