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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Sebri 300mg Tablet is used for the treatment of hypertension (high blood pressure) in adults. Additionally, it is used to reduce the risk of heart attack or stroke in adults. It contains Irbesartan, which widens and relaxes blood vessels. Thus, lowers high blood pressure. In some cases, you may experience nausea, vomiting, fatigue, and orthostatic hypotension. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

IRBESARTAN-300MG

Consume Type :

ORAL

Return Policy :

Not Returnable

About Sebri 300mg Tablet

Sebri 300mg Tablet belongs to a group of medicines known as angiotensin II receptor blockers indicated for the treatment of hypertension (high blood pressure) in adults. Additionally, Sebri 300mg Tablet is used to reduce the risk of heart attack or stroke in adults. Hypertension is a medical condition in which the blood pressure is elevated persistently in the arteries without any known cause. On the other hand, heart attack or stroke occurs due to blocked blood flow to the heart or brain, respectively.

Sebri 300mg Tablet works by blocking the action of a hormone called angiotensin II in the body, which causes the narrowing of blood vessels, leading to high blood pressure. Thereby, Sebri 300mg Tablet widens and relaxes blood vessels, lowering high blood pressure.

You can take Sebri 300mg Tablet irrespective of food and swallow it whole with a glass of water. Do not crush, chew, or break it. Your doctor will let you how often you should take your tablets based on your medical condition. In some cases, you may experience nausea, vomiting, fatigue, and orthostatic hypotension. Most of these side effects of Sebri 300mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor.

Sebri 300mg Tablet is not for pregnant women as its use during your pregnancy can cause injury and even death to your unborn baby. It is not known whether Sebri 300mg Tablet passes into your breast milk or not. Your doctor will decide if you will take Sebri 300mg Tablet while using Sebri 300mg Tablet and breastfeeding together. Prolonged intake of Sebri 300mg Tablet may cause high potassium in the blood (hyperkalemia). Avoid intake of potassium supplements with Sebri 300mg Tablet as it may lead to high potassium levels in the blood, so the doctor may ask you to have a regular check of your potassium level. Do not consume alcohol with Sebri 300mg Tablet as it may increase the risk of low blood pressure. Taking Sebri 300mg Tablet with painkillers (like aspirin and ibuprofen) can increase the risk of kidney problems and reduce the efficiency of Sebri 300mg Tablet.

Uses of Sebri 300mg Tablet

Treatment of Hypertension, Heart failure, Prevents heart attack & heart stroke.

Directions for Use

Swallow Sebri 300mg Tablet as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Sebri 300mg Tablet is used to treat high blood pressure and reduce the risk of heart attack or stroke. Sebri 300mg Tablet is an angiotensin II receptor blocker that decreases high blood pressure by widening and relaxing the blood vessels by blocks the action of a hormone called angiotensin II in the body which causes the narrowing of blood vessels leading to high blood pressure.

How Sebri 300mg Tablet Works

Sebri 300mg Tablet works by blocking the action of a hormone called angiotensin II in the body, which causes the narrowing of blood vessels, leading to high blood pressure. Thereby, Sebri 300mg Tablet widens and relaxes blood vessels, lowering high blood pressure.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Sebri 300mg Tablet

  • Nausea
  • Vomiting
  • Dizziness
  • Orthostatic hypotension
  • Fatigue

What if I have taken an overdose of Sebri 300mg Tablet

Do not take more than the prescribed dose of Sebri 300mg Tablet as it may cause overdose. The symptoms of overdose include low blood pressure, fast or slow heart rate. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Sebri 300mg Tablet is not recommended for people with impaired kidney function, diabetes or severe liver problems. Sebri 300mg Tablet may increase the risk of low blood pressure when taken with alcohol. Sebri 300mg Tablet may cause tiredness or dizziness in some people. Make sure you are not affected before driving. Breastfeeding women are advised to consult a doctor before taking Sebri 300mg Tablet. Avoid intake of potassium supplements with Sebri 300mg Tablet as it may lead to high potassium levels in the blood, so the doctor may ask you to have a regular check of your potassium level. Do not consume alcohol with Sebri 300mg Tablet as it may increase the risk of low blood pressure. Taking Sebri 300mg Tablet with painkillers (like aspirin and ibuprofen) can increase the risk of kidney problems and reduce the efficiency of Sebri 300mg Tablet.

Drug-Drug Interactions

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IrbesartanPotassium chloride
Severe
IrbesartanLofexidine
Severe

Drug-Drug Interactions

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IrbesartanPotassium chloride
Severe
How does the drug interact with Sebri 300mg Tablet:
Taking Sebri 300mg Tablet with Potassium chloride may increase potassium levels in the blood.

