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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Oct 22, 2024 | 7:38 PM IST
Stiloz 50 Tablet is used to treat pain in the legs due to insufficient blood flow (intermittent claudication). It also reduces cramping, numbness or weakness in the legs on walking in such patients. It contains Cilostazole, which works by widening the blood vessels and reducing the blood clotting time, thereby decreasing stickiness in blood vessels. Hence, increasing the blood supply to the limbs. It can also increase the distance you can walk without pain since it improves your leg's blood circulation. It is recommended in patients whose pain has not improved even after lifestyle changes like quitting smoking and doing regular exercise. In some cases, you may experience headaches, ankle swelling, diarrhoea, abnormal stools, vomiting, and nausea.
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Composition

CILOSTAZOLE-50MG

Manufacturer/Marketer

Glenmark Pharmaceuticals Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Stiloz 50 Tablet

Stiloz 50 Tablet contains vasodilator (blood vessel widening) medication, Cilostazole, which is primarily used to treat pain in the legs due to insufficient blood flow (intermittent claudication). It also reduces cramping, numbness or weakness in the legs on walking in such patients. Intermittent claudication is a peripheral vascular disease in which you have cramp-like pain in your legs when you walk and is caused by an insufficient blood supply in your legs.

Stiloz 50 Tablet works by widening the blood vessels and reducing the blood clotting time, thereby decreasing stickiness in blood vessels. Hence, increasing the blood supply to the limbs. It can also increase the distance you can walk without pain since it improves your leg's blood circulation. It is recommended in patients whose pain has not improved even after lifestyle changes like quitting smoking and doing regular exercise.

Stiloz 50 Tablet should be taken regularly in dose and duration as advised by the doctor. It would be best to take it on an empty stomach and at a fixed time every day. Your doctor will advise you on the exact dosage and how often you must take Stiloz 50 Tablet based on your medical condition. In some cases, you may experience headaches, ankle swelling, diarrhoea, abnormal stools, vomiting, and nausea. Most of these side effects of Stiloz 50 Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Stiloz 50 Tablet should not be stopped abruptly without consulting the doctor as it may lead to unpleasant side effects. Also, it is not suitable for some people. Inform your doctor before starting Stiloz 50 Tablet if you have any kidney or liver disease, plan to become pregnant, or are breastfeeding. Also, lifestyle changes should be continued with Stiloz 50 Tablet for best results. Do not take the Stiloz 50 Tablet if you ever had heart failure, chest pain, heart disease, and blood pressure. Before taking the Stiloz 50 Tablet , inform your doctor about your medical history and ongoing therapies to rule out any potential adverse effects or interactions.

Uses of Stiloz 50 Tablet

Treatment of Intermittent claudication

Medicinal Benefits

Stiloz 50 Tablet contains, Cilostazole, which is a vasodilator that works by widening the blood vessel and reducing the blood clotting time, thereby decreasing stickiness in blood vessels. Hence, increasing the blood supply to the limbs. It can also increase the distance you can walk without pain since it improves your legs' blood circulation. It is recommended in patients whose pain has not improved even after lifestyle changes like quitting smoking and doing regular exercise.

Directions for Use

Swallow the medicine as a whole with water; do not crush, break or chew it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Stiloz 50 Tablet

  • Headaches

  • Ankle swelling

  • Diarrhoea

  • Abnormal stools

  • Vomiting

  • Nausea

Drug Warnings

Stiloz 50 Tablet should not be given to the people allergic to Stiloz 50 Tablet , have low blood pressure (less than 90 mm of Hg), have had a heart attack, kidney disease, liver disease, pregnant women or planning to get pregnant and breastfeeding women. Do not take Stiloz 50 Tablet with grapefruit juice or St John wort plant as it might affect the absorption of Stiloz 50 Tablet .  Tell your doctor that you are using Stiloz 50 Tablet before undergoing any dental or other surgery. Your doctor might stop this medicine before the surgery. It is best to take Stiloz 50 Tablet on an empty stomach and at a fixed time every day. Stiloz 50 Tablet should not be stopped abruptly without consulting the doctor as it may lead to unpleasant side effects. Also, lifestyle changes should be continued with Stiloz 50 Tablet for best results and a speedy recovery.

Drug Interactions

Drug-Drug Interactions: Stiloz 50 Tablet interacts with some medicines, so it should be used with caution with blood thinners (rivaroxaban, aspirin), antibiotics (erythromycin, clarithromycin or rifampicin), anti-fungal  (ketoconazole), anti-hypertensive (diltiazem, lovastatin, simvastatin, atorvastatin),  anti-migraine (ergotamine, dihydroergotamine), sedatives or hypnotics (buspirone), certain antidepressants (fluoxetine and lithium), medicines to lower blood pressure (methyldopa), anti-Parkinson’s (levodopa, pramipexole, ropinirole), anti-epilepsy (phenobarbital, carbamazepine, phenytoin, rifampicin, primidone, oxcarbazepine, ethosuximide, valproate).

Drug-Food Interactions: Grapefruit juice intake and St. John’s wort (An herbal remedy for depression) should be avoided with Stiloz 50 Tablet as it may interact with Stiloz 50 Tablet to produce unpleasant side effects.

