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Written By ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Oct 9, 2024 | 12:40 PM IST
SZN 1000 Tablet is used to treat bowel diseases (ulcerative colitis, Crohn's disease), skin-related problems (psoriasis), and chronic joint diseases (rheumatoid arthritis, ankylosing spondylitis) in children and adults. It contains Sulfasalazine, which works as an inflammation reducer by acting locally, inhibiting the formation of a chemical known as prostaglandins, that control pain and inflammation. Thus, it helps reduce the inflammation of the intestine, skin, and joints. In some cases, you may experience a sore throat, a fever, unexplained bruising, or ringing in your ears (tinnitus). Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Manufacturer/Marketer

Hetero Healthcare Pvt Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Apr-26

for this medicine

About SZN 1000 Tablet

SZN 1000 Tablet is used to treat bowel diseases (ulcerative colitis, Crohn's disease), skin-related problems (psoriasis), and chronic joint diseases (rheumatoid arthritis, ankylosing spondylitis) in children and adults. 

SZN 1000 Tablet works as an inflammation reducer by acting locally, inhibiting the formation of a chemical known as prostaglandins, which control pain and inflammation. Together, it helps reduce the inflammation of the intestine, skin, and joints. 

Your doctor will advise you on how often you take your tablets based on your medical condition. In some cases, you may experience a sore throat, a fever, unexplained bruising, or ringing in your ears (tinnitus). Most of these side effects of SZN 1000 Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, please reach out to your doctor.

SZN 1000 Tablet can also lower your sperm count, leading to a temporary decrease in male fertility. In this case, you can speak to your doctor. Your doctor might arrange a blood test before you start taking SZN 1000 Tablet . You can continue taking SZN 1000 Tablet to prevent flares up during the pregnancy. Besides this, your doctor may prescribe additional folic acid supplements during pregnancy because SZN 1000 Tablet may reduce the level of folic acid in your body. SZN 1000 Tablet can be safely taken while you are breastfeeding unless the baby is premature or at risk of jaundice.

Uses of SZN 1000 Tablet

Treatment of Ulcerative colitis, Crohn's disease, Rheumatoid arthritis, Ankylosing spondylitis, Psoriatic arthritis, and Juvenile idiopathic arthritis.

Medicinal Benefits

SZN 1000 Tablet works by reducing the inflammation in the colon. It inhibits the formation of a chemical, prostaglandin, which controls inflammation. Together, they help in reducing the inflammation at all the sites like joints, skin, and bowel (intestines), thereby treating a wider range of joint, skin and bowel diseases, including ulcerative colitis, Crohn's disease, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, juvenile idiopathic arthritis. SZN 1000 Tablet is not a pain killer. Rather, it is an anti-inflammatory.

Directions for Use

SZN 1000 Tablet should not be used unless prescribed by a doctor. Take this medicine as directed by your doctor. Swallow SZN 1000 Tablet with a full glass of water. If required, the tablets can be broken in half to take a smaller dose. It should be taken with food to avoid an upset stomach. It is advised to drink plenty of water while taking SZN 1000 Tablet to prevent the formation of kidney stones.

Storage

Store in a cool and dry place away from sunlight

Side Effects of SZN 1000 Tablet

  • Headache
  • Indigestion
  • Nausea
  • Watery diarrhoea

Drug Warnings

 SZN 1000 Tablet treatment is generally considered to be safe during pregnancy, but its usage in pregnant mothers should be discussed with the doctor if planning for pregnancy. This medication should be avoided in breastfeeding mothers as it passes into the milk and causes jaundice and brain problems in infants less than 2 years of age. Tell your doctor if you have an allergy to any other sulpha drugs (sulfonamide antibiotic) as it may cause serious skin allergies like urticaria and stevens johnson’s syndrome. In men, an intake of SZN 1000 Tablet may lower the sperm count, which improves after stopping this medicine. Tell your doctor if you have asthma, wheezing, fever, breathing difficulties, sudden severe skin rash, unusual bleeding, sore throat, fever, unexplained bruising, or any other symptoms of infection. Use of SZN 1000 Tablet may change the colour of your urine, contact lenses, and tears to yellow/orange and even make your skin more sensitive to the sunlight. But, this is normal, harmless, and nothing to worry about. You may low folic acid in pregnancy while taking SZN 1000 Tablet so your doctor might prescribe you iron or folic acid supplements.

Drug Interactions

Drug-Drug Interaction: SZN 1000 Tablet may interact with blood thinner (warfarin), heart disease medicine (digoxin), iron supplements (folate), anti-diabetic medicine (glimepiride, glyburide, glipizide, antibiotics (methenamine), immune system affecting drug (azathioprine, mercaptopurine), anti-arthritis or anti-cancer drug (methotrexate) and anti TB drug (isoniazid). 

Drug-Food Interaction: No relevant interaction be found. 

Drug-Disease Interaction: SZN 1000 Tablet should not be given to the people affected with colitis intestinal obstruction, urinary obstruction, hematologic toxicity, hypersensitivity or allergic reactions, liver disease, porphyria and kidney disease.

Drug-Drug Interactions Checker List

  • WARFARIN
  • DIGOXIN
  • GLIMEPIRIDE
  • GLYBURIDE
  • GLIPIZIDE
  • METHENAMINE
  • AZATHIOPRINE
  • MERCAPTOPURINE
  • METHOTREXATE
  • ISONIAZID

Habit Forming

No

Diet & Lifestyle Advise

  •  It is advised to drink plenty of water to prevent the occurrence of kidney stones.

