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  3. Tecentriq 840 mg Injection 14 ml

Tecentriq 840 mg Injection 14 ml, Pack of 1 INJECTION
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Tecentriq 840 mg Injection is used for the treatment of Non-small cell lung cancer, Hepatocellular carcinoma, Biliary tract cancer, Small cell lung cancer and Metastatic melanoma. It contains Atezolizumab, which works by blocking the action of a certain protein in cancer cells. This helps the person's immune system to fight against the cancer cells, and helps to slow tumor growth.

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Composition :

ATEZOLIZUMAB-840MG

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Tecentriq 840 mg Injection

Tecentriq 840 mg Injection is an anti-cancer medicine used in the treatment of unresectable, stage II-IIIa non-small cell lung cancer (NSCLC). Tecentriq 840 mg Injection is also used in combination with other cancer medicine for the treatment of metastatic NSCLC (bevacizumab, paclitaxel, carboplatin), extensive-stage small cell lung cancer and biliary tract cancer (carboplatin, etoposide), metastatic melanoma (cobimetinib, vemurafenib), and unresectable hepatocellular cancer (bevacizumab).

Tecentriq 840 mg Injection contains Atezolizumab, which belongs to the class of monoclonal antibodies. It works by inhibiting the action of a programmed death ligand receptor-1 (PD-L1), thereby stopping the abnormal growth of cancer cells.

Tecentriq 840 mg Injection may cause certain side effects such as fatigue, cough, diarrhoea, nausea, vomiting, tiredness, itching, rash, headache, fever, shortness of breath, muscle/joint pain, abdominal pain, loss of appetite and injection site reactions. Inform your doctor if any of these side effects persist for longer. Tecentriq 840 mg Injection will be administered by an oncologist trained in administering anti-cancer agents. 

Avoid receiving Tecentriq 840 mg Injection and inform your doctor if you are allergic to it or any other components of it. This medicine is known to cause embryo-fetal toxicity. Hence, it is not recommended for use in pregnancy. Avoid breastfeeding while taking this Tecentriq 840 mg Injection. Before starting treatment with Tecentriq 840 mg Injection, tell your doctor if you have/had liver or kidney disease, autoimmune disorders such as ulcerative colitis or Crohn's disease, a history of organ transplants, received an allogeneic stem cell transplant, or had radiation treatment to the chest, and myasthenia gravis.

Uses of Tecentriq 840 mg Injection

Treatment of Non-small cell lung cancer, Hepatocellular carcinoma, Biliary tract cancer, Small cell lung cancer and Metastatic melanoma

Directions for Use

Tecentriq 840 mg Injection will be administered by a trained oncologist in the hospital setting. Hence, do not self-administer. Your doctor will decide the dose and duration of the treatment based on the severity and type of cancer.

Medicinal Benefits

Tecentriq 840 mg Injection contains Atezolizumab, which is used in the treatment of different types of cancers. It works by inhibiting the action of a programmed death ligand receptor-1 (PD-L1) that causes the multiplication of cancer cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other body parts.

How Tecentriq 840 mg Injection Works

Tecentriq 840 mg Injection contains Atezolizumab, which belongs to the class of monoclonal antibodies. It works by inhibiting the action of a programmed death ligand receptor-1 (PD-L1), thereby stopping the abnormal growth of cancer cells.

Storage

Store in a cool and dry place away from sunlight
Side effects of Tecentriq 840 mg Injection 14 ml
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

What if I have taken an overdose of Tecentriq 840 mg Injection

As Tecentriq 840 mg Injection is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away.

Drug Warnings

To treat your condition effectually, continue receiving Tecentriq 840 mg Injection for the period that your doctor has prescribed. Tecentriq 840 mg Injection may cause severe immune-mediated adverse reactions (IMAR) such as immune-mediated colitis, hepatitis, hepatotoxicity, nephritis, endocrinopathies, pneumonitis, cardiac problems, and dermatologic reactions. It may also cause infusion-related reactions in some patients. Therefore, caution should be exercised if you have/had liver or kidney disease, any history of organ transplant, gastrointestinal disorders, autoimmune disorders such as ulcerative colitis or Crohn’s disease, lung disease, heart problems, and breathing difficulty while receiving Tecentriq 840 mg Injection. This medicine may also cause severe infusion-related reactions. Hence, careful monitoring is recommended and discontinue the treatment if any severe infusion reactions occur. Inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment, as this medicine is known to cause embryo-fetal toxicity. Breastfeeding should be discontinued in nursing mothers during the treatment as it passes into breast milk and may cause a possible risk to the infant. This medicine is not recommended for use in children below 12 years of age as the safety and efficacy are not established.

