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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Sizep 50 mg Tablet is used to treat schizophrenia. Additionally, it is also used to reduce the risk of suicidal behaviour in patients with schizophrenia or other similar disorders. It contains Clozapine, which helps in improving mood, behaviour and thoughts. It may cause side effects such as tachycardia (fast heartbeat), dizziness, headache, tremor, sweating, dry mouth, nausea, constipation and visual disturbances. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

CLOZAPINE-50MG

Manufacturer/Marketer :

Tripada Lifecare Pvt Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Sizep 50 mg Tablet

Sizep 50 mg Tablet is used to treat schizophrenia. Additionally, Sizep 50 mg Tablet is also used to reduce the risk of suicidal behaviour in patients with schizophrenia or other similar disorders. Schizophrenia is a medical condition in which the person may feel, hear or see things that are not there, believe things that are not true, or feel unusually suspicious or confused.

Sizep 50 mg Tablet contains ‘Clozapine’, which works by blocking the effects of chemical receptors in the brain, such as dopamine and serotonin. Thus, it helps in improving mood, behaviour and thoughts.

You are advised to take Sizep 50 mg Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, Sizep 50 mg Tablet may cause side effects such as tachycardia (fast heartbeat), dizziness, headache, tremor, sweating, dry mouth, nausea, constipation and visual disturbances. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Please do not stop taking Sizep 50 mg Tablet suddenly, as it might cause withdrawal symptoms. Consult your doctor if you are pregnant. Do not take Sizep 50 mg Tablet if you are breastfeeding, as it may pass into breastmilk. Avoid driving as Sizep 50 mg Tablet may cause drowsiness and dizziness. Sizep 50 mg Tablet should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol with Sizep 50 mg Tablet as it could lead to increased drowsiness and dizziness. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Sizep 50 mg Tablet

Treatment of Schizophrenia

Directions for Use

Tablet/Capsule: Swallow it as a whole with a glass of water; do not chew or crush it.Orodispersible/Mouth dissolving tablet: Check the label for directions before use. Place the tablet in the mouth and allow it to dissolve.

Medicinal Benefits

Sizep 50 mg Tablet belongs to a group of medicines called antipsychotics. Sizep 50 mg Tablet is used to treat schizophrenia and to reduce the risk of suicidal behaviour in patients with schizophrenia or other similar disorders. Sizep 50 mg Tablet works by blocking the effects of chemical receptors in the brain, such as dopamine and serotonin, thereby helping in improving mood, behaviour and thoughts. Sizep 50 mg Tablet is used to treat schizophrenia when other antipsychotic drugs are ineffective or have caused severe adverse effects. Sizep 50 mg Tablet is also used to treat psychotic disorders in patients with Parkinson’s disease when standard treatments have failed.

How Sizep 50 mg Tablet Works

Sizep 50 mg Tablet contains ‘Clozapine’, which works by blocking the effects of chemical receptors in the brain, such as dopamine and serotonin. Thus, it helps in improving mood, behaviour and thoughts.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Sizep 50 mg Tablet

  • Tachycardia (fast heartbeat)
  • Dizziness
  • Headache
  • Tremor
  • Sweating
  • Low blood pressure
  • Dry mouth
  • Nausea
  • Constipation
  • Visual disturbances

What if I have taken an overdose of Sizep 50 mg Tablet

Do not take more than the prescribed dose of Sizep 50 mg Tablet as it may cause overdose. The symptoms of overdose include sedation, fast heart rate, high blood pressure, respiratory depression or failure, delirium (serious changes in mental abilities), coma or excess saliva production. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Sizep 50 mg Tablet if you are allergic to any of its contents if you have galactose intolerance, total lactase deficiency, glucose-galactose malabsorption, low number of white blood cells or if you are taking medicines that can cause low levels of white blood cells, bone marrow disorder, epilepsy, circulatory collapse (pronounced fall in blood pressure that can lead to unconsciousness), brain disorders, severe kidney disease, heart disease, liver disease with jaundice, liver failure or paralytic ileus (small intestine disorder). Inform your doctor if you have a low number of white blood cells or platelet count, orthostatic hypotension, epilepsy, enlarged prostate or difficulty urinating, glaucoma, severe constipation, diabetes, heart, liver or kidney problems. Consult your doctor if you are pregnant. Do not take Sizep 50 mg Tablet if you are breastfeeding, as it may pass into breastmilk.

