Selgin Tablet belongs to a class of antiparkinson drugs called monoamine oxidase-B inhibitors used in the treatment of Parkinson’s disease. Parkinson’s disease is a central nervous system disorder that affects movement. It causes stiffness, shaking, difficulty in walking, coordination and balance. In Parkinson’s patients, there is a decrease in dopamine (a chemical messenger that is important for movement control) levels as the nerve cells that produce dopamine begin to die.

Selgin Tablet contains Selegiline that works by inhibiting the action of an enzyme called monoamine oxidase-B that naturally breaks down dopamine. Thereby, increases the level of dopamine and restores its level in the brain thereby improving the symptoms of Parkinson’s disease.

Take Selgin Tablet with or without food as advised by your doctor and swallow whole with a glass of water. Do not crush, chew or break it. Your doctor will advise you how often you take Selgin Tablet based on your medical condition. Some people may experience a sore mouth, swollen gums, loss of balance, difficulty in controlling movements, headache, dizziness, nausea, sleep disorders, mouth ulcers or constipation. Most of these side effects of Selgin Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Selgin Tablet or any other medicines, please tell your doctor. Avoid taking Selgin Tablet if you are pregnant or breastfeeding and consult a doctor. Selgin Tablet is not recommended for children. If you are about to undergo any surgery, please inform your doctor that you are taking Selgin Tablet as it may interact with certain medicines used as a part of general anaesthesia. Avoid taking Selgin Tablet if you have stomach or duodenal ulcers, angina (chest pain), high blood pressure, major heart or blood vessel problems, hyperthyroidism (overactive thyroid gland), fast or irregular heartbeat, narrow-angle glaucoma, pheochromocytoma (tumour of the adrenal gland), prostatic adenoma (tumour of prostate gland), schizophrenia, advanced dementia (loss of memory and other thinking abilities). If you have sleep problems, anxiety, a history of stomach ulcers, kidney or liver problems, any unusual urges like excessive gambling or increased sexual behaviour, inform your doctor before taking Selgin Tablet .

Selgin Tablet is an antiparkinson agent that is used in the treatment of Parkinson’s disease. In Parkinson’s patients, the nerve cells that produce dopamine (a chemical messenger that is important for movement control) begin to die. So, there is a decrease in dopamine levels. Selgin Tablet works by inhibiting the action of the monoamine oxidase-B enzyme that naturally breaks down dopamine. Thereby, increases dopamine in the brain and restores its levels. Thus, it improves the symptoms of Parkinson’s disease. Selgin Tablet can be used alone or in combination with other medicines such as levodopa to reduce uncontrolled movements.

• Sore mouth
• Swollen gums
• Loss of balance
• Difficulty in controlling movements
• Headache
• Dizziness
• Nausea
• Sleep disorders
• Mouth ulcers
• Constipation

If you are known to be allergic to Selgin Tablet or any other medicines, please tell your doctor. Avoid taking Selgin Tablet if you are pregnant or breastfeeding and consult a doctor. Selgin Tablet is not recommended for children. If you are about to undergo any surgery, please inform your doctor that you are taking Selgin Tablet as it may interact with certain medicines used as a part of general anaesthesia. Avoid taking Selgin Tablet if you have stomach or duodenal ulcers, angina (chest pain), high blood pressure, major heart or blood vessel problems, hyperthyroidism (overactive thyroid gland), fast or irregular heartbeat, narrow-angle glaucoma, pheochromocytoma (tumour of the adrenal gland), prostatic adenoma (tumour of the prostate gland), schizophrenia, advanced dementia (loss of memory and other thinking abilities). If you have sleep problems, anxiety, a history of stomach ulcers, kidney or liver problems, unusual urges like excessive gambling or increased sexual behaviour, inform your doctor before taking Selgin Tablet .

Drug-Drug Interaction: Selgin Tablet may have interaction with other antiparkinson’s drugs (rasagiline, levodopa, dopamine, amantadine), antidepressants (escitalopram, citalopram, fluvoxamine, fluoxetine, sertraline, venlafaxine, paroxetine, protriptyline, amitriptyline, duloxetine), opioid pain killers (pethidine, tramadol, codeine, meperidine), antibiotic (linezolid), medicines for migraine (naratriptan, sumatriptan, zolmitriptan, rizatriptan), medicines used to treat heart problems (digitalis), drugs used to treat ovarian cancer (altretamine), antianxiety drug (clonazepam), pain reliever (ibuprofen).

Drug-Food Interaction: Avoid intake of tyramine-rich foods such as broad beans, Bovril,  mature cheese, fermented soya bean products, or yeast extracts with Selgin Tablet as it may cause severe high blood pressure leading to stroke, heart attack, or chest pain. Selgin Tablet may interact with proteins in the food. Also, avoid alcohol intake as it may increase side effects such as drowsiness, dizziness, or difficulty concentrating.

Drug-Disease Interaction: Avoid taking Selgin Tablet if you have stomach or duodenal ulcers, angina (chest pain), high blood pressure, major heart or blood vessel problems, hyperthyroidism (overactive thyroid gland), fast or irregular heartbeat, narrow-angle glaucoma, pheochromocytoma (tumor of the adrenal gland), prostatic adenoma (tumor of the prostate gland), schizophrenia, advanced dementia (loss of memory and other thinking abilities). If you have sleep problems, anxiety, a history of stomach ulcers, or kidney or liver problems, inform your doctor before taking Selgin Tablet .

• RASAGILINE
• LEVODOPA
• DOPAMINE
• AMANTADINE
• ESCITALOPRAM
• CITALOPRAM
• FLUVOXAMINE
• FLUOXETINE
• SERTRALINE
• PAROXETINE
• PROTRIPTYLINE
• AMITRIPTYLINE
• VENLAFAXINE
• DULOXETINE
• PETHIDINE
• TRAMADOL
• CODEINE
• MEPERIDINE
• LINEZOLID
• SUMATRIPTAN
• ZOLMITRIPTAN
• RIZATRIPTAN
• DIGITALIS
• CLONAZEPAM
• IBUPROFEN
• NARATRIPTAN
• ALTRETAMINE

• Avoid intake of tyramine rich foods such as broad beans, Bovril, mature cheese, fermented soya bean products or yeast extracts.
• Eat more fibre rich foods to ease constipation.
• Drink plenty of water to avoid headaches due to dehydration.
• Avoid consumption of alcohol as it may increase drowsiness.

• Selgin Tablet may cause abnormalities in certain laboratory test results such as liver function tests and blood tests. Therefore, inform your doctor or lab technician that you are on treatment with Selgin Tablet before undergoing any tests.
• Selgin Tablet should not be used at daily doses of more than 2.5 mg/day due to the risks associated with a change in the amount of chemical messenger in the brain called a neurotransmitter. 
• Selgin Tablet is contraindicated for use with medicine containing meperidine, as serious reactions have been experienced in patients taking both medications together. 

Parkinson’s disease: It is a disorder of the central nervous system that affects movement due to nerve cell damage in the brain which decreases the levels of dopamine and leads to symptoms such as stiffness, tremor in one hand, shaking, difficulty in walking, coordination, and balance. This condition can last for many years or life-long. Treatment with medicines along with physiotherapy may help to control the symptoms and provide a quality life for as long as possible.