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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
TOPIRATE 25MG TABLET is primarily indicated in the treatment of epilepsy and it can also be taken to prevent migraine. It contains Topiramate, which works by controlling the electrical activity of the brain. Thereby, it controls seizures and relieves the symptoms of migraine. It may cause side effects such as feeling sleepy, dizziness, diarrhoea and feeling sick. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

TOPIRAMATE-25MG

Manufacturer/Marketer :

Pulse Pharmaceuticals

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About TOPIRATE 25MG TABLET

TOPIRATE 25MG TABLET belongs to a group of medicines called “antiepileptic (AED)/ anticonvulsant agent' that is primarily indicated in the treatment of epilepsy (Monotherapy and Adjunctive therapy) and It can also be taken to prevent migraine. Epilepsy is a chronic disorder that is responsible for causing unprovoked, recurrent seizures in the body. A seizure is a sudden attack in the brain that makes a person lose control of their actions. Migraine is a mental condition that often causes intense or debilitating headaches with difficulty speaking, nausea, vomiting, and sensitivity to light or sound.

TOPIRATE 25MG TABLET is responsible for restoring the balance of neural activity by diminishing the spread of seizure movement in the brain. By controlling the electrical activity of the brain, it controls seizures and relieves the symptoms of migraine. Take TOPIRATE 25MG TABLET in an empty stomach without food with one glass of water. TOPIRATE 25MG TABLET is only available on prescription. It comes as tablets or capsules intended to be taken by mouth only. Swallow the medication as a whole without crushing or breaking it. TOPIRATE 25MG TABLET doses are sometimes advised according to the weight of children so the doctor will change the dose if the child gains or lose weight.

The possible side effects of topiramate include feeling sleepy, dizziness, diarrhoea and feeling sick. Some of the side effects do not even require medical attention and these are usually mild and go away by themselves. Consult with the doctor if any of these side effects continue or get worse with time.

The use of $mame is restricted in persons who are hypersensitive to it, so tell your doctor if you have any allergy to any of the chemical constituents present in this medicine. Tell your doctor if you ever had or already dealing with diarrhoea, glaucoma, metabolic acidosis, lung disease, breathing problems, liver disease, a blood disorder called acute porphyria etc. If a woman is pregnant or planning to pregnant then they should tell their doctor as the use of this medicine during pregnancy may increase the risk of cleft lip and/or cleft palate which is a birth defect in the newborn that may develop during early pregnancy.

Uses of TOPIRATE 25MG TABLET

Treatment of Epilepsy, Migraine.

Directions for Use

Tablet: It can be taken irrespective of meals. Swallow the tablet as a whole with a glass of water. Do not chew the tablet. Sprinkle capsule: You may swallow the capsule as a whole or you may open the capsule and sprinkle the entire contents on a teaspoon of soft food. Drink fluids immediately after eating this medicine and food mixture to make sure it is swallowed. Do not store this mixture for later use.

Medicinal Benefits

TOPIRATE 25MG TABLET is an antiepileptic (AED) medicine that is used to treat epilepsy in mono or adjunctive therapy and migraine. In Monotherapy epilepsy, TOPIRATE 25MG TABLET is suggested for patients above 2 years of age with partial-onset or primary generalized tonic-clonic seizures. In Adjunctive therapy epilepsy, TOPIRATE 25MG TABLET is suggested in patients of 2 to 16 years of age with partial-onset seizures or primary generalized tonic-clonic seizures while in patients more than 2 years of age, TOPIRATE 25MG TABLET is suggested in patients with seizures associated with Lennox-Gastaut syndrome (LGS). In migraine, TOPIRATE 25MG TABLET is suggested for prophylaxis of migraine. TOPIRATE 25MG TABLET works by blocking the voltage-dependent sodium and calcium channels and increasing the inhibitory actions of GABA. In epilepsy, TOPIRATE 25MG TABLET controls the uncontrolled activity of nerves in the brain and thus prevents or controls seizures. While in migraine, TOPIRATE 25MG TABLET tranquilizes the overactive nerve cells in the brain that are responsible for causing migraine.

How TOPIRATE 25MG TABLET Works

TOPIRATE 25MG TABLET is responsible for restoring the balance of neural activity by diminishing the spread of seizure movement in the brain. By controlling the electrical activity of the brain, it controls seizures and relieves the symptoms of migraine.