Drug-Drug Interactions

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ClozapineFlibanserin
Critical
ClozapineMetoclopramide
Critical

Drug-Drug Interactions

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ClozapineFlibanserin
Critical
How does the drug interact with Sizep 50 mg Tablet 10's:
When Flibanserin and Sizep 50 mg Tablet 10's are taken together, may increase side effects.

How to manage the interaction:
There may be a possibility of interaction between Sizep 50 mg Tablet 10's and Flibanserin, but it can be taken if prescribed by a doctor. If you notice any of these signs - like dizziness, drowsiness, fatigue, and difficulty concentrating, call a doctor right away. Do not stop using any medications without a doctor's advice.
ClozapineMetoclopramide
Critical
How does the drug interact with Sizep 50 mg Tablet 10's:
Co-administration of Metoclopramide with Sizep 50 mg Tablet 10's can increase the risk of side effects.

How to manage the interaction:
Taking Metoclopramide with Sizep 50 mg Tablet 10's is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.
ClozapineSparfloxacin
Critical
How does the drug interact with Sizep 50 mg Tablet 10's:
When Sizep 50 mg Tablet 10's is taken with Sparfloxacin, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Sizep 50 mg Tablet 10's with Sparfloxacin there may be a possibility of interaction, but it can be taken if prescribed by a doctor. Call a doctor immediately if you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without a doctor's advice.
ClozapinePimozide
Critical
How does the drug interact with Sizep 50 mg Tablet 10's:
When Sizep 50 mg Tablet 10's is taken with Pimozide, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Sizep 50 mg Tablet 10's with Pimozide there may be a possibility of interaction, but it can be taken if prescribed by a doctor. Call a doctor immediately if you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without a doctor's advice.
ClozapinePotassium citrate
Critical
How does the drug interact with Sizep 50 mg Tablet 10's:
Taking Sizep 50 mg Tablet 10's and Potassium citrate (in tablet or capsule form) together can increase the risk of stomach ulcers, bleeding, and other gastrointestinal injury.

How to manage the interaction:
Co-administration of Potassium citrate with Sizep 50 mg Tablet 10's is not recommended, as it may lead to an interaction, it can be taken if prescribed by the doctor. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
ClozapineRopinirole
Critical
How does the drug interact with Sizep 50 mg Tablet 10's:
When Ropinirole is taken with Sizep 50 mg Tablet 10's, it may not work as well.

How to manage the interaction:
Taking Ropinirole with Sizep 50 mg Tablet 10's is not recommended as it can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as drowsiness, low blood pressure, dizziness, and lightheadedness. Do not stop using any medications without consulting doctor.
ClozapineCisapride
Critical
How does the drug interact with Sizep 50 mg Tablet 10's:
When Sizep 50 mg Tablet 10's is taken with Cisapride, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Sizep 50 mg Tablet 10's with Cisapride there may be a possibility of interaction, but it can be taken if prescribed by a doctor. Call a doctor immediately if you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without a doctor's advice.
ClozapineDaratumumab
Severe
How does the drug interact with Sizep 50 mg Tablet 10's:
Taking daratumumab and Sizep 50 mg Tablet 10's may increase the risk of infection.

