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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Topirol 25 Tablet is primarily indicated in the treatment of epilepsy and it can also be taken to prevent migraine. It contains Topiramate, which works by controlling the electrical activity of the brain. Thereby, it controls seizures and relieves the symptoms of migraine. It may cause side effects such as feeling sleepy, dizziness, diarrhoea and feeling sick. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

TOPIRAMATE-25MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Topirol 25 Tablet

Topirol 25 Tablet belongs to a group of medicines called “antiepileptic (AED)/ anticonvulsant agent' that is primarily indicated in the treatment of epilepsy (Monotherapy and Adjunctive therapy) and It can also be taken to prevent migraine. Epilepsy is a chronic disorder that is responsible for causing unprovoked, recurrent seizures in the body. A seizure is a sudden attack in the brain that makes a person lose control of their actions. Migraine is a mental condition that often causes intense or debilitating headaches with difficulty speaking, nausea, vomiting, and sensitivity to light or sound.

Topirol 25 Tablet is responsible for restoring the balance of neural activity by diminishing the spread of seizure movement in the brain. By controlling the electrical activity of the brain, it controls seizures and relieves the symptoms of migraine. Take Topirol 25 Tablet in an empty stomach without food with one glass of water. Topirol 25 Tablet is only available on prescription. It comes as tablets or capsules intended to be taken by mouth only. Swallow the medication as a whole without crushing or breaking it. Topirol 25 Tablet doses are sometimes advised according to the weight of children so the doctor will change the dose if the child gains or lose weight.

The possible side effects of topiramate include feeling sleepy, dizziness, diarrhoea and feeling sick. Some of the side effects do not even require medical attention and these are usually mild and go away by themselves. Consult with the doctor if any of these side effects continue or get worse with time.

The use of $mame is restricted in persons who are hypersensitive to it, so tell your doctor if you have any allergy to any of the chemical constituents present in this medicine. Tell your doctor if you ever had or already dealing with diarrhoea, glaucoma, metabolic acidosis, lung disease, breathing problems, liver disease, a blood disorder called acute porphyria etc. If a woman is pregnant or planning to pregnant then they should tell their doctor as the use of this medicine during pregnancy may increase the risk of cleft lip and/or cleft palate which is a birth defect in the newborn that may develop during early pregnancy.

Uses of Topirol 25 Tablet

Treatment of Epilepsy, Migraine.

Directions for Use

Tablet: It can be taken irrespective of meals. Swallow the tablet as a whole with a glass of water. Do not chew the tablet. Sprinkle capsule: You may swallow the capsule as a whole or you may open the capsule and sprinkle the entire contents on a teaspoon of soft food. Drink fluids immediately after eating this medicine and food mixture to make sure it is swallowed. Do not store this mixture for later use.

Medicinal Benefits

Topirol 25 Tablet is an antiepileptic (AED) medicine that is used to treat epilepsy in mono or adjunctive therapy and migraine. In Monotherapy epilepsy, Topirol 25 Tablet is suggested for patients above 2 years of age with partial-onset or primary generalized tonic-clonic seizures. In Adjunctive therapy epilepsy, Topirol 25 Tablet is suggested in patients of 2 to 16 years of age with partial-onset seizures or primary generalized tonic-clonic seizures while in patients more than 2 years of age, Topirol 25 Tablet is suggested in patients with seizures associated with Lennox-Gastaut syndrome (LGS). In migraine, Topirol 25 Tablet is suggested for prophylaxis of migraine. Topirol 25 Tablet works by blocking the voltage-dependent sodium and calcium channels and increasing the inhibitory actions of GABA. In epilepsy, Topirol 25 Tablet controls the uncontrolled activity of nerves in the brain and thus prevents or controls seizures. While in migraine, Topirol 25 Tablet tranquilizes the overactive nerve cells in the brain that are responsible for causing migraine.

