Simbrinza Opthalmic Suspension 5 ml is indicated for lowering high intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Glaucoma is an eye disease that causes damage to the optic nerve and results in reduced vision. Ocular hypertension is increased pressure in the eye due to poor drainage of aqueous humour (fluid in the eye that maintains normal pressure by its continuous flow). 
 
Simbrinza Opthalmic Suspension 5 ml is a combination of two drugs: Brinzolamide (carbonic anhydrase inhibitor) and Brimonidine (alpha-2 adrenergic receptor agonist). Simbrinza Opthalmic Suspension 5 ml decreases the production of aqueous humour, thereby helping lower the increased pressure in the eye. 
 
In some cases, you may experience certain common side effects such as blurred vision, eye redness, discomfort, drowsiness and bad taste in the mouth. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Consult a doctor if you are pregnant or breastfeeding. Simbrinza Opthalmic Suspension 5 ml is not recommended for children below 18 years as the safety and effectiveness have not been established. Simbrinza Opthalmic Suspension 5 ml might cause dizziness, drowsiness, and abnormal/blurred vision, so drive only if you have clear vision. Avoid touching the tip of the dropper as it may contaminate the contents.

Simbrinza Opthalmic Suspension 5 ml is a combination of two drugs: Brinzolamide (carbonic anhydrase inhibitors) and Brimonidine (alpha-2 adrenergic receptor agonists). Simbrinza Opthalmic Suspension 5 ml is indicated for lowering high intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Simbrinza Opthalmic Suspension 5 ml decreases the production of aqueous humour, thereby helping lower the increased pressure in the eye. 

• Blurred/abnormal vision
• Eye redness
• Eye discomfort
• Drowsiness
• Bad taste in the mouth 
• Dry mouth
• Dizziness
• Eye surface inflammation
• Eye pain

Do not take Simbrinza Opthalmic Suspension 5 ml if you are allergic to any of its components, if you are taking monoamine oxidase inhibitors, antidepressants, if you have severe kidney problems or excess acidity in the blood. Inform your doctor if you have liver problems, narrow-angle glaucoma, dry eyes, cornea problems, coronary heart disease, depression, poor or disturbed blood circulation. Consult a doctor before using Simbrinza Opthalmic Suspension 5 ml if you are pregnant or breastfeeding. Simbrinza Opthalmic Suspension 5 ml is not recommended for children below 18 years as safety and effectiveness have not been established. Simbrinza Opthalmic Suspension 5 ml might cause dizziness, drowsiness, abnormal/blurred vision; so, drive only if you are alert.

Drug-Drug Interactions: Inform your doctor if you are taking digitalis glycoside (digoxin), drugs used to treat glaucoma (acetazolamide, methazolamide, dorzolamide), antipsychotics (chlorpromazine), an alkaloid (reserpine), antidepressants, antiviral, antifungal, anaesthetics, sedatives, opiates, and barbiturates.

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Inform your doctor if you have severe kidney problems, depression, heart problems, or excess acidity in the blood.

• DIGOXIN
• ACETAZOLAMIDE
• METHAZOLAMIDE
• DORZOLAMIDE
• CHLORPROMAZINE
• RESERPINE

• Include fresh fruits and vegetables in your diet.

• Avoid smoking and alcohol consumption.

• Avoid intake of baked foods such as cakes, cookies, doughnuts or fried items such as French fries and stick margarine as these foods may worsen glaucoma and damage the optic nerve.

• Cut down your coffee intake as it may increase pressure in the eye. Replace coffee with green tea.

• Avoid exercises such as any position where the head is lower than the body, like an inverted yoga pose, as it may increase pressure in the eye. Doing selective exercises is advised for glaucoma patients.

Glaucoma: It is an eye condition that causes damage to the optic nerve (essential for good vision) due to abnormally increased pressure in the eye. If it is not treated in time, it may cause blindness. Usually, there are no symptoms of glaucoma initially, except the slow loss of vision gradually. However, some symptoms include visible rainbow-coloured circles around bright lights or blurred vision. Rarely, glaucoma can develop suddenly with intense pain in the eye, visual disturbance or nausea.

Ocular hypertension: It is a condition caused by poor drainage of aqueous humour (fluid in the eye that maintains normal pressure by its continuous flow). This leads to a build-up of excess fluid in the eye, resulting in increased pressure inside the eye without any damage to the optic nerve. If ocular hypertension is not controlled, it may lead to glaucoma.