Storage

Store in a cool and dry place away from sunlight

Side Effects of TOPIRATE 25MG TABLET

  • Tingling of the arms and legs
  • Not feeling hungry
  • Nausea
  • Change in taste
  • Diarrhoea
  • Weight loss
  • Nervousness
  • Upper respiratory tract infection

What if I have taken an overdose of TOPIRATE 25MG TABLET

Do not take more than the prescribed dose of TOPIRATE 25MG TABLET as it may cause overdose. The symptoms of overdose include drowsiness, blurred vision, speech disturbance, convulsions (fits), double vision, abnormal coordination, stupor (a state of insensibility or near-unconsciousness), stomach pain, low blood pressure, lethargy, mentation impaired, depression, agitation and dizziness. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

TOPIRATE 25MG TABLET may cause a congenital disability called cleft lip in unborn baby, so the use of this medicine is not allowed in pregnant females. TOPIRATE 25MG TABLET may increase the body temperature and reduce sweating, so one should report it to the doctor if they are noticing decreased sweating and hot, dry skin. TOPIRATE 25MG TABLET may enhance the level of acid in the blood so one should tell their doctor if they have irregular heartbeats or loss of hunger. Before taking TOPIRATE 25MG TABLET, tell the doctor if you have diarrhoea, metabolic acidosis, eye problems, liver disease. TOPIRATE 25MG TABLET may affect the working of contraceptives that include the combined pill, vaginal ring, patches,progestogen-only contraceptive pill, and emergency contraception. So, one should tell their doctor if they are using any contraceptives to prevent pregnancy.

Drug-Drug Interactions

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TopiramateDesogestrel
Severe
TopiramateDoxepin
Severe

Drug-Drug Interactions

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TopiramateDesogestrel
Severe
How does the drug interact with TOPIRATE 25MG TABLET:
When Desogestrel is taken with TOPIRATE 25MG TABLET may reduce the blood levels and effects of Desogestrel.

How to manage the interaction:
There may be a possibility of interaction between Desogestrel and TOPIRATE 25MG TABLET, but it can be taken if prescribed by a doctor. If you notice any of these symptoms or if you're looking for other birth control options, it's important to contact your doctor right away. Do not stop using any medications without first talking to your doctor.
TopiramateDoxepin
Severe
How does the drug interact with TOPIRATE 25MG TABLET:
Coadministration of TOPIRATE 25MG TABLET and doxepin can increase body temperature and decrease sweating.

How to manage the interaction:
Co-administration of TOPIRATE 25MG TABLET and doxepin can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like drowsiness, dizziness, lightheadedness, decreased sweating or a fever, consult the doctor immediately. Drink plenty of fluids during warm weather and when exercising, and avoid activities requiring mental alertness, such as driving or operating hazardous machinery, until you know how the medications affect you. Do not stop using any medications without a doctor's advice.
TopiramateImipramine
Severe
How does the drug interact with TOPIRATE 25MG TABLET:
Combining Imipramine with TOPIRATE 25MG TABLET can increase the risk of overheating and reduced sweating.

How to manage the interaction:
There may be a possibility of interaction between TOPIRATE 25MG TABLET and Imipramine, but it can be taken if prescribed by a doctor. When taken together, your doctor can recommend other options that won't cause any problems. Just be careful and make sure to keep an eye out for any signs of reduced sweating and high body temperature. Do not discontinue any medications without consulting a doctor.
TopiramateClozapine
Severe
How does the drug interact with TOPIRATE 25MG TABLET:
TOPIRATE 25MG TABLET can cause increased body temperature and decreased sweating, and these effects may be worsened when combined with medications like clozapine.

How to manage the interaction:
Taking TOPIRATE 25MG TABLET with Clozapine together can possibly result in an interaction, but it can be taken if your doctor has advised it. Your doctor can recommend other options that won't cause problems when taken together. It's important to be careful and keep a close eye on your health. Do not stop using any medications without talking to your doctor.
TopiramateChlorpheniramine
Severe
How does the drug interact with TOPIRATE 25MG TABLET:
Taking Chlorpheniramine with TOPIRATE 25MG TABLET can increase the risk of side effects including high body temperatures and decreased sweating, sun stroke.

How to manage the interaction:
Although taking Chlorpheniramine and TOPIRATE 25MG TABLET together can result in an interaction, it can be taken if your doctor has advised it. During warm weather and when exercising, you should drink lots of fluids. If your sweating is less than usual or you have a fever, if you feel lightheaded or dizzy, consult a doctor. Avoid activities requiring mental attention such as driving or operating dangerous machinery. Do not discontinue any medications without a doctor's advice.
TopiramateThioridazine
Severe
How does the drug interact with TOPIRATE 25MG TABLET:
Combining TOPIRATE 25MG TABLET with Thioridazine can increase the risk of CNS depression.