How Topirol 25 Tablet Works

Topirol 25 Tablet is responsible for restoring the balance of neural activity by diminishing the spread of seizure movement in the brain. By controlling the electrical activity of the brain, it controls seizures and relieves the symptoms of migraine.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Topirol 25 Tablet

  • Tingling of the arms and legs
  • Not feeling hungry
  • Nausea
  • Change in taste
  • Diarrhoea
  • Weight loss
  • Nervousness
  • Upper respiratory tract infection

What if I have taken an overdose of Topirol 25 Tablet

Do not take more than the prescribed dose of Topirol 25 Tablet as it may cause overdose. The symptoms of overdose include drowsiness, blurred vision, speech disturbance, convulsions (fits), double vision, abnormal coordination, stupor (a state of insensibility or near-unconsciousness), stomach pain, low blood pressure, lethargy, mentation impaired, depression, agitation and dizziness. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Topirol 25 Tablet may cause a congenital disability called cleft lip in unborn baby, so the use of this medicine is not allowed in pregnant females. Topirol 25 Tablet may increase the body temperature and reduce sweating, so one should report it to the doctor if they are noticing decreased sweating and hot, dry skin. Topirol 25 Tablet may enhance the level of acid in the blood so one should tell their doctor if they have irregular heartbeats or loss of hunger. Before taking Topirol 25 Tablet , tell the doctor if you have diarrhoea, metabolic acidosis, eye problems, liver disease. Topirol 25 Tablet may affect the working of contraceptives that include the combined pill, vaginal ring, patches,progestogen-only contraceptive pill, and emergency contraception. So, one should tell their doctor if they are using any contraceptives to prevent pregnancy.

Drug-Drug Interactions

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TopiramateDesogestrel
Severe
TopiramateDexchlorpheniramine
Severe

Drug-Drug Interactions

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TopiramateDesogestrel
Severe
How does the drug interact with Topirol 25 Tablet:
When Desogestrel is taken with Topirol 25 Tablet may reduce the blood levels and effects of Desogestrel.

How to manage the interaction:
There may be a possibility of interaction between Desogestrel and Topirol 25 Tablet, but it can be taken if prescribed by a doctor. If you notice any of these symptoms or if you're looking for other birth control options, it's important to contact your doctor right away. Do not stop using any medications without first talking to your doctor.
TopiramateDexchlorpheniramine
Severe
How does the drug interact with Topirol 25 Tablet:
Co-administration of dexchlorpheniramine with Topirol 25 Tablet can increase the risk of Topirol 25 Tablet side effects like increased body temperature and decreased sweating especially in warm weather.

How to manage the interaction:
Taking Dexchlorpheniramine with Topirol 25 Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience decreased sweating, fever, or drowsiness, contact your doctor immediately. Make sure to hydrate yourself during warm weather or after exercise. Do not discontinue any medications without consulting your doctor.
TopiramateGlycopyrrolate
Severe
How does the drug interact with Topirol 25 Tablet:
Coadministration of Glycopyrrolate with Topirol 25 Tablet can increase the risk or severity of side effects like increased body temperature and decreased sweating.

How to manage the interaction:
Taking Glycopyrrolate with Topirol 25 Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience drowsiness, dizziness, lightheadedness, fever, chills, or decreased sweating, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
TopiramateKetamine
Severe
How does the drug interact with Topirol 25 Tablet:
Using ketamine together with Topirol 25 Tablet may increase side effects.

How to manage the interaction:
Although there is a possible interaction between Ketamine and Topirol 25 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
TopiramateBuprenorphine
Severe
How does the drug interact with Topirol 25 Tablet:
When buprenorphine is used with Topirol 25 Tablet, it may lead to significant adverse effects such as respiratory difficulties, unconsciousness.

How to manage the interaction:
Concomitant administration of buprenorphine alongside Topirol 25 Tablet can result in an interaction, it can be taken if a doctor has advised it. Do not exceed the doses, frequency, or duration of usage advised by a doctor. You should avoid driving or operating hazardous machinery until you're aware of how these medications effect you. Consult a doctor if you have any questions or concerns. Do not discontinue any medications without consulting a doctor.
TopiramateNorethisterone
Severe
How does the drug interact with Topirol 25 Tablet:
Coadministration of Norethisterone with Topirol 25 Tablet can reduce the blood levels and effects of norethindrone in the body. This increases the risk of severe bleeding and unintended pregnancy.

