Closin-50 mg Tablet is used to treat schizophrenia. Additionally, Closin-50 mg Tablet is also used to reduce the risk of suicidal behaviour in patients with schizophrenia or other similar disorders. Schizophrenia is a medical condition in which the person may feel, hear or see things that are not there, believe things that are not true, or feel unusually suspicious or confused.

Closin-50 mg Tablet contains ‘Clozapine’, which works by blocking the effects of chemical receptors in the brain, such as dopamine and serotonin. Thus, it helps in improving mood, behaviour and thoughts.

You are advised to take Closin-50 mg Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, Closin-50 mg Tablet may cause side effects such as tachycardia (fast heartbeat), dizziness, headache, tremor, sweating, dry mouth, nausea, constipation and visual disturbances. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Please do not stop taking Closin-50 mg Tablet suddenly, as it might cause withdrawal symptoms. Consult your doctor if you are pregnant. Do not take Closin-50 mg Tablet if you are breastfeeding, as it may pass into breastmilk. Avoid driving as Closin-50 mg Tablet may cause drowsiness and dizziness. Closin-50 mg Tablet should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol with Closin-50 mg Tablet as it could lead to increased drowsiness and dizziness. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Closin-50 mg Tablet belongs to a group of medicines called antipsychotics. Closin-50 mg Tablet is used to treat schizophrenia and to reduce the risk of suicidal behaviour in patients with schizophrenia or other similar disorders. Closin-50 mg Tablet works by blocking the effects of chemical receptors in the brain, such as dopamine and serotonin, thereby helping in improving mood, behaviour and thoughts. Closin-50 mg Tablet is used to treat schizophrenia when other antipsychotic drugs are ineffective or have caused severe adverse effects. Closin-50 mg Tablet is also used to treat psychotic disorders in patients with Parkinson’s disease when standard treatments have failed.

• Tachycardia (fast heartbeat)
• Dizziness
• Headache
• Tremor
• Sweating
• Low blood pressure
• Dry mouth
• Nausea
• Constipation
• Visual disturbances

Do not take Closin-50 mg Tablet if you are allergic to any of its contents if you have galactose intolerance, total lactase deficiency, glucose-galactose malabsorption, low number of white blood cells or if you are taking medicines that can cause low levels of white blood cells, bone marrow disorder, epilepsy, circulatory collapse (pronounced fall in blood pressure that can lead to unconsciousness), brain disorders, severe kidney disease, heart disease, liver disease with jaundice, liver failure or paralytic ileus (small intestine disorder). Inform your doctor if you have a low number of white blood cells or platelet count, orthostatic hypotension, epilepsy, enlarged prostate or difficulty urinating, glaucoma, severe constipation, diabetes, heart, liver or kidney problems. Consult your doctor if you are pregnant. Do not take Closin-50 mg Tablet if you are breastfeeding, as it may pass into breastmilk.

Drug-Drug Interactions: Closin-50 mg Tablet may interact with antipsychotic (aripiprazole, haloperidol, lurasidone, lithium, risperidone, quetiapine, olanzapine), anti-anxiety (lorazepam, alprazolam), anti-cholinergic (benztropine), anti-depressant (duloxetine, escitalopram, sertraline), anti-convulsant (divalproex sodium, clonazepam, lamotrigine),  muscle relaxants (carisoprodol, cyclobenzaprine),  antihistamines (cetirizine, diphenhydramine).

Drug-Food Interactions: Avoid consuming alcohol as it could lead to increased dizziness.

Drug-Disease Interactions: Inform your doctor if you have dementia (memory loss), CNS depression, liver disease, seizures, low blood pressure, diabetes, lipid alterations, weight gain, parkinsonism, acute alcohol intoxication, neuroleptic malignant syndrome (occurs due to reaction with antipsychotic drugs), tardive dyskinesia (repetitive, involuntary movements), QT interval prolongation, kidney impairment/disease, blood abnormalities, or hyperprolactinemia (higher levels of prolactin in the blood).

• ARIPIPRAZOLE
• OLANZAPINE
• RISPERIDONE
• QUETIAPINE
• HALOPERIDOL
• LURASIDONE
• LITHIUM
• LORAZEPAM
• ALPRAZOLAM
• BENZTROPINE MESYLATE
• DULOXETINE
• ESCITALOPRAM
• SERTRALINE
• DIVALPROEX SODIUM
• CLONAZEPAM
• LAMOTRIGINE

• Maintain a healthy diet and exercise regularly.
• Include fruits, vegetables, and fibre-rich food in your diet.
• Cut down on sugars, salts and saturated fats.
• Drink enough fluids to stay hydrated.
• Regularly attend therapy sessions.
• Perform meditation and yoga.
• Follow a regular sleep pattern.
• Avoid smoking and alcohol consumption.
• Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

• Regular monitoring of blood count is advised as Closin-50 mg Tablet may cause agranulocytosis (low white blood cells).

• Closin-50 mg Tablet may cause blood lipids (fats) alteration, which could lead to weight gain. Your doctor might monitor your weight and blood lipid levels regularly.

• If you have a liver disorder, regular liver function tests are recommended for as long as Closin-50 mg Tablet has been prescribed.

• Closin-50 mg Tablet might cause thrombosis (blood clotting in the vein). If you are due to have any surgery, inform your doctor that you are taking Closin-50 mg Tablet .

• Closin-50 mg Tablet might affect how your body controls temperature; therefore, be cautious while exercising, taking hot baths or sauna.

Schizophrenia: It is a severe mental illness in which the person may see, hear or feel things that are not there, believe things that are not true, or feel unusually suspicious or confused. Schizophrenia is a long-term disease that affects brain functioning. People with schizophrenia may seem like they have lost touch with reality, which might cause significant distress for the individual, their friends and family. The exact cause is unknown; however, conditions like genetics, environment, brain structure and function could be the risk factors. Symptoms include hallucinations, delusions, thought disorders, movement disorders, disorganised thinking, loss of interest, lack of emotions, etc.