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Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Sulfasafe DS Tablet is used to treat bowel diseases (ulcerative colitis, Crohn's disease), skin-related problems (psoriasis), and chronic joint diseases (rheumatoid arthritis, ankylosing spondylitis) in children and adults. It contains Sulfasalazine, which works as an inflammation reducer by acting locally, inhibiting the formation of a chemical known as prostaglandins, that control pain and inflammation. Thus, it helps reduce the inflammation of the intestine, skin, and joints. In some cases, you may experience a sore throat, a fever, unexplained bruising, or ringing in your ears (tinnitus). Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Manufacturer/Marketer :

Actus Health Care

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Sulfasafe DS Tablet

Sulfasafe DS Tablet is used to treat bowel diseases (ulcerative colitis, Crohn's disease), skin-related problems (psoriasis), and chronic joint diseases (rheumatoid arthritis, ankylosing spondylitis) in children and adults. 

Sulfasafe DS Tablet works as an inflammation reducer by acting locally, inhibiting the formation of a chemical known as prostaglandins, which control pain and inflammation. Together, it helps reduce the inflammation of the intestine, skin, and joints. 

Your doctor will advise you on how often you take your tablets based on your medical condition. In some cases, you may experience a sore throat, a fever, unexplained bruising, or ringing in your ears (tinnitus). Most of these side effects of Sulfasafe DS Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, please reach out to your doctor.

Sulfasafe DS Tablet can also lower your sperm count, leading to a temporary decrease in male fertility. In this case, you can speak to your doctor. Your doctor might arrange a blood test before you start taking Sulfasafe DS Tablet . You can continue taking Sulfasafe DS Tablet to prevent flares up during the pregnancy. Besides this, your doctor may prescribe additional folic acid supplements during pregnancy because Sulfasafe DS Tablet may reduce the level of folic acid in your body. Sulfasafe DS Tablet can be safely taken while you are breastfeeding unless the baby is premature or at risk of jaundice.

Uses of Sulfasafe DS Tablet

Treatment of Ulcerative colitis, Crohn's disease, Rheumatoid arthritis, Ankylosing spondylitis, Psoriatic arthritis, and Juvenile idiopathic arthritis.

Directions for Use

Sulfasafe DS Tablet should not be used unless prescribed by a doctor. Take this medicine as directed by your doctor. Swallow Sulfasafe DS Tablet with a full glass of water. If required, the tablets can be broken in half to take a smaller dose. It should be taken with food to avoid an upset stomach. It is advised to drink plenty of water while taking Sulfasafe DS Tablet to prevent the formation of kidney stones.

Medicinal Benefits

Sulfasafe DS Tablet works by reducing the inflammation in the colon. It inhibits the formation of a chemical, prostaglandin, which controls inflammation. Together, they help in reducing the inflammation at all the sites like joints, skin, and bowel (intestines), thereby treating a wider range of joint, skin and bowel diseases, including ulcerative colitis, Crohn's disease, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, juvenile idiopathic arthritis. Sulfasafe DS Tablet is not a pain killer. Rather, it is an anti-inflammatory.

How Sulfasafe DS Tablet Works

Sulfasafe DS Tablet works as an inflammation reducer by acting locally, inhibiting the formation of a chemical known as prostaglandins, which control pain and inflammation. Together, it helps reduce the inflammation of the intestine, skin, and joints.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Sulfasafe DS Tablet

  • Headache
  • Indigestion
  • Nausea
  • Watery diarrhoea

What if I have taken an overdose of Sulfasafe DS Tablet

Do not take more than the prescribed dose of Sulfasafe DS Tablet as it may cause overdose. The symptoms of overdose include stomach pain, seizures (fits), tiredness, nausea and vomiting. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

 Sulfasafe DS Tablet treatment is generally considered to be safe during pregnancy, but its usage in pregnant mothers should be discussed with the doctor if planning for pregnancy. This medication should be avoided in breastfeeding mothers as it passes into the milk and causes jaundice and brain problems in infants less than 2 years of age. Tell your doctor if you have an allergy to any other sulpha drugs (sulfonamide antibiotic) as it may cause serious skin allergies like urticaria and stevens johnson’s syndrome. In men, an intake of Sulfasafe DS Tablet may lower the sperm count, which improves after stopping this medicine. Tell your doctor if you have asthma, wheezing, fever, breathing difficulties, sudden severe skin rash, unusual bleeding, sore throat, fever, unexplained bruising, or any other symptoms of infection. Use of Sulfasafe DS Tablet may change the colour of your urine, contact lenses, and tears to yellow/orange and even make your skin more sensitive to the sunlight. But, this is normal, harmless, and nothing to worry about. You may low folic acid in pregnancy while taking Sulfasafe DS Tablet so your doctor might prescribe you iron or folic acid supplements.

Drug-Drug Interactions

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SulfasalazineCidofovir
Critical
SulfasalazineCidofovir
Critical

Drug-Drug Interactions

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SulfasalazineCidofovir
Critical
How does the drug interact with Sulfasafe DS Tablet 10's:
Coadministration of Cidofovir with Sulfasafe DS Tablet 10's can increase the risk or severity of kidney problems.