How to manage the interaction:
Although taking Sebri 300mg Tablet with Potassium chloride together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, or a slow or irregular heartbeat. Do not discontinue any medications without a doctor's advice.
IrbesartanLofexidine
Severe
How does the drug interact with Sebri 300mg Tablet:
Co-administration of Sebri 300mg Tablet with Lofexidine can decrease the low blood pressure, which may lead to side effects.

How to manage the interaction:
Taking Sebri 300mg Tablet with Lofexidine can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you notice any of these signs - slow heart rate, headache, feeling dizzy or lightheaded, or fainting - make sure to contact a doctor right away. Avoid activities requiring mental focus like driving, operating dangerous equipment. Be careful while getting up from a sitting or lying position. Do not discontinue any medications without consulting a doctor.
IrbesartanTizanidine
Severe
How does the drug interact with Sebri 300mg Tablet:
Combining Tizanidine with Sebri 300mg Tablet can increase the risk of low blood pressure.

How to manage the interaction:
Taking Sebri 300mg Tablet with Tizanidine together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you notice any of these signs - headache, dizziness, feeling lightheaded, or fainting, make sure to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
IrbesartanAmiloride
Severe
How does the drug interact with Sebri 300mg Tablet:
When used with Sebri 300mg Tablet, Amiloride may raise potassium levels in the blood. High potassium levels can cause hyperkalemia, which can lead to kidney failure, muscular paralysis, abnormal heart rhythm, and heart problems in extreme cases.

How to manage the interaction:
Although taking Amiloride and Sebri 300mg Tablet together may lead to an interaction it can be taken if prescribed by the doctor. However, consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, or a slow or irregular heartbeat. Do not discontinue any medications without a doctor's advice.
IrbesartanEnalapril
Severe
How does the drug interact with Sebri 300mg Tablet:
Due to additive or synergistic effects, coadministration of enalapril with Sebri 300mg Tablet may raise the risk of hyperkalemia, hypotension, syncope, and renal failure. In severe cases, hyperkalemia can lead to muscle paralysis,kidney damage, and cardiac problems. The risk is increased if you are elderly, dehydrated, or have a history of kidney or heart disease.

How to manage the interaction:
Although taking Enalapril together with Sebri 300mg Tablet may possibly result in an interaction, they can be taken together if prescribed by your doctor. However, contact your doctor immediately if you experience signs and symptoms of hyperkalemia, such as nausea, vomiting, confusion, numbness, tingling in hands and feet, and irregular heartbeat. It is advised to limit the intake of potassium-rich foods like tomatoes, bananas, mangoes, beans, and potassium-containing supplements. Do not discontinue any medication without consulting your doctor.
IrbesartanPotassium citrate
Severe
How does the drug interact with Sebri 300mg Tablet:
Taking Sebri 300mg Tablet with Potassium citrate may increase potassium levels in the blood, which can lead to kidney failure, muscular paralysis, and abnormal heart rhythm.

How to manage the interaction:
Although taking Sebri 300mg Tablet with Potassium citrate together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. It is essential to maintain proper fluid intake while taking these medications. It is advised to reduce the intake of potassium-rich foods. Do not discontinue any medications without a doctor's advice.
IrbesartanTrimethoprim
Severe
How does the drug interact with Sebri 300mg Tablet:
Taking Sebri 300mg Tablet with Trimethoprim may increase potassium levels in the blood and kidney problems.

How to manage the interaction:
Although taking Sebri 300mg Tablet with Trimethoprim together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult your doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, or a slow or irregular heartbeat. Do not discontinue any medications without a doctor's advice.
IrbesartanEnalapril
Severe
How does the drug interact with Sebri 300mg Tablet:
Using Enalapril together with Sebri 300mg Tablet may increase the risk of side effects such as low blood pressure, kidney function impairment, and a condition called hyperkalemia (high blood potassium).

How to manage the interaction:
Although taking Sebri 300mg Tablet with Enalapril together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, and feelings of heaviness in your legs. Do not stop using any medications without talking to a doctor.
IrbesartanRamipril
Severe
How does the drug interact with Sebri 300mg Tablet:
Taking Ramipril together with Sebri 300mg Tablet may increase the risk of side effects such as low blood pressure, kidney function impairment, and a condition called hyperkalemia (high blood potassium).

How to manage the interaction:
Although taking Sebri 300mg Tablet with Ramipril together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, or a slow or irregular heartbeat. Do not discontinue any medications without a doctor's advice.
IrbesartanMoexipril
Severe
How does the drug interact with Sebri 300mg Tablet:
Taking Sebri 300mg Tablet with Moexipril may cause low blood pressure, kidney function impairment, and increased potassium levels in the blood.