How to manage the interaction:
Co-administration of TOPIRATE 25MG TABLET with Thioridazine can possibly result in an interaction, but it can be taken if your doctor has advised it. Your doctor can recommend other options that won't cause problems when taken together. It's important to be careful and keep a close eye on your health. Do not stop using any medications without first talking to your doctor.
TopiramateBuprenorphine
Severe
How does the drug interact with TOPIRATE 25MG TABLET:
When buprenorphine is used with TOPIRATE 25MG TABLET, it may lead to significant adverse effects such as respiratory difficulties, unconsciousness.

How to manage the interaction:
Concomitant administration of buprenorphine alongside TOPIRATE 25MG TABLET can result in an interaction, it can be taken if a doctor has advised it. Do not exceed the doses, frequency, or duration of usage advised by a doctor. You should avoid driving or operating hazardous machinery until you're aware of how these medications effect you. Consult a doctor if you have any questions or concerns. Do not discontinue any medications without consulting a doctor.
TopiramateOxybutynin
Severe
How does the drug interact with TOPIRATE 25MG TABLET:
Co-administration of Oxybutynin and TOPIRATE 25MG TABLET can increase the risk of developing body temperature and decrease sweating.

How to manage the interaction:
Co-administration of Oxybutynin and TOPIRATE 25MG TABLET can lead to an interaction, it can be taken if advised by your doctor. Contact your doctor immediately if you experience symptoms like decreased sweating, fever, or drowsiness. Drink plenty of fluids during warm weather and when exercising, and do not discontinue any medications without consulting a doctor.
TopiramateMeclizine
Severe
How does the drug interact with TOPIRATE 25MG TABLET:
Taking TOPIRATE 25MG TABLET with meclizine can cause increased body temperature and decreased sweating.

How to manage the interaction:
Although there is a interaction between Meclizine and TOPIRATE 25MG TABLET, but it can be taken together if prescribed by your doctor. However, if you experience drowsiness, dizziness, or lightheadedness, increased body temperature and decreased sweating contact your doctor. Do not stop using any medications without a doctor's advice.
TopiramateDiphenhydramine
Severe
How does the drug interact with TOPIRATE 25MG TABLET:
TOPIRATE 25MG TABLET can induce elevated body temperature and decreased sweating, which can be exacerbated when combined with drugs that have similar effects, such as diphenhydramine.

How to manage the interaction:
Although taking Diphenhydramine with TOPIRATE 25MG TABLET can possibly result in an interaction, they can be taken together if prescribed by your doctor. It is essential to stay hydrated by drinking enough fluids, especially in hot weather and when doing physical activity. Contact your doctor immediately if you notice decreased sweating, fever, dizziness, drowsy, or lightheadedness. Do not discontinue using any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a balanced diet that consists of good fats, proteins, carbohydrates, vegetables, and fruit which helps the body and brain to work properly and keep a person healthy and energetic.

  • Fatigue is one of the primary reasons that trigger seizures in the body, so sleeping properly can help in relaxing the brain.

  • One should avoid the consumption of alcohol as it can trigger seizures in patients. Even one or two glasses can trigger epilepsy and worsen the side effects of TOPIRATE 25MG TABLET.

  • Keep yourself happy and avoid taking emotional stress as stress causes seizures. Persons who maintain healthy stress levels have reported that they have responded well to the medicine.

Habit Forming

No

Therapeutic Class

ANTICONVULSANT

TOPIRATE 25MG TABLET Substitute

Substitutes safety advice
  • Topamac 25 mg Tablet 10's

    12.69per tablet
  • Topaz-25 Tablet 15's

    7.65per tablet
  • Topirol 25 Tablet 10's

    9.54per tablet
  • Topamed-25 Tablet 10's

    by AYUR

    7.20per tablet
  • Nextop 25 Tablet 10's

    8.73per tablet
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Alcohol

Caution

Do not consume alcohol while taking TOPIRATE 25MG TABLET as alcohol can worsen the side effects of the TOPIRATE 25MG TABLET including sleepiness and dizziness

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Pregnancy

Unsafe

TOPIRATE 25MG TABLET is a Category D pregnancy drug. It is not recommended for use during pregnancy as it may cause an increase in the risk of the cleft lip that is a congenital disability in the unborn baby.

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Breast Feeding

Caution

Caution is advised when TOPIRATE 25MG TABLET is using in nursing mothers as this medicine may pass into breast milk.

