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Written By ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Dec 13, 2024 | 11:24 AM IST

Tecentriq 840 mg Injection is used for the treatment of Non-small cell lung cancer, Hepatocellular carcinoma, Biliary tract cancer, Small cell lung cancer and Metastatic melanoma. It contains Atezolizumab, which works by blocking the action of a certain protein in cancer cells. This helps the person's immune system to fight against the cancer cells, and helps to slow tumor growth.

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Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Tecentriq 840 mg Injection

Tecentriq 840 mg Injection is an anti-cancer medicine used in the treatment of unresectable, stage II-IIIa non-small cell lung cancer (NSCLC). Tecentriq 840 mg Injection is also used in combination with other cancer medicine for the treatment of metastatic NSCLC (bevacizumab, paclitaxel, carboplatin), extensive-stage small cell lung cancer and biliary tract cancer (carboplatin, etoposide), metastatic melanoma (cobimetinib, vemurafenib), and unresectable hepatocellular cancer (bevacizumab).

Tecentriq 840 mg Injection contains Atezolizumab, which belongs to the class of monoclonal antibodies. It works by inhibiting the action of a programmed death ligand receptor-1 (PD-L1), thereby stopping the abnormal growth of cancer cells.

Tecentriq 840 mg Injection may cause certain side effects such as fatigue, cough, diarrhoea, nausea, vomiting, tiredness, itching, rash, headache, fever, shortness of breath, muscle/joint pain, abdominal pain, loss of appetite and injection site reactions. Inform your doctor if any of these side effects persist for longer. Tecentriq 840 mg Injection will be administered by an oncologist trained in administering anti-cancer agents. 

Avoid receiving Tecentriq 840 mg Injection and inform your doctor if you are allergic to it or any other components of it. This medicine is known to cause embryo-fetal toxicity. Hence, it is not recommended for use in pregnancy. Avoid breastfeeding while taking this Tecentriq 840 mg Injection. Before starting treatment with Tecentriq 840 mg Injection, tell your doctor if you have/had liver or kidney disease, autoimmune disorders such as ulcerative colitis or Crohn's disease, a history of organ transplants, received an allogeneic stem cell transplant, or had radiation treatment to the chest, and myasthenia gravis.

Uses of Tecentriq 840 mg Injection

Treatment of Non-small cell lung cancer, Hepatocellular carcinoma, Biliary tract cancer, Small cell lung cancer and Metastatic melanoma

Medicinal Benefits

Tecentriq 840 mg Injection contains Atezolizumab, which is used in the treatment of different types of cancers. It works by inhibiting the action of a programmed death ligand receptor-1 (PD-L1) that causes the multiplication of cancer cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other body parts.

Directions for Use

Tecentriq 840 mg Injection will be administered by a trained oncologist in the hospital setting. Hence, do not self-administer. Your doctor will decide the dose and duration of the treatment based on the severity and type of cancer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Tecentriq 840 mg Injection

  • Nausea
  • Vomiting
  • Diarrhoea
  • Loss of appetite
  • Weakness
  • Cough
  • Fatigue
  • Headache
  • Fever
  • Back pain
  • Upper respiratory tract infections
  • Injection site reactions

Drug Warnings

To treat your condition effectually, continue receiving Tecentriq 840 mg Injection for the period that your doctor has prescribed. Tecentriq 840 mg Injection may cause severe immune-mediated adverse reactions (IMAR) such as immune-mediated colitis, hepatitis, hepatotoxicity, nephritis, endocrinopathies, pneumonitis, cardiac problems, and dermatologic reactions. It may also cause infusion-related reactions in some patients. Therefore, caution should be exercised if you have/had liver or kidney disease, any history of organ transplant, gastrointestinal disorders, autoimmune disorders such as ulcerative colitis or Crohn’s disease, lung disease, heart problems, and breathing difficulty while receiving Tecentriq 840 mg Injection. This medicine may also cause severe infusion-related reactions. Hence, careful monitoring is recommended and discontinue the treatment if any severe infusion reactions occur. Inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment, as this medicine is known to cause embryo-fetal toxicity. Breastfeeding should be discontinued in nursing mothers during the treatment as it passes into breast milk and may cause a possible risk to the infant. This medicine is not recommended for use in children below 12 years of age as the safety and efficacy are not established.