Drug-Drug Interactions

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AtezolizumabInfliximab
Severe
AtezolizumabCladribine
Severe

Drug-Drug Interactions

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AtezolizumabInfliximab
Severe
How does the drug interact with Tecentriq 840 mg Injection 14 ml:
Combining Infliximab with Tecentriq 840 mg Injection 14 ml can increase the risk or severity of developing infections.

How to manage the interaction:
Co-administration of Tecentriq 840 mg Injection 14 ml with Infliximab can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain, or burning during urination contact a doctor right away. Do not stop using any medications without talking to a doctor.
AtezolizumabCladribine
Severe
How does the drug interact with Tecentriq 840 mg Injection 14 ml:
The combined use of Tecentriq 840 mg Injection 14 ml with cladribine can increase the risk of side effects.

How to manage the interaction:
Co-administration of Tecentriq 840 mg Injection 14 ml with Cladribine can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any symptoms like infection, fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, or pain while urinating, contact a doctor right away. Do not stop using any medications without talking to a doctor.
AtezolizumabPomalidomide
Severe
How does the drug interact with Tecentriq 840 mg Injection 14 ml:
Taking Tecentriq 840 mg Injection 14 ml and Pomalidomide together may increase the risk of serious side effects.

How to manage the interaction:
Although taking Tecentriq 840 mg Injection 14 ml and Pomalidomide together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience any unusual symptoms, consult the doctor. Do not discontinue any medications without a doctor's advice.
AtezolizumabTofacitinib
Severe
How does the drug interact with Tecentriq 840 mg Injection 14 ml:
Using tofacitinib together with Tecentriq 840 mg Injection 14 ml may increase the risk of serious infections.

How to manage the interaction:
Although taking Tofacitinib and Tecentriq 840 mg Injection 14 ml together can evidently cause an interaction, it can be taken if your doctor has suggested it. However consult your doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without talking to your doctor.
AtezolizumabThalidomide
Severe
How does the drug interact with Tecentriq 840 mg Injection 14 ml:
Taking thalidomide with Tecentriq 840 mg Injection 14 ml may increase the risk of serious side effects.

How to manage the interaction:
Taking Thalidomide with Tecentriq 840 mg Injection 14 ml together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual symptoms, you should consult a doctor immediately. Do not stop using any medications without consulting your doctor.
AtezolizumabEtanercept
Severe
How does the drug interact with Tecentriq 840 mg Injection 14 ml:
When Tecentriq 840 mg Injection 14 ml is taken with Etanercept, the chance or severity of infection might be enhanced.

How to manage the interaction:
Although there is a possible interaction between Etanercept and Tecentriq 840 mg Injection 14 ml, you can take these medicines together if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
AtezolizumabLenalidomide
Severe
How does the drug interact with Tecentriq 840 mg Injection 14 ml:
Using Tecentriq 840 mg Injection 14 ml and Lenalidomide can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between Tecentriq 840 mg Injection 14 ml and Lenalidomide, but it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
AtezolizumabLeflunomide
Severe
How does the drug interact with Tecentriq 840 mg Injection 14 ml:
Taking leflunomide with Tecentriq 840 mg Injection 14 ml may raise the risk of severe infections.

How to manage the interaction:
Although there is an interaction between leflunomide and Tecentriq 840 mg Injection 14 ml, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
AtezolizumabBaricitinib
Severe
How does the drug interact with Tecentriq 840 mg Injection 14 ml:
Combining Tecentriq 840 mg Injection 14 ml with Baricitinib can increase the risk of developing a serious infection.

How to manage the interaction:
Taking Tecentriq 840 mg Injection 14 ml with Baricitinib together can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps strengthen muscles, reduces fatigue, aids in weight loss, and gives strength. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Getting adequate sleep while resting helps improve your health and mental ability and improves attention.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Eat food rich in antioxidants, such as berries, spinach, etc.
  • Foods containing fibre help with digestion. These include beans, peas, lentils, whole grains, nuts, and seeds.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC
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Alcohol

Consult your doctor

It is unknown whether Tecentriq 840 mg Injection interacts with alcohol. Consult your doctor for more information.

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Pregnancy

Unsafe

Tecentriq 840 mg Injection is not recommended for use in pregnancy as it may cause embryo-fetal toxicity and harm your foetus. Hence, if you are pregnant or planning to be pregnant, inform your doctor before receiving Tecentriq 840 mg Injection. You should not become pregnant while you are receiving Tecentriq 840 mg Injection for at least five months from the last dose of Tecentriq 840 mg Injection. Using effective birth control methods while on treatment is suggested.

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Breast Feeding

Unsafe

Tecentriq 840 mg Injection should not be taken if you are breastfeeding, as it passes into breast milk and may harm your infant. Avoid nursing your child while on treatment with this medicine and for at least five months from the last dose of medicine.

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Driving

Caution

Tecentriq 840 mg Injection will be administered to hospitalized patients. Driving is not recommended.