How to manage the interaction:
Taking norethisterone and Topirol 25 Tablet together can result in an interaction; it can be taken if your doctor has advised it. However, if you notice any symptoms of abnormal bleeding, hot flashes or vaginal dryness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
TopiramatePromazine
Severe
How does the drug interact with Topirol 25 Tablet:
Combining Promazine with Topirol 25 Tablet can increase the risk of overheating and reduced sweating.

How to manage the interaction:
Although there is a possible interaction between Topirol 25 Tablet and Promazine, you can take these medicines together if prescribed by your doctor. Your doctor can recommend other options that won't cause problems when taken together. It's important to be careful and keep a close eye on things. Do not stop using any medications without a doctor's advice.
TopiramatePheniramine
Severe
How does the drug interact with Topirol 25 Tablet:
Taking pheniramine with Topirol 25 Tablet can cause increased body temperature and decreased sweating.

How to manage the interaction:
Although there is a interaction between Pheniramine and Topirol 25 Tablet, but it can be taken if prescribed by a doctor. However, if you experience drowsiness, dizziness, or lightheadedness contact your doctor immediately. Do not stop using any medications without talking to your doctor.
TopiramateTriprolidine
Severe
How does the drug interact with Topirol 25 Tablet:
Combining Topirol 25 Tablet with Triprolidine can increase the risk of CNS depression.

How to manage the interaction:
Although there is a possible interaction between Triprolidine and Topirol 25 Tablet, you can take these medicines together if prescribed by your doctor. If you're having any of these symptoms like feeling too hot, feeling sleepy or dizzy, or having trouble thinking clearly, it's important to let your doctor know right away. They may be able to recommend different options for you that won't cause these problems. Do not discontinue any medications without first consulting your doctor.
TopiramateTolterodine
Severe
How does the drug interact with Topirol 25 Tablet:
Using Tolterodine with Topirol 25 Tablet can increase body temperature and decreased sweating.

How to manage the interaction:
Although there is an interaction between Tolterodine and Topirol 25 Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sleepiness, dizziness, or lightheadedness. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a balanced diet that consists of good fats, proteins, carbohydrates, vegetables, and fruit which helps the body and brain to work properly and keep a person healthy and energetic.

  • Fatigue is one of the primary reasons that trigger seizures in the body, so sleeping properly can help in relaxing the brain.

  • One should avoid the consumption of alcohol as it can trigger seizures in patients. Even one or two glasses can trigger epilepsy and worsen the side effects of Topirol 25 Tablet .

  • Keep yourself happy and avoid taking emotional stress as stress causes seizures. Persons who maintain healthy stress levels have reported that they have responded well to the medicine.

Habit Forming

No

Therapeutic Class

ANTICONVULSANT

Topirol 25 Tablet Substitute

Substitutes safety advice
  • Topamac 25 mg Tablet 10's

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    7.20per tablet
  • Nextop 25 Tablet 10's

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  • Topnil 25 Tablet 15's

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Alcohol

Caution

Do not consume alcohol while taking Topirol 25 Tablet as alcohol can worsen the side effects of the Topirol 25 Tablet including sleepiness and dizziness

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Pregnancy

Unsafe

Topirol 25 Tablet is a Category D pregnancy drug. It is not recommended for use during pregnancy as it may cause an increase in the risk of the cleft lip that is a congenital disability in the unborn baby.

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Breast Feeding

Caution

Caution is advised when Topirol 25 Tablet is using in nursing mothers as this medicine may pass into breast milk.

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Driving

Caution

Some persons may continue to face unpredictable seizures even after taking Topirol 25 Tablet and this medicine also affects thinking and motor skills and may affect vision. So patients should take caution before engaging in any activity including driving or operating any machine.