  •  Take low fibre foods such as white rice, white pasta, bread, egg, fish, tofu, butter, etc. to avoid triggering ulcerative colitis.

  •  Exercise regularly to suppress inflammation in the body.

  •  Manage stress by doing meditation and deep breathing exercises.

  •  Eat smaller meals to avoid pain in the stomach.

  •  Avoid foods that can increase or worsen ulcerative colitis such as milk, milk products, raw fruits and vegetables, beans, spicy foods, popcorn, artificial sweeteners, nuts, seeds, and fatty foods.

Special Advise

 It is advised to drink plenty of water to prevent the occurrence of kidney stones or crystalloids.

Disease/Condition Glossary

Ulcerative colitis: It is an inflammatory disease of the bowels that causes irritation, inflammation, and ulcers in the lining of the large intestine (colon).

Crohn’s disease: It is an inflammatory bowel disease (IBD) characterized by inflammation of the digestive tract.

Psoriasis: It is a skin disease in which our skin cells start multiplying faster, building up bumpy red patches covered with white scales.

Rheumatoid arthritis and Ankylosing spondylitis: They are the most common rheumatic diseases affecting joints and the spine, leading to chronic inflammation and painful conditions, ultimately leading to disability.

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Alcohol

Unsafe

It is not recommended to consume alcohol while taking SZN 1000 Tablet to avoid unpleasant side-effects.

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Pregnancy

Caution

SZN 1000 Tablet should be recommended in pregnancy only if required. In case, if prescribed to a pregnant woman, it is advised to increase the folate supplementation after consulting your doctor.

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Breast Feeding

Caution

SZN 1000 Tablet is excreted in breastmilk and is not recommended especially if the baby is premature or is at the risk of jaundice. It might cause kernicterus (excessive levels of bilirubin in the blood) in the new-born.

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Driving

Safe if prescribed

SZN 1000 Tablet does not affect the ability to drive. However, if you feel drowsy after taking SZN 1000 Tablet , it is advised not to drive.

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Liver

Unsafe

SZN 1000 Tablet is not recommended to use in patients suffering or having a history of liver diseases. In other people, rarely it can cause hepatitis (inflammation of the liver).

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Kidney

Unsafe

SZN 1000 Tablet is not recommended to use in patients suffering or having a history of kidney diseases. In other people, rarely it can cause inflammation of the kidneys.

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Children

Safe if prescribed

SZN 1000 Tablet should be advised in children only if prescribed by a child specialist.

Country of origin

India

Manufacturer/Marketer address

2Nd Floor, 8-3-166/7/1 Erragadda, Hyderabad-500018
Other Info - SZN0001

FAQs

SZN 1000 Tablet is used to treat bowel diseases (ulcerative colitis, Crohn's disease), skin-related problems (psoriasis), and chronic joint diseases (rheumatoid arthritis, ankylosing spondylitis).
Yes, SZN 1000 Tablet is contraindicated in patients with intestinal or urinary obstruction, patients with porphyria (liver disorders), and patients hypersensitive to sulfasalazine, its metabolites, sulfonamides, or salicylates.
Yes, SZN 1000 Tablet is said to affect fertility in males as it can cause a fall in sperm count. However, it is only affected by the time this medicine is taken.
Yes, SZN 1000 Tablet is safe to use in breastfeeding. However, please inform your doctor if the baby is premature or is at risk of jaundice as this medicine might not be advised in such cases.
Yes, SZN 1000 Tablet can affect the blood count but it is rare. There is a decrease in the number of white blood cells (infection-fighting cells). In some cases, the bone marrow might completely stop producing a specific type of white blood cell, this condition is known as agranulocytosis. It occurs within two months of starting this medicine and might be accompanied by symptoms such as fever and rash. This condition resolves within one or two weeks after this medicine is discontinued.
No, SZN 1000 Tablet is a disease-modifying anti-rheumatic drug’ (DMARD) and not a painkiller. So, if you are taking a painkiller before starting this medicine, you can continue taking it along with SZN 1000 Tablet .
No, SZN 1000 Tablet should be taken in the dose and duration as advised by the doctor. If you take it in more than the recommended dose, it might cause unpleasant side-effects. If you think your symptoms are not improving, please consult your doctor.
SZN 1000 Tablet in rare cases may cause blood disorders so your doctor may ask you to have blood count, electrolytes, urea, creatinine, and liver function tests every 3 months for the first year and every 6 months next year onwards.
If well tolerated you should take a prescribed dose of SZN 1000 Tablet while the disease remains in remission. Do not stop taking your medicine unless your doctor tells you to do so.
SZN 1000 Tablet may cause central nervous system adverse effects such as serious psychiatric problems including mania, depression, and psychosis, and these symptoms have been reported to occur only infrequently.
The side effects of SZN 1000 Tablet include headache, nausea, indigestion and watery diaarhoea. If these side effects persist or worsen, please consult your doctor.
SZN 1000 Tablet takes about 6 to 12 weeks to show the full effect. After using SZN 1000 Tablet , you might feel better in 4 weeks, although this can vary from person to person and some patients may notice improvement after 3 months. Do not stop taking SZN 1000 Tablet without first consulting your doctor.
SZN 1000 Tablet may affect the kidney function, although it is rare. Therefore, before using SZN 1000 Tablet , it is important that your kidney function remains normal. If your kidney functions become abnormal during treatment with SZN 1000 Tablet , please consult your doctor.
You are recommended to avoid using azathioprine along with SZN 1000 Tablet as it may decrease blood cell count, which can be a serious side effect. However, please consult your doctor before taking other medicines with SZN 1000 Tablet to avoid drug interactions.

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