How to manage the interaction:
Taking Sulfasafe DS Tablet 10's with Cidofovir is not recommended, but can be taken together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
SulfasalazineCidofovir
Critical
How does the drug interact with Sulfasafe DS Tablet 10's:
Using cidofovir together with Sulfasafe DS Tablet 10's may increase the risk of kidney problems.

How to manage the interaction:
Taking Sulfasafe DS Tablet 10's with Cidofovir is generally avoided, but can be taken together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
SulfasalazineLidocaine
Severe
How does the drug interact with Sulfasafe DS Tablet 10's:
Combining Sulfasafe DS Tablet 10's with Lidocaine can increase the risk of methemoglobinemia (a rare red blood cell disorder in which too little oxygen is delivered to the cells).

How to manage the interaction:
Co-administration of Sulfasafe DS Tablet 10's with Lidocaine can result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, tiredness, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not discontinue any medications without consulting a doctor.
SulfasalazineWarfarin
Severe
How does the drug interact with Sulfasafe DS Tablet 10's:
Coadministration of warfarin with Sulfasafe DS Tablet 10's can increase the risk of unusual bleeding disorder.

How to manage the interaction:
Although taking Sulfasafe DS Tablet 10's and warfarin together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache; and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
SulfasalazineLeflunomide
Severe
How does the drug interact with Sulfasafe DS Tablet 10's:
Taking Sulfasafe DS Tablet 10's with leflunomide can increase the risk or severity of side effects.

How to manage the interaction:
Although there is an interaction between Sulfasafe DS Tablet 10's and leflunomide, it can be taken if prescribed by a doctor. Contact a doctor immediately if you develop paleness, fatigue, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
SulfasalazineTacrolimus
Severe
How does the drug interact with Sulfasafe DS Tablet 10's:
Taking tacrolimus with Sulfasafe DS Tablet 10's will have an additive effect and may increase the risk of kidney problems.

How to manage the interaction:
Although taking tacrolimus and Sulfasafe DS Tablet 10's together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
SulfasalazineLevobupivacaine
Severe
How does the drug interact with Sulfasafe DS Tablet 10's:
Coadministration of Levobupivacaine with Sulfasafe DS Tablet 10's can increase the risk of methemoglobinemia (a rare red blood cell disorder).

How to manage the interaction:
Taking Levobupivacaine with Sulfasafe DS Tablet 10's together can result in an interaction, but it can be taken if your doctor has advised it. It is important to keep a close eye on any signs or symptoms of Methemoglobinemia. If you notice any of these symptoms like gray discoloration, nausea, headache, dizziness, fatigue, or shortness of breath, it's best to contact a doctor right away. They can help determine the cause and provide appropriate treatment. Do not discontinue any medications without consulting a doctor.
SulfasalazineDeferasirox
Severe
How does the drug interact with Sulfasafe DS Tablet 10's:
Coadministration of Deferasirox and Sulfasafe DS Tablet 10's may increase the risk or severity of kidney problems.

How to manage the interaction:
Although taking Sulfasafe DS Tablet 10's and Deferasirox together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm, seek immediate medical attention. Drink plenty of water if you experience diarrhoea or vomiting while taking these medications, as dehydration can potentially affect the kidneys. Do not discontinue any medications without a doctor's advice.
SulfasalazineTenofovir disoproxil
Severe
How does the drug interact with Sulfasafe DS Tablet 10's:
Coadministration of Sulfasafe DS Tablet 10's and Tenofovir disoproxil can increase the risk of kidney problems.

How to manage the interaction:
Taking Sulfasafe DS Tablet 10's and Tenofovir disoproxil together can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
SulfasalazineCiclosporin
Severe
How does the drug interact with Sulfasafe DS Tablet 10's:
Coadministration of Sulfasafe DS Tablet 10's with ciclosporin may significantly increase the side effects on kidneys.

How to manage the interaction:
Although there is a possible interaction between Sulfasafe DS Tablet 10's and ciclosporin, they can be taken together if your doctor has prescribed them. In case you experience any unusual side effects, consult a doctor. Do not stop using any medications without first talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  •  It is advised to drink plenty of water to prevent the occurrence of kidney stones.

  •  Take low fibre foods such as white rice, white pasta, bread, egg, fish, tofu, butter, etc. to avoid triggering ulcerative colitis.

  •  Exercise regularly to suppress inflammation in the body.

  •  Manage stress by doing meditation and deep breathing exercises.

  •  Eat smaller meals to avoid pain in the stomach.

  •  Avoid foods that can increase or worsen ulcerative colitis such as milk, milk products, raw fruits and vegetables, beans, spicy foods, popcorn, artificial sweeteners, nuts, seeds, and fatty foods.

