Sysdol MR 400 mg/325 mg/250 mg Tablet is used in the reduction of musculoskeletal pain and muscle spasm due to tissue injury, resolution of post surgery inflammation and oedema (swollen tissue with fluid). Pain can be temporary (acute) or long-term (chronic) in nature. Musculoskeletal pain can be caused due to soft tissue (muscle, tendon or ligaments) injury. Extreme tissue pain and inflammation caused by sprains, strains or trauma or post-surgery may require a prolonged amount of time to heal.

Sysdol MR 400 mg/325 mg/250 mg Tablet contains Ibuprofen, Paracetamol and Chlorzoxazone. Ibuprofen is known to have an analgesic and anti-inflammatory effect for reducing mild to moderate pain. It works by blocking the effect of a chemical known as prostaglandin responsible for inducing pain and inflammation in our body. Paracetamol acts as a mild analgesic (mild pain reducer) and antipyretic (fever reducer), which enhances the pain relief action of Ibuprofen. Chlorzoxazone is a muscle relaxant that helps by blocking nerve impulses or pain sensations sent by the brain and causes the relaxation of muscles.

Take Sysdol MR 400 mg/325 mg/250 mg Tablet as prescribed. Like all medicines, Sysdol MR 400 mg/325 mg/250 mg Tablet may cause side effects, although not everybody gets them. Nausea, indigestion,  diarrhoea, drowsiness, dizziness, heartburn, stomach pain and restlessness are a few common side effects of Sysdol MR 400 mg/325 mg/250 mg Tablet.

Do not take Sysdol MR 400 mg/325 mg/250 mg Tablet if you are allergic to painkillers like aspirin, paracetamol, naproxen or diclofenac. It is not recommended for use in children, people with liver disease, heart disease or gastric ulcers/bleeding problems. Sysdol MR 400 mg/325 mg/250 mg Tablet may be associated with a small increase in the risk of heart attack (myocardial infarction). Avoid consumption of alcohol as it may damage your liver and cause even more side effects on taking this drug. Consult your doctor if your symptoms of pain, inflammation and fever do not disappear even after ten days.

Sysdol MR 400 mg/325 mg/250 mg Tablet is composed of ibuprofen, chlorzoxazone and paracetamol primarily used to treat mild to moderate pain. Sysdol MR 400 mg/325 mg/250 mg Tablet plays a vital role in reducing pain and inflammation by blocking the release of chemical messengers which cause pain and fever. Sysdol MR 400 mg/325 mg/250 mg Tablet relieves pain and inflammation in arthritic conditions with the benefit of increased antibiotic penetration and micro-circulation at the injury site. Ibuprofen works by blocking the effect of a chemical known as prostaglandin responsible for inducing pain and inflammation in our body. Paracetamol has the advantage of producing lesser gastric irritation compared to other painkillers like aspirin. So, it is well tolerated in almost all age groups. Chlorzoxazone benefits in relaxing muscles to treat any type of musculoskeletal conditions like sprain, pain or injury. It is mainly prescribed for sports-related injuries. Overall it relieves muscle spasms or stiffness of musculoskeletal joints, thereby improving its movement.

• Nausea

• Indigestion

• Diarrhoea

• Drowsiness

• Dizziness

• Heartburn

• Stomach pain

• Restlessness

Sysdol MR 400 mg/325 mg/250 mg Tablet should be taken with caution if you have an active stomach ulcer, recent gastrointestinal bleeding, asthma, recent by-pass heart surgery, heart disease or history of allergy to any painkillers or analgesic. Avoid driving while consuming Sysdol MR 400 mg/325 mg/250 mg Tablet as it can cause dizziness in some individuals and hamper your focus and reflexes. Avoid concomitant consumption of drugs containing the same chemicals as Sysdol MR 400 mg/325 mg/250 mg Tablet as it can lead to overdosage and unwanted side effects. Immediately consult your doctor in case of persistent side effects like stomach pain on consumption of Sysdol MR 400 mg/325 mg/250 mg Tablet. Avoid consuming alcohol while you are on Sysdol MR 400 mg/325 mg/250 mg Tablet.

Drug-Drug Interaction: Sysdol MR 400 mg/325 mg/250 mg Tablet is shown to interact with various drugs. Some of them include pain killers (naproxen, aspirin, ibuprofen, tramadol, hydrocodone, oxycodone), lithium, anticancer/antimetabolites (methotrexate), blood thinner or anticoagulant (warfarin, coumadin, jantoven), blood pressure or heart medicine, nausea medicine (metoclopramide, domperidone), diuretic/water pills (thiazides, furosemide), a steroid medicine (prednisone), quinolones antibiotics (ciprofloxacin), respiratory medicines (theophyllines, ephedrine), cholesterol-reducing medicine (colestyramine) and antidepressants (duloxetine). These drugs may affect the working of Sysdol MR 400 mg/325 mg/250 mg Tablet and may alter its efficacy.

Drug-Food Interaction: Excessive intake of caffeine-containing food or drinks like coffee, tea, chocolate and some fizzy drinks should be avoided while taking Sysdol MR 400 mg/325 mg/250 mg Tablet. Taking them together may lead to drowsiness and dizziness and sleepiness. And also, consuming alcohol along with Sysdol MR 400 mg/325 mg/250 mg Tablet can cause excessive ingestion of alcohol and potentiate liver damage action of paracetamol. 

Drug-Disease Interaction: Sysdol MR 400 mg/325 mg/250 mg Tablet should not recommend for people having bleeding disorders, like haemophilia, von Willebrand disease or low blood platelets. Besides this, it should not be given to children suffering from influenza (flu) or chickenpox. It should also be avoided in case of the presence of gastric or duodenal ulcers.

• NAPROXEN
• ASPIRIN
• IBUPROFEN
• TRAMADOL
• HYDROCODONE
• OXYCODONE
• LITHIUM
• METHOTREXATE
• WARFARIN
• COUMADIN
• JANTOVEN
• METOCLOPRAMIDE
• DOMPERIDONE
• FUROSEMIDE
• PREDNISONE
• CIPROFLOXACIN
• THEOPHYLLINE
• EPHEDRINE
• CHOLESTYRAMINE
• DULOXETINE

• Include more glucosamine, chondroitin sulphate, vitamin D, calcium enriched supplements. Besides this, turmeric and fish oils can help in reducing inflammation in the tissue.

• Do not go for heavy exercise as it may increase your joint pain in arthritis. Instead, you can do stretching, low impact aerobic exercise like walking on treadmill, bike riding and swimming. You can also strengthen your muscles by lifting light weights.

• In chronic condition of arthritis or joint pain try to include fish like salmon, trout, tuna and sardines. These fishes are enriched with omega-3 fatty acids that minimize level of chemical called cytokines, which ramp up inflammation.

• Your sitting posture is important especially when you have pain and inflammation. Try to sit as little as possible and only for a short duration of time. Long term immobility is harmful in conditions like arthritis.  Use back support like a rolled up towel at the back of your spine curve to minimize pain. Keep your knees and hips at a right angle. Besides this, you can also use a foot rest if required.

Stop using Sysdol MR 400 mg/325 mg/250 mg Tablet and consult your doctor immediately if you are having bleeding from the rectum (back passage), have black sticky bowel motions (stools) or bloody diarrhoea.

Pain can be temporary (acute) or long-term (chronic) in nature. Musculoskeletal pain can be caused due to soft tissue (muscle, tendon or ligaments) injury. Extreme tissue pain and inflammation caused due to sprains, strains or trauma or post-surgery may require a prolonged amount of time to heal.