Drug-Disease Interactions: Stiloz 50 Tablet should be taken with caution in people with a bleeding problem, have had a heart attack, kidney disease, liver disease, pregnant women or planning to get pregnant and breastfeeding women.

Drug-Drug Interactions Checker List

  • ERYTHROMYCIN
  • CLARITHROMYCIN
  • RIFAMPICIN
  • DILTIAZEM
  • SIMVASTATIN
  • BUSPIRONE
  • LEVODOPA
  • VALPROATE

Habit Forming

No

Diet & Lifestyle Advise

  • Exercising regularly helps in improving overall health. Take a break between exercises if you feel uneasy. Finding the right exercise is the key.

  • Rest well, and get plenty of sleep.

  • Take proper care of your legs and feet.

  • Wear shoes that fit you well.

  • Check your feet daily for any cracks or sores.

  • Try to stay warm. Avoid cold temperatures.

  • Avoid smoking and alcohol consumption.

  • Meditation and yoga can help lower stress, decrease pain sensitivity and improves coping skills.

  • Acupuncture can be helpful by stimulating pressure points.

  • Using essential oils for massages can help increase circulation.

Disease/Condition Glossary

Intermittent claudication: Intermittent claudication, also known as vascular claudication, is a symptom in which muscle pain or mild exertion occurs during exercise. The pain is generally felt in the calf muscle. Symptoms include cramp, ache, fatigue, and numbness.

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Alcohol

Safe if prescribed

No interaction found; in case of any discomfort, consult your doctor.

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Pregnancy

Caution

Stiloz 50 Tablet is not recommended during pregnancy unless your doctor considers it essential. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

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Breast Feeding

Unsafe

Stiloz 50 Tablet is not recommended for breastfeeding mothers as it may harm the baby.

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Driving

Caution

Drive with caution, Stiloz 50 Tablet may cause blurry vision and dizziness or weariness may occur.

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Liver

Caution

Stiloz 50 Tablet to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Stiloz 50 Tablet to be taken with caution, especially if you have a history of kidney diseases/conditions. The dose may have to be adjusted by your doctor.

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Children

Unsafe

Stiloz 50 Tablet is not recommended for children. The safety and effectiveness of Stiloz 50 Tablet have not been established in children due to limited testing of this drug on children. If necessary, your doctor will decide whether to give Stiloz 50 Tablet or not.

Country of origin

India

Manufacturer/Marketer address

Glenmark Pharmaceuticals Limited, B/2, Mahalaxmi Chambers, 22, Bhulabhai Desai Road, Mumbai – 400 026.
Other Info - STI0144

Author Details

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FAQs

Stiloz 50 Tablet is used to treat intermittent claudication (pain in the legs due to insufficient blood flow). It also reduces cramping, numbness, or weakness in the legs when walking in such patients.
Stiloz 50 Tablet works by widening the blood vessel and reducing the blood clotting time, thereby decreasing stickiness in blood vessels. Hence, increasing the blood supply to the limbs. It can also increase the distance you can walk without pain since it improves your leg's blood circulation.
No, you should not stop taking Stiloz 50 Tablet even if you feel better as the pain might come back and become even worse.
Yes, taking Stiloz 50 Tablet can increase bleeding risk as it contains cilostazole, which increases bleeding time. So, please be very cautious while shaving, cutting fingernails or toenails, or using sharp objects to avoid bleeding. Let your doctor know before going any surgical procedure that you are taking Stiloz 50 Tablet .
No, it is a prescribed drug given by a physician for preventing specific medical conditions. Taking it on your own can cause unwanted side-effects.
If you forget to take Stiloz 50 Tablet at any time, take it as soon as you remember, then continue to take it at the usual times. Do not take a double dose to make up for a forgotten dose.
Yes, Stiloz 50 Tablet contains cilostazole which increases the blood clotting time. It works by preventing platelets (a type of blood cell) from sticking together and forming clots, preventing heart attack and stroke.
Stiloz 50 Tablet may cause side effects like headaches, ankle swelling, diarrhoea, abnormal stools, vomiting, and nausea. Most of these side effects of Stiloz 50 Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.
Stiloz 50 Tablet might lower the blood pressure; taking Stiloz 50 Tablet with blood pressure-lowering medicines might further decrease the blood pressure. Therefore, please consult the doctor before taking Stiloz 50 Tablet with other blood pressure-lowering medicines.
You may notice an improvement in 2-4 weeks. However, it might take 12 weeks to notice the full benefits of Stiloz 50 Tablet . Keep taking Stiloz 50 Tablet for the prescribed duration to treat your condition effectively.
No, do not smoke if you are taking Stiloz 50 Tablet as smoking might affect the working of Stiloz 50 Tablet .
You are advised to take Stiloz 50 Tablet for the duration prescribed by the doctor. The duration of treatment will depend upon your condition and response to the treatment.
Yes, you may need to stop taking Stiloz 50 Tablet a few days before surgery to avoid the increased risk of bleeding during the procedure. Let the doctor know if you are due to undergo surgery.
Stiloz 50 Tablet might lower the blood pressure as it widens the blood vessels. Therefore, if you have low blood pressure/high blood pressure or if you are taking blood pressure-lowering medicines, please consult the doctor.
Stiloz 50 Tablet is not advised for patients with heart failure due to its potential to increase platelet aggregation, which could lead to higher mortality rates in these individuals.

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