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Liver

Caution

Topirol 25 Tablet should be used with caution in patients with liver disease as the dosage needs to be reduced in patients dealing with liver disease.

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Kidney

Caution

Topirol 25 Tablet should be used with caution in patients with kidney disease as the dosage needs to be reduced in patients dealing with kidney disease.

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Children

Safe if prescribed

Topirol 25 Tablet is safe to use in children above 2 years only if prescribed by the doctor.

FAQs

Topirol 25 Tablet is primarily indicated in the treatment of epilepsy (Monotherapy and Adjunctive therapy), and it can also be used to prevent migraine.

Seizures can happen when the brain cells are not working properly or working faster than normal. Topirol 25 Tablet slows down these electrical signals to stop seizures.

No, you should take rest after taking this medicine as this medicine affects the thinking ability and vision of a person so avoid doing any task that requires mental alertness.

Topirol 25 Tablet acts by decreasing the spread of seizure activity in the brain. It also restores the normal balance of neurons which in turn calms the brain. In epilepsy, cells present in the brain talk to each other by generating electric signals. When these cells fail to work properly or working faster than normal then it causes seizures. Topirol 25 Tablet slows down these electrical signals and thus prevents or controls seizures. While in migraine, Topirol 25 Tablet tranquilizes the overactive nerve cells in the brain that are responsible for causing migraine.

Yes, the use of Topirol 25 Tablet is safe for long time use if suggested by the doctor.

Yes, Topirol 25 Tablet may affect the working of contraceptives that include the combined pill, vaginal ring, patches,progestogen-only contraceptive pill, and emergency contraception. Tell your doctor if you are using any type of contraceptives as the doctor may suggest using different types of contraceptives or combined hormonal contraceptives.

No, Topirol 25 Tablet does not affect fertility.

Generally, one should avoid consuming alcohol while taking Topirol 25 Tablet as it may make a person feel sleepy or tired and can cause seizures in some people with epilepsy.

Yes, studies have shown that Topirol 25 Tablet can cause hair loss (alopecia), but it is not a common side effect. If this happens, please consult your doctor and seek appropriate treatment.

Feeling sleepy is one of the most common side effects of Topirol 25 Tablet . It does not require medical attention, is usually mild and goes away over time. Consult the doctor if any of these side effects continue or worsen with time.

Do not stop taking Topirol 25 Tablet abruptly unless your doctor instructs you to. If you're using it to prevent migraines, your condition may worsen temporarily after you stop taking it. If you are using Topirol 25 Tablet for epilepsy, you may get seizures when you stop taking it. To prevent these withdrawal symptoms, your doctor may gradually reduce the dose of your Topirol 25 Tablet if required.

It depends on the medical condition you are being treated with Topirol 25 Tablet and response to the treatment.

No, Topirol 25 Tablet is not intended to treat anxiety.

The severe side effects caused by Topirol 25 Tablet include signs of glaucoma (blurred vision, difficulty seeing, and eye pain), kidney stones and a kidney infection (pain in your back, belly, or side, a burning sensation when you pee, or cloudy or smelly pee), metabolic acidosis (feeling sleepy, losing your appetite, and having an irregular heartbeat), and not sweating (especially in children). If this happens, consult your doctor immediately and seek medical attention.

Taking valproic acid when you are also taking Topirol 25 Tablet can cause your body temperature to drop to less than 95°F or 350C or cause tiredness, confusion, or coma. Taking these medicines may also raise the levels of ammonia in your blood. So, do not take these medications together. If you are required to, your doctor may guide you in taking them appropriately.

Topirol 25 Tablet is safe for children above two years of age only if prescribed by the doctor.

Weight loss and loss of appetite (anorexia) were two of the most commonly reported side effects. If you experience significant changes, seek medical advice from your healthcare professional.

The possible side effects of topiramate include feeling sleepy, dizziness, diarrhoea and feeling sick. Some side effects do not require medical attention; they are usually mild and go away alone. Consult the doctor if any of these side effects continue or worsen with time.

Country of origin

India

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - TOP0027

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