Drug Interactions

Drug-Drug Interactions: Tecentriq 840 mg Injection may have interaction with immunomodulator drugs (thalidomide), corticosteroids (prednisolone, methylprednisolone, prednisone), etc.

Drug-Food Interactions: Avoid alcohol consumption and smoking.

Dug-Disease Interactions: Tell your doctor if you have liver or kidney disease, heart problems, GI disorders, dermatitis, or a weak immune system before starting the treatment.

Drug-Drug Interactions Checker List

  • THALIDOMIDE
  • PREDNISOLONE
  • METHYLPREDNISOLONE

Habit Forming

No

Diet & Lifestyle Advise

  • Physical activity helps strengthen muscles, reduces fatigue, aids in weight loss, and gives strength. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Getting adequate sleep while resting helps improve your health and mental ability and improves attention.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Eat food rich in antioxidants, such as berries, spinach, etc.
  • Foods containing fibre help with digestion. These include beans, peas, lentils, whole grains, nuts, and seeds.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight.

Special Advise

  • Your doctor may suggest periodic liver function tests, kidney function tests, and lung function tests to monitor the function of the liver, kidney and lungs due to the use of Tecentriq 840 mg Injection.
  • Using contraceptive pills while using Tecentriq 840 mg Injection to prevent pregnancy is advised.
  • Thyroid function and adrenocorticotropic hormone levels will be monitored during treatment to avoid any life-threatening side effects.

Disease/Condition Glossary

Non-Small Cell Lung Cancer (NSCLC): It is the most common form of lung cancer, which occurs when cells that form the lining of the lung start growing uncontrollably. It is mostly seen in persons who smoke. Symptoms may include chest pain, weight loss, hoarseness, and difficulty breathing.

Hepatocellular carcinoma: It occurs when the cancer/ malignant cells grow out of control in the liver. This infects the liver, destroys the liver cells and affects the ability of the liver to work properly. Symptoms may include abdominal pain, loss of appetite, weight loss, and pale bowel motions.

Biliary tract cancer: Also known as bile duct cancer or Cholangiocarcinoma. It is a rare type of cancer in which the cancer cells grow abnormally in the epithelial cells lining the biliary tract. Symptoms may include abdominal pain, itching, fever, weight loss, changes in the colour of urine and stools, and jaundice.

Metastatic Malignant Melanoma: Melanoma is a type of skin cancer in which the cancer cells grow in melanocytes. It is mainly caused by harmful UV radiation from the sun. Malignant melanoma is common in fair-skinned and freckled individuals. It results in mole formation, typically on the skin of the face. Tecentriq 840 mg Injection is used in combination with ipilimumab in adults and children above 12 years of age.

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Alcohol

Consult your doctor

It is unknown whether Tecentriq 840 mg Injection interacts with alcohol. Consult your doctor for more information.

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Pregnancy

Unsafe

Tecentriq 840 mg Injection is not recommended for use in pregnancy as it may cause embryo-fetal toxicity and harm your foetus. Hence, if you are pregnant or planning to be pregnant, inform your doctor before receiving Tecentriq 840 mg Injection. You should not become pregnant while you are receiving Tecentriq 840 mg Injection for at least five months from the last dose of Tecentriq 840 mg Injection. Using effective birth control methods while on treatment is suggested.

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Breast Feeding

Unsafe

Tecentriq 840 mg Injection should not be taken if you are breastfeeding, as it passes into breast milk and may harm your infant. Avoid nursing your child while on treatment with this medicine and for at least five months from the last dose of medicine.

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Driving

Caution

Tecentriq 840 mg Injection will be administered to hospitalized patients. Driving is not recommended.

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Liver

Caution

If you have pre-existing or a history of liver problems, tell your doctor before receiving this medicine. Inform your doctor if you experience any symptoms, such as severe nausea or vomiting, right-sided upper stomach pain, easy bruising or bleeding, dark urine, or jaundice (yellowing of the skin or eyes). Your doctor may suggest tests to monitor your liver function while on treatment with this medicine.

