Tolplus MR Tablet is used to treat muscle spasms. It improves the movement of muscles and provides relief from pain and discomfort caused by the muscle spasm. A muscle spasm occurs due to involuntary contractions of a muscle. A spasm may be a twitch in the muscle or may feel tight or hard, like a knot.

Tolplus MR Tablet is a combination of two drugs: Tolperisone (muscle relaxant) and Paracetamol (pain killer). Tolperisone works on the spinal cord and brain to relieve contraction or muscle stiffness. It also increases the supply of blood to the muscles. Paracetamol is an analgesic (pain reliever) and an antipyretic (fever reducer). It inhibits cyclo-oxygenase (COX) enzymes that further prevent the formation of chemical messengers called 'prostaglandins' (PGs). These prostaglandins are produced at injury sites and cause pain and swelling. By blocking the COX enzyme's effect, lesser PGs are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site.

Your doctor will decide the dose and duration based on the severity of your pain. Common side effects of Tolplus MR Tablet include nausea, vomiting, dry mouth, dizziness, weakness and sleepiness. These side effects are not familiar to everyone and vary individually.

Let your doctor know if you use any prescription and non-prescription medications before starting Tolplus MR Tablet . Inform your doctor if you have any liver, heart or kidney diseases, myasthenia gravis (fatigue of muscles) and phenylketonuria (a genetic disorder that causes an amino acid build-up, phenylalanine) and alcohol dependency. Consult your doctor before taking Tolplus MR Tablet if you are pregnant or planning for pregnancy. Tolplus MR Tablet may cause dizziness, so drive only if you are alert and focused. Tolplus MR Tablet should not be given to children as safety has not been established. Avoid consuming alcohol and Tolplus MR Tablet as it could lead to increased dizziness and risk of liver damage.

Tolplus MR Tablet treats muscle spasms and consists of Tolperisone (muscle relaxant) and Paracetamol (pain killer). Tolperisone is a centrally-acting muscle relaxant. It works on the spinal cord and brain to relieve contraction or muscle stiffness. It also increases the supply of blood to the muscles. Paracetamol is an analgesic (pain reliever) and an antipyretic (fever reducer). It inhibits cyclo-oxygenase (COX) enzymes that further prevent the formation of chemical messengers called 'prostaglandins' (PGs). These prostaglandins are produced at injury sites and cause pain and swelling. By blocking the COX enzyme's effect, fewer PGs are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site.

• Nausea
• Vomiting
• Dry mouth
• Dizziness
• Weakness
• Sleepiness

Inform your doctor if you have any liver, heart or kidney diseases, myasthenia gravis (fatigue of muscles), phenylketonuria (a genetic disorder that causes a build-up of an amino acid, phenylalanine), and alcohol dependency before starting Tolplus MR Tablet . Consult your doctor before taking Tolplus MR Tablet if you are pregnant, planning for pregnancy or breastfeeding. Tolplus MR Tablet may cause dizziness, so drive only if you are alert and focused. Avoid consuming alcohol along with Tolplus MR Tablet as it could lead to increased dizziness and risk of liver damage. Tolplus MR Tablet is not recommended in children as safety and efficacy is not established.

Drug-Drug Interactions: Tolplus MR Tablet may interact with anticoagulants (warfarin), drugs treating vomiting (metoclopramide, domperidone), cholesterol-lowering medications (cholestyramine) and anti-cancer medications (imatinib).

Drug-Food Interactions: Alcohol consumption may cause dizziness and increases the risk of liver damage.

Drug-Disease Interactions: Before using Tolplus MR Tablet , let your doctor know if you have any liver, heart or kidney diseases, myasthenia gravis (fatigue of muscles), phenylketonuria (a genetic disorder that causes a build-up of an amino acid, phenylalanine), and alcohol dependency.

• WARFARIN
• METOCLOPRAMIDE
• DOMPERIDONE
• CHOLESTYRAMINE
• IMATINIB

• Exercising regularly helps in muscle stretching that is less likely to spasm, tear and sprain. Mild exercises such as jogging and walking are helpful for muscle stretching.
• Massages can also be helpful.
• Avoid freezing and hot temperatures.
• Avoid wearing tight-fitting clothes, instead, wear loose garments.
• Rest well and get plenty of sleep.
• To avoid developing pressure sores, change your position at least every two hours.
• Hot or cold therapy can haelp treat muscle spasms. Apply an ice-pack or hot-pack on the muscle for 15-20minutes.
• Stay hydrated, drink plenty of water.

• Let your doctor know that you are taking Tolplus MR Tablet if you are undergoing any medical tests.
• Tolplus MR Tablet may cause fluid retention (oedema), hence it is advised to monitor blood pressure and cardiovascular status in patients with a heart failure history.
• Explain a detail history to the doctor as use of Tolplus MR Tablet is contraindicated in patients with myasthenia gravis.

Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body.

Muscle spasm is the sudden involuntary contractions of the muscle, which can be painful and uncomfortable. When the nerve impulses that control the muscle movements are damaged or interrupted, it could lead to muscle spasms. A spasm may be a twitch in the muscle or may feel tight or hard, like a knot.