How to manage the interaction:
Although taking Sebri 300mg Tablet with Moexipril together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, or a slow or irregular heartbeat. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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IRBESARTAN-300MGPotassium rich foods
Moderate

Drug-Food Interactions

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IRBESARTAN-300MGPotassium rich foods
Moderate
Common Foods to Avoid:
Lentils, Orange Juice, Oranges, Raisins, Potatoes, Salmon Dried, Spinach, Sweet Potatoes, Tomatoes, Coconut Water, Beans, Beetroot, Broccoli, Bananas, Apricots, Avocado, Yogurt

How to manage the interaction:
Consuming potassium-containing substances during treatment with Sebri 300mg Tablet can lead to high potassium levels which may result in side effects like weakness, irregular heartbeat, confusion, tingling of the extremities, or feelings of heaviness in the legs. Avoid potassium-containing salt substitutes and over-the-counter potassium supplements during Sebri 300mg Tablet therapy.

Diet & Lifestyle Advise

  • Maintain a low-salt diet and minimize eating processed foods, as they contain more sodium. Try to replace salt with spices or herbs to add flavour to the food.
  • Regular exercise, such as cycling, walking, jogging, dancing, or swimming, should be done for a minimum of 30 minutes daily.
  • Chronic stress may also cause high blood pressure. Therefore, avoid stress by changing your expectations, readjusting your reactions to certain situations, and making time for yourself to do activities that you enjoy.
  • Maintain a diet that is rich in fruits, vegetables, whole grains and low-fat dairy products.
  • Avoid smoking and alcohol intake.

Habit Forming

No

Therapeutic Class

ANTI- HYPERTENSIVES

Sebri 300mg Tablet Substitute

Substitutes safety advice
  • Irovel 300 Tablet 10's

    28.08per tablet
  • XARB 300MG TABLET

    8.45per tablet
  • Aprovel 300mg Tablet

    22.31per tablet
  • Debipro 300mg Tablet

    15.03per tablet
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Alcohol

Caution

Not recommended. Sebri 300mg Tablet and alcohol together result in an abnormal decrease in blood pressure levels, thus strictly not to be taken together.

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Pregnancy

Unsafe

Not recommended in pregnant patients. Sebri 300mg Tablet is harmful to an unborn baby, especially in the first 3 months of pregnancy. Sebri 300mg Tablet is to be replaced with any other blood pressure-lowering drug on doctor consultation.

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Breast Feeding

Caution

Not recommended in breastfeeding patients. Enough data is not available on the usage of Sebri 300mg Tablet in breastfeeding mothers; thus, it is replaced with any alternative blood pressure-lowering agents in doctors' consultations.

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Driving

Safe if prescribed

Sebri 300mg Tablet is unlikely to affect your ability to drive or use heavy machines. However, occasionally, dizziness or slowness of movements may occur during the treatment of high blood pressure. If you experience these, talk to your doctor before attempting such activities.

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Liver

Caution

Sebri 300mg Tablet has been found to affect liver function in certain cases; thus, patients with liver problems should discuss with their doctor for proper guidance regarding treatment with this medication.

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Kidney

Caution

Sebri 300mg Tablet is not advised for patients with kidney disease as there have been cases of harmful interactions between kidney patients and Sebri 300mg Tablet. Patients are strictly advised to consult and discuss this medication with their doctors before taking it.

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Children

Safe if prescribed

It is safe to give to children under 12 years of age. No harmful interaction has been reported in patients under 12 years of age, yet doctor's consultation is advised.

FAQs

Sebri 300mg Tablet is indicated for the treatment of hypertension (high blood pressure) in adults. Additionally, it is used to reduce the risk of heart attack or stroke in adults.
Sebri 300mg Tablet may increase potassium levels in the blood (hyperkalemia). Therefore, it is recommended to avoid intake of potassium supplements and foods that are rich in potassium like coconut water, bananas and broccoli.
Only on doctors consultation, a patient can take Sebri 300mg Tablet with metformin which has been found to have a beneficial effect on kidneys in a diabetic patient with hypertension.
Not recommended in overweight patients as per studies conducted by researchers,Sebri 300mg Tablet causes weight gain in normal individuals and thus contraindicated in overweight patients.
Take the missed dose as soon as possible. if it has been too late then a patient is advised to jump to the next dose without attempting double dose to make up for the missed dose.
Absolutely safe to be used in patients with stomach ulcers as there has been no harmful interaction between Sebri 300mg Tablet and peptic ulcers except occasional nausea. Recently it has been found to have a protective role against stomach ulcers yet not approved for stomach diseases yet.

Country of origin

India
Other Info - SE17516

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