Setolac-MR Tablet is used to treat osteoarthritis, rheumatoid arthritis, pain, and muscle spasms. Osteoarthritis is a degenerative joint disease in which the two ends of the joints come together due to the breakdown of a protective covering (cartilage). Due to the absence of this protective covering, the joints rub against each other, leading to pain and stiffness. Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue), leading to joint pain and damage.
 
Setolac-MR Tablet is a combination of two drugs: Etodolac (NSAID) and Thiocolchicoside (Muscle relaxant). Etodolac blocks the effect of a chemical messenger known as cyclo-oxygenase (COX) enzyme that makes other chemical prostaglandins. By blocking the effect of COX enzymes, fewer prostaglandins are produced. This helps reduce mild to moderate pain and inflammation at the injured or damaged site. Thiocolchicoside works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements, thereby helping relieve pain due to muscle spasms.
 
You are advised to take Setolac-MR Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, Setolac-MR Tablet may cause common side effects such as nausea, vomiting, heartburn, stomach pain, and indigestion. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Consult your doctor if you are pregnant or breastfeeding. Setolac-MR Tablet may cause drowsiness and dizziness, so drive with caution. Setolac-MR Tablet is not recommended for children as safety and efficacy have not been established. Avoid consuming alcohol along with Setolac-MR Tablet as it could lead to increased dizziness; it might also increase the risk of stomach bleeding. Keep your doctor informed about your health condition and medicines to rule out any side effects/interactions.

Setolac-MR Tablet is a combination of two drugs: Etodolac (Non-Steroidal Anti-Inflammatory Drugs) and Thiocolchicoside (Muscle relaxant). Setolac-MR Tablet is used to treat osteoarthritis, rheumatoid arthritis, pain, and muscle spasms. Etodolac blocks the effect of a chemical messenger known as cyclo-oxygenase (COX) enzyme that makes another chemical, prostaglandins, which are produced at injury sites and cause pain and swelling. By blocking the effect of COX enzymes, fewer prostaglandins are produced. This helps reduce mild to moderate pain and inflammation at the injured or damaged site. Thiocolchicoside works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements, thereby helping relieve pain due to muscle spasms.

• Nausea
• Vomiting
• Heartburn
• Stomach pain
• Indigestion

Do not take Setolac-MR Tablet if you are allergic to any of its contents; if you have stomach ulcers, bleeding problems, clotting problems, inflammatory bowel disease, severe heart, liver or kidney problems, galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Inform your doctor if you have/had stomach bleeding or ulcers, heart failure, high blood pressure, diabetes, high cholesterol, kidney or liver impairment. Consult your doctor if you are pregnant or breastfeeding. Setolac-MR Tablet may cause drowsiness and dizziness, so drive only if you are alert. Setolac-MR Tablet is not recommended for children as safety has not been established. Stop taking Setolac-MR Tablet and consult your doctor immediately if you have stomach pain or any signs of bleeding in the intestine or stomach, such as blood in stools. Do not take any other NSAIDs for pain relief along with Setolac-MR Tablet unless prescribed.

Drug-Drug Interactions: Setolac-MR Tablet may interact with pain killers (aspirin, ibuprofen, naproxen, diclofenac), anti-depressants (duloxetine, escitalopram), cardiac glycoside (digoxin), anti-hypertensives (metoprolol), blood thinners (warfarin), anti-psychotic (lithium), immunosuppressants (cyclosporine), steroids (mifepristone), quinolone antibiotics, diuretics, and sedative drugs.

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Inform your doctor if you have heart failure, fluid retention (oedema), asthma, gastrointestinal ulcer/bleeding, high blood pressure, hyperkalemia (high levels of potassium), thrombosis (formation of clots), anaemia (low red blood cells), galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption, heart, kidney or liver problems.

• ASPIRIN
• IBUPROFEN
• NAPROXEN
• DICLOFENAC
• DULOXETINE
• ESCITALOPRAM
• DIGOXIN
• METOPROLOL
• WARFARIN
• LITHIUM
• CYCLOSPORINE
• MIFEPRESTONE

• Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.

• Performing yoga may also help in improving joint flexibility and pain management.

• Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.

• Get adequate sleep, as resting the muscles can help reduce inflammation and swelling.

• De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.

• Acupuncture, massage and physical therapy may also be helpful.

• Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.

• Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.

• Avoid smoking and alcohol consumption.

Pain: Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Pain may be dull or sharp; it might be constant or may come and go. The tolerance level of pain might vary from person to person. Pain can be generalized (overall body aches) or localized (affecting a specific area of the body). The common causes of pain include headache, muscle strain, cramps, cuts, bone fractures, and arthritis.

Osteoarthritis: It is a joint disease in which the two ends of the joints come together due to the breakdown of a protective covering called cartilage. Due to the absence of this protective covering, the joints rub against each other, leading to pain and stiffness. Symptoms include pain, stiffness, inflammation and tenderness.

Rheumatoid arthritis: It is an auto-immune disease (the body's immune system attacks its tissue), leading to joint pain and damage. Symptoms of rheumatoid arthritis include pain, swelling, stiffness, deformities and loss of joint function. 

Muscle spasms: The sudden involuntary contractions of the muscle can be painful and uncomfortable. When the nerve impulses that control the muscle movements are damaged or interrupted, it could lead to muscle spasms. Symptoms include muscle tightness, joint stiffness, unusual posture, difficulty in moving, and pain in affected muscles and joints. Fatigue (weakness), stress, extreme heat or cold, infection and tight clothing can trigger muscle spasms.