Shiril 25mg Tablet is used to treat schizophrenia or psychosis and bipolar disorder (manic depression). Schizophrenia is characterized by hallucinations symptoms (seeing or hearing things that are not real) and delusions (wrong beliefs). Manic episodes of excitement or depression characterize bipolar disorder. Shiril 25mg Tablet prevents the occurrence of these symptoms. 

Shiril 25mg Tablet contains ‘Thioridazine,’ which is an antipsychotic drug. It acts by blocking dopamine, a neurotransmitter in the brain responsible for developing schizophrenia and bipolar disorder symptoms. Shiril 25mg Tablet rebalances dopamine to improve thinking, mood and behaviour. It also blocks the other natural substance receptors in the brain, such as histamine and muscarinic, thereby preventing nausea and vomiting.

Take Shiril 25mg Tablet as prescribed by your doctor. You are advised to take Shiril 25mg Tablet as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience common side effects such as sleepiness, orthostatic hypotension (sudden lowering of blood pressure on standing), dry mouth, abnormality of voluntary movements, weight gain, urinary retention, constipation, muscle stiffness, and tremor. Most of these side effects of Shiril 25mg Tablet do not require medical attention and gradually resolve over time. However, if these side effects persist longer, please consult your doctor.

Do not take Shiril 25mg Tablet if you are allergic to Thioridazine or any other ingredients present in it. Before taking Shiril 25mg Tablet, talk to your doctor if you or your family have a history of blood clots, stroke or heart diseases and if you are above 65 years old and have a history of dementia (memory loss). Shiril 25mg Tablet is not recommended during pregnancy as it may affect the unborn baby. Tell your doctor if you are breastfeeding before taking Shiril 25mg Tablet. It is not recommended for use in children under 1 year of age. Shiril 25mg Tablet contains lactose, so it should not be given to people who are intolerant to some sugars. Please do not stop taking Shiril 25mg Tablet without your doctor’s advice, as it may lead to withdrawal symptoms.

Shiril 25mg Tablet works by helping to restore the balance of certain natural substances in the brain. The key action of Shiril 25mg Tablet is to block the dopamine receptors (D2) in the brain and correct dopamine's overactivity. Altogether, Shiril 25mg Tablet may help decrease hallucinations and help you think more clearly and positively about yourself, feel less agitated and take a more active part in everyday life. On the other hand, it also blocks histamine H1 and muscarinic M1 receptors in the vomiting centre, thereby preventing nausea and vomiting.

• Orthostatic hypotension (sudden lowering of blood pressure on standing)
• Sleepiness
• Dryness in mouth
• Urinary retention
• Weight gain
• Constipation
• Muscle stiffness
• Tremor

Do not take Shiril 25mg Tablet if you are allergic (hypersensitive) to Shiril 25mg Tablet or any ingredients present in it. Please consult your doctor before taking Shiril 25mg Tablet if you are pregnant or planning to conceive and breastfeed. Elderly patients (above 65 years) with dementia-related psychosis (memory loss) treated with antipsychotic drugs are at increased risk of death. Shiril 25mg Tablet injection is not recommended for treating patients with dementia-related psychosis. Do not abruptly stop taking the medication, as it may cause withdrawal symptoms, especially suicidal thoughts in young adults. If you are an asthmatic patient, please inform your doctor before taking a Shiril 25mg Tablet injection, as it may cause life-threatening allergic-type reactions, including anaphylactic symptoms. Before taking Shiril 25mg Tablet, talk to your doctor if you have a history of blood clots, alcohol or drug abuse, fits (seizures), Parkinson's disease, hypothyroidism (reduced activity of the thyroid gland), stroke or heart diseases and glaucoma (increased pressure in the eye).

Drug-drug interactions: Shiril 25mg Tablet may interact with some medications, including antidepressants (citalopram, escitalopram, bupropion), medicines for Parkinson’s disease (levodopa), antiepileptic ( carbamazepine, phenobarbital), medicines that control heartbeat ( amiodarone, disopyramide, quinidine), medicines used to calm emotion and mental disorder (olanzapine, prochlorperazine) antihypertensive (clonidine, guanethidine, propranolol), antibiotic (moxifloxacin) and medication used to treat mental illness (lithium).

Drug-food interactions: Shiril 25mg Tablet may interact with grapefruit and alcohol and increase the risk of side effects.

Drug-disease interactions: Shiril 25mg Tablet should be used with caution in patients with heart problems such as QT prolongation (heart rhythm problem), acute alcohol abuse, central nervous system (CNS) depression, hypokalemia (low levels of potassium in your blood), enlarged prostate gland, dementia, stroke, seizures, respiratory problems, Parkinson's disease, diabetes and liver or kidney problems.

• CITALOPRAM
• ESCITALOPRAM
• BUPROPION
• LEVODOPA
• CARBAMAZEPINE
• PHENOBARBITAL
• AMIDODARONE
• DISOPYRAMIDE
• QUINIDINE
• OLANZAPINE
• PROCHLORPERAZINE
• CLONIDINE
• GUANETHIDINE
• PROPRANOLOL
• MOXIFLOXACIN
• LITHIUM

• Monitor your mood. Keep track of your mood regularly, including factors such as sleep, medicine and activities that can impact your mood. Exercise daily.
• Exercise is nice to relieve tension. It can also avoid the weight gain that can be a side effect of your bipolar medication.
• You may also practice calming techniques such as meditation and deep breathing exercises.
• Get some normal sleep. Having enough sleep will help to stabilize your mood.
• Eat a healthy diet. Certain foods may affect your mood more than others. Consider keeping a food log to track what you eat and how certain foods make you feel. Talk to your doctor or nutritionist about foods that may help stabilize your mood.
• Stay optimistic. It will take time for your symptoms to improve after you start bipolar therapy, but you will feel relaxed knowing that you will get better and that the worst is most definitely behind you.
• A person should take a healthy diet that includes lots of fruits and vegetables, lean meats, skinless poultry, nuts, fish, whole grains, plant-based oils and low-fat dairy products will help to keep a person in good health.

• Geriatric patients with dementia-related psychosis treated with Shiril 25mg Tablet are at an increased risk of death, and please consult your doctor before taking Shiril 25mg Tablet.
• Monitor the levels of electrolytes (salts such as potassium and magnesium) in your blood, blood sugar and cholesterol level, and body weight while taking Shiril 25mg Tablet. 
• Regularly visit your optician for an eye examination as Shiril 25mg Tablet is known to cause eye problems.
• Maintaining a healthy lifestyle and sticking to your treatment plan will help you do that.

Schizophrenia (psychosis): It is a mental illness in which brain information processing is affected. Patients with schizophrenia develop symptoms such as hallucinations (seeing or hearing unreal things), delusions (false beliefs) and become withdrawal from society. They lose the ability to differentiate reality from false beliefs. Schizophrenia and bipolar disorder may occur due to genetic factors, alcohol or drug abuse, or mental trauma. Schizophrenia may also occur due to brain injuries or diseases.

Bipolar disorder: Patients with bipolar disorders have mood swings ranging from manic episodes of heightened excitement to severe depression. It may occur due to genetic factors, alcohol or drug abuse and mental trauma. It used to be known as manic depression.