Habit Forming

No

Therapeutic Class

GASTROINTESTINAL AGENTS

Sulfasafe DS Tablet Substitute

Substitutes safety advice
  • Saaz-DS Tablet 10's

    15.75per tablet
  • Sazo 1000 Tablet 15's

    16.62per tablet
  • Salazar DS Tablet 10's

    17.19per tablet
  • Sulseas-DS Tablet 15's

    16.59per tablet
  • SZN 1000 Tablet 10's

    14.31per tablet
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Alcohol

Unsafe

It is not recommended to consume alcohol while taking Sulfasafe DS Tablet to avoid unpleasant side-effects.

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Pregnancy

Caution

Sulfasafe DS Tablet should be recommended in pregnancy only if required. In case, if prescribed to a pregnant woman, it is advised to increase the folate supplementation after consulting your doctor.

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Breast Feeding

Caution

Sulfasafe DS Tablet is excreted in breastmilk and is not recommended especially if the baby is premature or is at the risk of jaundice. It might cause kernicterus (excessive levels of bilirubin in the blood) in the new-born.

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Driving

Safe if prescribed

Sulfasafe DS Tablet does not affect the ability to drive. However, if you feel drowsy after taking Sulfasafe DS Tablet , it is advised not to drive.

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Liver

Unsafe

Sulfasafe DS Tablet is not recommended to use in patients suffering or having a history of liver diseases. In other people, rarely it can cause hepatitis (inflammation of the liver).

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Kidney

Unsafe

Sulfasafe DS Tablet is not recommended to use in patients suffering or having a history of kidney diseases. In other people, rarely it can cause inflammation of the kidneys.

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Children

Safe if prescribed

Sulfasafe DS Tablet should be advised in children only if prescribed by a child specialist.

FAQs

Sulfasafe DS Tablet is used to treat bowel diseases (ulcerative colitis, Crohn's disease), skin-related problems (psoriasis), and chronic joint diseases (rheumatoid arthritis, ankylosing spondylitis).
Yes, Sulfasafe DS Tablet is contraindicated in patients with intestinal or urinary obstruction, patients with porphyria (liver disorders), and patients hypersensitive to sulfasalazine, its metabolites, sulfonamides, or salicylates.
Yes, Sulfasafe DS Tablet is said to affect fertility in males as it can cause a fall in sperm count. However, it is only affected by the time this medicine is taken.
Yes, Sulfasafe DS Tablet is safe to use in breastfeeding. However, please inform your doctor if the baby is premature or is at risk of jaundice as this medicine might not be advised in such cases.
Yes, Sulfasafe DS Tablet can affect the blood count but it is rare. There is a decrease in the number of white blood cells (infection-fighting cells). In some cases, the bone marrow might completely stop producing a specific type of white blood cell, this condition is known as agranulocytosis. It occurs within two months of starting this medicine and might be accompanied by symptoms such as fever and rash. This condition resolves within one or two weeks after this medicine is discontinued.
No, Sulfasafe DS Tablet is a disease-modifying anti-rheumatic drug’ (DMARD) and not a painkiller. So, if you are taking a painkiller before starting this medicine, you can continue taking it along with Sulfasafe DS Tablet .
No, Sulfasafe DS Tablet should be taken in the dose and duration as advised by the doctor. If you take it in more than the recommended dose, it might cause unpleasant side-effects. If you think your symptoms are not improving, please consult your doctor.
Sulfasafe DS Tablet in rare cases may cause blood disorders so your doctor may ask you to have blood count, electrolytes, urea, creatinine, and liver function tests every 3 months for the first year and every 6 months next year onwards.
If well tolerated you should take a prescribed dose of Sulfasafe DS Tablet while the disease remains in remission. Do not stop taking your medicine unless your doctor tells you to do so.
Sulfasafe DS Tablet may cause central nervous system adverse effects such as serious psychiatric problems including mania, depression, and psychosis, and these symptoms have been reported to occur only infrequently.
The side effects of Sulfasafe DS Tablet include headache, nausea, indigestion and watery diaarhoea. If these side effects persist or worsen, please consult your doctor.
Sulfasafe DS Tablet takes about 6 to 12 weeks to show the full effect. After using Sulfasafe DS Tablet , you might feel better in 4 weeks, although this can vary from person to person and some patients may notice improvement after 3 months. Do not stop taking Sulfasafe DS Tablet without first consulting your doctor.
Sulfasafe DS Tablet may affect the kidney function, although it is rare. Therefore, before using Sulfasafe DS Tablet , it is important that your kidney function remains normal. If your kidney functions become abnormal during treatment with Sulfasafe DS Tablet , please consult your doctor.
You are recommended to avoid using azathioprine along with Sulfasafe DS Tablet as it may decrease blood cell count, which can be a serious side effect. However, please consult your doctor before taking other medicines with Sulfasafe DS Tablet to avoid drug interactions.

Country of origin

INDIA

Manufacturer/Marketer address

4507, TNHB Colony, Villapuram, Madurai, Tamil Nadu, 625012, India
Other Info - SUL0143

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