How to manage the interaction:
There may be a possibility of interaction between Daratumumab and Sizep 50 mg Tablet 10's, but it can be taken if prescribed by a doctor. If you're having any of these symptoms like fever, chills, sore throat, or muscle aches, it's important to contact your doctor right away. They may be able to recommend other options for you that won't cause any problems with your current medication. Don't worry, there are solutions available to help you feel better. Do not discontinue any medications without first consulting your doctor.
ClozapineTetrabenazine
Severe
How does the drug interact with Sizep 50 mg Tablet 10's:
Coadministration of Tetrabenazine with Sizep 50 mg Tablet 10's together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Although taking Tetrabenazine and Sizep 50 mg Tablet 10's together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
ClozapinePropylthiouracil
Severe
How does the drug interact with Sizep 50 mg Tablet 10's:
Combining Propylthiouracil with Sizep 50 mg Tablet 10's can increase the risk of infection.

How to manage the interaction:
Taking Propylthiouracil with Sizep 50 mg Tablet 10's together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, and pain during urination. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a healthy diet and exercise regularly.
  • Include fruits, vegetables, and fibre-rich food in your diet.
  • Cut down on sugars, salts and saturated fats.
  • Drink enough fluids to stay hydrated.
  • Regularly attend therapy sessions.
  • Perform meditation and yoga.
  • Follow a regular sleep pattern.
  • Avoid smoking and alcohol consumption.
  • Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

Habit Forming

No

Therapeutic Class

PSYCHOTHERAPEUTICS

Sizep 50 mg Tablet Substitute

Substitutes safety advice
  • Sizopin 50 Tablet 10's

    5.22per tablet
  • SKIZORIL 50MG TABLET

    5.22per tablet
  • Alkepin ODT 50 Tablet 10's

    by AYUR

    5.22per tablet
  • Cipin 50 mg Tablet 10's

    5.22per tablet
  • Closin-50 mg Tablet 10's

    5.22per tablet
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Sizep 50 mg Tablet as it may cause increased drowsiness.

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Pregnancy

Caution

Sizep 50 mg Tablet belongs to pregnancy category B. Please consult your doctor if you are pregnant before taking this medicine; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Unsafe

Sizep 50 mg Tablet is not recommended for use during breastfeeding.

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Driving

Unsafe

Sizep 50 mg Tablet causes tiredness, dizziness and vision problems. Do not drive or operate machinery if you experience these symptoms.

bannner image

Liver

Consult your doctor

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have liver problems or any concerns regarding this.

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Kidney

Consult your doctor

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney problems or any concerns regarding this.

bannner image

Children

Unsafe

Sizep 50 mg Tablet should not be given to children as safety and effectiveness have not been established.

FAQs

Sizep 50 mg Tablet is used to treat schizophrenia. Additionally, it is also used to reduce the risk of suicidal behaviour in patients with schizophrenia or other similar disorders.
Sizep 50 mg Tablet works by blocking the effects of chemical receptors in the brain, such as dopamine and serotonin, thereby improving mood, behaviour and thoughts.
Do not discontinue Sizep 50 mg Tablet without consulting your doctor, as it could cause withdrawal symptoms. To treat your condition effectually, continue taking Sizep 50 mg Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Sizep 50 mg Tablet .
Sizep 50 mg Tablet may cause agranulocytosis (low levels of white blood cells), making you more prone to infections. Consult your doctor immediately if you experience flu-like symptoms, sore throat or fever.
Dry mouth could be a side-effect of Sizep 50 mg Tablet . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.
Orthostatic hypotension could be a side-effect of Sizep 50 mg Tablet . Orthostatic hypotension is a sudden lowering in blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking; instead, lie down and get up slowly only when you feel better.
Sizep 50 mg Tablet may cause tachycardia (fast heartbeat). Talk to your doctor if you experience irregular or fast heartbeat even at rest, chest pain, unexplained tiredness or breathing problems.
Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take your regular dose. Please don't take a double dose to make up for a missed one.

Country of origin

India

Manufacturer/Marketer address

3 Yogi Complex, Nr Doordarshan, Kendra, Thaltej, Ahmedabad, India 380054.
Other Info - SIZ0031

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