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Liver

Caution

If you have pre-existing or a history of liver problems, tell your doctor before receiving this medicine. Inform your doctor if you experience any symptoms, such as severe nausea or vomiting, right-sided upper stomach pain, easy bruising or bleeding, dark urine, or jaundice (yellowing of the skin or eyes). Your doctor may suggest tests to monitor your liver function while on treatment with this medicine.

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Kidney

Caution

If you have a pre-existing or a history of kidney diseases, inform your doctor before receiving Tecentriq 840 mg Injection. Tell your doctor if you have little or no urination, swelling in your feet or ankles, or blood in your urine. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Tecentriq 840 mg Injection is not recommended for use in children under 12 years old as the safety and efficacy are not established.

Have a query?

FAQs

Tecentriq 840 mg Injection is used to treat Non-small cell lung cancer, Hepatocellular carcinoma, Biliary tract cancer, Small cell lung cancer and Metastatic melanoma.

Tecentriq 840 mg Injection contains Atezolizumab, which works by inhibiting the action of a programmed death receptor-1 (PD-L1) that causes the multiplication of cancerous cells.

Tecentriq 840 mg Injection may alter the function of your immune system and trigger an attack on healthy organs and tissues in any part of your body. These issues can occasionally worsen or even become dangerous. You can have more than one of these problems at the same time. These problems may happen anytime during your treatment or even after your treatment has ended. Therefore, please consult your doctor if you experience any changes in your body or if you have any concerns.

You should call your doctor right away if you experience any of the following severe side effects Such as chest pain, severe shortness of breath, or difficulty breathing.

Tecentriq 840 mg Injection is not recommended for use during pregnancy as it may cause embryo-fetal toxicity and harm foetus. Hence, if you are pregnant or planning to be pregnant, inform your doctor before receiving Tecentriq 840 mg Injection.

It is unknown whether Tecentriq 840 mg Injection passes into human milk. Therefore, Tecentriq 840 mg Injection is not recommended during breastfeeding and for at least 5 months after the last dose. However, if you are breastfeeding, take your doctor’s advice.

Yes, Tecentriq 840 mg Injection may affect fertility in women which may affect the ability to have children. Therefore, please inform your doctor if you have any concerns.

Yes, Tecentriq 840 mg Injection can cause hair loss (alopecia) as a side effect. This tends to resolve once treatment is stopped. However, please consult your doctor if you have any concerns.

Reduction in the size of the tumour or slowing of its growth can be a sign that the treatment is effective. Improvement in symptoms such as pain, breathing difficulties, or other cancer-related symptoms. Regular blood tests and other scans such as CT, MRI, or PET scans can show changes in tumour markers or other indicators of cancer activity.

To relieve rashes and dry, itchy skin, use a moisturizer. Wear protective clothes, stay out of direct sunlight, and use sunscreen with an SPF of at least 15. If you have a rash, avoid swimming because the chlorine in the water can worsen it. Avoid hot water baths and dress comfortably in cotton clothing. After therapy ends, your skin will usually improve.

Increase fluid intake by drinking plenty of fluids, especially water, to help soften stools. Include high-fibre foods such as whole grains, fruits, vegetables, legumes, and nuts. Engage in regular physical activity, such as walking, to help stimulate bowel movements. Limit foods and beverages that can cause gas, such as broccoli, cabbage, and carbonated drinks.

Yes, nausea and extreme tiredness (fatigue) are common side effects of Tecentriq 840 mg Injection. These symptoms occur because Tecentriq 840 mg Injection affects your immune system, which can lead to various side effects. To reduce nausea, eat smaller, more frequent meals. Stay away from oily, hot, salty, and fried foods.

Changes in taste is a common side effect of Tecentriq 840 mg Injection. To improve your taste, brush your teeth, gums, and tongue gently with a soft-bristled toothbrush and mild toothpaste. Rinse your mouth frequently with a mild solution of water, baking soda, and salt. You can also add different seasonings and flavours to find what tastes good to you.

Avoid coffee, which can cause dehydration, and foods that are fatty, fried, spicy, or excessively sweet, as these might cause nausea. Avoid smoking and alcohol consumption. Do not take any other medicines and vaccines without consulting your doctor.

The common side effects of Tecentriq 840 mg Injection are fatigue, cough, diarrhoea, nausea, vomiting, tiredness, itching, rash, headache, fever, shortness of breath, muscle/joint pain, abdominal pain, loss of appetite (hunger) and injection site reactions. If any of these side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Bayer Ag, Mã¼Llerstr. 178, 13353 Berlin
Other Info - TEC0091

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 9:32 AM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/761034s043lbl.pdf
  2. https://www.tecentriq.com/
  3. https://medlineplus.gov/druginfo/meds/a616035.html
  4. https://reference.medscape.com/drug/tecentriq-atezolizumab-1000098
  5. https://www.drugs.com/atezolizumab.html
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