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Driving

Caution

Some persons may continue to face unpredictable seizures even after taking TOPIRATE 25MG TABLET and this medicine also affects thinking and motor skills and may affect vision. So patients should take caution before engaging in any activity including driving or operating any machine.

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Liver

Caution

TOPIRATE 25MG TABLET should be used with caution in patients with liver disease as the dosage needs to be reduced in patients dealing with liver disease.

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Kidney

Caution

TOPIRATE 25MG TABLET should be used with caution in patients with kidney disease as the dosage needs to be reduced in patients dealing with kidney disease.

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Children

Safe if prescribed

TOPIRATE 25MG TABLET is safe to use in children above 2 years only if prescribed by the doctor.

FAQs

TOPIRATE 25MG TABLET is primarily indicated in the treatment of epilepsy (Monotherapy and Adjunctive therapy), and it can also be used to prevent migraine.
Seizures can happen when the brain cells are not working properly or working faster than normal. TOPIRATE 25MG TABLET slows down these electrical signals to stop seizures.
No, you should take rest after taking this medicine as this medicine affects the thinking ability and vision of a person so avoid doing any task that requires mental alertness.
TOPIRATE 25MG TABLET acts by decreasing the spread of seizure activity in the brain. It also restores the normal balance of neurons which in turn calms the brain. In epilepsy, cells present in the brain talk to each other by generating electric signals. When these cells fail to work properly or working faster than normal then it causes seizures. TOPIRATE 25MG TABLET slows down these electrical signals and thus prevents or controls seizures. While in migraine, TOPIRATE 25MG TABLET tranquilizes the overactive nerve cells in the brain that are responsible for causing migraine.
Yes, the use of TOPIRATE 25MG TABLET is safe for long time use if suggested by the doctor.
Yes, TOPIRATE 25MG TABLET may affect the working of contraceptives that include the combined pill, vaginal ring, patches,progestogen-only contraceptive pill, and emergency contraception. Tell your doctor if you are using any type of contraceptives as the doctor may suggest using different types of contraceptives or combined hormonal contraceptives.
No, TOPIRATE 25MG TABLET does not affect fertility.
Generally, one should avoid consuming alcohol while taking TOPIRATE 25MG TABLET as it may make a person feel sleepy or tired and can cause seizures in some people with epilepsy.
Yes, studies have shown that TOPIRATE 25MG TABLET can cause hair loss (alopecia), but it is not a common side effect. If this happens, please consult your doctor and seek appropriate treatment.
Feeling sleepy is one of the most common side effects of TOPIRATE 25MG TABLET. It does not require medical attention, is usually mild and goes away over time. Consult the doctor if any of these side effects continue or worsen with time.
Do not stop taking TOPIRATE 25MG TABLET abruptly unless your doctor instructs you to. If you're using it to prevent migraines, your condition may worsen temporarily after you stop taking it. If you are using TOPIRATE 25MG TABLET for epilepsy, you may get seizures when you stop taking it. To prevent these withdrawal symptoms, your doctor may gradually reduce the dose of your TOPIRATE 25MG TABLET if required.
It depends on the medical condition you are being treated with TOPIRATE 25MG TABLET and response to the treatment.
No, TOPIRATE 25MG TABLET is not intended to treat anxiety.
The severe side effects caused by TOPIRATE 25MG TABLET include signs of glaucoma (blurred vision, difficulty seeing, and eye pain), kidney stones and a kidney infection (pain in your back, belly, or side, a burning sensation when you pee, or cloudy or smelly pee), metabolic acidosis (feeling sleepy, losing your appetite, and having an irregular heartbeat), and not sweating (especially in children). If this happens, consult your doctor immediately and seek medical attention.
Taking valproic acid when you are also taking TOPIRATE 25MG TABLET can cause your body temperature to drop to less than 95°F or 350C or cause tiredness, confusion, or coma. Taking these medicines may also raise the levels of ammonia in your blood. So, do not take these medications together. If you are required to, your doctor may guide you in taking them appropriately.
TOPIRATE 25MG TABLET is safe for children above two years of age only if prescribed by the doctor.
Weight loss and loss of appetite (anorexia) were two of the most commonly reported side effects. If you experience significant changes, seek medical advice from your healthcare professional.
The possible side effects of topiramate include feeling sleepy, dizziness, diarrhoea and feeling sick. Some side effects do not require medical attention; they are usually mild and go away alone. Consult the doctor if any of these side effects continue or worsen with time.

Country of origin

India

Manufacturer/Marketer address

4F10, Ballad Estates, Tarnaka, Hyderabad - 500017, TS, India.
Other Info - TOP0025

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