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Kidney

Caution

If you have a pre-existing or a history of kidney diseases, inform your doctor before receiving Tecentriq 840 mg Injection. Tell your doctor if you have little or no urination, swelling in your feet or ankles, or blood in your urine. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Tecentriq 840 mg Injection is not recommended for use in children under 12 years old as the safety and efficacy are not established.

Country of origin

India

Manufacturer/Marketer address

Bayer Ag, Mã¼Llerstr. 178, 13353 Berlin
Other Info - TEC0091

FAQs

Tecentriq 840 mg Injection is used to treat Non-small cell lung cancer, Hepatocellular carcinoma, Biliary tract cancer, Small cell lung cancer and Metastatic melanoma.
Tecentriq 840 mg Injection contains Atezolizumab, which works by inhibiting the action of a programmed death receptor-1 (PD-L1) that causes the multiplication of cancerous cells.
Tecentriq 840 mg Injection may alter the function of your immune system and trigger an attack on healthy organs and tissues in any part of your body. These issues can occasionally worsen or even become dangerous. You can have more than one of these problems at the same time. These problems may happen anytime during your treatment or even after your treatment has ended. Therefore, please consult your doctor if you experience any changes in your body or if you have any concerns.
You should call your doctor right away if you experience any of the following severe side effects Such as chest pain, severe shortness of breath, or difficulty breathing.
Tecentriq 840 mg Injection is not recommended for use during pregnancy as it may cause embryo-fetal toxicity and harm foetus. Hence, if you are pregnant or planning to be pregnant, inform your doctor before receiving Tecentriq 840 mg Injection.
It is unknown whether Tecentriq 840 mg Injection passes into human milk. Therefore, Tecentriq 840 mg Injection is not recommended during breastfeeding and for at least 5 months after the last dose. However, if you are breastfeeding, take your doctor’s advice.
Yes, Tecentriq 840 mg Injection may affect fertility in women which may affect the ability to have children. Therefore, please inform your doctor if you have any concerns.
Yes, Tecentriq 840 mg Injection can cause hair loss (alopecia) as a side effect. This tends to resolve once treatment is stopped. However, please consult your doctor if you have any concerns.
Reduction in the size of the tumour or slowing of its growth can be a sign that the treatment is effective. Improvement in symptoms such as pain, breathing difficulties, or other cancer-related symptoms. Regular blood tests and other scans such as CT, MRI, or PET scans can show changes in tumour markers or other indicators of cancer activity.
To relieve rashes and dry, itchy skin, use a moisturizer. Wear protective clothes, stay out of direct sunlight, and use sunscreen with an SPF of at least 15. If you have a rash, avoid swimming because the chlorine in the water can worsen it. Avoid hot water baths and dress comfortably in cotton clothing. After therapy ends, your skin will usually improve.
Increase fluid intake by drinking plenty of fluids, especially water, to help soften stools. Include high-fibre foods such as whole grains, fruits, vegetables, legumes, and nuts. Engage in regular physical activity, such as walking, to help stimulate bowel movements. Limit foods and beverages that can cause gas, such as broccoli, cabbage, and carbonated drinks.
Yes, nausea and extreme tiredness (fatigue) are common side effects of Tecentriq 840 mg Injection. These symptoms occur because Tecentriq 840 mg Injection affects your immune system, which can lead to various side effects. To reduce nausea, eat smaller, more frequent meals. Stay away from oily, hot, salty, and fried foods.
Changes in taste is a common side effect of Tecentriq 840 mg Injection. To improve your taste, brush your teeth, gums, and tongue gently with a soft-bristled toothbrush and mild toothpaste. Rinse your mouth frequently with a mild solution of water, baking soda, and salt. You can also add different seasonings and flavours to find what tastes good to you.
Avoid coffee, which can cause dehydration, and foods that are fatty, fried, spicy, or excessively sweet, as these might cause nausea. Avoid smoking and alcohol consumption. Do not take any other medicines and vaccines without consulting your doctor.
The common side effects of Tecentriq 840 mg Injection are fatigue, cough, diarrhoea, nausea, vomiting, tiredness, itching, rash, headache, fever, shortness of breath, muscle/joint pain, abdominal pain, loss of appetite (hunger) and injection site reactions. If any of these side effects persist or worsen, please consult your doctor.

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